(Q36484641)

14 August 2017

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title

Plasmid engineering for controlled and sustained gene expression for nonviral gene therapy (English)

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14 August 2017

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2

Wim E Hennink

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14 August 2017

Ethlinn V B van Gaal

1

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14 August 2017

Daan J A Crommelin

series ordinal

3

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14 August 2017

Enrico Mastrobattista

series ordinal

4

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14 August 2017

publication date

26 May 2006

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14 August 2017

published in

Pharmaceutical Research

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14 August 2017

volume

23

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14 August 2017

issue

6

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14 August 2017

page(s)

1053-1074

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Adenoviral expression of vascular endothelial growth factor-C induces lymphangiogenesis in the skin

14 August 2017

cites work

1 reference

https://api.crossref.org/works/10.1007%2FS11095-006-0164-2

Analysis of cell-specific promoters for viral gene therapy targeted at the vascular endothelium

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11095-006-0164-2

Efficient transfer of chromosome-based DNA constructs into mammalian cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11095-006-0164-2

Inactivation of the very strong HCMV immediate early promoter by DNA CpG methylation in vitro

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11095-006-0164-2

Requirements for effective inhibition of immunostimulatory CpG motifs by neutralizing motifs.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11095-006-0164-2

Regulation of endothelin-1 expression in normal and transfected endothelial cells.

21 January 2018

1 reference

12 December 2020

The role of CpG motifs in immunostimulation and gene therapy

1 reference

12 December 2020

Silencing of episomal transgene expression by plasmid bacterial DNA elements in vivo

1 reference

12 December 2020

Use of a tissue-specific promoter for targeted expression of the herpes simplex virus thymidine kinase gene in cervical carcinoma cells.

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12 December 2020

DNA injection into single cells of intact mice

1 reference

12 December 2020

Latest developments and in vivo use of the Tet system: ex vivo and in vivo delivery of tetracycline-regulated genes.

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12 December 2020

Gene delivery by a steroid-peptide nucleic acid conjugate

1 reference

12 December 2020

A novel T7 RNA polymerase autogene for efficient cytoplasmic expression of target genes

1 reference

12 December 2020

Increased maintenance and persistence of transgenes by excision of expression cassettes from plasmid sequences in vivo.

1 reference

12 December 2020

T7 RNA polymerase mutants with altered promoter specificities

1 reference

12 December 2020

Gene therapy of brain and endocrine tumors.

1 reference

12 December 2020

A radiation-controlled molecular switch for use in gene therapy of cancer.

1 reference

12 December 2020

A strategy for enhancing the transcriptional activity of weak cell type-specific promoters.

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12 December 2020

Modulation of gene expression made easy

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12 December 2020

Somatic integration and long-term transgene expression in normal and haemophilic mice using a DNA transposon system

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12 December 2020

Conditional gene targeting for cancer gene therapy

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12 December 2020

Tight control of gene expression in mammalian cells by tetracycline-responsive promoters

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12 December 2020

Establishment of an oriP/EBNA1-based episomal vector transcribing human genomic beta-globin in cultured murine fibroblasts

1 reference

12 December 2020

Advances in gene targeting methods

1 reference

12 December 2020

Gene therapy targeting for hepatocellular carcinoma: selective and enhanced suicide gene expression regulated by a hypoxia-inducible enhancer linked to a human alpha-fetoprotein promoter

1 reference

12 December 2020

A 9-nt segment of a cellular mRNA can function as an internal ribosome entry site (IRES) and when present in linked multiple copies greatly enhances IRES activity

1 reference

12 December 2020

Development of a hypoxia-responsive vector for tumor-specific gene therapy

1 reference

12 December 2020

Cell type specific and glucose responsive expression of interleukin-4 by using insulin promoter and water soluble lipopolymer

1 reference

12 December 2020

Sequence motifs in adenoviral DNA block immune activation by stimulatory CpG motifs

1 reference

12 December 2020

Transcriptional regulation of the tissue-type plasminogen-activator gene in human endothelial cells: identification of nuclear factors that recognise functional elements in the tissue-type plasminogen-activator gene promoter

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12 December 2020

Molecular approaches to chemo-radiotherapy.

