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Frizzled and LRP5/6 receptors for Wnt/β-catenin signaling
scientific article
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scholarly article
1 reference
stated in
Europe PubMed Central
PMCID
3504444
retrieved
14 August 2017
review article
1 reference
stated in
Europe PubMed Central
title
Frizzled and LRP5/6 receptors for Wnt/β-catenin signaling
(English)
1 reference
stated in
Europe PubMed Central
PMCID
3504444
retrieved
14 August 2017
main subject
Wnt-Frizzled-LRP5/6 complex
1 reference
stated in
Gene Ontology release 2020-05-02
Gene Ontology ID
GO:1990851
author name string
Bryan T MacDonald
series ordinal
1
1 reference
stated in
Europe PubMed Central
PMCID
3504444
retrieved
14 August 2017
Xi He
series ordinal
2
1 reference
stated in
Europe PubMed Central
PMCID
3504444
retrieved
14 August 2017
publication date
1 December 2012
1 reference
stated in
Europe PubMed Central
PMCID
3504444
retrieved
14 August 2017
published in
Cold Spring Harbor Perspectives in Biology
1 reference
stated in
Europe PubMed Central
PMCID
3504444
retrieved
14 August 2017
volume
4
1 reference
stated in
Europe PubMed Central
PMCID
3504444
retrieved
14 August 2017
issue
12
1 reference
stated in
Europe PubMed Central
PMCID
3504444
retrieved
14 August 2017
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β-catenin-dependent Wnt signaling in C. elegans: teaching an old dog a new trick
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30 September 2017
Structural basis of Wnt recognition by Frizzled
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30 September 2017
Wnt/β-catenin signaling requires interaction of the Dishevelled DEP domain and C terminus with a discontinuous motif in Frizzled
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30 September 2017
Cell cycle control of Wnt/β-catenin signalling by conductin/axin2 through CDC20
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30 September 2017
Wnt/β-catenin signaling and AXIN1 regulate apoptosis triggered by inhibition of the mutant kinase BRAFV600E in human melanoma.
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The extracellular loops of Smoothened play a regulatory role in control of Hedgehog pathway activation
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30 September 2017
Secreted Wingless-interacting molecule (Swim) promotes long-range signaling by maintaining Wingless solubility
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30 September 2017
Adenomatous polyposis coli (APC) regulates multiple signaling pathways by enhancing glycogen synthase kinase-3 (GSK-3) activity
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Waif1/5T4 inhibits Wnt/β-catenin signaling and activates noncanonical Wnt pathways by modifying LRP6 subcellular localization.
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Inhibition of GSK3 by Wnt signalling--two contrasting models
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30 September 2017
Structural Basis of Wnt Signaling Inhibition by Dickkopf Binding to LRP5/6
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30 September 2017
Structural and Functional Studies of LRP6 Ectodomain Reveal a Platform for Wnt Signaling
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30 September 2017
Crystal structures of the extracellular domain of LRP6 and its complex with DKK1
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30 September 2017
Wnt antagonists bind through a short peptide to the first β-propeller domain of LRP5/6
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30 September 2017
Dissecting molecular differences between Wnt coreceptors LRP5 and LRP6
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30 September 2017
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30 September 2017
Coordinated action of CK1 isoforms in canonical Wnt signaling.
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30 September 2017
Transmembrane protein 198 promotes LRP6 phosphorylation and Wnt signaling activation
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30 September 2017
Pointing in the right direction: new developments in the field of planar cell polarity.
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30 September 2017
LRP6 mediates cAMP generation by G protein-coupled receptors through regulating the membrane targeting of Gα(s).
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30 September 2017
MESD is essential for apical localization of megalin/LRP2 in the visceral endoderm
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30 September 2017
Vangl2 promotes Wnt/planar cell polarity-like signaling by antagonizing Dvl1-mediated feedback inhibition in growth cone guidance
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30 September 2017
Amer1/WTX couples Wnt-induced formation of PtdIns(4,5)P2 to LRP6 phosphorylation
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30 September 2017
Dishevelled interacts with the DIX domain polymerization interface of Axin to interfere with its function in down-regulating β-catenin
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30 September 2017
Wnt signaling requires sequestration of glycogen synthase kinase 3 inside multivesicular endosomes
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30 September 2017
Importance of the extracellular loops in G protein-coupled receptors for ligand recognition and receptor activation
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30 September 2017
Mitogen-activated protein kinases promote WNT/beta-catenin signaling via phosphorylation of LRP6.
