(Q36471209)

14 August 2017

1 reference

title

How to control NO production in cells: N(omega),N(omega)-dimethyl-L-arginine dimethylaminohydrolase as a novel drug target (English)

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14 August 2017

Markus Knipp

1

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14 August 2017

publication date

1 June 2006

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14 August 2017

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14 August 2017

volume

7

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14 August 2017

issue

6

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14 August 2017

page(s)

879-889

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Nitric oxide synthases: properties and catalytic mechanism

14 August 2017

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Effect of inhibition of nitric oxide synthase on chronic tension-type headache: a randomised crossover trial

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Nitric oxide synthase inhibition as therapy for sepsis: a decade of promise

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Simvastatin decreases nitric oxide overproduction and reverts the impaired vascular responsiveness induced by endotoxic shock in rats

21 January 2018

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Blocking NO synthesis: how, where and why?

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Reversal of endotoxin-mediated shock by NG-methyl-L-arginine, an inhibitor of nitric oxide synthesis

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An open-label dose escalation study of the nitric oxide synthase inhibitor, N(G)-methyl-L-arginine hydrochloride (546C88), in patients with septic shock. Glaxo Wellcome International Septic Shock Study Group.

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Pharmacokinetics of the nitric oxide synthase inhibitor L-NG-methylarginine hydrochloride in patients with septic shock. Glaxo Wellcome International Septic Shock Study Group.

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Multiple-center, randomized, placebo-controlled, double-blind study of the nitric oxide synthase inhibitor 546C88: effect on survival in patients with septic shock

21 January 2018

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A dose-response study of nitric oxide synthase inhibition in different vascular beds in man.

21 January 2018

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Nitric oxide synthase inhibition in migraine

21 January 2018

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https://api.crossref.org/works/10.1002%2FCBIC.200500527

Nitric oxide synthase inhibition: a new principle in the treatment of migraine attacks

21 January 2018

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Human muscular dystrophy: elevation of urinary dimethylarginines

21 January 2018

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Association between cerebrospinal fluid levels of asymmetric dimethyl-L-arginine, an endogenous inhibitor of endothelial nitric oxide synthase, and cerebral vasospasm in a primate model of subarachnoid hemorrhage

21 January 2018

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Transcriptional control: an activating role for arginine methylation.

21 January 2018

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Nucleolin interacts with several ribosomal proteins through its RGG domain.

21 January 2018

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Exposure on cell surface and extensive arginine methylation of ewing sarcoma (EWS) protein

21 January 2018

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21 January 2018

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21 January 2018

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Accumulation of an endogenous inhibitor of nitric oxide synthesis in chronic renal failure

21 January 2018

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Inactivation of macrophage nitric oxide synthase activity by NG-methyl-L-arginine

21 January 2018

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Purification and characterization of particulate endothelium-derived relaxing factor synthase from cultured and native bovine aortic endothelial cells

21 January 2018

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Accumulation of endogenous inhibitors for nitric oxide synthesis and decreased content of L‐arginine in regenerated endothelial cells

21 January 2018

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21 January 2018

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Endogenous Dimethylarginine as an Inhibitor of Nitric Oxide Synthesis

21 January 2018

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Inhibition of nitric oxide activity by arginine analogs in human renal arteries

21 January 2018

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21 January 2018

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Regulation of nitric oxide synthesis by dimethylarginine dimethylaminohydrolase

21 January 2018

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Asymmetric dimethylarginine causes hypertension and cardiac dysfunction in humans and is actively metabolized by dimethylarginine dimethylaminohydrolase

21 January 2018

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https://api.crossref.org/works/10.1002%2FCBIC.200500527

Dimethylarginine dimethylaminohydrolase regulates nitric oxide synthesis: genetic and physiological evidence

21 January 2018

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Nitric oxide donors: chemical activities and biological applications

21 January 2018

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https://api.crossref.org/works/10.1002%2FCBIC.200500527

Irreversible inactivation of macrophage and brain nitric oxide synthase by L-NG-methylarginine requires NADPH-dependent hydroxylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.200500527

The human liver clears both asymmetric and symmetric dimethylarginine

21 January 2018

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https://api.crossref.org/works/10.1002%2FCBIC.200500527

Na+ - and Cl- -coupled active transport of nitric oxide synthase inhibitors via amino acid transport system B(0,+)

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.200500527

Role of macula densa NOS in tubuloglomerular feedback

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.200500527

Identification of microbial dimethylarginine dimethylaminohydrolase enzymes

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.200500527

Structural and functional characterization of the Zn(II) site in dimethylargininase-1 (DDAH-1) from bovine brain. Zn(II) release activates DDAH-1.

