(Q36464020)

14 August 2017

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title

Inhibiting bacterial fatty acid synthesis (English)

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14 August 2017

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Yong-Mei Zhang

1

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14 August 2017

Stephen W White

series ordinal

2

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14 August 2017

Charles O Rock

series ordinal

3

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14 August 2017

language of work or name

English

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publication date

28 April 2006

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Journal of Biological Chemistry

14 August 2017

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14 August 2017

281

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14 August 2017

26

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14 August 2017

17541-17544

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Bacterial Membrane Lipids: Where Do We Stand?

14 August 2017

1 reference

https://api.crossref.org/works/10.1074%2FJBC.R600004200

THE STRUCTURAL BIOLOGY OF TYPE II FATTY ACID BIOSYNTHESIS

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.R600004200

Bacterial fatty acid biosynthesis: targets for antibacterial drug discovery

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.R600004200

Coenzyme A: back in action

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.R600004200

Multi-subunit acetyl-CoA carboxylases

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.R600004200

Herbicide sensitivity determinant of wheat plastid acetyl-CoA carboxylase is located in a 400-amino acid fragment of the carboxyltransferase domain

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.R600004200

Identification and characterization of the first class of potent bacterial acetyl-CoA carboxylase inhibitors with antibacterial activity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.R600004200

Crystal structure of the carboxyltransferase domain of acetyl-coenzyme A carboxylase

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.R600004200

Molecular basis for the inhibition of the carboxyltransferase domain of acetyl-coenzyme-A carboxylase by haloxyfop and diclofop.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.R600004200

Structure-based inhibitor design of AccD5, an essential acyl-CoA carboxylase carboxyltransferase domain of Mycobacterium tuberculosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.R600004200

Characterization and inhibitor discovery of one novel malonyl-CoA: acyl carrier protein transacylase (MCAT) from Helicobacter pylori.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.R600004200

β-Ketoacyl-Acyl Carrier Protein Synthase III (FabH) Is Essential for Bacterial Fatty Acid Synthesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.R600004200

Regulation of fatty acid elongation and initiation by acyl-acyl carrier protein in Escherichia coli.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.R600004200

Inhibition of beta-ketoacyl-acyl carrier protein synthase III (FabH) by acyl-acyl carrier protein in Escherichia coli.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.R600004200

Identification, substrate specificity, and inhibition of the Streptococcus pneumoniae beta-ketoacyl-acyl carrier protein synthase III (FabH).

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.R600004200

First X-ray cocrystal structure of a bacterial FabH condensing enzyme and a small molecule inhibitor achieved using rational design and homology modeling

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.R600004200

1,2-dithiole-3-ones as potent inhibitors of the bacterial 3-ketoacyl acyl carrier protein synthase III (FabH)

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.R600004200

Determination of selectivity and efficacy of fatty acid synthesis inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.R600004200

Anthrabenzoxocinones from Streptomyces sp. as liver X receptor ligands and antibacterial agents

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.R600004200

beta-Ketoacyl-ACP synthase I of Escherichia coli: nucleotide sequence of the fabB gene and identification of the cerulenin binding residue.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.R600004200

Structure of the complex between the antibiotic cerulenin and its target, beta-ketoacyl-acyl carrier protein synthase

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.R600004200

Inhibition of beta-ketoacyl-acyl carrier protein synthases by thiolactomycin and cerulenin. Structure and mechanism

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.R600004200

Discovery of FabH/FabF inhibitors from natural products

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.R600004200

Discovery of bacterial fatty acid synthase inhibitors from a Phoma species as antimicrobial agents using a new antisense-based strategy.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.R600004200

A missense mutation in the fabB (beta-ketoacyl-acyl carrier protein synthase I) gene confers tiolactomycin resistance to Escherichia coli.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.R600004200

Analogues of thiolactomycin as potential anti-malarial and anti-trypanosomal agents.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.R600004200

Thiolactomycin and related analogues as novel anti-mycobacterial agents targeting KasA and KasB condensing enzymes in Mycobacterium tuberculosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.R600004200

