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GCN2 sustains mTORC1 suppression upon amino acid deprivation by inducing Sestrin2.
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stated in
Europe PubMed Central
PMCID
4691887
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26543160%20AND%20SRC:MED&resulttype=core&format=json
retrieved
29 February 2020
title
GCN2 sustains mTORC1 suppression upon amino acid deprivation by inducing Sestrin2
(English)
1 reference
stated in
Europe PubMed Central
PMCID
4691887
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26543160%20AND%20SRC:MED&resulttype=core&format=json
retrieved
29 February 2020
author
Jiangbin Ye
series ordinal
1
1 reference
stated in
Europe PubMed Central
PMCID
4691887
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26543160%20AND%20SRC:MED&resulttype=core&format=json
retrieved
29 February 2020
Min Peng
series ordinal
3
1 reference
stated in
Europe PubMed Central
PMCID
4691887
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26543160%20AND%20SRC:MED&resulttype=core&format=json
retrieved
29 February 2020
Costas Koumenis
series ordinal
7
1 reference
stated in
Europe PubMed Central
PMCID
4691887
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26543160%20AND%20SRC:MED&resulttype=core&format=json
retrieved
29 February 2020
Craig B. Thompson
series ordinal
8
object named as
Craig B Thompson
1 reference
stated in
Europe PubMed Central
PMCID
4691887
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26543160%20AND%20SRC:MED&resulttype=core&format=json
retrieved
29 February 2020
author name string
Wilhelm Palm
series ordinal
2
1 reference
stated in
Europe PubMed Central
PMCID
4691887
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26543160%20AND%20SRC:MED&resulttype=core&format=json
retrieved
29 February 2020
Bryan King
series ordinal
4
1 reference
stated in
Europe PubMed Central
PMCID
4691887
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26543160%20AND%20SRC:MED&resulttype=core&format=json
retrieved
29 February 2020
Tullia Lindsten
series ordinal
5
1 reference
stated in
Europe PubMed Central
PMCID
4691887
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26543160%20AND%20SRC:MED&resulttype=core&format=json
retrieved
29 February 2020
Ming O Li
series ordinal
6
1 reference
stated in
Europe PubMed Central
PMCID
4691887
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26543160%20AND%20SRC:MED&resulttype=core&format=json
retrieved
29 February 2020
publication date
5 November 2015
1 reference
stated in
Europe PubMed Central
PMCID
4691887
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26543160%20AND%20SRC:MED&resulttype=core&format=json
retrieved
29 February 2020
published in
Genes & Development
1 reference
stated in
Europe PubMed Central
PMCID
4691887
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26543160%20AND%20SRC:MED&resulttype=core&format=json
retrieved
29 February 2020
volume
29
1 reference
stated in
Europe PubMed Central
PMCID
4691887
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26543160%20AND%20SRC:MED&resulttype=core&format=json
retrieved
29 February 2020
issue
22
1 reference
stated in
Europe PubMed Central
PMCID
4691887
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26543160%20AND%20SRC:MED&resulttype=core&format=json
retrieved
29 February 2020
page(s)
2331-2336
1 reference
stated in
Europe PubMed Central
PMCID
4691887
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26543160%20AND%20SRC:MED&resulttype=core&format=json
retrieved
29 February 2020
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Translational Upregulation of an Individual p21Cip1 Transcript Variant by GCN2 Regulates Cell Proliferation and Survival under Nutrient Stress
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PubMed Central
reference URL
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Metabolism. Differential regulation of mTORC1 by leucine and glutamine
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30 September 2017
Metabolism. Lysosomal amino acid transporter SLC38A9 signals arginine sufficiency to mTORC1
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30 September 2017
SLC38A9 is a component of the lysosomal amino acid sensing machinery that controls mTORC1
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4691887
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30 September 2017
Sestrins inhibit mTORC1 kinase activation through the GATOR complex
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4691887
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30 September 2017
The Sestrins interact with GATOR2 to negatively regulate the amino-acid-sensing pathway upstream of mTORC1
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4691887
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30 September 2017
Sestrins function as guanine nucleotide dissociation inhibitors for Rag GTPases to control mTORC1 signaling
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30 September 2017
Making new contacts: the mTOR network in metabolism and signalling crosstalk
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30 September 2017
The eIF2α/ATF4 pathway is essential for stress-induced autophagy gene expression
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30 September 2017
ER-stress-induced transcriptional regulation increases protein synthesis leading to cell death.
