(Q36435632)

14 August 2017

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title

The future of antisense oligonucleotides in the treatment of respiratory diseases (English)

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14 August 2017

Marina Ulanova

1

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14 August 2017

Alan D Schreiber

series ordinal

2

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14 August 2017

A Dean Befus

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3

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14 August 2017

1 January 2006

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14 August 2017

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14 August 2017

20

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14 August 2017

1

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14 August 2017

1-11

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https://scigraph.springernature.com/pub.10.2165/00063030-200620010-00001

14 August 2017

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cites work

Control of alternative splicing by antisense oligonucleotides as a potential chemotherapy: effects on gene expression

1 reference

https://api.crossref.org/works/10.2165%2F00063030-200620010-00001

A review of the issues in the pharmacokinetics and toxicology of phosphorothioate antisense oligonucleotides

21 January 2018

1 reference

https://api.crossref.org/works/10.2165%2F00063030-200620010-00001

Inhibition of allergic inflammation in the airways using aerosolized antisense to Syk kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.2165%2F00063030-200620010-00001

Cationic lipids employed for antisense oligodeoxynucleotide transport may inhibit vascular cell adhesion molecule-1 expression in human endothelial cells: a word of caution

21 January 2018

1 reference

https://api.crossref.org/works/10.2165%2F00063030-200620010-00001

The Syk protein tyrosine kinase is essential for Fcgamma receptor signaling in macrophages and neutrophils

21 January 2018

1 reference

https://api.crossref.org/works/10.2165%2F00063030-200620010-00001

Abrogation of the Fc gamma receptor IIA-mediated phagocytic signal by stem-loop Syk antisense oligonucleotides

21 January 2018

1 reference

https://api.crossref.org/works/10.2165%2F00063030-200620010-00001

Hypermethylation of Syk gene in promoter region associated with oncogenesis and metastasis of gastric carcinoma

21 January 2018

1 reference

https://api.crossref.org/works/10.2165%2F00063030-200620010-00001

Lyn tyrosine kinase is important for IL-5-stimulated eosinophil differentiation

21 January 2018

1 reference

https://api.crossref.org/works/10.2165%2F00063030-200620010-00001

Vitravene--another piece in the mosaic

21 January 2018

1 reference

https://api.crossref.org/works/10.2165%2F00063030-200620010-00001

Inhibition of antigen-induced eosinophilia and airway hyperresponsiveness by antisense oligonucleotides directed against the common beta chain of IL-3, IL-5, GM-CSF receptors in a rat model of allergic asthma

21 January 2018

1 reference

https://api.crossref.org/works/10.2165%2F00063030-200620010-00001

Isolated bronchi from asthmatics are hyperresponsive to adenosine, which apparently acts indirectly by liberation of leukotrienes and histamine

21 January 2018

1 reference

https://api.crossref.org/works/10.2165%2F00063030-200620010-00001

Aerosolized Syk antisense suppresses Syk expression, mediator release from macrophages, and pulmonary inflammation

21 January 2018

1 reference

https://api.crossref.org/works/10.2165%2F00063030-200620010-00001

Inhibition of antigen-induced eosinophilia and late phase airway hyperresponsiveness by an IL-5 antisense oligonucleotide in mouse models of asthma

21 January 2018

1 reference

https://api.crossref.org/works/10.2165%2F00063030-200620010-00001

Effect of RNA silencing of polo-like kinase-1 (PLK1) on apoptosis and spindle formation in human cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.2165%2F00063030-200620010-00001

Inhibition of respiratory syncytial virus infection with intranasal siRNA nanoparticles targeting the viral NS1 gene

21 January 2018

1 reference

12 December 2020

Angiogenesis inhibitors: a rational strategy for radiosensitization in the treatment of non-small-cell lung cancer?