Synthesis and structure-activity relationships of thiotetronic acid analogues of thiolactomycin.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.R600004200

Analogues of thiolactomycin: potential drugs with enhanced anti-mycobacterial activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.R600004200

Biphenyl-based analogues of thiolactomycin, active against Mycobacterium tuberculosis mtFabH fatty acid condensing enzyme

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.R600004200

Acetylene-based analogues of thiolactomycin, active against Mycobacterium tuberculosis mtFabH fatty acid condensing enzyme

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.R600004200

Structure-activity relationships at the 5-position of thiolactomycin: an intact (5R)-isoprene unit is required for activity against the condensing enzymes from Mycobacterium tuberculosis and Escherichia coli

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.R600004200

A flexible route to (5R)-thiolactomycin, a naturally occurring inhibitor of fatty acid synthesis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.R600004200

inhA, a gene encoding a target for isoniazid and ethionamide in Mycobacterium tuberculosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.R600004200

Molecular basis of triclosan activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.R600004200

Broad spectrum antimicrobial biocides target the FabI component of fatty acid synthesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.R600004200

Structure-activity studies of the inhibition of FabI, the enoyl reductase from Escherichia coli, by triclosan: kinetic analysis of mutant FabIs.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.R600004200

Modification of the NADH of the isoniazid target (InhA) from Mycobacterium tuberculosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.R600004200

Crystal structure and function of the isoniazid target of Mycobacterium tuberculosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.R600004200

A mechanism of drug action revealed by structural studies of enoyl reductase

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.R600004200

Mechanism of triclosan inhibition of bacterial fatty acid synthesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.R600004200

The isoniazid-NAD adduct is a slow, tight-binding inhibitor of InhA, the Mycobacterium tuberculosis enoyl reductase: adduct affinity and drug resistance

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.R600004200

Inhibition of InhA, the enoyl reductase from Mycobacterium tuberculosis, by triclosan and isoniazid.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.R600004200

Structural basis and mechanism of enoyl reductase inhibition by triclosan

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.R600004200

Characterization of Streptococcus pneumoniae enoyl-(acyl-carrier protein) reductase (FabK).

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.R600004200

Discovery of a novel and potent class of FabI-directed antibacterial agents

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.R600004200

Identification and characterization of inhibitors of bacterial enoyl-acyl carrier protein reductase

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.R600004200

Indole Naphthyridinones as Inhibitors of Bacterial Enoyl-ACP Reductases FabI and FabK

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.R600004200

A clone of methicillin-resistant Staphylococcus aureus among professional football players.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.R600004200

Identification of inhibitors of bacterial enoyl-acyl carrier protein reductase

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.R600004200

Evaluation of epigallocatechin gallate and related plant polyphenols as inhibitors of the FabG and FabI reductases of bacterial type II fatty-acid synthase

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.R600004200

Cofactor-induced conformational rearrangements establish a catalytically competent active site and a proton relay conduit in FabG.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.R600004200

Identification, characterization, and inhibition of Plasmodium falciparum beta-hydroxyacyl-acyl carrier protein dehydratase (FabZ).

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.R600004200

Structure elucidation of Sch 538415, a novel acyl carrier protein synthase inhibitor from a microorganism

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.R600004200

Crystal structure of Streptococcus pneumoniae acyl carrier protein synthase: an essential enzyme in bacterial fatty acid biosynthesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.R600004200

Crystal structures of substrate binding to Bacillus subtilis holo-(acyl carrier protein) synthase reveal a novel trimeric arrangement of molecules resulting in three active sites

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.R600004200

Anthranilate 4H-oxazol-5-ones: novel small molecule antibacterial acyl carrier protein synthase (AcpS) inhibitors.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.R600004200

Use of structure-based drug design approaches to obtain novel anthranilic acid acyl carrier protein synthase inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.R600004200

The antibiotic activity of N-pentylpantothenamide results from its conversion to ethyldethia-coenzyme a, a coenzyme a antimetabolite