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30 September 2017
Structural Analysis of the Interaction between Dishevelled2 and Clathrin AP-2 Adaptor, A Critical Step in Noncanonical Wnt Signaling
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30 September 2017
Wnt isoform-specific interactions with coreceptor specify inhibition or potentiation of signaling by LRP6 antibodies
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30 September 2017
Beyond rhodopsin: G protein-coupled receptor structure and modeling incorporating the beta2-adrenergic and adenosine A(2A) crystal structures
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30 September 2017
Inhibition of tumorigenesis driven by different Wnt proteins requires blockade of distinct ligand-binding regions by LRP6 antibodies
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30 September 2017
Gbetagamma activates GSK3 to promote LRP6-mediated beta-catenin transcriptional activity
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PubMed Central
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30 September 2017
Stability elements in the LRP6 cytoplasmic tail confer efficient signalling upon DIX-dependent polymerization
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30 September 2017
Requirement of prorenin receptor and vacuolar H+-ATPase-mediated acidification for Wnt signaling
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30 September 2017
Reconstitution of a frizzled8.Wnt3a.LRP6 signaling complex reveals multiple Wnt and Dkk1 binding sites on LRP6
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30 September 2017
Cell cycle control of wnt receptor activation
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30 September 2017
G Protein-coupled receptor kinases phosphorylate LRP6 in the Wnt pathway.
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30 September 2017
Tankyrase inhibition stabilizes axin and antagonizes Wnt signalling
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30 September 2017
A new look at TCF and beta-catenin through the lens of a divergent C. elegans Wnt pathway
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30 September 2017
Wnt/beta-catenin signaling: components, mechanisms, and diseases
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30 September 2017
Regulation of phosphatidylinositol kinases and metabolism by Wnt3a and Dvl
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30 September 2017
Sequence requirement and subtype specificity in the high-affinity interaction between human frizzled and dishevelled proteins
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30 September 2017
Cooperative folding and ligand-binding properties of LRP6 beta-propeller domains
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30 September 2017
Inhibition of GSK3 phosphorylation of beta-catenin via phosphorylated PPPSPXS motifs of Wnt coreceptor LRP6.
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30 September 2017
Electrochemical cues regulate assembly of the Frizzled/Dishevelled complex at the plasma membrane during planar epithelial polarization.
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30 September 2017
Direct inhibition of GSK3beta by the phosphorylated cytoplasmic domain of LRP6 in Wnt/beta-catenin signaling
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30 September 2017
Hedgehog signaling in development and cancer.
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30 September 2017
Wnt3a-mediated formation of phosphatidylinositol 4,5-bisphosphate regulates LRP6 phosphorylation
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30 September 2017
Alternative wnt signaling is initiated by distinct receptors.
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30 September 2017
Wnt3a and Dkk1 regulate distinct internalization pathways of LRP6 to tune the activation of beta-catenin signaling
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30 September 2017
LRP6 transduces a canonical Wnt signal independently of Axin degradation by inhibiting GSK3's phosphorylation of beta-catenin
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30 September 2017
Wnt signal amplification via activity, cooperativity, and regulation of multiple intracellular PPPSP motifs in the Wnt co-receptor LRP6.
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30 September 2017
Multiple PPPS/TP motifs act in a combinatorial fashion to transduce Wnt signaling through LRP6.
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PubMed Central
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30 September 2017
Initiation of Wnt signaling: control of Wnt coreceptor Lrp6 phosphorylation/activation via frizzled, dishevelled and axin functions.
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30 September 2017
Endocytosis: a positive or a negative influence on Wnt signalling?
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30 September 2017
The Frizzled family of unconventional G-protein-coupled receptors
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30 September 2017
Dynamic recruitment of axin by Dishevelled protein assemblies
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30 September 2017
Wnt induces LRP6 signalosomes and promotes dishevelled-dependent LRP6 phosphorylation
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30 September 2017
Functional redundancy of GSK-3alpha and GSK-3beta in Wnt/beta-catenin signaling shown by using an allelic series of embryonic stem cell lines
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30 September 2017
Wilms tumor suppressor WTX negatively regulates WNT/beta-catenin signaling
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30 September 2017
Protein phosphatase 1 regulates assembly and function of the beta-catenin degradation complex
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30 September 2017
The Inheritance and Expression of Fused, a New Mutation in the House Mouse
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30 September 2017
beta-catenin destruction complex: insights and questions from a structural perspective
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30 September 2017
The Wnt code: cnidarians signal the way.