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30 September 2017
Amino acid signalling upstream of mTOR
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30 September 2017
Metabolic stress controls mTORC1 lysosomal localization and dimerization by regulating the TTT-RUVBL1/2 complex.
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30 September 2017
Pyruvate kinase M2 promotes de novo serine synthesis to sustain mTORC1 activity and cell proliferation.
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30 September 2017
mTOR signaling in growth control and disease
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30 September 2017
Nutrient starvation elicits an acute autophagic response mediated by Ulk1 dephosphorylation and its subsequent dissociation from AMPK.
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30 September 2017
AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1
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30 September 2017
Ragulator-Rag complex targets mTORC1 to the lysosomal surface and is necessary for its activation by amino acids
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30 September 2017
GCN2 protein kinase is required to activate amino acid deprivation responses in mice treated with the anti-cancer agent L-asparaginase.
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4691887
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30 September 2017
Bidirectional transport of amino acids regulates mTOR and autophagy
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4691887
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30 September 2017
Regulation of TORC1 by Rag GTPases in nutrient response
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4691887
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30 September 2017
The Rag GTPases bind raptor and mediate amino acid signaling to mTORC1
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4691887
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30 September 2017
Reinitiation involving upstream ORFs regulates ATF4 mRNA translation in mammalian cells
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30 September 2017
An integrated stress response regulates amino acid metabolism and resistance to oxidative stress
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PubMed Central
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30 September 2017
Mutations that bypass tRNA binding activate the intrinsically defective kinase domain in GCN2.
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PubMed Central
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30 September 2017
Regulated translation initiation controls stress-induced gene expression in mammalian cells
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PubMed Central
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30 September 2017
Uncharged tRNA activates GCN2 by displacing the protein kinase moiety from a bipartite tRNA-binding domain
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4691887
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30 September 2017
Amino acid sufficiency and mTOR regulate p70 S6 kinase and eIF-4E BP1 through a common effector mechanism
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PubMed Central
reference URL
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30 September 2017
The eIF-2 alpha kinases: regulators of protein synthesis in starvation and stress
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4691887
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30 September 2017
The histidyl-tRNA synthetase-related sequence in the eIF-2 alpha protein kinase GCN2 interacts with tRNA and is required for activation in response to starvation for different amino acids
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4691887
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30 September 2017
Evidence for translational regulation of the activator of general amino acid control in yeast
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4691887
retrieved
30 September 2017
Juxtaposition of domains homologous to protein kinases and histidyl-tRNA synthetases in GCN2 protein suggests a mechanism for coupling GCN4 expression to amino acid availability
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4691887
retrieved
30 September 2017
Phosphorylation of initiation factor 2 alpha by protein kinase GCN2 mediates gene-specific translational control of GCN4 in yeast
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4691887
retrieved
30 September 2017
Amino Acid-Dependent mTORC1 Regulation by the Lysosomal Membrane Protein SLC38A9
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4691887
retrieved
28 June 2018
Sestrin2 inhibits mTORC1 through modulation of GATOR complexes
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4691887
retrieved
28 June 2018
The GCN2-ATF4 pathway is critical for tumour cell survival and proliferation in response to nutrient deprivation.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4691887
retrieved
28 June 2018
Amino acid availability regulates p70 S6 kinase and multiple translation factors
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4691887
retrieved
28 June 2018
Preservation of liver protein synthesis during dietary leucine deprivation occurs at the expense of skeletal muscle mass in mice deleted for eIF2 kinase GCN2.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4691887
retrieved
21 September 2018
Dimerization is required for activation of eIF2 kinase Gcn2 in response to diverse environmental stress conditions
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4691887
retrieved
21 September 2018
Genetic and biochemical evidence for yeast GCN2 protein kinase polymerization
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/26543160
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Identifiers
DOI
10.1101/GAD.269324.115
1 reference
stated in
Europe PubMed Central
PMCID
4691887
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26543160%20AND%20SRC:MED&resulttype=core&format=json
retrieved
29 February 2020
PMCID
4691887
1 reference
stated in
Europe PubMed Central
PMCID
4691887
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26543160%20AND%20SRC:MED&resulttype=core&format=json
retrieved
29 February 2020
PubMed ID
26543160
1 reference
stated in
Europe PubMed Central
PMCID
4691887
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26543160%20AND%20SRC:MED&resulttype=core&format=json
retrieved
29 February 2020
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