(Q36402496)

14 August 2017

An antagonist peptide mediates positive selection and CD4 lineage commitment of MHC class II-restricted T cells in the absence of CD4 (English)

1 reference

14 August 2017

1 reference

Henry Kao

1

1 reference

14 August 2017

Paul M Allen

series ordinal

2

1 reference

14 August 2017

language of work or name

English

0 references

publication date

1 January 2005

1 reference

Journal of Experimental Medicine

14 August 2017

1 reference

14 August 2017

201

1 reference

14 August 2017

1

1 reference

14 August 2017

149-158

1 reference

CD4/CD8 coreceptors in thymocyte development, selection, and lineage commitment: analysis of the CD4/CD8 lineage decision

14 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2212763

Positive and negative selection of T cells

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2212763

T-cell development and the CD4-CD8 lineage decision

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2212763

Positive selection of CD4(+) T cells is induced in vivo by agonist and inhibited by antagonist peptides

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2212763

Association of the adaptor molecule LAT with CD4 and CD8 coreceptors identifies a new coreceptor function in T cell receptor signal transduction

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2212763

Selection of the T cell repertoire.

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2212763

A kinetic threshold between negative and positive selection based on the longevity of the T cell receptor-ligand complex

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2212763

In vivo antagonism of a T cell response by an endogenously expressed ligand

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2212763

Antagonist peptide selects thymocytes expressing a class II major histocompatibility complex-restricted T cell receptor into the CD8 lineage

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2212763

Altered peptide ligands induce quantitatively but not qualitatively different intracellular signals in primary thymocytes

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2212763

HD mice: a novel mouse mutant with a specific defect in the generation of CD4(+) T cells

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2212763

CD3 ligation on immature thymocytes generates antagonist-like signals appropriate for CD8 lineage commitment, independently of T cell receptor specificity

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2212763

Disruption of the CD4-major histocompatibility complex class II interaction blocks the development of CD4(+) T cells in vivo

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2212763

Selection of antigen-specific T cells by a single IEk peptide combination

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2212763

CD8 lineage commitment in the absence of CD8.

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2212763

The efficiency of CD4 recruitment to ligand-engaged TCR controls the agonist/partial agonist properties of peptide-MHC molecule ligands

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2212763

Structural basis for T cell recognition of altered peptide ligands: a single T cell receptor can productively recognize a large continuum of related ligands

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2212763

The cytoplasmic domain of CD4 promotes the development of CD4 lineage T cells

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2212763

Antigen presentation and T cell development in H2-M-deficient mice

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2212763

H2-M mutant mice are defective in the peptide loading of class II molecules, antigen presentation, and T cell repertoire selection

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2212763

Mice lacking H2-M complexes, enigmatic elements of the MHC class II peptide-loading pathway

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2212763

Regulated expression of human CD4 rescues helper T cell development in mice lacking expression of endogenous CD4.

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2212763

T cell receptor antagonist peptides induce positive selection

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2212763

Regulation of T cell receptor expression in immature CD4+CD8+ thymocytes by p56lck tyrosine kinase: basis for differential signaling by CD4 and CD8 in immature thymocytes expressing both coreceptor molecules

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2212763

Negative selection of CD4+ CD8+ thymocytes by T-cell receptor peptide antagonists

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2212763

Cell-cell adhesion mediated by CD8 and MHC class I molecules

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2212763

The CD4 and CD8 T cell surface antigens are associated with the internal membrane tyrosine-protein kinase p56lck

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2212763

Interaction between CD4 and class II MHC molecules mediates cell adhesion

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2212763

RAG-1-deficient mice have no mature B and T lymphocytes

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2212763

Signal for T-cell differentiation to a CD4 cell lineage is delivered by CD4 transmembrane region and/or cytoplasmic tail

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2212763

Alterations in CD4-binding regions of the MHC class II molecule I-Ek do not impede CD4+ T cell development.

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2212763

In vivo expression of a TCR antagonist: T cells escape central tolerance but are antagonized in the periphery

28 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2212763

The influence of the MAPK pathway on T cell lineage commitment

28 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2212763

Limits to the differential avidity model of T cell selection in the thymus.

28 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2212763

Mature T cell reactivity altered by peptide agonist that induces positive selection

28 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2212763

Development of mature CD8+ thymocytes: selection rather than instruction?

28 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2212763

Specificity and flexibility in thymic selection

28 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2212763

Developmental regulation of thymocyte susceptibility to deletion by "self"-peptide

28 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2212763

A role for the cytoplasmic tail of the beta chain of CD8 in thymic selection

28 June 2018

1 reference

https://api.crossref.org/works/10.1084%2FJEM.20041574

Evidence for a differential avidity model of T cell selection in the thymus

21 January 2018

1 reference

https://api.crossref.org/works/10.1084%2FJEM.20041574

Peptide-induced positive selection of TCR transgenic thymocytes in a coreceptor-independent manner.

21 January 2018

1 reference

https://api.crossref.org/works/10.1084%2FJEM.20041574

TCR signaling for initiation and completion of thymocyte positive selection has distinct requirements for ligand quality and presenting cell type.