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30 September 2017
Monounsaturated fatty acid modification of Wnt protein: its role in Wnt secretion
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30 September 2017
Wnt/beta-catenin signaling in development and disease
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30 September 2017
Phosphoinositides in cell regulation and membrane dynamics
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PubMed Central
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30 September 2017
Caveolin is necessary for Wnt-3a-dependent internalization of LRP6 and accumulation of beta-catenin
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PubMed Central
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30 September 2017
A critical role for endocytosis in Wnt signaling
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PubMed Central
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30 September 2017
Internalization is required for proper Wingless signaling in Drosophila melanogaster
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30 September 2017
CKI, there's more than one: casein kinase I family members in Wnt and Hedgehog signaling
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30 September 2017
The low density lipoprotein receptor-related protein 6 interacts with glycogen synthase kinase 3 and attenuates activity
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30 September 2017
A dual-kinase mechanism for Wnt co-receptor phosphorylation and activation
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30 September 2017
Casein kinase 1 gamma couples Wnt receptor activation to cytoplasmic signal transduction
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30 September 2017
Rapid, Wnt-induced changes in GSK3beta associations that regulate beta-catenin stabilization are mediated by Galpha proteins
1 reference
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3504444
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30 September 2017
The role of the cysteine-rich domain of Frizzled in Wingless-Armadillo signaling
1 reference
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3504444
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30 September 2017
Genetic evidence that Drosophila frizzled controls planar cell polarity and Armadillo signaling by a common mechanism
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3504444
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30 September 2017
Frat is dispensable for canonical Wnt signaling in mammals
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3504444
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30 September 2017
Shisa promotes head formation through the inhibition of receptor protein maturation for the caudalizing factors, Wnt and FGF.
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3504444
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30 September 2017
The Wnt signaling pathway in development and disease
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3504444
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30 September 2017
LDL receptor-related proteins 5 and 6 in Wnt/beta-catenin signaling: arrows point the way
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3504444
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30 September 2017
Boca-dependent maturation of beta-propeller/EGF modules in low-density lipoprotein receptor proteins.
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3504444
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30 September 2017
Casein kinase Iepsilon modulates the signaling specificities of dishevelled
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3504444
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30 September 2017
A mechanism for Wnt coreceptor activation
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3504444
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30 September 2017
Direct binding of the PDZ domain of Dishevelled to a conserved internal sequence in the C-terminal region of Frizzled
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3504444
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30 September 2017
Mesd encodes an LRP5/6 chaperone essential for specification of mouse embryonic polarity
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3504444
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30 September 2017
Structural basis for recruitment of glycogen synthase kinase 3beta to the axin-APC scaffold complex
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3504444
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30 September 2017
Signaling of rat Frizzled-2 through phosphodiesterase and cyclic GMP
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3504444
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30 September 2017
The protein kinase complement of the human genome
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3504444
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30 September 2017
Mutant frizzled-4 disrupts retinal angiogenesis in familial exudative vitreoretinopathy
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3504444
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30 September 2017
Direct interaction of Frizzled-1, -2, -4, and -7 with PDZ domains of PSD-95
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3504444
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30 September 2017
Control of beta-catenin phosphorylation/degradation by a dual-kinase mechanism
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3504444
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30 September 2017
Insights into Wnt binding and signalling from the structures of two Frizzled cysteine-rich domains
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3504444
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30 September 2017
Crystal structure of glycogen synthase kinase 3 beta: structural basis for phosphate-primed substrate specificity and autoinhibition
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3504444
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30 September 2017
A common phosphate binding site explains the unique substrate specificity of GSK3 and its inactivation by phosphorylation
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3504444
retrieved
30 September 2017
Synergistic activation of the Wnt signaling pathway by Dvl and casein kinase Iepsilon
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3504444
retrieved
30 September 2017
Implications for familial hypercholesterolemia from the structure of the LDL receptor YWTD-EGF domain pair
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3504444