1 reference

12 December 2020

Engineering synthetic vectors for improved DNA delivery: insights from intracellular pathways

1 reference

12 December 2020

Viral vectors for gene transfer: a review of their use in the treatment of human diseases

1 reference

12 December 2020

Enhancement of gene expression under hypoxic conditions using fragments of the human vascular endothelial growth factor and the erythropoietin genes

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12 December 2020

Autoregulated, bidirectional and multicistronic gas-inducible mammalian as well as lentiviral expression vectors

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12 December 2020

Polycation-DNA complexes for gene delivery: a comparison of the biopharmaceutical properties of cationic polypeptides and cationic lipids

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12 December 2020

Gene therapy for human genetic disease?

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12 December 2020

Spatial and temporal control of expression of therapeutic genes using heat shock protein promoters

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12 December 2020

Use of the radiation-inducible WAF1 promoter to drive iNOS gene therapy as a novel anti-cancer treatment

1 reference

12 December 2020

Air-conditioning for regulated transgene expression

1 reference

12 December 2020

Mdr1 promoter-driven tumor necrosis factor-alpha expression for a chemotherapy-controllable combined in vivo gene therapy and chemotherapy of tumors

1 reference

12 December 2020

Amplification of AKT2 in human pancreatic cells and inhibition of AKT2 expression and tumorigenicity by antisense RNA

1 reference

12 December 2020

Tumor-specific transgene expression from the human telomerase reverse transcriptase promoter enables targeting of the therapeutic effects of the Bax gene to cancers.

1 reference

12 December 2020

Transcriptional targeting for ovarian cancer gene therapy

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12 December 2020

Osteocalcin-directed gene therapy for prostate-cancer bone metastasis

1 reference

12 December 2020

Gas-inducible transgene expression in mammalian cells and mice

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12 December 2020

Regulated gene expression systems

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12 December 2020

Therapeutic efficacy of the suicide gene driven by the promoter of vascular endothelial growth factor gene against hypoxic tumor cells

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12 December 2020

Pathways of removal of free DNA vector ends in normal and DNA-PKcs-deficient SCID mouse hepatocytes transduced with rAAV vectors

1 reference

12 December 2020

Sp1 transcription factor binds DNA and activates transcription even when the binding site is CpG methylated

1 reference

12 December 2020

Genetic prodrug activation therapy for breast cancer: A phase I clinical trial of erbB-2-directed suicide gene expression

1 reference

12 December 2020

Utilization of variant-type of human alpha-fetoprotein promoter in gene therapy targeting for hepatocellular carcinoma

1 reference

12 December 2020

Polycistronic viral vectors

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12 December 2020

Gene therapy for hepatoma cells using a retrovirus vector carrying herpes simplex virus thymidine kinase gene under the control of human alpha-fetoprotein gene promoter

1 reference

12 December 2020

Muscle-specific enhancement of gene expression by incorporation of SV40 enhancer in the expression plasmid

1 reference

12 December 2020

Effect of a DNA nuclear targeting sequence on gene transfer and expression of plasmids in the intact vasculature

1 reference

12 December 2020

Comment on the use of the cre/loxP recombinase system for gene therapy vectors

1 reference

12 December 2020

Endothelial cell-specific transcriptional targeting from a hybrid long terminal repeat retrovirus vector containing human prepro-endothelin-1 promoter sequences

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12 December 2020

Antiprogestin-controllable transgene regulation in vivo

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12 December 2020

The glucose-regulated proteins: stress induction and clinical applications

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12 December 2020

Heat-induced gene expression as a novel targeted cancer gene therapy strategy.

1 reference

12 December 2020

Dimerizer-regulated gene expression

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12 December 2020

Functional analysis of the human vascular cell adhesion molecule 1 promoter

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12 December 2020

Transcriptional control: an essential component of cancer gene therapy strategies?

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12 December 2020

Radiation to control gene expression

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12 December 2020

Nuclear entry of nonviral vectors

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12 December 2020

Use of the glucose starvation-inducible glucose-regulated protein 78 promoter in suicide gene therapy of murine fibrosarcoma.

