(Q36380837)

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Enforced Bcl-2 expression inhibits antigen-mediated clonal elimination of peripheral B cells in an antigen dose-dependent manner and promotes receptor editing in autoreactive, immature B cells

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Europe PubMed Central

PMC publication ID

13 August 2017

Enforced Bcl-2 expression inhibits antigen-mediated clonal elimination of peripheral B cells in an antigen dose-dependent manner and promotes receptor editing in autoreactive, immature B cells (English)

1 reference

Europe PubMed Central

PMC publication ID

13 August 2017

Andreas Strasser

object named as

A Strasser

7

0 references

Stanley J. Korsmeyer

5

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S Korsmeyer

1 reference

Europe PubMed Central

PMC publication ID

13 August 2017

author name string

J Lang

1

1 reference

Europe PubMed Central

PMC publication ID

13 August 2017

B Arnold

2

1 reference

Europe PubMed Central

PMC publication ID

13 August 2017

G Hammerling

3

1 reference

Europe PubMed Central

PMC publication ID

13 August 2017

A W Harris

4

1 reference

Europe PubMed Central

PMC publication ID

13 August 2017

D Russell

6

1 reference

Europe PubMed Central

PMC publication ID

13 August 2017

D Nemazee

8

1 reference

Europe PubMed Central

PMC publication ID

13 August 2017

language of work or name

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publication date

1 November 1997

1 reference

Europe PubMed Central

PMC publication ID

13 August 2017

Journal of Experimental Medicine

1 reference

Europe PubMed Central

PMC publication ID

13 August 2017

186

1 reference

Europe PubMed Central

PMC publication ID

13 August 2017

9

1 reference

Europe PubMed Central

PMC publication ID

13 August 2017

1513-1522

1 reference

Europe PubMed Central

PMC publication ID

13 August 2017

Self-antigen does not accelerate immature B cell apoptosis, but stimulates receptor editing as a consequence of developmental arrest.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2199120

30 September 2017

BCR ligation induces receptor editing in IgM+IgD- bone marrow B cells in vitro

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2199120

30 September 2017

Constitutive Bcl-2 expression during immunoglobulin heavy chain-promoted B cell differentiation expands novel precursor B cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2199120

30 September 2017

B cells are exquisitely sensitive to central tolerance and receptor editing induced by ultralow affinity, membrane-bound antigen.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2199120

30 September 2017

The "clonal selection hypothesis" and current concepts of B cell tolerance

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2199120

30 September 2017

Clonal selection and learning in the antibody system

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2199120

30 September 2017

bcl-x exhibits regulated expression during B cell development and activation and modulates lymphocyte survival in transgenic mice.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2199120

30 September 2017

Bcl-2 and Fas/APO-1 regulate distinct pathways to lymphocyte apoptosis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2199120

30 September 2017

Programmed cell death by bcl-2-dependent and independent mechanisms in B lymphoma cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2199120

30 September 2017

Receptor editing: an approach by autoreactive B cells to escape tolerance

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2199120

30 September 2017

Receptor editing in self-reactive bone marrow B cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2199120

30 September 2017

Bcl-2-deficient mice demonstrate fulminant lymphoid apoptosis, polycystic kidneys, and hypopigmented hair

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2199120

30 September 2017

Analysis of B cell tolerance in vitro

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2199120

30 September 2017

Disappearance of the lymphoid system in Bcl-2 homozygous mutant chimeric mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2199120

30 September 2017

Bcl-2 heterodimerizes in vivo with a conserved homolog, Bax, that accelerates programmed cell death

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2199120

30 September 2017

bcl-x, a bcl-2-related gene that functions as a dominant regulator of apoptotic cell death

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2199120

30 September 2017

The regulated expression of B lineage associated genes during B cell differentiation in bone marrow and fetal liver

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2199120

30 September 2017

Developmental regulation of the Bcl-2 protein and susceptibility to cell death in B lymphocytes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2199120

30 September 2017

Negative selection of lymphocytes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2199120

30 September 2017

Bcl-2 expression promotes B- but not T-lymphoid development in scid mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2199120

30 September 2017

Bcl-2 protein expression during murine development

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2199120

30 September 2017

Regulation of apoptosis in the immune system

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2199120

30 September 2017

Bcl-2 expression during T-cell development: early loss and late return occur at specific stages of commitment to differentiation and survival

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2199120

30 September 2017

Activation-induced apoptosis in lymphocytes.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2199120

30 September 2017

Apoptosis in the pathogenesis and treatment of disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2199120

30 September 2017

Mechanisms and genes of cellular suicide

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2199120

30 September 2017

Insights from transgenic mice regarding the role of bcl-2 in normal and neoplastic lymphoid cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2199120

30 September 2017

Cross-linking of membrane immunoglobulin D, in the absence of T cell help, kills mature B cells in vivo

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2199120

30 September 2017

Bad, a heterodimeric partner for Bcl-XL and Bcl-2, displaces Bax and promotes cell death

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2199120

30 September 2017

Inactivation of Bcl-2 by phosphorylation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2199120

30 September 2017

The proportion of B-cell subsets expressing kappa and lambda light chains changes following antigenic selection

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2199120

30 September 2017

Expression of Bcl-2, Bcl-x, and Bax after T cell activation and IL-2 withdrawal

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2199120

30 September 2017

Regulation of lymphocyte survival by the bcl-2 gene family

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2199120

30 September 2017

bcl-xLx is the major bcl-x mRNA form expressed during murine development and its product localizes to mitochondria

