(Q36392365)

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The Tipper-Strominger Hypothesis and Triggering of Allostery in Penicillin-Binding Protein 2a of Methicillin-Resistant Staphylococcus aureus (MRSA).

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scholarly article

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8 March 2020

The Tipper-Strominger Hypothesis and Triggering of Allostery in Penicillin-Binding Protein 2a of Methicillin-Resistant Staphylococcus aureus (MRSA) (English)

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8 March 2020

methicillin-resistant Staphylococcus aureus

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Staphylococcus aureus

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based on heuristic

inferred from title

3

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8 March 2020

4

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Mayland Chang

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8 March 2020

Shahriar Mobashery

5

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Shahriar Mobashery

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8 March 2020

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Jennifer Fishovitz

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8 March 2020

Negin Taghizadeh

2

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8 March 2020

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18 May 2015

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8 March 2020

Journal of the American Chemical Society

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8 March 2020

137

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8 March 2020

20

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8 March 2020

6500-6505

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8 March 2020

Missense mutations in PBP2A Affecting ceftaroline susceptibility detected in epidemic hospital-acquired methicillin-resistant Staphylococcus aureus clonotypes ST228 and ST247 in Western Switzerland archived since 1998

1 reference

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30 September 2017

PBP2a mutations causing high-level Ceftaroline resistance in clinical methicillin-resistant Staphylococcus aureus isolates.

1 reference

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30 September 2017

Disruption of Allosteric Response as an Unprecedented Mechanism of Resistance to Antibiotics

1 reference

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30 September 2017

Neutral β-Lactams Inactivate High Molecular Mass Penicillin-Binding Proteins of Class B1, Including PBP2a of MRSA.

1 reference

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30 September 2017

The emergence of mecC methicillin-resistant Staphylococcus aureus

1 reference

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30 September 2017

How allosteric control of Staphylococcus aureus penicillin binding protein 2a enables methicillin resistance and physiological function

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4686766

30 September 2017

Bio-inspired synthesis yields a tricyclic indoline that selectively resensitizes methicillin-resistant Staphylococcus aureus (MRSA) to β-lactam antibiotics

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4686766

30 September 2017

Allostery in disease and in drug discovery

1 reference

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30 September 2017

Systems-level antimicrobial drug and drug synergy discovery

1 reference

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30 September 2017

Intrinsic antibiotic resistance: mechanisms, origins, challenges and solutions

1 reference

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30 September 2017

Reactions of all Escherichia coli lytic transglycosylases with bacterial cell wall.

1 reference

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30 September 2017

Distinct single-cell morphological dynamics under beta-lactam antibiotics

1 reference

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30 September 2017

Structural Insights into the Anti-methicillin-resistant Staphylococcus aureus (MRSA) Activity of Ceftobiprole

1 reference

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30 September 2017

Restoring methicillin-resistant Staphylococcus aureus susceptibility to β-lactam antibiotics

1 reference

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30 September 2017

Identification of genetic determinants and enzymes involved with the amidation of glutamic acid residues in the peptidoglycan of Staphylococcus aureus

1 reference

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30 September 2017

Peptidoglycan turnover and recycling in Gram-positive bacteria

1 reference

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30 September 2017

Ceftaroline: a novel cephalosporin with activity against methicillin-resistant Staphylococcus aureus

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4686766

30 September 2017

Ceftaroline: a comprehensive update

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4686766

30 September 2017

Molecular basis and phenotype of methicillin resistance in Staphylococcus aureus and insights into new beta-lactams that meet the challenge.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4686766

30 September 2017

Frameworks for understanding long-range intra-protein communication

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4686766

30 September 2017

Staphylococcus aureus PBP4 is essential for beta-lactam resistance in community-acquired methicillin-resistant strains

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4686766

30 September 2017

Allosteric regulation and catalysis emerge via a common route.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4686766

30 September 2017

Co-opting the cell wall in fighting methicillin-resistant Staphylococcus aureus: potent inhibition of PBP 2a by two anti-MRSA beta-lactam antibiotics

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4686766

30 September 2017

Allostery and cooperativity revisited

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4686766

30 September 2017

Antibiotic resistant Staphylococcus aureus: a paradigm of adaptive power

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4686766

30 September 2017

Structural basis for the beta lactam resistance of PBP2a from methicillin-resistant Staphylococcus aureus

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4686766

30 September 2017

The carboxyl terminus of peptidoglycan stem peptides is a determinant for methicillin resistance in Staphylococcus aureus

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4686766

30 September 2017

An acquired and a native penicillin-binding protein cooperate in building the cell wall of drug-resistant staphylococci

1 reference

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30 September 2017

Mechanism of action of penicillins: a proposal based on their structural similarity to acyl-D-alanyl-D-alanine

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4686766

30 September 2017

Transition state structures of a dipeptide related to the mode of action of beta-lactam antibiotics

1 reference

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30 September 2017

Properties of a novel PBP2A protein homolog from Staphylococcus aureus strain LGA251 and its contribution to the β-lactam-resistant phenotype.

1 reference

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28 June 2018

Conformation of penicillin as a transition-state analog of the substrate of peptidoglycan transpeptidase.

1 reference

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1 reference

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21 September 2018

Pharmacodynamics of ceftaroline against Staphylococcus aureus studied in an in vitro pharmacokinetic model of infection

1 reference

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Characterization of methicillin-resistant Staphylococcus aureus displaying increased MICs of ceftaroline

1 reference

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Antagonism of chemical genetic interaction networks resensitize MRSA to β-lactam antibiotics.

1 reference

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21 September 2018

Shared functional attributes between the mecA gene product of Staphylococcus sciuri and penicillin-binding protein 2a of methicillin-resistant Staphylococcus aureus.

1 reference

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21 September 2018

Subcutaneous administration of cefepime

1 reference

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1 reference

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Activation for catalysis of penicillin-binding protein 2a from methicillin-resistant Staphylococcus aureus by bacterial cell wall

1 reference

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21 September 2018

Crystal structures of complexes between the R61 DD-peptidase and peptidoglycan-mimetic beta-lactams: a non-covalent complex with a "perfect penicillin".

1 reference

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21 September 2018

The basis for resistance to beta-lactam antibiotics by penicillin-binding protein 2a of methicillin-resistant Staphylococcus aureus

1 reference

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Analysis of Staphylococcus aureus clinical isolates with reduced susceptibility to ceftaroline: an epidemiological and structural perspective

1 reference

https://pubmed.ncbi.nlm.nih.gov/25964995

12 December 2020

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10.1021/JACS.5B01374

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8 March 2020

1 reference

Europe PubMed Central

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8 March 2020

1 reference

Europe PubMed Central

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8 March 2020

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