(Q36068277)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15761468%20AND%20SRC:MED&resulttype=core&format=json

9 January 2020

review article

1 reference

title

Towards safe, non-viral therapeutic gene expression in humans (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15761468%20AND%20SRC:MED&resulttype=core&format=json

9 January 2020

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15761468%20AND%20SRC:MED&resulttype=core&format=json

9 January 2020

2

Hans J Lipps

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15761468%20AND%20SRC:MED&resulttype=core&format=json

9 January 2020

author name string

Dominic J Glover

series ordinal

1

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15761468%20AND%20SRC:MED&resulttype=core&format=json

9 January 2020

publication date

1 April 2005

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15761468%20AND%20SRC:MED&resulttype=core&format=json

9 January 2020

published in

Nature Reviews Genetics

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15761468%20AND%20SRC:MED&resulttype=core&format=json

9 January 2020

volume

6

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15761468%20AND%20SRC:MED&resulttype=core&format=json

9 January 2020

page(s)

299-310

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15761468%20AND%20SRC:MED&resulttype=core&format=json

9 January 2020

issue

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15761468%20AND%20SRC:MED&resulttype=core&format=json

https://scigraph.springernature.com/pub.10.1038/nrg1577

9 January 2020

exact match

0 references

cites work

Sustained correction of X-linked severe combined immunodeficiency by ex vivo gene therapy

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Third-generation, self-inactivating gp91(phox) lentivector corrects the oxidase defect in NOD/SCID mouse-repopulating peripheral blood-mobilized CD34+ cells from patients with X-linked chronic granulomatous disease

31 March 2020

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Researchers and regulators reflect on first gene therapy death

31 March 2020

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HIV-1 integration in the human genome favors active genes and local hotspots

31 March 2020

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Lentiviral vector transduction of NOD/SCID repopulating cells results in multiple vector integrations per transduced cell: risk of insertional mutagenesis

31 March 2020

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Murine leukemia induced by retroviral gene marking

31 March 2020

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Transcription start regions in the human genome are favored targets for MLV integration

31 March 2020

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A serious adverse event after successful gene therapy for X-linked severe combined immunodeficiency

31 March 2020

1 reference

LMO2-associated clonal T cell proliferation in two patients after gene therapy for SCID-X1

31 March 2020

1 reference

The LMO2 T-cell oncogene is activated via chromosomal translocations or retroviral insertion during gene therapy but has no mandatory role in normal T-cell development

31 March 2020

1 reference

Gene therapy insertional mutagenesis insights

31 March 2020

1 reference

Progress and problems with the use of viral vectors for gene therapy

31 March 2020

1 reference

Gene therapy: optimising DNA delivery to the nucleus

31 March 2020

1 reference

Gene therapy. Safer and virus-free?

31 March 2020

1 reference

Polyethylenimine/DNA complexes shielded by transferrin target gene expression to tumors after systemic application

31 March 2020

1 reference

Nuclear targeting signal recognition: a key control point in nuclear transport?

31 March 2020

1 reference

Influence of cargo size on Ran and energy requirements for nuclear protein import

31 March 2020

1 reference

Novel shielded transferrin-polyethylene glycol-polyethylenimine/DNA complexes for systemic tumor-targeted gene transfer

31 March 2020

1 reference

Enhancement of MSH receptor- and GAL4-mediated gene transfer by switching the nuclear import pathway

31 March 2020

1 reference

Transferrin-modified liposomes equipped with a pH-sensitive fusogenic peptide: an artificial viral-like delivery system

31 March 2020

1 reference

Gene delivery: a single nuclear localization signal peptide is sufficient to carry DNA to the cell nucleus

31 March 2020

1 reference

A modular DNA carrier protein based on the structure of diphtheria toxin mediates target cell-specific gene delivery

31 March 2020

1 reference

A multi-domain protein system based on the HC fragment of tetanus toxin for targeting DNA to neuronal cells

31 March 2020

1 reference

In vivo and in vitro correction of the mdx dystrophin gene nonsense mutation by short-fragment homologous replacement

31 March 2020

1 reference

Application of SFHR to gene therapy of monogenic disorders

31 March 2020

1 reference

A general model for site-specific recombination by the integrase family recombinases

31 March 2020

1 reference

Site-specific recombination in mammalian cells expressing the Int recombinase of bacteriophage HK022.

31 March 2020

1 reference

Mammalian genomes contain active recombinase recognition sites

31 March 2020

1 reference

Stable nonviral genetic correction of inherited human skin disease.

