(Q36477211)

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Human β-cell killing by autoreactive preproinsulin-specific CD8 T cells is predominantly granule-mediated with the potency dependent upon T-cell receptor avidity

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Europe PubMed Central

PMC publication ID

14 August 2017

Human β-cell killing by autoreactive preproinsulin-specific CD8 T cells is predominantly granule-mediated with the potency dependent upon T-cell receptor avidity (English)

1 reference

Europe PubMed Central

PMC publication ID

14 August 2017

Deborah Kronenberg

object named as

Deborah Kronenberg

2

0 references

Martin Eichmann

object named as

Martin Eichmann

5

0 references

object named as

David K Cole

8

0 references

object named as

Mark Peakman

10

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Andrew K Sewell

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Andrew K Sewell

9

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author name string

Robin R Knight

1

1 reference

Europe PubMed Central

PMC publication ID

14 August 2017

Min Zhao

3

1 reference

Europe PubMed Central

PMC publication ID

14 August 2017

Guo Cai Huang

4

1 reference

Europe PubMed Central

PMC publication ID

14 August 2017

Anna Bulek

6

1 reference

Europe PubMed Central

PMC publication ID

14 August 2017

Linda Wooldridge

7

1 reference

Europe PubMed Central

PMC publication ID

14 August 2017

Ania Skowera

11

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Europe PubMed Central

PMC publication ID

14 August 2017

language of work or name

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publication date

30 August 2012

1 reference

Europe PubMed Central

PMC publication ID

14 August 2017

number of pages

9

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based on heuristic

inferred from page(s)

1 reference

Europe PubMed Central

PMC publication ID

14 August 2017

62

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Europe PubMed Central

PMC publication ID

14 August 2017

1

1 reference

Europe PubMed Central

PMC publication ID

14 August 2017

205-213

1 reference

Europe PubMed Central

PMC publication ID

14 August 2017

copyright license

Creative Commons Attribution-NonCommercial-NoDerivs 3.0 Unported

27 August 2021

1 reference

April 2022 Public Data File from Crossref

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0 references

Circulating preproinsulin signal peptide-specific CD8 T cells restricted by the susceptibility molecule HLA-A24 are expanded at onset of type 1 diabetes and kill β-cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3526019

30 September 2017

Structural basis for the killing of human beta cells by CD8(+) T cells in type 1 diabetes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3526019

30 September 2017

Demonstration of islet-autoreactive CD8 T cells in insulitic lesions from recent onset and long-term type 1 diabetes patients.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3526019

30 September 2017

Intravital imaging of CTLs killing islet cells in diabetic mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3526019

30 September 2017

A single autoimmune T cell receptor recognizes more than a million different peptides

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3526019

30 September 2017

Diabetogenic T lymphocytes in human Type 1 diabetes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3526019

30 September 2017

Simultaneous detection of circulating autoreactive CD8+ T-cells specific for different islet cell-associated epitopes using combinatorial MHC multimers.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3526019

30 September 2017

The role of perforin and granzymes in diabetes.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3526019

30 September 2017

Etanercept treatment in children with new-onset type 1 diabetes: pilot randomized, placebo-controlled, double-blind study

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3526019

30 September 2017

Analysis of islet inflammation in human type 1 diabetes.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3526019

30 September 2017

CTLs are targeted to kill beta cells in patients with type 1 diabetes through recognition of a glucose-regulated preproinsulin epitope

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3526019

30 September 2017

Cytotoxic T-lymphocyte-mediated killing of human pancreatic islet cells in vitro

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3526019

30 September 2017

Localization of type 1 diabetes susceptibility to the MHC class I genes HLA-B and HLA-A

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3526019

30 September 2017

Fas Ligand Interactions Contribute to CD8+ T-Cell-Mediated Control of West Nile Virus Infection in the Central Nervous System

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3526019

30 September 2017

The ABCs of granule-mediated cytotoxicity: new weapons in the arsenal

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3526019

30 September 2017

Autoreactive CD8 T cells in organ-specific autoimmunity: emerging targets for therapeutic intervention.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3526019

30 September 2017

Efficient identification of HLA-A*2402-restricted cytomegalovirus-specific CD8(+) T-cell epitopes by a computer algorithm and an enzyme-linked immunospot assay.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3526019

30 September 2017

Reduced incidence and delayed onset of diabetes in perforin-deficient nonobese diabetic mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3526019

30 September 2017

Requirement of Fas for the development of autoimmune diabetes in nonobese diabetic mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3526019

30 September 2017

Molecular mechanisms of lymphocyte-mediated cytotoxicity and their role in immunological protection and pathogenesis in vivo

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3526019

30 September 2017

Alkalinizing the intralysosomal pH inhibits degranulation of human neutrophils

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3526019

30 September 2017

TLR9 blockade inhibits activation of diabetogenic CD8+ T cells and delays autoimmune diabetes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3526019

28 June 2018

Rapid CD8+ T cell repertoire focusing and selection of high-affinity clones into memory following primary infection with a persistent human virus: human cytomegalovirus

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3526019

21 September 2018

The development of new density gradient media for purifying human islets and islet-quality assessments

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3526019

21 September 2018

Promiscuous CTL recognition of viral epitopes on multiple human leukocyte antigens: biological validation of the proposed HLA A24 supertype

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3526019

21 September 2018

In situ characterization of autoimmune phenomena and expression of HLA molecules in the pancreas in diabetic insulitis

1 reference

https://pubmed.ncbi.nlm.nih.gov/22936177

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Beta 2-microglobulin-deficient NOD mice do not develop insulitis or diabetes

1 reference

https://pubmed.ncbi.nlm.nih.gov/22936177

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Acidification is essential for maintaining the structure and function of lytic granules of CTL. Effect of concanamycin A, an inhibitor of vacuolar type H(+)-ATPase, on CTL-mediated cytotoxicity

1 reference

https://pubmed.ncbi.nlm.nih.gov/22936177

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Time-resolved fluorometric assay for natural killer activity using target cells labelled with a fluorescence enhancing ligand

1 reference

https://pubmed.ncbi.nlm.nih.gov/22936177

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

T cell receptor engagement of peptide-major histocompatibility complex class I does not modify CD8 binding

1 reference

https://pubmed.ncbi.nlm.nih.gov/22936177

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.2337/DB12-0315

1 reference

Europe PubMed Central

PMC publication ID

14 August 2017

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

14 August 2017

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

14 August 2017

ResearchGate publication ID

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