1 reference

12 December 2020

Side-effects of a systemic injection of linear polyethylenimine-DNA complexes

1 reference

12 December 2020

Pharmacokinetics and tolerability of intravenous trecovirsen (GEM 91), an antisense phosphorothioate oligonucleotide, in HIV-positive subjects

1 reference

12 December 2020

New drugs and treatment for respiratory syncytial virus

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12 December 2020

Antisense oligonucleotides for haematological malignancies

1 reference

12 December 2020

The Fc(epsilon)RIbeta subunit functions as an amplifier of Fc(epsilon)RIgamma-mediated cell activation signals

1 reference

12 December 2020

A polyribonucleotide containing alternation P=O and P=S linkages.

1 reference

12 December 2020

Positional cloning of a novel gene influencing asthma from chromosome 2q14.

1 reference

12 December 2020

Inhibition of high affinity basic fibroblast growth factor binding by oligonucleotides

1 reference

12 December 2020

Induction of apoptosis in small-cell lung cancer cells by an antisense oligodeoxynucleotide targeting the Bcl-2 coding sequence

1 reference

12 December 2020

A controlled study of adenoviral-vector-mediated gene transfer in the nasal epithelium of patients with cystic fibrosis

1 reference

12 December 2020

Antisense therapy for cancer--the time of truth

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12 December 2020

Oligonucleotide-based strategies to reduce gene expression.

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12 December 2020

CpG motifs in bacterial DNA and their immune effects

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12 December 2020

Preparation and characterization of cationic PLGA nanospheres as DNA carriers.

1 reference

12 December 2020

Progressive loss of Syk and abnormal proliferation in breast cancer cells

1 reference

12 December 2020

Cyclooxygenase-2 modulates the insulin-like growth factor axis in non-small-cell lung cancer

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12 December 2020

Progress in antisense technology.

1 reference

12 December 2020

Inhibition of Rous sarcoma virus replication and cell transformation by a specific oligodeoxynucleotide

1 reference

12 December 2020

Gene silencing with STAT6 specific siRNAs blocks eotaxin release in IL-4/TNFalpha stimulated human epithelial cells

1 reference

12 December 2020

DNA-polycation nanospheres as non-viral gene delivery vehicles

1 reference

12 December 2020

Peptide nucleic acids (PNAs): potential antisense and anti-gene agents

1 reference

12 December 2020

Stem cell factor is encoded at the SI locus of the mouse and is the ligand for the c-kit tyrosine kinase receptor

1 reference

12 December 2020

Gene therapy for human small-cell lung carcinoma by inactivation of Skp-2 with virally mediated RNA interference

1 reference

12 December 2020

Selective silencing by RNAi of a dominant allele that causes amyotrophic lateral sclerosis

1 reference

12 December 2020

Critical role for the tyrosine kinase Syk in signalling through the high affinity IgE receptor of mast cells

1 reference

12 December 2020

Inhaled p38alpha mitogen-activated protein kinase antisense oligonucleotide attenuates asthma in mice.

1 reference

12 December 2020

Immunotherapeutic uses of CpG oligodeoxynucleotides

1 reference

12 December 2020

Antitumor activity and pharmacokinetics of a mixed-backbone antisense oligonucleotide targeted to the RIalpha subunit of protein kinase A after oral administration

1 reference

12 December 2020

Respirable antisense oligonucleotides: a new drug class for respiratory disease

1 reference

12 December 2020

Ribozyme structures and mechanisms

1 reference

12 December 2020

Phosphorothioate oligodeoxynucleotides bind to basic fibroblast growth factor, inhibit its binding to cell surface receptors, and remove it from low affinity binding sites on extracellular matrix

1 reference

12 December 2020

Treatment of allergic airway inflammation and hyperresponsiveness by antisense-induced local blockade of GATA-3 expression

1 reference

12 December 2020

An RNA external guide sequence ribozyme targeting human interleukin-4 receptor alpha mRNA.