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.R600004200

Acyl carrier protein is a cellular target for the antibacterial action of the pantothenamide class of pantothenate antimetabolites

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.R600004200

A pantothenate kinase from Staphylococcus aureus refractory to feedback regulation by coenzyme A.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.R600004200

Structure-activity relationships and enzyme inhibition of pantothenamide-type pantothenate kinase inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.R600004200

Characterization of a new pantothenate kinase isoform from Helicobacter pylori

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.R600004200

From genetic footprinting to antimicrobial drug targets: examples in cofactor biosynthetic pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.R600004200

Inhibitors of phosphopantetheine adenylyltransferase.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.R600004200

The crystal structure of a novel bacterial adenylyltransferase reveals half of sites reactivity

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.R600004200

The crystal structures of phosphopantetheine adenylyltransferase with bound substrates reveal the enzyme's catalytic mechanism

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.R600004200

A Novel Adenylate Binding Site Confers Phosphopantetheine Adenylyltransferase Interactions with Coenzyme A

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.R600004200

A type II pathway for fatty acid biosynthesis presents drug targets in Plasmodium falciparum

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.R600004200

Mutational analysis of the triclosan-binding region of enoyl-ACP (acyl-carrier protein) reductase from Plasmodium falciparum

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.R600004200

Synthesis and antitumor activity of an inhibitor of fatty acid synthase

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.R600004200

Reduced food intake and body weight in mice treated with fatty acid synthase inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.R600004200

Differential effects of a centrally acting fatty acid synthase inhibitor in lean and obese mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.R600004200

Long-term effects of a fatty acid synthase inhibitor on obese mice: food intake, hypothalamic neuropeptides, and UCP3.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.R600004200

Effect of a fatty acid synthase inhibitor on food intake and expression of hypothalamic neuropeptides

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.R600004200

Role of malonyl-CoA in the hypothalamic control of food intake and energy expenditure.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.R600004200

A role for hypothalamic malonyl-CoA in the control of food intake

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.R600004200

Prediction of mechanisms of action of antibacterial compounds by gene expression profiling.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.R600004200

Discovering the mechanism of action of novel antibacterial agents through transcriptional profiling of conditional mutants

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.R600004200

Purification, characterization, and identification of novel inhibitors of the beta-ketoacyl-acyl carrier protein synthase III (FabH) from Staphylococcus aureus

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.R600004200

Structure-based design, synthesis, and study of potent inhibitors of beta-ketoacyl-acyl carrier protein synthase III as potential antimicrobial agents

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.R600004200

Slow-tight-binding inhibition of enoyl-acyl carrier protein reductase from Plasmodium falciparum by triclosan

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.R600004200

Erratum: A triclosan-resistant bacterial enzyme

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.R600004200

Inhibition of fatty acid synthesis by the antibiotic cerulenin. Specific inactivation of beta-ketoacyl-acyl carrier protein synthetase

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.R600004200

Inhibition of fatty acid synthesis by the antibiotic thiolactomycin

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.R600004200

Effect of thiolactomycin on the individual enzymes of the fatty acid synthase system in Escherichia coli

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.R600004200

Thiolactomycin, a new antibiotic. IV. Biological properties and chemotherapeutic activity in mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.R600004200

Enoyl-acyl carrier protein reductase (fabI) plays a determinant role in completing cycles of fatty acid elongation in Escherichia coli

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.R600004200

Characterization of Sfp, a Bacillus subtilis phosphopantetheinyl transferase for peptidyl carrier protein domains in peptide synthetases

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.R600004200

N1-(substituted) pantothenamides, antimetabolites of pantothenic acid

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.R600004200

21 January 2018

Identifiers

DOI

10.1074/JBC.R600004200

1 reference

release_2uxctyjtjnhlffglmfa3zyct7q

14 August 2017

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/2uxctyjtjnhlffglmfa3zyct7q

mapped directly with Wikidata item

24 November 2022

based on heuristic

1 reference