(Q36444526)

14 August 2017

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title

Role of L-type Ca2+ channels in iron transport and iron-overload cardiomyopathy (English)

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14 August 2017

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Gavin Y Oudit

1

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14 August 2017

Maria G Trivieri

2

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14 August 2017

Neelam Khaper

3

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14 August 2017

Peter P Liu

4

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14 August 2017

Peter H Backx

5

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14 August 2017

language of work or name

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8 April 2006

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Journal of Molecular Medicine

14 August 2017

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14 August 2017

84

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14 August 2017

5

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14 August 2017

349-364

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https://scigraph.springernature.com/pub.10.1007/s00109-005-0029-x

14 August 2017

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cites work

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Mineralocorticoid status and endocrine dysfunction in severe hemochromatosis.

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Iron overload and cardiovascular complications in dialysis patients

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Modulation of iron uptake in heart by L-type Ca2+ channel modifiers: possible implications in iron overload.

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Friedreich's Ataxia: disease mechanisms, antioxidant and Coenzyme Q10 therapy

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Earliest cardiac toxicity induced by iron overload selectively inhibits electrical conduction

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Iron Lactate-Induced Osteomalacia in Association with Osteoblast Dynamics

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12 December 2020

Cardiac HCN channels: structure, function, and modulation

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12 December 2020

Enhancement of salvage of reperfused ischemic myocardium by diltiazem

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12 December 2020

Thyrotropin (TSH)-releasing hormone stimulates TSH beta promoter activity by two distinct mechanisms involving calcium influx through L type Ca2+ channels and protein kinase C.

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12 December 2020

Stunned myocardium and the attenuation of stunning by calcium antagonists

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Inherited haemoglobin disorders: an increasing global health problem

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12 December 2020

Iron, atherosclerosis, and ischemic heart disease

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12 December 2020

Functional properties of Cav1.3 (alpha1D) L-type Ca2+ channel splice variants expressed by rat brain and neuroendocrine GH3 cells.

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12 December 2020

Labile plasma iron in iron overload: redox activity and susceptibility to chelation

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12 December 2020

Structure and regulation of voltage-gated Ca2+ channels

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12 December 2020

Modulation by mexiletine of action potentials, L-type Ca current and delayed rectifier K current recorded from isolated rabbit atrioventricular nodal myocytes

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12 December 2020

Slowly inactivating sodium currents are reduced by exposure to oxidative stress

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12 December 2020

Hypoparathyroidism in beta-thalassemic patients

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12 December 2020

Congenital dyserythropoietic anemia type II: epidemiology, clinical appearance, and prognosis based on long-term observation

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12 December 2020

Insulin granule dynamics in pancreatic beta cells

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12 December 2020

Calcium channel selectivity for divalent and monovalent cations. Voltage and concentration dependence of single channel current in ventricular heart cells

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12 December 2020

A mutation in SLC11A3 is associated with autosomal dominant hemochromatosis

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12 December 2020

Serum ferritin is a marker of morbidity and mortality in hemodialysis patients

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12 December 2020

Lipophilic antioxidants and iron status in ESRD patients on hemodialysis

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12 December 2020

Genetic and clinical features of hemoglobin H disease in Chinese patients

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12 December 2020

Regulatory defects in liver and intestine implicate abnormal hepcidin and Cybrd1 expression in mouse hemochromatosis

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12 December 2020

Iron overload cardiomyopathies: new insights into an old disease

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12 December 2020

Knockout-transgenic mouse model of sickle cell disease

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12 December 2020

Hephaestin, a ceruloplasmin homologue implicated in intestinal iron transport, is defective in the sla mouse

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12 December 2020

Conservation of ferritin heavy subunit gene structure: implications for the regulation of ferritin gene expression

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12 December 2020

Bone histomorphometry in children and adolescents with beta-thalassemia disease: iron-associated focal osteomalacia.

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12 December 2020

What causes sudden death in heart failure?