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30 September 2017
LDL-receptor-related protein 6 is a receptor for Dickkopf proteins
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3504444
retrieved
30 September 2017
Low-density lipoprotein receptor-related protein-5 binds to Axin and regulates the canonical Wnt signaling pathway
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3504444
retrieved
30 September 2017
Structural basis of the recognition of the dishevelled DEP domain in the Wnt signaling pathway
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3504444
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30 September 2017
An LDL-receptor-related protein mediates Wnt signalling in mice
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3504444
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30 September 2017
LDL-receptor-related proteins in Wnt signal transduction
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3504444
retrieved
30 September 2017
arrow encodes an LDL-receptor-related protein essential for Wingless signalling
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3504444
retrieved
30 September 2017
The C-terminal cytoplasmic Lys-thr-X-X-X-Trp motif in frizzled receptors mediates Wnt/beta-catenin signalling
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3504444
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30 September 2017
Interaction of dishevelled and Xenopus axin-related protein is required for wnt signal transduction
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3504444
retrieved
30 September 2017
A GSK3beta phosphorylation site in axin modulates interaction with beta-catenin and Tcf-mediated gene expression
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3504444
retrieved
30 September 2017
Axin and Frat1 interact with dvl and GSK, bridging Dvl to GSK in Wnt-mediated regulation of LEF-1.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3504444
retrieved
30 September 2017
Wnt-induced dephosphorylation of axin releases beta-catenin from the axin complex
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3504444
retrieved
30 September 2017
DIX domains of Dvl and axin are necessary for protein interactions and their ability to regulate beta-catenin stability
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3504444
retrieved
30 September 2017
Phosphorylation of axin, a Wnt signal negative regulator, by glycogen synthase kinase-3beta regulates its stability
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3504444
retrieved
30 September 2017
Biochemical characterization of Wnt-frizzled interactions using a soluble, biologically active vertebrate Wnt protein
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3504444
retrieved
30 September 2017
Axin prevents Wnt-3a-induced accumulation of beta-catenin
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3504444
retrieved
30 September 2017
An extracellular beta-propeller module predicted in lipoprotein and scavenger receptors, tyrosine kinases, epidermal growth factor precursor, and extracellular matrix components
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3504444
retrieved
30 September 2017
Differential recruitment of Dishevelled provides signaling specificity in the planar cell polarity and Wingless signaling pathways
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3504444
retrieved
30 September 2017
Cloning of a novel member of the low-density lipoprotein receptor family
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3504444
retrieved
30 September 2017
Isolation and characterization of LRP6, a novel member of the low density lipoprotein receptor gene family
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3504444
retrieved
30 September 2017
Dishevelled activates JNK and discriminates between JNK pathways in planar polarity and wingless signaling
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3504444
retrieved
30 September 2017
GBP, an inhibitor of GSK-3, is implicated in Xenopus development and oncogenesis
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3504444
retrieved
30 September 2017
Axil, a member of the Axin family, interacts with both glycogen synthase kinase 3beta and beta-catenin and inhibits axis formation of Xenopus embryos
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3504444
retrieved
30 September 2017
Axin, a negative regulator of the wnt signaling pathway, directly interacts with adenomatous polyposis coli and regulates the stabilization of beta-catenin
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3504444
retrieved
30 September 2017
Functional interaction of an axin homolog, conductin, with beta-catenin, APC, and GSK3beta
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3504444
retrieved
30 September 2017
Axin, a negative regulator of the Wnt signaling pathway, forms a complex with GSK-3beta and beta-catenin and promotes GSK-3beta-dependent phosphorylation of beta-catenin
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3504444
retrieved
30 September 2017
The mouse Fused locus encodes Axin, an inhibitor of the Wnt signaling pathway that regulates embryonic axis formation
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3504444
retrieved
30 September 2017
Casein kinase 2 associates with and phosphorylates dishevelled
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3504444
retrieved
30 September 2017
A new member of the frizzled family from Drosophila functions as a Wingless receptor
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3504444
retrieved
30 September 2017
Dishevelled is a component of the frizzled signaling pathway in Drosophila
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3504444
retrieved
30 September 2017
Tissue polarity genes of Drosophila regulate the subcellular location for prehair initiation in pupal wing cells
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3504444
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30 September 2017
Signaling by wingless in Drosophila
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3504444
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30 September 2017
Multiple functions of segment polarity genes in Drosophila
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3504444
retrieved
30 September 2017
A Drosophila tissue polarity locus encodes a protein containing seven potential transmembrane domains
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3504444
retrieved
30 September 2017
Wnt signals across the plasma membrane to activate the beta-catenin pathway by forming oligomers containing its receptors, Frizzled and LRP.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3504444
retrieved
30 September 2017
Wnt signalling: What The X@# is WTX?