1 reference

12 December 2020

The NF-kappa B/Rel and I kappa B gene families: mediators of immune response and inflammation

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12 December 2020

Unlocking the potential of the human genome with RNA interference

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12 December 2020

Cationic lipids improve antisense oligonucleotide uptake and prevent degradation in cultured cells and in human serum

1 reference

12 December 2020

Noninvasive delivery of small inhibitory RNA and other reagents to pulmonary alveoli in mice

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12 December 2020

Potent inhibition of respiratory syncytial virus by combination treatment with 2-5A antisense and ribavirin

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12 December 2020

Mucosal gene expression vaccine: a novel vaccine strategy for respiratory syncytial virus

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12 December 2020

Inhibition of respiratory viruses by nasally administered siRNA.

1 reference

12 December 2020

Phase II trial with ISIS 5132 in patients with small-cell (SCLC) and non-small cell (NSCLC) lung cancer. A European Organization for Research and Treatment of Cancer (EORTC) Early Clinical Studies Group report

1 reference

12 December 2020

Intranasal gene transfer by chitosan-DNA nanospheres protects BALB/c mice against acute respiratory syncytial virus infection

1 reference

12 December 2020

A novel bispecific antisense oligonucleotide inhibiting both bcl-2 and bcl-xL expression efficiently induces apoptosis in tumor cells.

1 reference

12 December 2020

Influence of basic fibroblast growth factor on the proliferation of non-small cell lung cancer cell lines

1 reference

12 December 2020

Lipid-DNA complexes induce potent activation of innate immune responses and antitumor activity when administered intravenously

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12 December 2020

Antisense therapeutics: from theory to clinical practice

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12 December 2020

Gene transfer for cytokine functional studies in the lung: the multifunctional role of GM-CSF in pulmonary inflammation.

1 reference

12 December 2020

A phase I/II study of LY900003, an antisense inhibitor of protein kinase C-alpha, in combination with cisplatin and gemcitabine in patients with advanced non-small cell lung cancer

1 reference

12 December 2020

Exogenous surfactant as a drug delivery agent

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12 December 2020

Association of the ADAM33 gene with asthma and bronchial hyperresponsiveness

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12 December 2020

Potent and nontoxic antisense oligonucleotides containing locked nucleic acids

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12 December 2020

Short interfering RNAs can induce unexpected and divergent changes in the levels of untargeted proteins in mammalian cells

1 reference

12 December 2020

Induction of apoptosis and chemosensitization of mesothelioma cells by Bcl-2 and Bcl-xL antisense treatment.

1 reference

12 December 2020

A comparison of linear and branched polyethylenimine (PEI) with DCChol/DOPE liposomes for gene delivery to epithelial cells in vitro and in vivo

1 reference

12 December 2020

Effective inhibition of influenza virus production in cultured cells by external guide sequences and ribonuclease P.

1 reference

12 December 2020

Characterization of a common susceptibility locus for asthma-related traits

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12 December 2020

Stimulation of macrophage Fc gamma RIIIA activates the receptor-associated protein tyrosine kinase Syk and induces phosphorylation of multiple proteins including p95Vav and p62/GAP-associated protein

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12 December 2020

A novel antisense oligonucleotide targeting survivin expression induces apoptosis and sensitizes lung cancer cells to chemotherapy

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12 December 2020

DNA antisense therapy for asthma in an animal model

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12 December 2020

Differential control of the tyrosine kinases Lyn and Syk by the two signaling chains of the high affinity immunoglobulin E receptor

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12 December 2020

Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans

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12 December 2020

Novel cationic cardiolipin analogue-based liposome for efficient DNA and small interfering RNA delivery in vitro and in vivo

1 reference

12 December 2020

Inhibition of signal transducer and activator of transcription 1 attenuates allergen-induced airway inflammation and hyperreactivity.

1 reference

12 December 2020

New asthma drugs acting on gene expression.