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12 December 2020

Outcomes in hypertensive patients at high cardiovascular risk treated with regimens based on valsartan or amlodipine: the VALUE randomised trial

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12 December 2020

Activation of L-type calcium channels is required for gap junction-mediated intercellular calcium signaling in osteoblastic cells

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12 December 2020

Calcium-antagonist drugs

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12 December 2020

Regulation of transferrin receptor 2 protein levels by transferrin

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12 December 2020

Role of HFE in iron metabolism, hereditary haemochromatosis, anaemia of chronic disease, and secondary iron overload

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12 December 2020

Acute iron intoxication: treatment controversies.

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12 December 2020

Multicentre study on prevalence of endocrine complications in thalassaemia major. Italian Working Group on Endocrine Complications in Non-endocrine Diseases

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12 December 2020

The cardiomyopathy of idiopathic hemochromatosis

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12 December 2020

Control of cellular iron homeostasis by iron-responsive elements in vivo.

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12 December 2020

The genetics of inherited sideroblastic anemias.

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12 December 2020

Post-transcriptional expression of DMT1 in the heart of rat

1 reference

12 December 2020

Optical mapping reveals conduction slowing and impulse block in iron-overload cardiomyopathy.

1 reference

12 December 2020

Myocardial Failure and Shock in Iron Poisoning

1 reference

12 December 2020

A mouse model for beta 0-thalassemia

1 reference

12 December 2020

Animal models for X-linked sideroblastic anemia.

1 reference

12 December 2020

Isoform-specific regulation of mood behavior and pancreatic beta cell and cardiovascular function by L-type Ca 2+ channels

1 reference

12 December 2020

Generation of action potentials in a mathematical model of corticotrophs

1 reference

12 December 2020

Chemistry and biochemistry of 4-hydroxynonenal, malonaldehyde and related aldehydes

1 reference

12 December 2020

Pituitary gland height evaluated by MR in patients with beta-thalassemia major: a marker of pituitary gland function

1 reference

12 December 2020

Vitamin C-induced decomposition of lipid hydroperoxides to endogenous genotoxins

1 reference

12 December 2020

Ionic remodeling of sinoatrial node cells by heart failure

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12 December 2020

Ionic remodeling of cardiac Purkinje cells by congestive heart failure

1 reference

12 December 2020

Apolipoprotein E epsilon4 allele as a genetic risk factor for left ventricular failure in homozygous beta-thalassemia

1 reference

12 December 2020

Calcium influx through L-type channels is required for selective activation of extracellular signal-regulated kinase by gonadotropin-releasing hormone

1 reference

12 December 2020

The gene TFR2 is mutated in a new type of haemochromatosis mapping to 7q22.

1 reference

12 December 2020

Enhanced oxidative stress in haemodialysis patients receiving intravenous iron therapy

1 reference

12 December 2020

Plasma membrane Ca2+ release-activated Ca2+ channels with a high selectivity for Ca2+ identified by patch-clamp recording in rat liver cells

1 reference

12 December 2020

L-type calcium channels: highs and new lows

1 reference

12 December 2020

L-type calcium channel abundance and function with cardiac hypertrophy and failure: a review

1 reference

12 December 2020

Stimulation of Ca2+ influx in alpha T3-1 gonadotrophs via the cAMP/PKA signaling system.

1 reference

12 December 2020

Cardiac excitation-contraction coupling

1 reference

12 December 2020

The C282Y mutation causing hereditary hemochromatosis does not produce a null allele

1 reference

12 December 2020

A novel MHC class I-like gene is mutated in patients with hereditary haemochromatosis

1 reference

12 December 2020

Survival in medically treated patients with homozygous beta-thalassemia

1 reference

12 December 2020

A calcium antagonist vs a non-calcium antagonist hypertension treatment strategy for patients with coronary artery disease. The International Verapamil-Trandolapril Study (INVEST): a randomized controlled trial

1 reference

12 December 2020

Screening hepcidin for mutations in juvenile hemochromatosis: identification of a new mutation (C70R)

1 reference

12 December 2020

Decreased sodium and increased transient outward potassium currents in iron-loaded cardiac myocytes. Implications for the arrhythmogenesis of human siderotic heart disease

1 reference

12 December 2020

Arterial stiffness and endothelial function in patients with beta-thalassemia major

