(Q36379368)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16441228%20AND%20SRC:MED&resulttype=core&format=json

16 January 2020

review article

1 reference

title

Protein lysine acetylation in normal and leukaemic haematopoiesis: HDACs as possible therapeutic targets in adult AML (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16441228%20AND%20SRC:MED&resulttype=core&format=json

16 January 2020

0 references

1 reference

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16441228%20AND%20SRC:MED&resulttype=core&format=json

16 January 2020

Bjørn Tore Gjertsen

6

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16441228%20AND%20SRC:MED&resulttype=core&format=json

16 January 2020

author name string

Øystein Bruserud

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16441228%20AND%20SRC:MED&resulttype=core&format=json

16 January 2020

Camilla Stapnes

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16441228%20AND%20SRC:MED&resulttype=core&format=json

16 January 2020

Anita Ryningen

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16441228%20AND%20SRC:MED&resulttype=core&format=json

16 January 2020

Nina Anensen

5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16441228%20AND%20SRC:MED&resulttype=core&format=json

16 January 2020

language of work or name

English

0 references

publication date

1 February 2006

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16441228%20AND%20SRC:MED&resulttype=core&format=json

Expert Opinion on Therapeutic Targets

16 January 2020

published in

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16441228%20AND%20SRC:MED&resulttype=core&format=json

16 January 2020

volume

10

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16441228%20AND%20SRC:MED&resulttype=core&format=json

16 January 2020

issue

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16441228%20AND%20SRC:MED&resulttype=core&format=json

16 January 2020

page(s)

51-68

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16441228%20AND%20SRC:MED&resulttype=core&format=json

Adult acute myeloid leukaemia.

16 January 2020

cites work

1 reference

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Targeted therapies in myeloid leukemia

21 January 2018

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Acetylation: a regulatory modification to rival phosphorylation?

21 January 2018

1 reference

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Acetylation of histones and transcription-related factors

21 January 2018

1 reference

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Lysine acetylation and the bromodomain: a new partnership for signaling

21 January 2018

1 reference

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Crystal structure of the nucleosome core particle at 2.8 A resolution

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.1.51

Transcription regulation by histone methylation: interplay between different covalent modifications of the core histone tails

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.1.51

Histone acetylation reduces nucleosome core particle linking number change

21 January 2018

1 reference

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Histone deacetylase inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.1.51

Histone deacetylases (HDACs): characterization of the classical HDAC family

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.1.51

Important roles of reversible acetylation in the function of hematopoietic transcription factors.

21 January 2018

1 reference

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Class II histone deacetylases: from sequence to function, regulation, and clinical implication

21 January 2018

1 reference

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The Sir2 family of protein deacetylases

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.1.51

Cloning and functional characterization of HDAC11, a novel member of the human histone deacetylase family

21 January 2018

1 reference

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Prospects: histone deacetylase inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.1.51

HDA2 and HDA3 are related proteins that interact with and are essential for the activity of the yeast histone deacetylase HDA1

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.1.51

Histone deacetylase 4 associates with extracellular signal-regulated kinases 1 and 2, and its cellular localization is regulated by oncogenic Ras

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.1.51

Caspase-dependent regulation of histone deacetylase 4 nuclear-cytoplasmic shuttling promotes apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.1.51

Assembly of the SMRT-histone deacetylase 3 repression complex requires the TCP-1 ring complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.1.51

The diverse superfamily of lysine acetyltransferases and their roles in leukemia and other diseases

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.1.51

Epigenetic and chromatin modifiers as targeted therapy of hematologic malignancies

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.1.51

Gatekeeper pathways and cellular background in the pathogenesis and therapy of AML.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.1.51

Upstream and downstream of erythroid transcription factor GATA-1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.1.51

Altered interaction of HDAC5 with GATA-1 during MEL cell differentiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.1.51

Possible regulation of Wilms' tumour gene 1 (WT1) expression by the paired box genes PAX2 and PAX8 and by the haematopoietic transcription factor GATA-1 in human acute myeloid leukaemias.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.1.51

Analysis of the relationship between Scl transcription factor complex protein expression patterns and the effects of LiCl on ATRA-induced differentiation in blast cells from patients with acute myeloid leukemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.1.51

Stimulation of NF-E2 DNA binding by CREB-binding protein (CBP)-mediated acetylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.1.51

NF-E2 disrupts chromatin structure at human beta-globin locus control region hypersensitive site 2 in vitro