1 reference

12 December 2020

Small interfering RNA-induced transcriptional gene silencing in human cells

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12 December 2020

The transcription factor GATA-3 is necessary and sufficient for Th2 cytokine gene expression in CD4 T cells

1 reference

12 December 2020

Adenovector-mediated gene transfer of active transforming growth factor-beta1 induces prolonged severe fibrosis in rat lung

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12 December 2020

Identification of COX17 as a therapeutic target for non-small cell lung cancer

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12 December 2020

Administration of antisense phosphorothioate oligonucleotide to the p65 subunit of NF-kappaB inhibits established asthmatic reaction in mice

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12 December 2020

Cationic lipids enhance cytokine and cell influx levels in the lung following administration of plasmid: cationic lipid complexes

1 reference

12 December 2020

Cationic lipids enhance cellular uptake and activity of phosphorothioate antisense oligonucleotides

1 reference

12 December 2020

Synthetic small inhibiting RNAs: efficient tools to inactivate oncogenic mutations and restore p53 pathways.

1 reference

12 December 2020

siRNA agents inhibit oncogene expression and attenuate human tumor cell growth

1 reference

12 December 2020

Local administration of antisense phosphorothioate oligonucleotides to the c-kit ligand, stem cell factor, suppresses airway inflammation and IL-4 production in a murine model of asthma

1 reference

12 December 2020

Inhibition of human non-small cell lung tumors by a c-Met antisense/U6 expression plasmid strategy

1 reference

12 December 2020

Increased radiation-induced apoptosis and altered cell cycle progression of human lung cancer cell lines by antisense oligodeoxynucleotides targeting p53 and p21(WAF1/CIP1).

1 reference

12 December 2020

Is irrelevant cleavage the price of antisense efficacy?

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12 December 2020

The Syk tyrosine kinase suppresses malignant growth of human breast cancer cells

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12 December 2020

Short interfering RNA (siRNA)-mediated RNA interference (RNAi) in human cells

1 reference

12 December 2020

Morpholino oligos: making sense of antisense?

1 reference

12 December 2020

Src-family kinases: rheostats of immune cell signaling

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12 December 2020

Inhibition of SARS-CoV replication by siRNA.

1 reference

12 December 2020

Adenosine-induced bronchoconstriction and contraction of airway smooth muscle from allergic rabbits with late-phase airway obstruction: evidence for an inducible adenosine A1 receptor

1 reference

12 December 2020

Therapeutic potential of antisense Bcl-2 as a chemosensitizer for cancer therapy

1 reference

12 December 2020

Role of Toll-like receptors in antisense and siRNA [corrected].

1 reference

12 December 2020

Oblimersen sodium (Genasense bcl-2 antisense oligonucleotide): a rational therapeutic to enhance apoptosis in therapy of lung cancer

1 reference

12 December 2020

Innovations in oligonucleotide drug delivery

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12 December 2020

Antisense oligonucleotides for cancer therapy-an overview

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12 December 2020

A novel anti-apoptosis gene, survivin, expressed in cancer and lymphoma

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12 December 2020

Selective elimination of mRNAs in vivo: complementary oligodeoxynucleotides promote RNA degradation by an RNase H-like activity

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12 December 2020

Modulation of the classical multidrug resistance (MDR) phenotype by RNA interference (RNAi).

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12 December 2020

A system for stable expression of short interfering RNAs in mammalian cells

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12 December 2020

Cloning and identification of the gene gob-5, which is expressed in intestinal goblet cells in mice

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12 December 2020

Therapeutic potential of RNA interference

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12 December 2020

Prolonged circulation time and enhanced accumulation in malignant exudates of doxorubicin encapsulated in polyethylene-glycol coated liposomes

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12 December 2020

Novel antisense and peptide nucleic acid strategies for controlling gene expression

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12 December 2020

Intracellular distribution and mechanism of delivery of oligonucleotides mediated by cationic lipids

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12 December 2020

Role of gob-5 in mucus overproduction and airway hyperresponsiveness in asthma

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12 December 2020

Allele-specific silencing of dominant disease genes

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12 December 2020

Syk tyrosine kinase participates in beta1-integrin signaling and inflammatory responses in airway epithelial cells

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12 December 2020

RNA interference: a potent tool for gene-specific therapeutics

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12 December 2020

10.2165/00063030-200620010-00001

Identifiers

DOI

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Dimensions Publication ID

14 August 2017

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