31 March 2020

1 reference

Site-specific genomic integration produces therapeutic Factor IX levels in mice

31 March 2020

1 reference

Flp recombinase promotes site-specific DNA recombination in embryonic stem cells and transgenic mice

31 March 2020

1 reference

Improved properties of FLP recombinase evolved by cycling mutagenesis.

31 March 2020

1 reference

Site-specific recombination in eukaryotic cells mediated by mutant lambda integrases: implications for synaptic complex formation and the reactivity of episomal DNA segments

31 March 2020

1 reference

Protein and DNA requirements of the bacteriophage HP1 recombination system: a model for intasome formation

31 March 2020

1 reference

Phage R4 integrase mediates site-specific integration in human cells

31 March 2020

1 reference

Phage integrases for the construction and manipulation of transgenic mammals

31 March 2020

1 reference

A phage integrase directs efficient site-specific integration in human cells

31 March 2020

1 reference

Site-specific genomic integration in mammalian cells mediated by phage phiC31 integrase

31 March 2020

1 reference

PhiC31 integrase-mediated nonviral genetic correction of junctional epidermolysis bullosa

31 March 2020

1 reference

Injection of genetically engineered fibroblasts corrects regenerated human epidermolysis bullosa skin tissue

31 March 2020

1 reference

Nucleofection of muscle-derived stem cells and myoblasts with phiC31 integrase: stable expression of a full-length-dystrophin fusion gene by human myoblasts

31 March 2020

1 reference

Brief expression of a GFP cre fusion gene in embryonic stem cells allows rapid retrieval of site-specific genomic deletions

31 March 2020

1 reference

Ability of the hydrophobic FGF and basic TAT peptides to promote cellular uptake of recombinant Cre recombinase: a tool for efficient genetic engineering of mammalian genomes

31 March 2020

1 reference

Nuclear targeting determinants of the phage P1 cre DNA recombinase

31 March 2020

1 reference

Enhanced efficiency through nuclear localization signal fusion on phage PhiC31-integrase: activity comparison with Cre and FLPe recombinase in mammalian cells

31 March 2020

1 reference

Rapid evolution of a protein in vitro by DNA shuffling

31 March 2020

1 reference

Directed evolution of a recombinase for improved genomic integration at a native human sequence

31 March 2020

1 reference

Directed evolution of the site specificity of Cre recombinase

31 March 2020

1 reference

Alteration of Cre recombinase site specificity by substrate-linked protein evolution.

31 March 2020

1 reference

Kinetics and frequency of adeno-associated virus site-specific integration into human chromosome 19 monitored by quantitative real-time PCR.

31 March 2020

1 reference

Adeno-associated virus site-specifically integrates into a muscle-specific DNA region

31 March 2020

1 reference

Roles of adeno-associated virus Rep protein and human chromosome 19 in site-specific recombination

31 March 2020

1 reference

AAV-mediated factor IX gene transfer to skeletal muscle in patients with severe hemophilia B.

31 March 2020

1 reference

Epitope mapping of human anti-adeno-associated virus type 2 neutralizing antibodies: implications for gene therapy and virus structure

31 March 2020

1 reference

Quantitative analysis of the packaging capacity of recombinant adeno-associated virus

31 March 2020

1 reference

Adeno-associated virus vectors integrate at chromosome breakage sites

31 March 2020

1 reference

AAV serotype 2 vectors preferentially integrate into active genes in mice

31 March 2020

1 reference

Observed incidence of tumorigenesis in long-term rodent studies of rAAV vectors.

31 March 2020

1 reference

Targeted integration of adeno-associated virus-derived plasmids in transfected human cells.

31 March 2020

1 reference

Requirements for adeno-associated virus-derived non-viral vectors to achieve stable and site-specific integration of plasmid DNA in liver carcinoma cells

31 March 2020

1 reference

Efficient integration of recombinant adeno-associated virus DNA vectors requires a p5-rep sequence in cis.

31 March 2020

1 reference

Transgene expression after rep-mediated site-specific integration into chromosome 19.

31 March 2020

1 reference

Targeted integration of foreign DNA into a defined locus on chromosome 19 in K562 cells using AAV-derived components

31 March 2020

1 reference

Positive and negative effects of adeno-associated virus Rep on AAVS1-targeted integration

31 March 2020

1 reference

Site-specific integration of adeno-associated virus-based plasmid vectors in lipofected HeLa cells

31 March 2020

1 reference

A p5 integration efficiency element mediates Rep-dependent integration into AAVS1 at chromosome 19.