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.1.51

Transcription factor GATA-2 gene is located near 3q21 breakpoints in myeloid leukemia.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.1.51

mSin3A regulates murine erythroleukemia cell differentiation through association with the TAL1 (or SCL) transcription factor

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.1.51

TAL1/SCL induces leukemia by inhibiting the transcriptional activity of E47/HEB.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.1.51

Loss of PU.1 expression following inhibition of histone deacetylases

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.1.51

Inhibition of CBP-mediated protein acetylation by the Ets family oncoprotein PU.1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.1.51

Mutations of the PU.1 Ets domain are specifically associated with murine radiation-induced, but not human therapy-related, acute myeloid leukaemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.1.51

Acute myeloid leukemia induced by graded reduction of a lineage-specific transcription factor, PU.1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.1.51

Suppression of myeloid transcription factors and induction of STAT response genes by AML-specific Flt3 mutations

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.1.51

Heterozygous PU.1 mutations are associated with acute myeloid leukemia.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.1.51

Friend virus-induced erythroleukemia and the multistage nature of cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.1.51

Genetic pathways in therapy-related myelodysplasia and acute myeloid leukemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.1.51

Regulation of p53 responses by post-translational modifications

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.1.51

Post-translational modification of p53 in tumorigenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.1.51

Post-translational modifications and activation of p53 by genotoxic stresses

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.1.51

Functional analysis of the roles of posttranslational modifications at the p53 C terminus in regulating p53 stability and activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.1.51

Global transcriptional program of p53 target genes during the process of apoptosis and cell cycle progression

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.1.51

The p53 pathway: positive and negative feedback loops

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.1.51

DNA damage activates p53 through a phosphorylation-acetylation cascade

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.1.51

Serine15 phosphorylation stimulates p53 transactivation but does not directly influence interaction with HDM2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.1.51

Mdm2-mediated NEDD8 conjugation of p53 inhibits its transcriptional activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.1.51

Genes causing inherited cancer as beacons to identify the mechanisms of chemoresistance

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.1.51

Impairment of p53 acetylation, stability and function by an oncogenic transcription factor

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.1.51

Acetylation of p53 augments its site-specific DNA binding both in vitro and in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.1.51

Activation of p53 sequence-specific DNA binding by acetylation of the p53 C-terminal domain

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.1.51

p53 sites acetylated in vitro by PCAF and p300 are acetylated in vivo in response to DNA damage

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.1.51

p300/CBP-mediated p53 acetylation is commonly induced by p53-activating agents and inhibited by MDM2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.1.51

DeltaN-p53, a natural isoform of p53 lacking the first transactivation domain, counteracts growth suppression by wild-type p53.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.1.51

Regulation of human p53 activity and cell localization by alternative splicing

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.1.51

p53 isoforms can regulate p53 transcriptional activity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.1.51

Blocking platelet-derived growth factor-D/platelet-derived growth factor receptor beta signaling inhibits human renal cell carcinoma progression in an orthotopic mouse model

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.1.51

Is targeted chemotherapy an alternative to immunotherapy in chronic lymphocytic leukemia?

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.1.51

HDAC6 regulates Hsp90 acetylation and chaperone-dependent activation of glucocorticoid receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.1.51

Inhibition of histone deacetylase 6 acetylates and disrupts the chaperone function of heat shock protein 90: a novel basis for antileukemia activity of histone deacetylase inhibitors.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.1.51

Modulating molecular chaperone Hsp90 functions through reversible acetylation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.1.51

The co-workers of actin filaments: from cell structures to signals

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.1.51

In vivo destabilization of dynamic microtubules by HDAC6-mediated deacetylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.1.51

Bmf is a possible mediator in histone deacetylase inhibitors FK228 and CBHA-induced apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.1.51

Cytoplasmic sequestration of HDAC7 from mitochondrial and nuclear compartments upon initiation of apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.1.51

Regulation of peroxisome proliferator-activated receptor gamma coactivator 1 alpha (PGC-1 alpha ) and mitochondrial function by MEF2 and HDAC5

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.1.51

Calorie restriction, SIRT1 and metabolism: understanding longevity

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.1.51

SIRT3, a human SIR2 homologue, is an NAD-dependent deacetylase localized to mitochondria

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.1.51

SIRT3, a mitochondrial sirtuin deacetylase, regulates mitochondrial function and thermogenesis in brown adipocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.1.51

Sin3: a flexible regulator of global gene expression and genome stability.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.1.51