21 January 2018

1 reference

https://api.crossref.org/works/10.1084%2FJEM.20041574

The repertoire of T cells shaped by a single MHC/peptide ligand.

21 January 2018

1 reference

https://api.crossref.org/works/10.1084%2FJEM.20041574

Thymic selection by a single MHC/peptide ligand produces a semidiverse repertoire of CD4+ T cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1084%2FJEM.20041574

MHC class II-specific T cells can develop in the CD8 lineage when CD4 is absent.

21 January 2018

1 reference

https://api.crossref.org/works/10.1084%2FJEM.20041574

Signals through CD8 or CD4 can induce commitment to the CD4 lineage in the thymus.

21 January 2018

1 reference

https://api.crossref.org/works/10.1084%2FJEM.20041574

Lck activity controls CD4/CD8 T cell lineage commitment.

21 January 2018

1 reference

https://api.crossref.org/works/10.1084%2FJEM.20041574

The quantity of TCR signal determines positive selection and lineage commitment of T cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1084%2FJEM.20041574

Requirement for sustained MAPK signaling in both CD4 and CD8 lineage commitment: a threshold model

21 January 2018

1 reference

https://api.crossref.org/works/10.1084%2FJEM.20041574

Another view of the selective model of thymocyte selection.

21 January 2018

1 reference

https://api.crossref.org/works/10.1084%2FJEM.20041574

Evidence for a stochastic mechanism in the differentiation of mature subsets of T lymphocytes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1084%2FJEM.20041574

Helper T cells without CD4: control of leishmaniasis in CD4-deficient mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1084%2FJEM.20041574

CD4 augments the response of a T cell to agonist but not to antagonist ligands

21 January 2018

1 reference

https://api.crossref.org/works/10.1084%2FJEM.20041574

Direct observation of ligand recognition by T cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1084%2FJEM.20041574

Regulation of lineage commitment distinct from positive selection.

21 January 2018

1 reference

https://api.crossref.org/works/10.1084%2FJEM.20041574

CD4 promotes breadth in the TCR repertoire

21 January 2018

1 reference

https://api.crossref.org/works/10.1084%2FJEM.20041574

Immature CD4(+)CD8(+) thymocytes form a multifocal immunological synapse with sustained tyrosine phosphorylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1084%2FJEM.20041574

Selection and function of CD4+ T lymphocytes in transgenic mice expressing mutant MHC class II molecules deficient in their interaction with CD4.

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2212763

TCR transgenic mice in which usage of transgenic alpha- and beta-chains is highly dependent on the level of selecting ligand.

21 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2212763

Regulation of thymocyte lineage commitment by the level of classical protein kinase C activity.

21 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2212763

A peptide antigen antagonist prevents the differentiation of T cell receptor transgenic thymocytes.

21 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2212763

Participation of CD4 coreceptor molecules in T-cell repertoire selection

21 September 2018

1 reference

https://api.crossref.org/works/10.1084%2FJEM.20041574

TCR activation of ZAP70 is impaired in CD4+CD8+ thymocytes as a consequence of intrathymic interactions that diminish available p56lck

21 January 2018

1 reference

12 December 2020

Positive selection of T cells induced by viral delivery of neopeptides to the thymus

1 reference

12 December 2020

Positive and Negative CD4+ Thymocyte Selection by a Single MHC Class II/Peptide Ligand Affected by Its Expression Level in the Thymus

1 reference

12 December 2020

Selection of a broad repertoire of CD4+ T cells in H-2Ma0/0 mice

1 reference

12 December 2020

High- and low-potency ligands with similar affinities for the TCR: the importance of kinetics in TCR signaling

1 reference

12 December 2020

Ligand-specific selection of MHC class II-restricted thymocytes in fetal thymic organ culture

1 reference

12 December 2020

Inducible Expression of a p56Lck Transgene Reveals a Central Role for Lck in the Differentiation of CD4 SP Thymocytes

1 reference

12 December 2020

Coreceptor reversal in the thymus: signaled CD4+8+ thymocytes initially terminate CD8 transcription even when differentiating into CD8+ T cells

1 reference

12 December 2020

Strength of signaling by CD4 and CD8 coreceptor tails determines the number but not the lineage direction of positively selected thymocytes

1 reference

12 December 2020

Complete dissection of the Hb(64-76) determinant using T helper 1, T helper 2 clones, and T cell hybridomas

1 reference

12 December 2020

Helper T-cell development in the absence of CD4-p56 Ick association

1 reference

12 December 2020

Thymic selection of cytotoxic T cells independent of CD8 alpha-Lck association

1 reference

12 December 2020

A vector driving the expression of foreign cDNAs in the MHC class II-positive cells of transgenic mice

1 reference

12 December 2020

Positive and negative thymocyte selection induced by different concentrations of a single peptide

1 reference

12 December 2020

Strong agonist ligands for the T cell receptor do not mediate positive selection of functional CD8+ T cells

1 reference

12 December 2020

Identifiers

DOI

10.1084/JEM.20041574

1 reference

14 August 2017

1 reference

14 August 2017

PubMed publication ID

15630142

1 reference