31 March 2020

1 reference

Site-specific integration of an adeno-associated virus vector plasmid mediated by regulated expression of rep based on Cre-loxP recombination

31 March 2020

1 reference

Conditional site-specific integration into human chromosome 19 by using a ligand-dependent chimeric adeno-associated virus/Rep protein

31 March 2020

1 reference

Tethering human immunodeficiency virus 1 integrase to a DNA site directs integration to nearby sequences

31 March 2020

1 reference

Correct integration mediated by integrase-LexA fusion proteins incorporated into HIV-1.

31 March 2020

1 reference

Fusion proteins consisting of human immunodeficiency virus type 1 integrase and the designed polydactyl zinc finger protein E2C direct integration of viral DNA into specific sites

31 March 2020

1 reference

Cul7/p185/p193 binding to simian virus 40 large T antigen has a role in cellular transformation

31 March 2020

1 reference

Structure of the replicative helicase of the oncoprotein SV40 large tumour antigen

31 March 2020

1 reference

The EBV nuclear antigen 1 (EBNA1) enhances B cell immortalization several thousandfold

31 March 2020

1 reference

The DNA segregation mechanism of Epstein-Barr virus nuclear antigen 1

31 March 2020

1 reference

Sequences adjacent to oriP improve the persistence of Epstein-Barr virus-based episomes in B cells

31 March 2020

1 reference

Safety-modified episomal vectors for human gene therapy.

31 March 2020

1 reference

Epstein-Barr virus vectors provide prolonged robust factor IX expression in mice

31 March 2020

1 reference

Stable correction of a genetic deficiency in human cells by an episome carrying a 115 kb genomic transgene

31 March 2020

1 reference

A vector based on the SV40 origin of replication and chromosomal S/MARs replicates episomally in CHO cells

31 March 2020

1 reference

An episomal mammalian replicon: sequence-independent binding of the origin recognition complex

31 March 2020

1 reference

An episomally replicating vector binds to the nuclear matrix protein SAF-A in vivo

31 March 2020

1 reference

Localization and dynamics of small circular DNA in live mammalian nuclei

31 March 2020

1 reference

Chromatin loops are selectively anchored using scaffold/matrix-attachment regions

31 March 2020

1 reference

Computational and in vitro analysis of destabilized DNA regions in the interferon gene cluster: potential of predicting functional gene domains

31 March 2020

1 reference

Extension of chromatin accessibility by nuclear matrix attachment regions.

31 March 2020

1 reference

Mitotic stability of an episomal vector containing a human scaffold/matrix-attached region is provided by association with nuclear matrix

31 March 2020

1 reference

SAF-Box, a conserved protein domain that specifically recognizes scaffold attachment region DNA.

31 March 2020

1 reference

Exploiting a minimal system to study the epigenetic control of DNA replication: the interplay between transcription and replication.

31 March 2020

1 reference

Nuclear scaffold/matrix attached region modules linked to a transcription unit are sufficient for replication and maintenance of a mammalian episome

31 March 2020

1 reference

Induction of DNA replication by transcription in the region upstream of the human c-myc gene in a model replication system

31 March 2020

1 reference

The origin recognition complex marks a replication origin in the human TOP1 gene promoter

31 March 2020

1 reference

Construction of artificial chromosomes in yeast

31 March 2020

1 reference

Human artificial chromosomes containing chromosome 17 alphoid DNA maintain an active centromere in murine cells but are not stable

31 March 2020

1 reference

Formation of de novo centromeres and construction of first-generation human artificial microchromosomes

31 March 2020

1 reference

Human artificial chromosomes generated by modification of a yeast artificial chromosome containing both human alpha satellite and single-copy DNA sequences.

31 March 2020

1 reference

Mammalian artificial chromosome formation from circular alphoid input DNA does not require telomere repeats

31 March 2020

1 reference

Generation of a human X-derived minichromosome using telomere-associated chromosome fragmentation.

31 March 2020

1 reference

Mini-chromosomes derived from the human Y chromosome by telomere directed chromosome breakage

31 March 2020

1 reference

A functional neo-centromere formed through activation of a latent human centromere and consisting of non-alpha-satellite DNA

31 March 2020

1 reference

Construction of neocentromere-based human minichromosomes by telomere-associated chromosomal truncation.

31 March 2020

1 reference

Construction of neocentromere-based human minichromosomes for gene delivery and centromere studies

31 March 2020

1 reference

Analysis of mitotic and expression properties of human neocentromere-based transchromosomes in mice

31 March 2020

1 reference

Stable gene expression from a mammalian artificial chromosome

31 March 2020

1 reference

Functional complementation of a genetic deficiency with human artificial chromosomes.

31 March 2020

1 reference

Functional human CFTR produced by a stable minichromosome

31 March 2020

1 reference

A structurally defined mini-chromosome vector for the mouse germ line.