1 reference

12 December 2020

Uptake of non-transferrin-bound iron by both reductive and nonreductive processes is modulated by intracellular iron

1 reference

12 December 2020

Redox metals in Alzheimer's disease

1 reference

12 December 2020

Persistence of antihypertensive efficacy after missed doses: comparison of amlodipine and nifedipine gastrointestinal therapeutic system

1 reference

12 December 2020

Morbidity and mortality patterns of thalassaemia major patients in Hong Kong: retrospective study

1 reference

12 December 2020

Left ventricular diastolic Doppler characteristics in beta-thalassemia major

1 reference

12 December 2020

HFE Mutation and Dietary Iron Content Interact to Increase Ischemia/Reperfusion Injury of the Heart in Mice

1 reference

12 December 2020

Serum markers of stored body iron are not appropriate markers of health effects of iron: a focus on serum ferritin

1 reference

12 December 2020

Regulation of mitochondrial iron accumulation by Yfh1p, a putative homolog of frataxin

1 reference

12 December 2020

Assembly of human frataxin is a mechanism for detoxifying redox-active iron

1 reference

12 December 2020

Bone and joint involvement in genetic hemochromatosis: role of cirrhosis and iron overload

1 reference

12 December 2020

Prevalence of a haemochromatosis among men with clinically significant bradyarrhythmias

1 reference

12 December 2020

Characterization of the gonadotrophin-releasing hormone calcium response in single alpha T3-1 pituitary gonadotroph cells

1 reference

12 December 2020

Calcium channels: mechanisms of selectivity, permeation, and block

1 reference

12 December 2020

The antioxidant effects of a novel iron chelator salicylaldehyde isonicotinoyl hydrazone in the prevention of H(2)O(2) injury in adult cardiomyocytes

1 reference

12 December 2020

Inhibition of iron transport across human intestinal epithelial cells by hepcidin

1 reference

12 December 2020

Regulation of the transferrin-independent iron transport system in cultured cells

1 reference

12 December 2020

African iron overload

1 reference

12 December 2020

Iron trafficking in the mitochondrion: novel pathways revealed by disease.

1 reference

12 December 2020

Depression of contractility in isolated rabbit myocardium following exposure to iron: role of free radicals

1 reference

12 December 2020

Characterization of Fe2+ and Fe3+ transport by iron-loaded cardiac myocytes

1 reference

12 December 2020

Disorders of iron metabolism

1 reference

12 December 2020

Calcium channel blockers: pharmacology and place in therapy of pediatric hypertension

1 reference

12 December 2020

Electrophysiology of stimulus-secretion coupling in human beta-cells

1 reference

12 December 2020

Mammalian tissue oxygen levels modulate iron-regulatory protein activities in vivo

1 reference

12 December 2020

Effects of grapefruit juice and smoking on verapamil concentrations in steady state

1 reference

12 December 2020

Iron and peripheral arterial disease: revisiting the iron hypothesis in a different light

1 reference

12 December 2020

Identification of a human heme exporter that is essential for erythropoiesis

1 reference

12 December 2020

Hemodynamic effects of experimental iron poisoning.

1 reference

12 December 2020

Interaction of verapamil and cimetidine: stereochemical aspects of drug metabolism, drug disposition and drug action

1 reference

12 December 2020

Oxidative stress and antioxidant status in beta-thalassemia major: iron overload and depletion of lipid-soluble antioxidants

1 reference

12 December 2020

L-type Ca2+ channels provide a major pathway for iron entry into cardiomyocytes in iron-overload cardiomyopathy

1 reference

12 December 2020

Differential expression of ionic channels in rat anterior pituitary cells

1 reference

12 December 2020

1 reference

12 December 2020

Management of sickle cell disease.

1 reference

12 December 2020

Long-term survival in patients with hereditary hemochromatosis

1 reference

12 December 2020

Molecular bases of cellular iron toxicity

1 reference

12 December 2020

Hemochromatosis due to mutations in transferrin receptor 2.

