(Q36478840)

14 August 2017

The MDM2-a splice variant of MDM2 alters transformation in vitro and the tumor spectrum in both Arf- and p53-null models of tumorigenesis (English)

1 reference

14 August 2017

Erin L Volk

1

1 reference

14 August 2017

Liying Fan

2

1 reference

14 August 2017

Katja Schuster

3

1 reference

14 August 2017

Jerold E Rehg

4

1 reference

14 August 2017

Linda C Harris

5

1 reference

14 August 2017

2 June 2009

1 reference

Molecular Cancer Research

14 August 2017

1 reference

14 August 2017

7

1 reference

14 August 2017

6

1 reference

14 August 2017

863-869

1 reference

MDM2-A, a common Mdm2 splice variant, causes perinatal lethality, reduced longevity and enhanced senescence

14 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3526663

Identification and characterization of a novel Mdm2 splice variant acutely induced by the chemotherapeutic agents adriamycin and actinomycin D

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3526663

Analysis of transformation and tumorigenicity using mouse embryonic fibroblast cells

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3526663

Genotoxic stress induces coordinately regulated alternative splicing of the p53 modulators MDM2 and MDM4.

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3526663

Regulation of hdm2 by stress-induced hdm2alt1 in tumor and nontumorigenic cell lines correlating with p53 stability

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3526663

Stabilization of E2F1 protein by MDM2 through the E2F1 ubiquitination pathway

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3526663

Expression of alternatively and aberrantly spliced transcripts of the MDM2 mRNA is not tumor-specific.

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3526663

MDM2 does not influence p53-mediated sensitivity to DNA-damaging drugs

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3526663

Alternative and aberrant splicing of MDM2 mRNA in human cancer

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3526663

Alternative and aberrant messenger RNA splicing of the mdm2 oncogene in invasive breast cancer

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3526663

Stabilization of the MDM2 oncoprotein by interaction with the structurally related MDMX protein

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3526663

MDM2 suppresses p73 function without promoting p73 degradation

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3526663

Alternatively spliced mdm2 transcripts with loss of p53 binding domain sequences: transforming ability and frequent detection in human cancer.

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3526663

Tumorigenic potential associated with enhanced expression of a gene that is amplified in a mouse tumor cell line

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3526663

Amplification of a gene encoding a p53-associated protein in human sarcomas

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3526663

The mdm-2 oncogene product forms a complex with the p53 protein and inhibits p53-mediated transactivation

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3526663

Amplification and overexpression of the MDM2 gene in a subset of human malignant gliomas without p53 mutations.

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3526663

Tumor promotion by Mdm2 splice variants unable to bind p53.

28 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3526663

Tumor spectrum in ARF-deficient mice.

21 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3526663

Short alternative splice transcripts of the mdm2 oncogene correlate to malignancy in human astrocytic neoplasms.

21 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3526663

Transformation of C3H10T1/2 cells by N-ethyl-N-nitrosourea occurs as a single, low frequency, mutation-like event

21 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3526663

Excessive stimulation of salivary gland growth by isoproterenol

21 September 2018

1 reference

12 December 2020

Optimal N-ethyl-N-nitrosourea (ENU) doses for inbred mouse strains

1 reference

12 December 2020

An alternatively spliced HDM2 product increases p53 activity by inhibiting HDM2

1 reference

12 December 2020

The RING domain of Mdm2 can inhibit cell proliferation

1 reference

12 December 2020

Novel mdm2 splice variants identified in pediatric rhabdomyosarcoma tumors and cell lines

1 reference

12 December 2020

MDM2 gene amplification in metastatic osteosarcoma

1 reference

12 December 2020

Non-syntenic amplification of MDM2 and MYCN in human neuroblastoma

1 reference

12 December 2020

10.1158/1541-7786.MCR-08-0418

Identifiers

DOI

1 reference

14 August 2017

1 reference

14 August 2017

PubMed publication ID

19491200

1 reference