1 reference

12 December 2020

Site-directed genome modification: derivatives of DNA-modifying enzymes as targeting tools

1 reference

12 December 2020

Cloning of human telomerase catalytic subunit (hTERT) gene promoter and identification of proximal core promoter sequences essential for transcriptional activation in immortalized and cancer cells

1 reference

12 December 2020

Reduced inflammatory response to plasmid DNA vectors by elimination and inhibition of immunostimulatory CpG motifs

1 reference

12 December 2020

Coupling of importin beta binding peptide on plasmid DNA: transfection efficiency is increased by modification of lipoplex's physico-chemical properties

1 reference

12 December 2020

Transcription regulation and animal diversity

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12 December 2020

A novel promoter for vascular endothelial growth factor receptor (flt-1) that confers endothelial-specific gene expression

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12 December 2020

Site-directed genome modification: nucleic acid and protein modules for targeted integration and gene correction.

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12 December 2020

Cell type specificity of the human endoglin promoter

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12 December 2020

The DNA methylation paradox

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12 December 2020

Safety-modified episomal vectors for human gene therapy.

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12 December 2020

Improved properties of FLP recombinase evolved by cycling mutagenesis

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12 December 2020

The mifepristone-inducible gene regulatory system in mouse models of disease and gene therapy.

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12 December 2020

Tissue-specific gene therapy directed to tumor angiogenesis.

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12 December 2020

Strategies to accomplish targeted expression of transgenes in ovarian cancer for molecular therapeutic applications

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12 December 2020

Tetracycline-regulated secretion of human (pro)insulin following plasmid-mediated transfection of human muscle

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12 December 2020

Mammalian genomes contain active recombinase recognition sites

1 reference

12 December 2020

Polyethylenimine-mediated suicide gene transfer induces a therapeutic effect for hepatocellular carcinoma in vivo by using an Epstein-Barr virus-based plasmid vector

1 reference

12 December 2020

Endothelial-specific gene expression directed by the tie gene promoter in vivo.

1 reference

12 December 2020

The use of the L-plastin promoter for adenoviral-mediated, tumor-specific gene expression in ovarian and bladder cancer cell lines

1 reference

12 December 2020

A vector based on the SV40 origin of replication and chromosomal S/MARs replicates episomally in CHO cells

1 reference

12 December 2020

Highly efficient gene transfer into murine liver achieved by intravenous administration of naked Epstein-Barr virus (EBV)-based plasmid vectors.

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12 December 2020

Regulation of endothelial nitric oxide synthase activity and gene expression

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12 December 2020

Up to 100-fold increase of apparent gene expression in the presence of Epstein-Barr virus oriP sequences and EBNA1: implications of the nuclear import of plasmids

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12 December 2020

A unified theory of gene expression

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12 December 2020

Up-regulation of vascular endothelial growth factor expression in a rat glioma is conferred by two distinct hypoxia-driven mechanisms

1 reference

12 December 2020

A transcriptional feedback loop for tissue-specific expression of highly cytotoxic genes which incorporates an immunostimulatory component

1 reference

12 December 2020

Gene therapy: designer promoters for tumour targeting

1 reference

12 December 2020

Targeting gene expression to endothelial cells in transgenic mice using the human intercellular adhesion molecule 2 promoter

1 reference

12 December 2020

Employment of the mdr1 promoter for the chemotherapy-inducible expression of therapeutic genes in cancer gene therapy

1 reference

12 December 2020

Hypoxia-inducible factor-1 modulates gene expression in solid tumors and influences both angiogenesis and tumor growth.

1 reference

12 December 2020

Targeting gene expression to tumor cells with loss of wild-type p53 function

1 reference

12 December 2020

Cytoplasmic expression of a reporter gene by co-delivery of T7 RNA polymerase and T7 promoter sequence with cationic liposomes

1 reference

12 December 2020

Gene therapy progress and prospects: episomally maintained self-replicating systems.

1 reference

12 December 2020

Prostate-specific antigen (PSA) promoter-driven androgen-inducible expression of sodium iodide symporter in prostate cancer cell lines.