21 January 2018

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https://api.crossref.org/works/10.1002%2FCBIC.200500527

Characterization of dimethylargininase from bovine brain: evidence for a zinc binding site.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.200500527

Purification, cDNA cloning and expression of human NG,NG-dimethylarginine dimethylaminohydrolase

21 January 2018

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https://api.crossref.org/works/10.1002%2FCBIC.200500527

Identification of two human dimethylarginine dimethylaminohydrolases with distinct tissue distributions and homology with microbial arginine deiminases

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.200500527

Characterization of a transient covalent adduct formed during dimethylarginine dimethylaminohydrolase catalysis

21 January 2018

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https://api.crossref.org/works/10.1002%2FCBIC.200500527

Biological significance of endogenous methylarginines that inhibit nitric oxide synthases

21 January 2018

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https://api.crossref.org/works/10.1002%2FCBIC.200500527

Intracellular localization of dimethylarginine dimethylaminohydrolase overexpressed in an endothelial cell line

21 January 2018

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https://api.crossref.org/works/10.1002%2FCBIC.200500527

Dimethylarginine dimethylaminohydrolase and endothelial dysfunction in failing hearts

21 January 2018

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https://api.crossref.org/works/10.1002%2FCBIC.200500527

Chromosomal localization, gene structure, and expression pattern of DDAH1: comparison with DDAH2 and implications for evolutionary origins

21 January 2018

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Dimethylarginine dimethylaminohydrolase (DDAH) as a nerve-injury-associated molecule: mRNA localization in the rat brain and its coincident up-regulation with neuronal NO synthase (nNOS) in axotomized motoneurons

21 January 2018

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Structural insights into the hydrolysis of cellular nitric oxide synthase inhibitors by dimethylarginine dimethylaminohydrolase

21 January 2018

1 reference

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Zn(II)-free dimethylargininase-1 (DDAH-1) is inhibited upon specific Cys-S-nitrosylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.200500527

Crystal structures of arginine deiminase with covalent reaction intermediates; implications for catalytic mechanism.

21 January 2018

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A continuous spectrophotometric assay for dimethylarginine dimethylaminohydrolase

21 January 2018

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The lysosomal cysteine proteases

21 January 2018

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Estrogen stimulates dimethylarginine dimethylaminohydrolase activity and the metabolism of asymmetric dimethylarginine

21 January 2018

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Novel mechanism for endothelial dysfunction: dysregulation of dimethylarginine dimethylaminohydrolase

21 January 2018

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https://api.crossref.org/works/10.1002%2FCBIC.200500527

Homocysteine impairs the nitric oxide synthase pathway: role of asymmetric dimethylarginine

21 January 2018

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Homocysteine increases the production of asymmetric dimethylarginine in cultured neurons

21 January 2018

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Pravastatin restores DDAH activity and endothelium-dependent relaxation of rat aorta after exposure to glycated protein

21 January 2018

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Effect of Shear Stress on Asymmetric Dimethylarginine Release From Vascular Endothelial Cells

21 January 2018

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Erythropoietin increases asymmetric dimethylarginine in endothelial cells: role of dimethylarginine dimethylaminohydrolase

21 January 2018

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S-nitrosylation of dimethylarginine dimethylaminohydrolase regulates enzyme activity: further interactions between nitric oxide synthase and dimethylarginine dimethylaminohydrolase

21 January 2018

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Isolation and characterization of a novel monomeric zinc- and heme-containing protein from bovine brain.

21 January 2018

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Cysteine-Zn2+ complexes: unique molecular switches for inducible nitric oxide synthase-derived NO.

21 January 2018

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Zinc metabolism in the brain: relevance to human neurodegenerative disorders

21 January 2018

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Regulation of zinc homeostasis by inducible NO synthase-derived NO: nuclear metallothionein translocation and intranuclear Zn2+ release

21 January 2018

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Femtomolar sensitivity of metalloregulatory proteins controlling zinc homeostasis

21 January 2018

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Transition Metal Speciation in the Cell: Insights from the Chemistry of Metal Ion Receptors

21 January 2018

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Detection of nitric oxide interaction with zinc finger proteins

21 January 2018

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Inhibition of the catalytic activity of alcohol dehydrogenase by nitric oxide is associated with S nitrosylation and the release of zinc.

21 January 2018

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Zinc is a potent inhibitor of the apoptotic protease, caspase-3. A novel target for zinc in the inhibition of apoptosis

21 January 2018

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21 January 2018

Zinc and brain injury

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Metabolism of asymmetric dimethylarginines is regulated in the lung developmentally and with pulmonary hypertension induced by hypobaric hypoxia

21 January 2018

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Genome-wide examination of myoblast cell cycle withdrawal during differentiation

21 January 2018

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all-trans-Retinoic acid increases nitric oxide synthesis by endothelial cells: a role for the induction of dimethylarginine dimethylaminohydrolase.

21 January 2018

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Expression of DDAH1 in chick and rat embryos

21 January 2018

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Dimethylarginine dimethylaminohydrolase overexpression suppresses graft coronary artery disease

21 January 2018

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Aspirin reduces endothelial cell senescence

21 January 2018

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Aspirin protects endothelial cells from oxidative stress--possible synergism with vitamin E.