1 reference

12 December 2020

Taurine supplementation reduces oxidative stress and improves cardiovascular function in an iron-overload murine model

1 reference

12 December 2020

The haemochromatotic human pancreas: a quantitative immunohistochemical and ultrastructural study

1 reference

12 December 2020

Arterial stiffness and wave reflections in patients with sickle cell disease

1 reference

12 December 2020

Spontaneous transients of [Ca2+]i depend on external calcium and the activation of L-type voltage-gated calcium channels in a clonal pituitary cell line (AtT-20) of cultured mouse corticotropes

1 reference

12 December 2020

Effect of hepcidin on intestinal iron absorption in mice.

1 reference

12 December 2020

Ferroportin/IREG-1/MTP-1/SLC40A1 modulates the uptake of iron at the apical membrane of enterocytes

1 reference

12 December 2020

Efficacy of deferoxamine in preventing complications of iron overload in patients with thalassemia major

1 reference

12 December 2020

Negative inotropic effect of diazepam in isolated guinea pig heart

1 reference

12 December 2020

Association of heart failure in homozygous beta-thalassemia with the major histocompatibility complex

1 reference

12 December 2020

Antioxidant status and lipid peroxidation in hereditary haemochromatosis

1 reference

12 December 2020

Autosomal-dominant hemochromatosis is associated with a mutation in the ferroportin (SLC11A3) gene

1 reference

12 December 2020

Friedreich's ataxia, no changes in mitochondrial labile iron in human lymphoblasts and fibroblasts: a decrease in antioxidative capacity?

1 reference

12 December 2020

The effect of iron stores on corrected QT dispersion in patients undergoing peritoneal dialysis

1 reference

12 December 2020

Progression of iron overload in sickle cell disease

1 reference

12 December 2020

Multicentric origin of hemochromatosis gene (HFE) mutations

1 reference

12 December 2020

Thalassemia--a global public health problem

1 reference

12 December 2020

NADH oxidase activity of rat cardiac sarcoplasmic reticulum regulates calcium-induced calcium release

1 reference

12 December 2020

Survival of children with sickle cell disease

1 reference

12 December 2020

Idebenone delays the onset of cardiac functional alteration without correction of Fe-S enzymes deficit in a mouse model for Friedreich ataxia

1 reference

12 December 2020

Hereditary hemochromatosis--a new look at an old disease

1 reference

12 December 2020

Clinical consequences of acquired transfusional iron overload in adults

1 reference

12 December 2020

Parenteral iron formulations: a comparative toxicologic analysis and mechanisms of cell injury

1 reference

12 December 2020

Cardiac alterations in 36 consecutive patients with idiopathic haemochromatosis: polygraphic and echocardiographic evaluation.

1 reference

12 December 2020

The efficacy of diazepam in the treatment of acute iron overload in rats.

1 reference

12 December 2020

Excitation-transcription coupling mediated by zinc influx through voltage-dependent calcium channels

1 reference

12 December 2020

Genetic or pharmacological iron chelation prevents MPTP-induced neurotoxicity in vivo: a novel therapy for Parkinson's disease

1 reference

12 December 2020

The role of Doppler left ventricular filling indexes and Doppler tissue echocardiography in the assessment of cardiac involvement in hereditary hemochromatosis

1 reference

12 December 2020

Suppression of Ca2+ influx through L-type voltage-dependent calcium channels by hydroxyl radical in mouse cerebral cortical neurons

1 reference

12 December 2020

Diastolic Dysfunction

1 reference

12 December 2020

Survival and causes of death in thalassaemia major

1 reference

12 December 2020

Insulin sensitivity and beta-cell secretion in thalassaemia major with secondary haemochromatosis: assessment by oral glucose tolerance test

1 reference

12 December 2020

1 reference

12 December 2020

Developmental regulation of the L-type calcium channel alpha1C subunit expression in heart.

