(Q36454100)

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Structure-Based Design and Biological Evaluation of Triphenyl Scaffold-Based Hybrid Compounds as Hydrolytically Stable Modulators of a LuxR-Type Quorum Sensing Receptor

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scholarly article

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Europe PubMed Central

PMC publication ID

14 August 2017

Structure-Based Design and Biological Evaluation of Triphenyl Scaffold-Based Hybrid Compounds as Hydrolytically Stable Modulators of a LuxR-Type Quorum Sensing Receptor (English)

1 reference

Europe PubMed Central

PMC publication ID

14 August 2017

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Helen Blackwell

2

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Helen E Blackwell

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Europe PubMed Central

PMC publication ID

14 August 2017

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Matthew C O'Reilly

1

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Europe PubMed Central

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14 August 2017

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publication date

2 November 2015

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Europe PubMed Central

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14 August 2017

ACS Infectious Diseases

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Europe PubMed Central

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14 August 2017

2

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Europe PubMed Central

PMC publication ID

14 August 2017

1

1 reference

Europe PubMed Central

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14 August 2017

32-38

1 reference

Europe PubMed Central

PMC publication ID

14 August 2017

A Comparative Analysis of Synthetic Quorum Sensing Modulators in Pseudomonas aeruginosa: New Insights into Mechanism, Active Efflux Susceptibility, Phenotypic Response, and Next-Generation Ligand Design

1 reference

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30 September 2017

Small molecule disruption of quorum sensing cross-regulation in pseudomonas aeruginosa causes major and unexpected alterations to virulence phenotypes

1 reference

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30 September 2017

Mutational analysis of the quorum-sensing receptor LasR reveals interactions that govern activation and inhibition by nonlactone ligands

1 reference

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30 September 2017

Active efflux influences the potency of quorum sensing inhibitors in Pseudomonas aeruginosa.

1 reference

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30 September 2017

A quorum-sensing inhibitor blocks Pseudomonas aeruginosa virulence and biofilm formation

1 reference

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30 September 2017

10 x '20 Progress--development of new drugs active against gram-negative bacilli: an update from the Infectious Diseases Society of America

1 reference

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30 September 2017

Bacterial quorum sensing: its role in virulence and possibilities for its control

1 reference

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30 September 2017

Inhibition of the production of the Pseudomonas aeruginosa virulence factor pyocyanin in wild-type cells by quorum sensing autoinducer-mimics

1 reference

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30 September 2017

Applications of small molecule activators and inhibitors of quorum sensing in Gram-negative bacteria

1 reference

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30 September 2017

Design, synthesis, and biological evaluation of abiotic, non-lactone modulators of LuxR-type quorum sensing

1 reference

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30 September 2017

Thiolactone modulators of quorum sensing revealed through library design and screening

1 reference

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30 September 2017

Synopsis of some recent tactical application of bioisosteres in drug design

1 reference

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30 September 2017

Quorum sensing in Gram-negative bacteria: small-molecule modulation of AHL and AI-2 quorum sensing pathways

1 reference

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30 September 2017

Macromolecular inhibition of quorum sensing: enzymes, antibodies, and beyond

1 reference

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30 September 2017

Jamming bacterial communication: new approaches for the treatment of infectious diseases

1 reference

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30 September 2017

Molecular Basis for the Recognition of Structurally Distinct Autoinducer Mimics by the Pseudomonas aeruginosa LasR Quorum-Sensing Signaling Receptor

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4709822

30 September 2017

Evaluation of a focused library of N-aryl L-homoserine lactones reveals a new set of potent quorum sensing modulators

1 reference

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30 September 2017

The biology and future prospects of antivirulence therapies

1 reference

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30 September 2017

Modulation of bacterial quorum sensing with synthetic ligands: systematic evaluation of N-acylated homoserine lactones in multiple species and new insights into their mechanisms of action