21 January 2018

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Antioxidative properties of acetylsalicylic Acid on vascular tissues from normotensive and spontaneously hypertensive rats

21 January 2018

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Aspirin induces nitric oxide release from vascular endothelium: a novel mechanism of action

21 January 2018

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Overexpression of dimethylarginine dimethylaminohydrolase enhances tumor hypoxia: an insight into the relationship of hypoxia and angiogenesis in vivo.

21 January 2018

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Overexpression of dimethylarginine dimethylaminohydrolase reduces tissue asymmetric dimethylarginine levels and enhances angiogenesis

21 January 2018

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Selective substrate-based inhibitors of mammalian dimethylarginine dimethylaminohydrolase.

21 January 2018

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Searching for DDAH inhibitors: S-nitroso-L-homocysteine is a chemical lead

21 January 2018

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Synthesis of L-thiocitrulline, L-homothiocitrulline, and S-methyl-L-thiocitrulline: a new class of potent nitric oxide synthase inhibitors

21 January 2018

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Inactivation of two diverse enzymes in the amidinotransferase superfamily by 2-chloroacetamidine: dimethylargininase and peptidylarginine deiminase

21 January 2018

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Structure-activity relationships for inhibition of cysteine protease activity and development of Plasmodium falciparum by peptidyl vinyl sulfones

21 January 2018

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Inhibition of dimethylarginine dimethylaminohydrolase (DDAH) and arginine deiminase (ADI) by pentafluorophenyl (PFP) sulfonates.

21 January 2018

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Nitric oxide in asthma. Pathogenic, therapeutic, or diagnostic?

21 January 2018

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https://api.crossref.org/works/10.1002%2FCBIC.200500527

Role of nitric oxide in inflammation

21 January 2018

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https://api.crossref.org/works/10.1002%2FCBIC.200500527

Nitric oxide in myocardial ischemia/reperfusion injury

21 January 2018

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https://api.crossref.org/works/10.1002%2FCBIC.200500527

Pharmacological characterization of nitric oxide production in a rat model of meningitis

21 January 2018

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https://api.crossref.org/works/10.1002%2FCBIC.200500527

Inhibition of neuronal nitric oxide synthase prevents MPTP-induced parkinsonism in baboons.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.200500527

Nitric oxide in the nervous system

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.200500527

Total nitric oxide production is low in patients with chronic renal disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.200500527

Plasma from ESRD patients inhibits nitric oxide synthase activity in cultured human and bovine endothelial cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.200500527

Asymmetric dimethylarginine (ADMA): a novel risk factor for endothelial dysfunction: its role in hypercholesterolemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.200500527

Plasma concentration of asymmetric dimethylarginine, an endogenous inhibitor of nitric oxide synthase, is elevated in monkeys with hyperhomocyst(e)inemia or hypercholesterolemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.200500527

Elevation of asymmetrical dimethylarginine may mediate endothelial dysfunction during experimental hyperhomocyst(e)inaemia in humans

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.200500527

Elevated levels of plasma homocyst(e)ine and asymmetric dimethylarginine in elderly patients with stroke

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.200500527

Increased endogenous nitric oxide synthase inhibitor in patients with congestive heart failure

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.200500527

Elevated endogenous nitric oxide synthase inhibitor in schizophrenic plasma may reflect abnormalities in brain nitric oxide production.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.200500527

A new method for the liquid chromatography analysis of methylated arginines in biological fluids and tissues by o-phthaldialdehyde postcolumn derivatization

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.200500527

Increased (E)-4-hydroxy-2-nonenal and asymmetric dimethylarginine concentrations and decreased nitric oxide concentrations in the plasma of patients with major depression

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.200500527

Raised plasma levels of asymmetric dimethylarginine are associated with cardiovascular events, disease activity, and organ damage in patients with systemic lupus erythematosus

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.200500527

Plasma concentration of asymmetric dimethylarginine, an endogenous inhibitor of nitric oxide synthase, is elevated in hyperthyroid patients

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.200500527

Decrease of 3-methylhistidine and increase of NG,NG-dimethylarginine in the urine of patients with muscular dystrophy

21 January 2018

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https://api.crossref.org/works/10.1002%2FCBIC.200500527

Impaired nitric oxide synthase pathway in diabetes mellitus: role of asymmetric dimethylarginine and dimethylarginine dimethylaminohydrolase

21 January 2018

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https://api.crossref.org/works/10.1002%2FCBIC.200500527

Water extract of Helicobacter pylori inhibits duodenal mucosal alkaline secretion in anesthetized rats.

21 January 2018

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https://api.crossref.org/works/10.1002%2FCBIC.200500527

Plasma levels of asymmetric dimethylarginine (ADMA), an endogenous nitric oxide synthase inhibitor, are elevated in sickle cell disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.200500527

Deimination of Myelin Basic Protein. 2. Effect of Methylation of MBP on Its Deimination by Peptidylarginine Deiminase†

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.200500527

Characterization and Manipulation of the Pseudomonas aeruginosa Dimethylarginine Dimethylaminohydrolase Monomer–Dimer Equilibrium

21 January 2018

1 reference

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21 January 2018

Identifiers

DOI

10.1002/CBIC.200500527

1 reference

14 August 2017

1 reference