(Q36481702)

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G protein-coupled estrogen receptor mediates the up-regulation of fatty acid synthase induced by 17β-estradiol in cancer cells and cancer-associated fibroblasts

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Europe PubMed Central

PMC publication ID

14 August 2017

G protein-coupled estrogen receptor mediates the up-regulation of fatty acid synthase induced by 17β-estradiol in cancer cells and cancer-associated fibroblasts (English)

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Europe PubMed Central

PMC publication ID

14 August 2017

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G protein-coupled receptor

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cancer-associated fibroblast

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Diego Sisci

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Europe PubMed Central

PMC publication ID

14 August 2017

author name string

Maria Francesca Santolla

1

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Europe PubMed Central

PMC publication ID

14 August 2017

Rosamaria Lappano

2

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Europe PubMed Central

PMC publication ID

14 August 2017

Paola De Marco

3

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Europe PubMed Central

PMC publication ID

14 August 2017

Marco Pupo

4

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Europe PubMed Central

PMC publication ID

14 August 2017

Adele Vivacqua

5

1 reference

Europe PubMed Central

PMC publication ID

14 August 2017

Sergio Abonante

7

1 reference

Europe PubMed Central

PMC publication ID

14 August 2017

Domenico Iacopetta

8

1 reference

Europe PubMed Central

PMC publication ID

14 August 2017

Anna Rita Cappello

9

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Europe PubMed Central

PMC publication ID

14 August 2017

Vincenza Dolce

10

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Europe PubMed Central

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14 August 2017

Marcello Maggiolini

11

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Europe PubMed Central

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14 August 2017

language of work or name

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publication date

7 November 2012

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Europe PubMed Central

PMC publication ID

14 August 2017

Journal of Biological Chemistry

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Europe PubMed Central

PMC publication ID

14 August 2017

287

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Europe PubMed Central

PMC publication ID

14 August 2017

52

1 reference

Europe PubMed Central

PMC publication ID

14 August 2017

43234-43245

1 reference

Europe PubMed Central

PMC publication ID

14 August 2017

Bisphenol A induces gene expression changes and proliferative effects through GPER in breast cancer cells and cancer-associated fibroblasts.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3527911

28 June 2018

Insulin-like growth factor-I regulates GPER expression and function in cancer cells

1 reference

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28 June 2018

MIBE acts as antagonist ligand of both estrogen receptor α and GPER in breast cancer cells.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3527911

28 June 2018

The G protein-coupled receptor 30 is up-regulated by hypoxia-inducible factor-1alpha (HIF-1alpha) in breast cancer cells and cardiomyocytes

1 reference

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28 June 2018

G protein-coupled receptors: novel targets for drug discovery in cancer

1 reference

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28 June 2018

Nuclear alternate estrogen receptor GPR30 mediates 17beta-estradiol-induced gene expression and migration in breast cancer-associated fibroblasts

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3527911

28 June 2018

Fatty acid synthase inhibitor cerulenin suppresses liver metastasis of colon cancer in mice

1 reference

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28 June 2018

Estriol acts as a GPR30 antagonist in estrogen receptor-negative breast cancer cells.

1 reference

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28 June 2018

Cancer associated fibroblasts (CAFs) in tumor microenvironment

1 reference

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28 June 2018

c-Jun activation is required for 4-hydroxytamoxifen-induced cell death in breast cancer cells.

1 reference

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28 June 2018

The unfolding stories of GPR30, a new membrane-bound estrogen receptor.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3527911

28 June 2018

G protein-coupled receptor 30 expression is up-regulated by EGF and TGF alpha in estrogen receptor alpha-positive cancer cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3527911

28 June 2018

Mechanisms of estrogen signaling and gene expression via GPR30

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3527911

28 June 2018

Fatty acid synthase: a metabolic enzyme and candidate oncogene in prostate cancer

1 reference

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28 June 2018

Estrogenic GPR30 signalling induces proliferation and migration of breast cancer cells through CTGF

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3527911

28 June 2018

The tumor microenvironment and its contribution to tumor evolution toward metastasis

1 reference

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28 June 2018

Control of cell growth and survival by enzymes of the fatty acid synthesis pathway in HCT-116 colon cancer cells.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3527911

28 June 2018

The novel estrogen receptor, G protein-coupled receptor 30, mediates the proliferative effects induced by 17beta-estradiol on mouse spermatogonial GC-1 cell line.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3527911

28 June 2018

P53 mutations in stromal fibroblasts sensitize tumors against chemotherapy.

1 reference

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28 June 2018

Estrogen-related cancer microenvironment of breast carcinoma

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3527911

28 June 2018

Epidermal growth factor induces G protein-coupled receptor 30 expression in estrogen receptor-negative breast cancer cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3527911

28 June 2018

Estrogen signaling through the transmembrane G protein-coupled receptor GPR30.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3527911

28 June 2018

Phosphorylation of activation function-1 regulates proteasome-dependent nuclear mobility and E6-associated protein ubiquitin ligase recruitment to the estrogen receptor beta

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3527911

28 June 2018

Fatty acid synthase and the lipogenic phenotype in cancer pathogenesis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3527911

28 June 2018

Up-regulation of acetyl-CoA carboxylase alpha and fatty acid synthase by human epidermal growth factor receptor 2 at the translational level in breast cancer cells.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3527911

28 June 2018

G protein-coupled receptor 30 (GPR30) mediates gene expression changes and growth response to 17beta-estradiol and selective GPR30 ligand G-1 in ovarian cancer cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3527911

28 June 2018

17beta-estradiol, genistein, and 4-hydroxytamoxifen induce the proliferation of thyroid cancer cells through the g protein-coupled receptor GPR30.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3527911

28 June 2018

Targeting fatty acid synthase in breast and endometrial cancer: An alternative to selective estrogen receptor modulators?

