(Q36404935)

14 August 2017

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title

Methods to analyze big data in pharmacogenomics research (English)

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14 August 2017

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3

Marylyn D Ritchie

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14 August 2017

Ruowang Li

1

1 reference

PubMed ID

28612644

14 August 2017

Dokyoon Kim

series ordinal

2

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14 August 2017

14 June 2017

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14 August 2017

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14 August 2017

18

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14 August 2017

8

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14 August 2017

807-820

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Genome-wide association studies in pharmacogenomics.

14 August 2017

1 reference

https://api.crossref.org/works/10.2217%2FPGS-2016-0152

Big Data: Astronomical or Genomical?

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FPGS-2016-0152

A common BIM deletion polymorphism mediates intrinsic resistance and inferior responses to tyrosine kinase inhibitors in cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FPGS-2016-0152

A genome-wide association study of overall survival in pancreatic cancer patients treated with gemcitabine in CALGB 80303

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FPGS-2016-0152

A genome-wide association study identifies novel loci for paclitaxel-induced sensory peripheral neuropathy in CALGB 40101.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FPGS-2016-0152

SLCO1B1 variants and statin-induced myopathy--a genomewide study

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FPGS-2016-0152

A genome-wide association study of acenocoumarol maintenance dosage.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FPGS-2016-0152

A genome-wide association study confirms VKORC1, CYP2C9, and CYP4F2 as principal genetic determinants of warfarin dose

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FPGS-2016-0152

A genome-wide scan for common genetic variants with a large influence on warfarin maintenance dose

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FPGS-2016-0152

Chemotherapeutic drug susceptibility associated SNPs are enriched in expression quantitative trait loci

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FPGS-2016-0152

Understanding the molecular mechanisms underlying mood stabilizer treatments in bipolar disorder: Potential involvement of epigenetics.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FPGS-2016-0152

Does DNA methylation influence the effects of psychiatric drugs?

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FPGS-2016-0152

Protein quantitative trait loci identify novel candidates modulating cellular response to chemotherapy

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FPGS-2016-0152

Effects of CYP4F2 genetic polymorphisms and haplotypes on clinical outcomes in patients initiated on warfarin therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FPGS-2016-0152

A genome-wide association study identifies variants in KCNIP4 associated with ACE inhibitor-induced cough

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FPGS-2016-0152

Copy number polymorphisms and anticancer pharmacogenomics

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FPGS-2016-0152

A genome-wide approach to identify genetic variants that contribute to etoposide-induced cytotoxicity.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FPGS-2016-0152

Intronic polymorphism in CYP3A4 affects hepatic expression and response to statin drugs

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FPGS-2016-0152

Global pharmacogenomics: distribution of CYP3A5 polymorphisms and phenotypes in the Brazilian population

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FPGS-2016-0152

Methodological and statistical issues in pharmacogenomics

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FPGS-2016-0152

Generating genome-scale candidate gene lists for pharmacogenomics

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FPGS-2016-0152

IL28B is associated with response to chronic hepatitis C interferon-alpha and ribavirin therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FPGS-2016-0152

Genome-wide association of IL28B with response to pegylated interferon-alpha and ribavirin therapy for chronic hepatitis C

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FPGS-2016-0152

Genetic variation in IL28B predicts hepatitis C treatment-induced viral clearance

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FPGS-2016-0152

Identification of genetic variants contributing to cisplatin-induced cytotoxicity by use of a genomewide approach

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FPGS-2016-0152

Genome-wide meta-analysis identifies variants associated with platinating agent susceptibility across populations

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FPGS-2016-0152

Comprehensive genetic analysis of cytarabine sensitivity in a cell-based model identifies polymorphisms associated with outcome in AML patients

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FPGS-2016-0152

Association of cytochrome P450 2C19 genotype with the antiplatelet effect and clinical efficacy of clopidogrel therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FPGS-2016-0152

Clinical Pharmacogenetics Implementation Consortium (CPIC) guidelines for codeine therapy in the context of cytochrome P450 2D6 (CYP2D6) genotype

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FPGS-2016-0152

Lower tacrolimus daily dose requirements and acute rejection rates in the CYP3A5 nonexpressers than expressers

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FPGS-2016-0152

Genetics of gene expression in primary immune cells identifies cell type-specific master regulators and roles of HLA alleles

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FPGS-2016-0152

Identification, replication, and functional fine-mapping of expression quantitative trait loci in primary human liver tissue

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FPGS-2016-0152

Trait-associated SNPs are more likely to be eQTLs: annotation to enhance discovery from GWAS

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FPGS-2016-0152

Metabolomic Signatures for Drug Response Phenotypes: Pharmacometabolomics Enables Precision Medicine.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FPGS-2016-0152

Identification and validation of genetic variants that influence transcription factor and cell signaling protein levels.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FPGS-2016-0152

HDAC2 regulates atypical antipsychotic responses through the modulation of mGlu2 promoter activity.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FPGS-2016-0152

Current status and future prospects for epigenetic psychopharmacology

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FPGS-2016-0152

Epigenetic side-effects of common pharmaceuticals: a potential new field in medicine and pharmacology

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FPGS-2016-0152

Copy number variants in pharmacogenetic genes

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FPGS-2016-0152

Copy number variability analysis of pharmacogenes in patients with lymphoma, leukemia, hepatocellular, and lung carcinoma using The Cancer Genome Atlas data

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FPGS-2016-0152

Addressing population-specific multiple testing burdens in genetic association studies