1 reference

12 December 2020

Iron metabolism and the IRE/IRP regulatory system: an update

1 reference

12 December 2020

Balancing acts: molecular control of mammalian iron metabolism

1 reference

12 December 2020

Hemojuvelin is essential for dietary iron sensing, and its mutation leads to severe iron overload

1 reference

12 December 2020

Loss of cyclophilin D reveals a critical role for mitochondrial permeability transition in cell death

1 reference

12 December 2020

1 reference

12 December 2020

Novel vascular biology of third-generation L-type calcium channel antagonists: ancillary actions of amlodipine

1 reference

12 December 2020

Hemojuvelin: a supposed role in iron metabolism one year after its discovery

1 reference

12 December 2020

Non-transferrin-bound iron in the serum of hemodialysis patients who receive ferric saccharate: no correlation to peroxide generation

1 reference

12 December 2020

Survival in beta-thalassaemia major in the UK: data from the UK Thalassaemia Register

1 reference

12 December 2020

Diferric transferrin regulates transferrin receptor 2 protein stability

1 reference

12 December 2020

Differential accumulation of non-transferrin-bound iron by cardiac myocytes and fibroblasts

1 reference

12 December 2020

Association between increased iron stores and impaired endothelial function in patients with hereditary hemochromatosis

1 reference

12 December 2020

Differences in apparent pore sizes of low and high voltage-activated Ca2+ channels

1 reference

12 December 2020

Malondialdehyde inhibits cardiac contractile function in ventricular myocytes via a p38 mitogen-activated protein kinase-dependent mechanism

1 reference

12 December 2020

Iron-dependent regulation of the divalent metal ion transporter

1 reference

12 December 2020

Block of current through single calcium channels by Fe, Co, and Ni. Location of the transition metal binding site in the pore

1 reference

12 December 2020

Blockade of current through single calcium channels by Cd2+, Mg2+, and Ca2+. Voltage and concentration dependence of calcium entry into the pore

1 reference

12 December 2020

The mitochondrial superoxide dismutase A16V polymorphism in the cardiomyopathy associated with hereditary haemochromatosis.

1 reference

12 December 2020

The importance of non-transferrin bound iron in disorders of iron metabolism

1 reference

12 December 2020

Targeted mutagenesis of the murine transferrin receptor-2 gene produces hemochromatosis

1 reference

12 December 2020

Mutations in HFE2 cause iron overload in chromosome 1q-linked juvenile hemochromatosis

1 reference

12 December 2020

The molecular basis of ferroportin-linked hemochromatosis

1 reference

12 December 2020

Blood pressure and heart rate in young thalassemia major patients.

1 reference

12 December 2020

Lethal thalassemia after insertional disruption of the mouse major adult beta-globin gene

1 reference

12 December 2020

Myocarditis in beta-thalassemia major. A cause of heart failure

1 reference

12 December 2020

Cloning and characterization of a mammalian proton-coupled metal-ion transporter

1 reference

12 December 2020

The beta-thalassemias

1 reference

12 December 2020

Heme deficiency in erythroid lineage causes differentiation arrest and cytoplasmic iron overload

1 reference

12 December 2020

Transgenic knockout mice with exclusively human sickle hemoglobin and sickle cell disease

1 reference

12 December 2020

Parathyroid cells express dihydropyridine-sensitive cation currents and L-type calcium channel subunits

1 reference

12 December 2020

Effect of sulfhydryl oxidation on ionic and gating currents associated with L-type calcium channels in isolated guinea-pig ventricular myocytes

1 reference

12 December 2020

Inhibition of calcineurin and sarcolemmal Ca2+ influx protects cardiac morphology and ventricular function in K(v)4.2N transgenic mice

1 reference

12 December 2020

Determination of non-transferrin-bound iron in genetic hemochromatosis using a new HPLC-based method

1 reference

12 December 2020

Regulatory networks for the control of body iron homeostasis and their dysregulation in HFE mediated hemochromatosis

1 reference

12 December 2020

Oxygen free radicals and excitation-contraction coupling.

1 reference

12 December 2020

Hepcidin regulates cellular iron efflux by binding to ferroportin and inducing its internalization

1 reference

12 December 2020

Iron supplementation generates hydroxyl radical in vivo. An ESR spin-trapping investigation

1 reference

12 December 2020

10.1007/S00109-005-0029-X

Identifiers

DOI

1 reference

14 August 2017

1 reference