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3527911

28 June 2018

Fatty acid synthase and cancer: new application of an old pathway

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3527911

28 June 2018

Mechanism of apoptosis induced by the inhibition of fatty acid synthase in breast cancer cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3527911

28 June 2018

Fibroblasts in cancer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3527911

28 June 2018

Stromal fibroblasts present in invasive human breast carcinomas promote tumor growth and angiogenesis through elevated SDF-1/CXCL12 secretion

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3527911

28 June 2018

The estrogenic activity of synthetic progestins used in oral contraceptives enhances fatty acid synthase-dependent breast cancer cell proliferation and survival.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3527911

28 June 2018

Stromal fibroblasts in cancer initiation and progression

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3527911

28 June 2018

Identity of an estrogen membrane receptor coupled to a G protein in human breast cancer cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3527911

28 June 2018

Fatty acid synthase as a tumor marker: its extracellular expression in human breast cancer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3527911

28 June 2018

The G protein-coupled receptor GPR30 mediates c-fos up-regulation by 17beta-estradiol and phytoestrogens in breast cancer cells.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3527911

28 June 2018

Estrogen receptor-alpha directs ordered, cyclical, and combinatorial recruitment of cofactors on a natural target promoter

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3527911

28 June 2018

Progesterone stimulates adipocyte determination and differentiation 1/sterol regulatory element-binding protein 1c gene expression. potential mechanism for the lipogenic effect of progesterone in adipose tissue

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3527911

28 June 2018

Estrogen-induced activation of Erk-1 and Erk-2 requires the G protein-coupled receptor homolog, GPR30, and occurs via trans-activation of the epidermal growth factor receptor through release of HB-EGF

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3527911

28 June 2018

Fatty-acid synthase and human cancer: new perspectives on its role in tumor biology

1 reference

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28 June 2018

Fatty acid synthase expression in endometrial carcinoma: correlation with cell proliferation and hormone receptors

1 reference

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28 June 2018

Coordinate regulation of lipogenic gene expression by androgens: evidence for a cascade mechanism involving sterol regulatory element binding proteins

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3527911

28 June 2018

Androgens stimulate fatty acid synthase in the human prostate cancer cell line LNCaP.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3527911

28 June 2018

Effect of oestradiol and insulin on the proliferative pattern and on oestrogen and progesterone receptor contents in MCF-7 cells

1 reference

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1 reference

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De novo lipogenesis protects cancer cells from free radicals and chemotherapeutics by promoting membrane lipid saturation

1 reference

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21 September 2018

17 beta-estradiol activates rapid signaling pathways involved in rat pachytene spermatocytes apoptosis through GPR30 and ER alpha.

1 reference

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21 September 2018

A new membrane G protein-coupled receptor (GPR30) is involved in the cardiac effects of 17beta-estradiol in the male rat.

1 reference

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21 September 2018

Polyunsaturation in lipid membranes: dynamic properties and lateral pressure profiles.

1 reference

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1 reference

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21 September 2018

Virtual and biomolecular screening converge on a selective agonist for GPR30.

1 reference

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21 September 2018

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1 reference

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C75 inhibits food intake by increasing CNS glucose metabolism

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Transcriptome analysis of HER2 reveals a molecular connection to fatty acid synthesis.

1 reference

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21 September 2018

Role of the phosphatidylinositol 3'-kinase/PTEN/Akt kinase pathway in the overexpression of fatty acid synthase in LNCaP prostate cancer cells.

1 reference

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21 September 2018

Inhibition of fatty acid synthetases by the antibiotic cerulenin

1 reference

https://pubmed.ncbi.nlm.nih.gov/23135268

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The estrogen receptor binds tightly to its responsive element as a ligand-induced homodimer

1 reference

https://pubmed.ncbi.nlm.nih.gov/23135268

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cooperative binding of steroid hormone receptors contributes to transcriptional synergism at target enhancer elements

1 reference

https://pubmed.ncbi.nlm.nih.gov/23135268

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inhibition of fatty acid synthesis induces programmed cell death in human breast cancer cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/23135268

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A non-radioactive method for inexpensive quantitative RT-PCR

1 reference

https://pubmed.ncbi.nlm.nih.gov/23135268

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The lipogenesis pathway as a cancer target

1 reference

https://pubmed.ncbi.nlm.nih.gov/23135268

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1074/JBC.M112.417303

1 reference

Europe PubMed Central

PMC publication ID

14 August 2017

release_s5z2rnj5pva3re5k5wlgubulgm

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24 November 2022

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mapped directly with Wikidata item

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

14 August 2017

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

14 August 2017

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