(Q36430147)

14 August 2017

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title

Caspases at the crossroads of immune-cell life and death (English)

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14 August 2017

Richard M Siegel

1

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14 August 2017

1 April 2006

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Nature Reviews Immunology

14 August 2017

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14 August 2017

6

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14 August 2017

308-317

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14 August 2017

4

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Caspases: an ancient cellular sword of Damocles

14 August 2017

1 reference

Caspases: killer proteases

21 January 2018

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Inflammatory caspases: linking an intracellular innate immune system to autoinflammatory diseases

21 January 2018

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The Drosophila caspase Dredd is required to resist gram-negative bacterial infection

21 January 2018

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The biochemistry of apoptosis

21 January 2018

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The role of BH3-only proteins in the immune system

21 January 2018

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Three-dimensional structure of the apoptosome: implications for assembly, procaspase-9 binding, and activation.

21 January 2018

1 reference

A unified model for apical caspase activation

21 January 2018

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The CD95(APO-1/Fas) DISC and beyond

21 January 2018

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SPOTS: signaling protein oligomeric transduction structures are early mediators of death receptor-induced apoptosis at the plasma membrane

21 January 2018

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Membrane oligomerization and cleavage activates the caspase-8 (FLICE/MACHalpha1) death signal

21 January 2018

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The long form of FLIP is an activator of caspase-8 at the Fas death-inducing signaling complex

21 January 2018

1 reference

The role of c-FLIP in modulation of CD95-induced apoptosis

21 January 2018

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Viral FLICE-inhibitory proteins (FLIPs) prevent apoptosis induced by death receptors

21 January 2018

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The multifaceted role of Fas signaling in immune cell homeostasis and autoimmunity

21 January 2018

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Die and let live: eliminating dangerous lymphocytes

21 January 2018

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Fas triggers an alternative, caspase-8-independent cell death pathway using the kinase RIP as effector molecule

21 January 2018

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Lymphoproliferation disorder in mice explained by defects in Fas antigen that mediates apoptosis

21 January 2018

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An inherited disorder of lymphocyte apoptosis: the autoimmune lymphoproliferative syndrome

21 January 2018

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The autoimmune lymphoproliferative syndrome. A disorder of human lymphocyte apoptosis

21 January 2018

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T cell-specific ablation of Fas leads to Fas ligand-mediated lymphocyte depletion and inflammatory pulmonary fibrosis

21 January 2018

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Lpr and gld: single gene models of systemic autoimmunity and lymphoproliferative disease

21 January 2018

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Targeted disruption of the mouse Caspase 8 gene ablates cell death induction by the TNF receptors, Fas/Apo1, and DR3 and is lethal prenatally.

21 January 2018

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Fas-mediated apoptosis and activation-induced T-cell proliferation are defective in mice lacking FADD/Mort1

21 January 2018

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Requirement for Casper (c-FLIP) in regulation of death receptor-induced apoptosis and embryonic development

21 January 2018

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Cellular FLICE-inhibitory protein is required for T cell survival and cycling

21 January 2018

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Conditional Fas-associated death domain protein (FADD): GFP knockout mice reveal FADD is dispensable in thymic development but essential in peripheral T cell homeostasis

21 January 2018

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Essential role for caspase 8 in T-cell homeostasis and T-cell-mediated immunity

21 January 2018

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An essential role for c-FLIP in the efficient development of mature T lymphocytes

21 January 2018

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FADD/MORT1 regulates the pre-TCR checkpoint and can function as a tumour suppressor

21 January 2018

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Caspase-8 serves both apoptotic and nonapoptotic roles

21 January 2018

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FADD and caspase-8 are required for cytokine-induced proliferation of hemopoietic progenitor cells.

21 January 2018

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Negative selection--clearing out the bad apples from the T-cell repertoire

21 January 2018

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Negative selection of semimature CD4(+)8(-)HSA+ thymocytes requires the BH3-only protein Bim but is independent of death receptor signaling

21 January 2018

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Caspase enzyme activity is not essential for apoptosis during thymocyte development

21 January 2018

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Early activation of caspases during T lymphocyte stimulation results in selective substrate cleavage in nonapoptotic cells

21 January 2018

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Caspase activation is required for T cell proliferation

21 January 2018

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Cellular FLIP (long form) regulates CD8+ T cell activation through caspase-8-dependent NF-kappa B activation

21 January 2018

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Pleiotropic defects in lymphocyte activation caused by caspase-8 mutations lead to human immunodeficiency

21 January 2018

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Inherited human Caspase 10 mutations underlie defective lymphocyte and dendritic cell apoptosis in autoimmune lymphoproliferative syndrome type II

21 January 2018

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A dominant interfering mutant of FADD/MORT1 enhances deletion of autoreactive thymocytes and inhibits proliferation of mature T lymphocytes

21 January 2018

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A role for FADD in T cell activation and development

21 January 2018

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The requirements for Fas-associated death domain signaling in mature T cell activation and survival

21 January 2018

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Modifications and intracellular trafficking of FADD/MORT1 and caspase-8 after stimulation of T lymphocytes.