1 reference

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30 September 2017

Targeting virulence: a new paradigm for antimicrobial therapy

1 reference

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30 September 2017

N-phenylacetanoyl-L-homoserine lactones can strongly antagonize or superagonize quorum sensing in Vibrio fischeri

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4709822

30 September 2017

Molecular insights into quorum sensing in the human pathogen Pseudomonas aeruginosa from the structure of the virulence regulator LasR bound to its autoinducer

1 reference

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30 September 2017

The antibiotic resistome: the nexus of chemical and genetic diversity

1 reference

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30 September 2017

A structurally unrelated mimic of a Pseudomonas aeruginosa acyl-homoserine lactone quorum-sensing signal.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4709822

30 September 2017

Novel Pseudomonas aeruginosa quorum-sensing inhibitors identified in an ultra-high-throughput screen.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4709822

30 September 2017

Antibody interference with N-acyl homoserine lactone-mediated bacterial quorum sensing

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4709822

30 September 2017

Bacterial small-molecule signaling pathways

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4709822

30 September 2017

Small molecule inhibitors of bacterial quorum sensing and biofilm formation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4709822

30 September 2017

Quorum quenching enzyme activity is widely conserved in the sera of mammalian species

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4709822

30 September 2017

Pathogen-host interactions in Pseudomonas aeruginosa pneumonia

1 reference

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30 September 2017

Attenuation of Pseudomonas aeruginosa virulence by quorum sensing inhibitors

1 reference

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30 September 2017

Microarray analysis of Pseudomonas aeruginosa quorum-sensing regulons: effects of growth phase and environment

1 reference

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30 September 2017

Induction and inhibition of Pseudomonas aeruginosa quorum sensing by synthetic autoinducer analogs

1 reference

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30 September 2017

N-acylhomoserine lactones undergo lactonolysis in a pH-, temperature-, and acyl chain length-dependent manner during growth of Yersinia pseudotuberculosis and Pseudomonas aeruginosa

1 reference

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30 September 2017

Listening in on bacteria: acyl-homoserine lactone signalling

1 reference

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30 September 2017

Establishment of Pseudomonas aeruginosa infection: lessons from a versatile opportunist

1 reference

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30 September 2017

Comparative analyses of N-acylated homoserine lactones reveal unique structural features that dictate their ability to activate or inhibit quorum sensing

1 reference

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30 September 2017

The epidemic of antibiotic-resistant infections: a call to action for the medical community from the Infectious Diseases Society of America

1 reference

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30 September 2017

Synthesis and molecular modeling provide insight into a Pseudomonas aeruginosa quorum sensing conundrum

1 reference

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Small Molecules That Modulate Quorum Sensing and Control Virulence inPseudomonas aeruginosa

1 reference

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28 June 2018

Potent Irreversible Inhibitors of LasR Quorum Sensing in Pseudomonas aeruginosa

1 reference

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21 September 2018

Highly potent inhibitors of quorum sensing in Staphylococcus aureus revealed through a systematic synthetic study of the group-III autoinducing peptide

1 reference

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21 September 2018

Chemical methods to interrogate bacterial quorum sensing pathways

1 reference

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21 September 2018

Design, synthesis and biological evaluation of non-natural modulators of quorum sensing in Pseudomonas aeruginosa.

1 reference

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Live cell labeling of native intracellular bacterial receptors using aniline-catalyzed oxime ligation.

1 reference

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21 September 2018

Covalent inhibition of bacterial quorum sensing.

1 reference

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21 September 2018

Human and murine paraoxonase 1 are host modulators of Pseudomonas aeruginosa quorum-sensing

1 reference

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21 September 2018

Synthesis and stability of small molecule probes for Pseudomonas aeruginosa quorum sensing modulation

1 reference

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21 September 2018

Identifiers

10.1021/ACSINFECDIS.5B00112

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PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

14 August 2017

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

14 August 2017

ResearchGate publication ID

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