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FPGS-2016-0152

Bayesian statistical methods for genetic association studies

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FPGS-2016-0152

The success of pharmacogenomics in moving genetic association studies from bench to bedside: study design and implementation of precision medicine in the post-GWAS era.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FPGS-2016-0152

Electronic health record design and implementation for pharmacogenomics: a local perspective

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FPGS-2016-0152

Integration of genomics into the electronic health record: mapping terra incognita

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FPGS-2016-0152

PLINK: a tool set for whole-genome association and population-based linkage analyses

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FPGS-2016-0152

GenABEL: an R library for genome-wide association analysis

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FPGS-2016-0152

Genome-wide efficient mixed-model analysis for association studies

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FPGS-2016-0152

FaST linear mixed models for genome-wide association studies

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FPGS-2016-0152

Traversing the conceptual divide between biological and statistical epistasis: systems biology and a more modern synthesis

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FPGS-2016-0152

Genome-wide strategies for detecting multiple loci that influence complex diseases.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FPGS-2016-0152

Selecting SNPs in two-stage analysis of disease association data: a model-free approach

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FPGS-2016-0152

A testing framework for identifying susceptibility genes in the presence of epistasis

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FPGS-2016-0152

Detecting gene-gene interactions that underlie human diseases

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FPGS-2016-0152

A gene-gene interaction between polymorphisms in the OCT2 and MATE1 genes influences the renal clearance of metformin

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FPGS-2016-0152

Dopamine transporter DAT and receptor DRD2 variants affect risk of lethal cocaine abuse: a gene-gene-environment interaction

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FPGS-2016-0152

Multifactor-dimensionality reduction reveals high-order interactions among estrogen-metabolism genes in sporadic breast cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FPGS-2016-0152

Multifactor dimensionality reduction software for detecting gene-gene and gene-environment interactions.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FPGS-2016-0152

Multifactor dimensionality reduction for detecting gene-gene and gene-environment interactions in pharmacogenomics studies

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FPGS-2016-0152

A generalized combinatorial approach for detecting gene-by-gene and gene-by-environment interactions with application to nicotine dependence

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FPGS-2016-0152

BOOST: A fast approach to detecting gene-gene interactions in genome-wide case-control studies

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FPGS-2016-0152

EPIBLASTER-fast exhaustive two-locus epistasis detection strategy using graphical processing units

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FPGS-2016-0152

Bayesian inference of epistatic interactions in case-control studies.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FPGS-2016-0152

Identification of genetic interaction networks via an evolutionary algorithm evolved Bayesian network

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FPGS-2016-0152

Bayesian neural networks for detecting epistasis in genetic association studies

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FPGS-2016-0152

On safari to Random Jungle: a fast implementation of Random Forests for high-dimensional data

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FPGS-2016-0152

Tuning ReliefF for Genome-Wide Genetic Analysis

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FPGS-2016-0152

Using biological knowledge to uncover the mystery in the search for epistasis in genome-wide association studies

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FPGS-2016-0152

Linking pathway gene expressions to the growth inhibition response from the National Cancer Institute's anticancer screen and drug mechanism of action.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FPGS-2016-0152

Databases in the area of pharmacogenetics

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FPGS-2016-0152

PGMD: a comprehensive manually curated pharmacogenomic database

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FPGS-2016-0152

The Comparative Toxicogenomics Database (CTD).

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FPGS-2016-0152

DGIdb: mining the druggable genome

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FPGS-2016-0152

KEGG: kyoto encyclopedia of genes and genomes

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FPGS-2016-0152

Gene ontology: tool for the unification of biology

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FPGS-2016-0152

Gene Expression Omnibus: NCBI gene expression and hybridization array data repository

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FPGS-2016-0152

PharmGKB: the Pharmacogenetics Knowledge Base

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FPGS-2016-0152

RNA-Seq: a revolutionary tool for transcriptomics

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FPGS-2016-0152

RNA sequencing: advances, challenges and opportunities

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FPGS-2016-0152

Principles and challenges of genomewide DNA methylation analysis

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FPGS-2016-0152

Next-generation proteomics: towards an integrative view of proteome dynamics.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FPGS-2016-0152

Statistical Methods in Integrative Genomics

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FPGS-2016-0152

Integrative clustering of multiple genomic data types using a joint latent variable model with application to breast and lung cancer subtype analysis

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FPGS-2016-0152

AWclust: point-and-click software for non-parametric population structure analysis

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FPGS-2016-0152

Genetic clustering of European cancer patients indicates that opioid-mediated pain relief is independent of ancestry

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FPGS-2016-0152

Methods of integrating data to uncover genotype-phenotype interactions

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FPGS-2016-0152

Integrating heterogeneous high-throughput data for meta-dimensional pharmacogenomics and disease-related studies

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FPGS-2016-0152

Genome-wide variation of cytosine modifications between European and African populations and the implications for complex traits

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FPGS-2016-0152

Systematic identification of genomic markers of drug sensitivity in cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FPGS-2016-0152

Integration Analysis of Three Omics Data Using Penalized Regression Methods: An Application to Bladder Cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FPGS-2016-0152

A Bayesian integrative genomic model for pathway analysis of complex traits

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FPGS-2016-0152

A community effort to assess and improve drug sensitivity prediction algorithms.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FPGS-2016-0152

'Big data', Hadoop and cloud computing in genomics

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FPGS-2016-0152

Evidence for epistatic interactions in antiepileptic drug resistance

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FPGS-2016-0152

Application of principal component analysis to pharmacogenomic studies in Canada

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FPGS-2016-0152

21 January 2018

Identifiers

DOI

10.2217/PGS-2016-0152

1 reference

14 August 2017

1 reference

PubMed ID

28612644