1 reference

12 December 2020

Tetracycline-controlled transcription in eukaryotes: novel transactivators with graded transactivation potential

1 reference

12 December 2020

Gene therapy progress and prospects: nonviral vectors.

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12 December 2020

Sequence requirements for plasmid nuclear import

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12 December 2020

Novel approaches to reversing anti-cancer drug resistance using gene-specific therapeutics

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12 December 2020

CpG-depleted plasmid DNA vectors with enhanced safety and long-term gene expression in vivo

1 reference

12 December 2020

Optimization of cis-acting elements for gene expression from nonviral vectors in vivo

1 reference

12 December 2020

Cell-specific nuclear import of plasmid DNA.

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12 December 2020

In vitro and in vivo targeting of gene expression to melanoma cells

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12 December 2020

Differential expression of tissue-specific promoters by gene gun.

1 reference

12 December 2020

Exchange of viral promoter/enhancer elements with heterologous regulatory sequences generates targeted hybrid long terminal repeat vectors for gene therapy of melanoma.

1 reference

12 December 2020

Sleeping beauty transposition: biology and applications for molecular therapy

1 reference

12 December 2020

Post-transcriptional regulation of vascular endothelial growth factor by hypoxia

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12 December 2020

DNA methylation: past, present and future directions

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12 December 2020

Tetracycline-controlled transcriptional regulation systems: advances and application in transgenic animal modeling

1 reference

12 December 2020

Expression of the fms-like tyrosine kinase 4 gene becomes restricted to lymphatic endothelium during development.

1 reference

12 December 2020

Gene insertion and long-term expression in lung mediated by the Sleeping Beauty transposon system

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12 December 2020

Nonviral gene delivery: techniques and implications for molecular medicine.

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12 December 2020

Cell type specific and inducible promoters for vectors in gene therapy as an approach for cell targeting

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12 December 2020

Contribution of Plasmid DNA to Inflammation in the Lung after Administration of Cationic Lipid:pDNA Complexes

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12 December 2020

Noninfectious gene transfer and expression systems for cancer gene therapy.

1 reference

12 December 2020

Towards safe, non-viral therapeutic gene expression in humans.

1 reference

12 December 2020

Genetic prodrug activation therapy

1 reference

12 December 2020

Use of L-plastin promoter to develop an adenoviral system that confers transgene expression in ovarian cancer cells but not in normal mesothelial cells

1 reference

12 December 2020

In vivo correction of murine tyrosinemia type I by DNA-mediated transposition.

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12 December 2020

Linear DNAs concatemerize in vivo and result in sustained transgene expression in mouse liver

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12 December 2020

Import of plasmid DNA into the nucleus is sequence specific

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12 December 2020

Radio-responsive recA promoter significantly increases TNFalpha production in recombinant clostridia after 2 Gy irradiation

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12 December 2020

CpG island protects Rous sarcoma virus-derived vectors integrated into nonpermissive cells from DNA methylation and transcriptional suppression

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12 December 2020

A novel nonviral cytoplasmic gene expression system and its implications in cancer gene therapy.

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12 December 2020

Cationic polymer based gene delivery systems

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12 December 2020

Nonviral gene therapy and its delivery systems

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12 December 2020

The sequence of spacers between the consensus sequences modulates the strength of prokaryotic promoters

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12 December 2020

Controlling mammalian gene expression with small molecules

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12 December 2020

Progress and problems with the use of viral vectors for gene therapy

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12 December 2020

The expression of vascular endothelial platelet endothelial cell adhesion molecule-1 is not regulated by IFN-gamma treatment of C6 tumors in vivo.

1 reference

12 December 2020

Episomal vectors for gene expression in mammalian cells

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12 December 2020

Modification of vascular tone using iNOS under the control of a radiation-inducible promoter

1 reference

12 December 2020

A regulated, NFkappaB-assisted import of plasmid DNA into mammalian cell nuclei

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12 December 2020

Optimizing radiation-responsive gene promoters for radiogenetic cancer therapy.

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12 December 2020

10.1007/S11095-006-0164-2

Identifiers

DOI

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14 August 2017

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