(Q36445921)

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Bortezomib induces DNA hypomethylation and silenced gene transcription by interfering with Sp1/NF-kappaB-dependent DNA methyltransferase activity in acute myeloid leukemia

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Europe PubMed Central

PMC publication ID

14 August 2017

Bortezomib induces DNA hypomethylation and silenced gene transcription by interfering with Sp1/NF-kappaB-dependent DNA methyltransferase activity in acute myeloid leukemia (English)

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Europe PubMed Central

PMC publication ID

14 August 2017

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Guido Marcucci

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John C Byrd

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Michael A Caligiuri

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Michael A Caligiuri

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Rebecca B Klisovic

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Rebecca B Klisovic

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Ramiro Garzon

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Shujun Liu

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Jiuxia Pang

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Zhiliang Xie

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Robert A Baiocchi

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Robert A Baiocchi

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Danilo Perrotti

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Danilo Perrotti

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Tamara Vukosavljevic

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Pierluigi Porcu

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Pierluigi Porcu

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Zhongfa Liu

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14 August 2017

Jianhua Yu

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14 August 2017

Esther Lehmann

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Mitsui Takeki

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14 August 2017

Kenneth K Chan

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14 August 2017

Lai-Chu Wu

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14 August 2017

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14 December 2007

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14 August 2017

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10

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111

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4

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14 August 2017

2364-2373

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Europe PubMed Central

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14 August 2017

The PP2A inhibitor SET regulates natural killer cell IFN-gamma production

1 reference

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30 September 2017

Transcriptional control of human T-BET expression: the role of Sp1.

1 reference

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30 September 2017

Characterization of in vitro and in vivo hypomethylating effects of decitabine in acute myeloid leukemia by a rapid, specific and sensitive LC-MS/MS method

1 reference

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30 September 2017

DNA hypermethylation of myeloid cells, a novel therapeutic target in MDS and AML.

1 reference

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30 September 2017

Decitabine--bedside to bench

1 reference

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30 September 2017

Proteasome inhibition as novel treatment strategy in leukaemia

1 reference

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30 September 2017

The proteasomal ATPase complex is required for stress-induced transcription in yeast

1 reference

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30 September 2017

The proteasome: a utility tool for transcription?

1 reference

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30 September 2017

Sumoylation inhibits cleavage of Sp1 N-terminal negative regulatory domain and inhibits Sp1-dependent transcription

1 reference

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30 September 2017

The tumor suppressor PP2A is functionally inactivated in blast crisis CML through the inhibitory activity of the BCR/ABL-regulated SET protein

1 reference

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30 September 2017

Overexpression of the ETS-related gene, ERG, predicts a worse outcome in acute myeloid leukemia with normal karyotype: a Cancer and Leukemia Group B study

1 reference

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30 September 2017

The ubiquitin-proteasome pathway and its role in cancer

1 reference

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30 September 2017

5-Aza-deoxycytidine induces selective degradation of DNA methyltransferase 1 by a proteasomal pathway that requires the KEN box, bromo-adjacent homology domain, and nuclear localization signal

1 reference

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30 September 2017

1 reference

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30 September 2017

Global assessment of promoter methylation in a mouse model of cancer identifies ID4 as a putative tumor-suppressor gene in human leukemia

1 reference

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30 September 2017

Efficient infection of human natural killer cells with an EBV/retroviral hybrid vector.

1 reference

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30 September 2017

Specific method for the determination of genomic DNA methylation by liquid chromatography-electrospray ionization tandem mass spectrometry

1 reference

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30 September 2017

The proteasome: a suitable antineoplastic target

1 reference

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30 September 2017

Physical and functional association of RNA polymerase II and the proteasome

1 reference

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30 September 2017

Targeting proteasome inhibition in hematologic malignancies

1 reference

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30 September 2017

The IKK NF-kappa B system: a treasure trove for drug development

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2234064

30 September 2017

Gene silencing in cancer in association with promoter hypermethylation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2234064

30 September 2017

Inhibition of NF-kappaB by ZAS3, a zinc-finger protein that also binds to the kappaB motif.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2234064

30 September 2017

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1 reference

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30 September 2017

DNMT1 is required to maintain CpG methylation and aberrant gene silencing in human cancer cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2234064

30 September 2017

Preferential induction of apoptosis for primary human leukemic stem cells

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30 September 2017

Regulation of the activity of Sp1-related transcription factors.

1 reference

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30 September 2017

Regulation of transcription of the Dnmt1 gene by Sp1 and Sp3 zinc finger proteins

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30 September 2017

Worms gang up on bacteria

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30 September 2017

NF-kappa B as a therapeutic target in multiple myeloma

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30 September 2017

Sp1 and krüppel-like factor family of transcription factors in cell growth regulation and cancer

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30 September 2017

The 19S regulatory particle of the proteasome is required for efficient transcription elongation by RNA polymerase II.

1 reference

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30 September 2017

Expression of DNA methyltransferases DNMT1, 3A, and 3B in normal hematopoiesis and in acute and chronic myelogenous leukemia

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How the cyclin became a cyclin: regulated proteolysis in the cell cycle

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The ubiquitin-proteasome pathway and pathogenesis of human diseases

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The regulatory particle of the Saccharomyces cerevisiae proteasome.

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30 September 2017

Functional interference of Sp1 and NF-kappaB through the same DNA binding site

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The estrogen receptor CpG island is methylated in most hematopoietic neoplasms.

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Hypermethylation-associated inactivation indicates a tumor suppressor role for p15INK4B.

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A cooperative interaction between NF-kappa B and Sp1 is required for HIV-1 enhancer activation.

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A targeting sequence directs DNA methyltransferase to sites of DNA replication in mammalian nuclei

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Expression of constitutively active nuclear-kappa B RelA transcription factor in blasts of acute myeloid leukemia

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RIL, a LIM gene on 5q31, is silenced by methylation in cancer and sensitizes cancer cells to apoptosis.

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Phase I study of bortezomib in refractory or relapsed acute leukemias

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21 September 2018

Methylation profiling in acute myeloid leukemia.

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21 September 2018

Hypermethylation of the 5' region of the calcitonin gene is a property of human lymphoid and acute myeloid malignancies

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12 December 2020

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Proteasome inhibition measurements: clinical application

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12 December 2020

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The fundamental role of epigenetic events in cancer

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Identifiers

10.1182/BLOOD-2007-08-110171

1 reference

Europe PubMed Central

PMC publication ID

14 August 2017

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

14 August 2017

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

14 August 2017

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