The SIN3 deacetylase complex represses genes encoding mitochondrial proteins: implications for the regulation of energy metabolism

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.1.51

Mitochondrial histone-like DNA-binding proteins are essential for normal cell growth and mitochondrial function in Crithidia fasciculata.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.1.51

Structures of a histone deacetylase homologue bound to the TSA and SAHA inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.1.51

Structural snapshots of human HDAC8 provide insights into the class I histone deacetylases

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.1.51

Sodium butyrate induces transcription from the G alpha(i2) gene promoter through multiple Sp1 sites in the promoter and by activating the MEK-ERK signal transduction pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.1.51

The histone deacetylase inhibitor valproic acid alters sensitivity towards all trans retinoic acid in acute myeloblastic leukemia cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.1.51

Valproic acid defines a novel class of HDAC inhibitors inducing differentiation of transformed cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.1.51

Valproic acid alters chromatin structure by regulation of chromatin modulation proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.1.51

Sequence-specific potentiation of topoisomerase II inhibitors by the histone deacetylase inhibitor suberoylanilide hydroxamic acid

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.1.51

Modified fatty acids and their possible therapeutic targets in malignant diseases

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.1.51

21 January 2018

Differentiation therapy

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.1.51

Phenylbutyrate attenuates the expression of Bcl-X(L), DNA-PK, caveolin-1, and VEGF in prostate cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.1.51

Identification of thiols and glutathione conjugates of depsipeptide FK228 (FR901228), a novel histone protein deacetylase inhibitor, in the blood

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.1.51

A phase I trial of depsipeptide (FR901228) in patients with advanced cancer.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.1.51

A class of hybrid polar inducers of transformed cell differentiation inhibits histone deacetylases.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.1.51

Transcriptional signature of histone deacetylase inhibition in multiple myeloma: biological and clinical implications

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.1.51

Phase I study of an oral histone deacetylase inhibitor, suberoylanilide hydroxamic acid, in patients with advanced cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.1.51

Clinical development of histone deacetylase inhibitors as anticancer agents

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.1.51

A review of depsipeptide and other histone deacetylase inhibitors in clinical trials

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.1.51

Treatment of myelodysplastic syndromes with valproic acid alone or in combination with all-trans retinoic acid

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.1.51

Increase in platelet count in older, poor-risk patients with acute myeloid leukemia or myelodysplastic syndrome treated with valproic acid and all-trans retinoic acid

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.1.51

Clinical trial of valproic acid and all-trans retinoic acid in patients with poor-risk acute myeloid leukemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.1.51

Frequent mutations in the ligand-binding domain of PML-RARalpha after multiple relapses of acute promyelocytic leukemia: analysis for functional relationship to response to all-trans retinoic acid and histone deacetylase inhibitors in vitro and in v

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.1.51

A phase 1 and pharmacodynamic study of depsipeptide (FK228) in chronic lymphocytic leukemia and acute myeloid leukemia.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.1.51

Targeted immunotherapy in acute myeloblastic leukemia: from animals to humans.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.1.51

Biological treatment in acute myelogenous leukaemia: how should T-cell targeting immunotherapy be combined with intensive chemotherapy?

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.1.51

The histone deacetylase inhibitor Trichostatin A modulates CD4+ T cell responses

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.1.51

Discrete roles for histone acetylation in human T helper 1 cell-specific gene expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.1.51

Proteomics in acute myelogenous leukaemia (AML): methodological strategies and identification of protein targets for novel antileukaemic therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.1.51

New strategies in the treatment of acute myelogenous leukemia (AML): in vitro culture of aml cells--the present use in experimental studies and the possible importance for future therapeutic approaches.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.1.51

Caspase-dependent, geldanamycin-enhanced cleavage of co-chaperone p23 in leukemic apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.1.51

MicroRNA biogenesis and cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.1.51

A microRNA polycistron as a potential human oncogene

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.1.51

Theophylline restores histone deacetylase activity and steroid responses in COPD macrophages.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.1.51

Antileukemia activity of the combination of 5-aza-2'-deoxycytidine with valproic acid

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.1.51

Cytogenetics in acute leukemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.1.51

The myeloid master regulator transcription factor PU.1 is inactivated by AML1-ETO in t(8;21) myeloid leukemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.1.51

21 January 2018

Identifiers

DOI

10.1517/14728222.10.1.51

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16441228%20AND%20SRC:MED&resulttype=core&format=json

16 January 2020

1 reference