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3504444
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28 June 2018
Mest/Peg1 inhibits Wnt signalling through regulation of LRP6 glycosylation
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3504444
retrieved
28 June 2018
The DIX domain of Dishevelled confers Wnt signaling by dynamic polymerization
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3504444
retrieved
28 June 2018
Wingless/Wnt signal transduction requires distinct initiation and amplification steps that both depend on Arrow/LRP.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3504444
retrieved
28 June 2018
The apical determinants aPKC and dPatj regulate Frizzled-dependent planar cell polarity in the Drosophila eye.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3504444
retrieved
28 June 2018
Glycogen synthase kinase-3 beta mutagenesis identifies a common binding domain for GBP and Axin.
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3504444
retrieved
28 June 2018
EGF receptor/Rolled MAP kinase signalling protects cells against activated Armadillo in the Drosophila eye.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3504444
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28 June 2018
Pathway specificity by the bifunctional receptor frizzled is determined by affinity for wingless
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3504444
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28 June 2018
Structure and expression of conserved Wnt pathway components in the demosponge Amphimedon queenslandica.
1 reference
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3504444
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21 September 2018
Overview of the mutation spectrum in familial exudative vitreoretinopathy and Norrie disease with identification of 21 novel variants in FZD4, LRP5, and NDP.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3504444
retrieved
21 September 2018
CKIepsilon/discs overgrown promotes both Wnt-Fz/beta-catenin and Fz/PCP signaling in Drosophila
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3504444
retrieved
21 September 2018
Endocytic trafficking of Wingless and its receptors, Arrow and DFrizzled-2, in the Drosophila wing
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3504444
retrieved
21 September 2018
Phosphorylation of frizzled-3.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3504444
retrieved
21 September 2018
Loss of caveolin-1 causes the hyper-proliferation of intestinal crypt stem cells, with increased sensitivity to whole body gamma-radiation
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3504444
retrieved
21 September 2018
Caveolin-1-deficient mice have an increased mammary stem cell population with upregulation of Wnt/beta-catenin signaling.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3504444
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21 September 2018
Arrow (LRP6) and Frizzled2 cooperate to degrade Wingless in Drosophila imaginal discs
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3504444
retrieved
21 September 2018
The Wnt signalling effector Dishevelled forms dynamic protein assemblies rather than stable associations with cytoplasmic vesicles.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3504444
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21 September 2018
Trimeric G protein-dependent frizzled signaling in Drosophila
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3504444
retrieved
21 September 2018
Wg/Wnt signal can be transmitted through arrow/LRP5,6 and Axin independently of Zw3/Gsk3beta activity
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3504444
retrieved
21 September 2018
Boca, an endoplasmic reticulum protein required for wingless signaling and trafficking of LDL receptor family members in Drosophila.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3504444
retrieved
21 September 2018
Ligand receptor interactions in the Wnt signaling pathway in Drosophila
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3504444
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21 September 2018
Signaling specificity by Frizzled receptors in Drosophila.
1 reference
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3504444
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21 September 2018
Wingless transduction by the Frizzled and Frizzled2 proteins of Drosophila.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3504444
retrieved
21 September 2018
Casein kinase I transduces Wnt signals
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3504444
retrieved
21 September 2018
Use of dsRNA-mediated genetic interference to demonstrate that frizzled and frizzled 2 act in the wingless pathway.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3504444
retrieved
21 September 2018
Antagonism between EGFR and Wingless signalling in the larval cuticle of Drosophila.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3504444
retrieved
21 September 2018
The DIX domain targets dishevelled to actin stress fibres and vesicular membranes
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3504444
retrieved
5 December 2018
Mutations affecting the pattern of the larval cuticle inDrosophila melanogaster : I. Zygotic loci on the second chromosome
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/23209147
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Identifiers
DOI
10.1101/CSHPERSPECT.A007880
1 reference
stated in
Europe PubMed Central
PMCID
3504444
retrieved
14 August 2017
PMCID
3504444
1 reference
stated in
Europe PubMed Central
PMCID
3504444
retrieved
14 August 2017
PubMed ID
23209147
1 reference
stated in
Europe PubMed Central
PMCID
3504444
retrieved
14 August 2017
ResearchGate publication ID
233840264
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