21 January 2018

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Phosphorylation of FADD at serine 194 by CKIalpha regulates its nonapoptotic activities

21 January 2018

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A Function of Fas-Associated Death Domain Protein in Cell Cycle Progression Localized to a Single Amino Acid at Its C-Terminal Region

21 January 2018

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Viral FLIP impairs survival of activated T cells and generation of CD8+ T cell memory.

21 January 2018

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The caspase 8 inhibitor c-FLIP(L) modulates T-cell receptor-induced proliferation but not activation-induced cell death of lymphocytes

21 January 2018

1 reference

Caspase-8 deficiency in T cells leads to a lethal lymphoinfiltrative immune disorder

21 January 2018

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A role for caspases in controlling IL-4 expression in T cells

21 January 2018

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Cellular FLIP (long isoform) overexpression in T cells drives Th2 effector responses and promotes immunoregulation in experimental autoimmune encephalomyelitis.

21 January 2018

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Cellular FLIP long form-transgenic mice manifest a Th2 cytokine bias and enhanced allergic airway inflammation.

21 January 2018

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Caspase activity is required for stimulated B lymphocytes to enter the cell cycle

21 January 2018

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Cutting edge: innate immunity conferred by B cells is regulated by caspase-8.

21 January 2018

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Caspase-3 regulates cell cycle in B cells: a consequence of substrate specificity

21 January 2018

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Essential contribution of caspase 3/CPP32 to apoptosis and its associated nuclear changes

21 January 2018

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Specific involvement of caspases in the differentiation of monocytes into macrophages

21 January 2018

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Platelet formation is the consequence of caspase activation within megakaryocytes

21 January 2018

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The caspase-8 inhibitor FLIP promotes activation of NF-kappaB and Erk signaling pathways

21 January 2018

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CARMA1, BCL-10 and MALT1 in lymphocyte development and activation.

21 January 2018

1 reference

PDK1 nucleates T cell receptor-induced signaling complex for NF-kappaB activation

21 January 2018

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MALT1/paracaspase is a signaling component downstream of CARMA1 and mediates T cell receptor-induced NF-kappaB activation

21 January 2018

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Requirement for caspase-8 in NF-kappaB activation by antigen receptor.

21 January 2018

1 reference

Regulation of an ATG7-beclin 1 program of autophagic cell death by caspase-8

21 January 2018

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Induction of necrotic-like cell death by tumor necrosis factor alpha and caspase inhibitors: novel mechanism for killing virus-infected cells

21 January 2018

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Inhibition of caspases increases the sensitivity of L929 cells to necrosis mediated by tumor necrosis factor.

21 January 2018

1 reference

Drosophila peptidoglycan recognition protein LC (PGRP-LC) acts as a signal-transducing innate immune receptor

21 January 2018

1 reference

Caspase-mediated processing of the Drosophila NF-kappaB factor Relish

21 January 2018

1 reference

The role of ubiquitination in Drosophila innate immunity.

21 January 2018

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Ubiquitin signalling in the NF-kappaB pathway

21 January 2018

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Neuroprotection by the inhibition of apoptosis

21 January 2018

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A mechanistic role for cardiac myocyte apoptosis in heart failure

21 January 2018

1 reference

Some preliminary experiments on vision without inversion of the retinal image

21 January 2018

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A combinatorial approach defines specificities of members of the caspase family and granzyme B. Functional relationships established for key mediators of apoptosis

21 January 2018

1 reference

Cellular FLIP long form augments caspase activity and death of T cells through heterodimerization with and activation of caspase-8.

21 January 2018

1 reference

In situ trapping of activated initiator caspases reveals a role for caspase-2 in heat shock-induced apoptosis.

21 January 2018

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Caspase-activation pathways in apoptosis and immunity

21 January 2018

1 reference

Inhibition of fas death signals by FLIPs

31 March 2020

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Differential requirement of caspases during naive T cell proliferation

31 March 2020

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p53-dependent impairment of T-cell proliferation in FADD dominant-negative transgenic mice

31 March 2020

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Caspase-8 activity prevents type 2 cytokine responses and is required for protective T cell-mediated immunity against Trypanosoma cruzi infection

31 March 2020

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Involvement of caspase-cleaved and intact adaptor protein 1 complex in endosomal remodeling in maturing dendritic cells

31 March 2020

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Cutting edge: FADD is not required for antigen receptor-mediated NF-kappaB activation

31 March 2020

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Dominant interfering Fas gene mutations impair apoptosis in a human autoimmune lymphoproliferative syndrome

31 March 2020

1 reference

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7 January 2021

based on heuristic

Identifiers

DOI

10.1038/NRI1809

1 reference

14 August 2017

1 reference

PubMed ID

16557262