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2199120

30 September 2017

Bcl-XL displays restricted distribution during T cell development and inhibits multiple forms of apoptosis but not clonal deletion in transgenic mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2199120

30 September 2017

Clonal deletion of autoreactive B lymphocytes in bone marrow chimeras

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2199120

30 September 2017

Expression in transgenic mice of class I histocompatibility antigens controlled by the metallothionein promoter

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2199120

30 September 2017

Deregulated Bcl-2-immunoglobulin transgene expands a resting but responsive immunoglobulin M and D-expressing B-cell population

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2199120

30 September 2017

Murine lambda gene rearrangements: the stochastic model prevails over the ordered model

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2199120

30 September 2017

Peripheral deletion of self-reactive B cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2199120

30 September 2017

Elimination from peripheral lymphoid tissues of self-reactive B lymphocytes recognizing membrane-bound antigens

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2199120

30 September 2017

Enforced BCL2 expression in B-lymphoid cells prolongs antibody responses and elicits autoimmune disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2199120

30 September 2017

Differential effects of Bcl-2 on T and B cells in transgenic mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2199120

30 September 2017

Bcl-xL rescues WEHI 231 B lymphocytes from oxidant-mediated death following diverse apoptotic stimuli.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2199120

30 September 2017

Immature surface Ig+ B cells can continue to rearrange kappa and lambda L chain gene loci

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2199120

28 June 2018

Transitional B cells are the target of negative selection in the B cell compartment

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2199120

28 June 2018

Antigen-induced B-cell death and elimination during germinal-centre immune responses

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2199120

28 June 2018

Competition for follicular niches excludes self-reactive cells from the recirculating B-cell repertoire.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2199120

28 June 2018

bcl-2-immunoglobulin transgenic mice demonstrate extended B cell survival and follicular lymphoproliferation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2199120

28 June 2018

Reduced life span of anergic self-reactive B cells in a double-transgenic model

1 reference

https://api.crossref.org/works/10.1084%2FJEM.186.9.1513

21 January 2018

Elimination of self-reactive B lymphocytes proceeds in two stages: arrested development and cell death.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2199120

21 September 2018

The bcl-2 gene product inhibits clonal deletion of self-reactive B lymphocytes in the periphery but not in the bone marrow

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2199120

21 September 2018

Physiological cell death in B lymphocytes: I. Differential susceptibility of WEHI-231 sublines to anti-Ig induced physiological cell death and lack of correlation with bcl-2 expression.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2199120

21 September 2018

Role of bcl-2 and IL-5 in the regulation of anti-IgM-induced growth arrest and apoptosis in immature B cell lines. A cooperative regulation model for B cell clonal deletion.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2199120

21 September 2018

Signaling properties of anti-immunoglobulin--resistant variants of WEHI-231 B lymphoma cells.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2199120

21 September 2018

Soluble antigen can cause enhanced apoptosis of germinal-centre B cells.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2199120

21 September 2018

CD95 (Fas)-dependent elimination of self-reactive B cells upon interaction with CD4+T cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2199120

21 September 2018

Functional immunoglobulin transgenes guide ordered B-cell differentiation in Rag-1-deficient mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2199120

21 October 2018

Heterodimerization with Bax is required for Bcl-2 to repress cell death

1 reference

https://api.crossref.org/works/10.1084%2FJEM.186.9.1513

21 January 2018

Clonal deletion of B lymphocytes in a transgenic mouse bearing anti-MHC class I antibody genes

1 reference

https://pubmed.ncbi.nlm.nih.gov/9348309

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Antigen-induced apoptotic death of Ly-1 B cells responsible for autoimmune disease in transgenic mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/9348309

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Distinct mechanisms of extrathymic T cell tolerance due to differential expression of self antigen

1 reference

https://pubmed.ncbi.nlm.nih.gov/9348309

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The role of bcl-XL in CD40-mediated rescue from anti-mu-induced apoptosis in WEHI-231 B lymphoma cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/9348309

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Modulation of anti-IgM-induced B cell apoptosis by Bcl-xL and CD40 in WEHI-231 cells. Dissociation from cell cycle arrest and dependence on the avidity of the antibody-IgM receptor interaction

1 reference

https://pubmed.ncbi.nlm.nih.gov/9348309

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Radiation-induced apoptosis is differentially regulated in primary B cells from normal mice and mice with the CBA/N X-linked immunodeficiency

1 reference

https://pubmed.ncbi.nlm.nih.gov/9348309

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A day in the life of the Bcl-2 protein: does the turnover rate of Bcl-2 serve as a biological clock for cellular lifespan regulation?

1 reference

https://pubmed.ncbi.nlm.nih.gov/9348309

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Re-evaluation of the probabilities for productive rearrangements on the κ andλloci

1 reference

https://pubmed.ncbi.nlm.nih.gov/9348309

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

CD5-mediated negative regulation of antigen receptor-induced growth signals in B-1 B cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/9348309

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A functional B cell receptor transgene allows efficient IL-7-independent maturation of B cell precursors

1 reference

https://pubmed.ncbi.nlm.nih.gov/9348309

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Expression of the Bcl-2 protein in murine and human thymocytes and in peripheral T lymphocytes

1 reference

https://pubmed.ncbi.nlm.nih.gov/9348309

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Antigen-receptor cross-linking induces peritoneal B-cell apoptosis in normal but not autoimmunity-prone mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/9348309

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1084/JEM.186.9.1513

1 reference

Europe PubMed Central

PMC publication ID

13 August 2017

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

13 August 2017

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

13 August 2017

ResearchGate publication ID

0 references

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