31 March 2020

1 reference

Stability of a functional murine satellite DNA-based artificial chromosome across mammalian species

31 March 2020

1 reference

Introduction and expression of the 400 kilobase amyloid precursor protein gene in transgenic mice [corrected]

31 March 2020

1 reference

A method for high efficiency YAC lipofection into murine embryonic stem cells

31 March 2020

1 reference

In vitro and in vivo delivery of intact BAC DNA -- comparison of different methods

31 March 2020

1 reference

Transfer of YACs up to 2.3 Mb intact into human cells with polyethylenimine

31 March 2020

1 reference

Functional delivery of large genomic DNA to human cells with a peptide-lipid vector

31 March 2020

1 reference

Efficient transfer of chromosome-based DNA constructs into mammalian cells

31 March 2020

1 reference

Using nuclear targeting signals to enhance non-viral gene transfer

31 March 2020

1 reference

The fundamental role of epigenetic events in cancer

31 March 2020

1 reference

Inhibitors of DNA methylation and histone deacetylation activate cytomegalovirus promoter-controlled reporter gene expression in human glioblastoma cell line U87.

31 March 2020

1 reference

Methylation of episomal plasmids as a barrier to transient gene expression via a synthetic delivery vector

31 March 2020

1 reference

In vivo activity of murine de novo methyltransferases, Dnmt3a and Dnmt3b

31 March 2020

1 reference

Long-term in vivo expression of retrovirus-mediated gene transfer in mouse fibroblast implants

31 March 2020

1 reference

Synthetic muscle promoters: activities exceeding naturally occurring regulatory sequences

31 March 2020

1 reference

Short and highly efficient synthetic promoters for melanoma-specific gene expression.

31 March 2020

1 reference

Promoter suppression in cultured mammalian cells can be blocked by the chicken beta-globin chromatin insulator 5'HS4 and matrix/scaffold attachment regions

31 March 2020

1 reference

Performance- and safety-enhanced lentiviral vectors containing the human interferon-beta scaffold attachment region and the chicken beta-globin insulator

31 March 2020

1 reference

Expression of a transgene encoded on a non-viral episomal vector is not subject to epigenetic silencing by cytosine methylation

31 March 2020

1 reference

Silencing of episomal transgene expression by plasmid bacterial DNA elements in vivo

31 March 2020

1 reference

An araC-controlled bacterial cre expression system to produce DNA minicircle vectors for nuclear and mitochondrial gene therapy.

31 March 2020

1 reference

Minicircle DNA vectors devoid of bacterial DNA result in persistent and high-level transgene expression in vivo

31 March 2020

1 reference

Removal of a cryptic intron and subcellular localization of green fluorescent protein are required to mark transgenic Arabidopsis plants brightly

31 March 2020

1 reference

Successful interference with cellular immune responses to immunogenic proteins encoded by recombinant viral vectors

31 March 2020

1 reference

CD4+CD25+ regulatory T cells inhibit immune-mediated transgene rejection

31 March 2020

1 reference

Induction of antigen-specific CD4+ T-cell anergy and deletion by in vivo viral gene transfer

31 March 2020

1 reference

Imaging transgene expression in live animals

31 March 2020

1 reference

Efficient expression of naked dna delivered intraarterially to limb muscles of nonhuman primates

31 March 2020

1 reference

DNA electrotransfer: its principles and an updated review of its therapeutic applications

31 March 2020

1 reference

Loss of binding and entry of liposome-DNA complexes decreases transfection efficiency in differentiated airway epithelial cells

31 March 2020

1 reference

Toxicity and immunomodulatory activity of liposomal vectors formulated with cationic lipids toward immune effector cells

31 March 2020

1 reference

Evidence for the role of proteoglycans in cation-mediated gene transfer

31 March 2020

1 reference

Chloride accumulation and swelling in endosomes enhances DNA transfer by polyamine-DNA polyplexes

31 March 2020

1 reference

Development of animal models for adeno-associated virus site-specific integration

31 March 2020

1 reference

7 January 2021

Adeno-associated virus Rep proteins target DNA sequences to a unique locus in the human genome

1 reference

7 January 2021

Circular intermediates of recombinant adeno-associated virus have defined structural characteristics responsible for long-term episomal persistence in muscle tissue

1 reference

7 January 2021

Adeno-associated virus Rep78 protein and terminal repeats enhance integration of DNA sequences into the cellular genome

1 reference

7 January 2021

A chimeric Ty3/Moloney murine leukemia virus integrase protein is active in vivo

1 reference

7 January 2021