(Q36499104)

14 August 2017

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title

A brief overview of mechanisms of mitochondrial toxicity from NRTIs (English)

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14 August 2017

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James J Kohler

1

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PubMed ID

16758472

14 August 2017

William Lewis

series ordinal

2

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PubMed ID

16758472

14 August 2017

language of work or name

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1 April 2007

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Environmental and Molecular Mutagenesis

14 August 2017

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14 August 2017

48

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14 August 2017

3-4

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14 August 2017

166-172

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The mitochondrial generation of hydrogen peroxide. General properties and effect of hyperbaric oxygen

14 August 2017

1 reference

Effects of (-)-2'-deoxy-3'-thiacytidine (3TC) 5'-triphosphate on human immunodeficiency virus reverse transcriptase and mammalian DNA polymerases alpha, beta, and gamma

21 January 2018

1 reference

Azidothymidine triphosphate is an inhibitor of both human immunodeficiency virus type 1 reverse transcriptase and DNA polymerase gamma

21 January 2018

1 reference

Mitochondrial dna depletion, oxidative stress, and mutation: mechanisms of dysfunction from nucleoside reverse transcriptase inhibitors

21 January 2018

1 reference

Combined antiretroviral therapy causes cardiomyopathy and elevates plasma lactate in transgenic AIDS mice

21 January 2018

1 reference

Effects of antiviral nucleoside analogs on human DNA polymerases and mitochondrial DNA synthesis

21 January 2018

1 reference

Mitochondrial function in neurodegeneration and ageing

21 January 2018

1 reference

Lactic acidosis in HIV infected patients: a systematic review of published cases

21 January 2018

1 reference

7 January 2021

Depletion of muscle mitochondrial DNA in AIDS patients with zidovudine-induced myopathy

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7 January 2021

HIV-1 infection and AIDS.

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7 January 2021

What is oxidative stress?

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7 January 2021

Expression of cytochrome c oxidase subunits encoded by mitochondrial or nuclear DNA in the muscle of patients with zidovudine myopathy.

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7 January 2021

Mitochondrial DNA and nucleoside toxicity

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7 January 2021

Effect of nucleoside reverse transcriptase inhibitors on mitochondrial DNA synthesis in rats and humans

1 reference

7 January 2021

Changes in mitochondrial DNA as a marker of nucleoside toxicity in HIV-infected patients

1 reference

7 January 2021

Mitochondrial:nuclear DNA ratios in peripheral blood cells from human immunodeficiency virus (HIV)-infected patients who received selected HIV antiretroviral drug regimens

1 reference

7 January 2021

Mitochondrial myopathy caused by long-term zidovudine therapy

1 reference

7 January 2021

AZT treatment induces molecular and ultrastructural oxidative damage to muscle mitochondria. Prevention by antioxidant vitamins

1 reference

7 January 2021

The human mitochondrial deoxynucleotide carrier and its role in the toxicity of nucleoside antivirals

1 reference

7 January 2021

Efficient incorporation of anti-HIV deoxynucleotides by recombinant yeast mitochondrial DNA polymerase

1 reference

7 January 2021

Tat protein of human immunodeficiency virus type 1 represses expression of manganese superoxide dismutase in HeLa cells

1 reference

7 January 2021

Phosphorylation of 3'-azido-3'-deoxythymidine and selective interaction of the 5'-triphosphate with human immunodeficiency virus reverse transcriptase

1 reference

7 January 2021

The mitochondrial DNA polymerase as a target of oxidative damage

1 reference

7 January 2021

The 5'-triphosphates of 3'-azido-3'-deoxythymidine and 2', 3'-dideoxynucleosides inhibit DNA polymerase gamma by different mechanisms

1 reference

7 January 2021

DNA polymerase gamma, the mitochondrial replicase

1 reference

7 January 2021

Pharmacology of nucleoside and nucleotide reverse transcriptase inhibitor-induced mitochondrial toxicity.

1 reference

7 January 2021

Mitochondrial dysfunction and nucleoside reverse transcriptase inhibitor therapy: experimental clarifications and persistent clinical questions

1 reference

7 January 2021

Mitochondrial toxicity of antiviral drugs

1 reference

7 January 2021

Zidovudine induces molecular, biochemical, and ultrastructural changes in rat skeletal muscle mitochondria

1 reference

7 January 2021

Mammalian DNA polymerases alpha, beta, gamma, delta, and epsilon incorporate fialuridine (FIAU) monophosphate into DNA and are inhibited competitively by FIAU Triphosphate

1 reference

7 January 2021

Cardiac mitochondrial DNA polymerase-gamma is inhibited competitively and noncompetitively by phosphorylated zidovudine

1 reference

7 January 2021

Cardiac dysfunction occurs in the HIV-1 transgenic mouse treated with zidovudine

1 reference

7 January 2021

Mitochondrial toxicity of nrti antiviral drugs: an integrated cellular perspective

1 reference

7 January 2021

Transgenic expression of the deoxynucleotide carrier causes mitochondrial damage that is enhanced by NRTIs for AIDS.

1 reference

7 January 2021

Differential incorporation and removal of antiviral deoxynucleotides by human DNA polymerase gamma

1 reference

7 January 2021

The development of mitochondrial medicine

1 reference

7 January 2021

HIV infection and advanced age emerging epidemiological, clinical, and management issues

1 reference

7 January 2021

Mitochondrial biogenesis defects and neuromuscular disorders

1 reference

7 January 2021

Accumulation of mitochondrial DNA mutations in human immunodeficiency virus-infected patients treated with nucleoside-analogue reverse-transcriptase inhibitors

1 reference

7 January 2021

Mitochondrial dysfunction: patient monitoring and toxicity management

1 reference

7 January 2021

Hepatic failure and lactic acidosis due to fialuridine (FIAU), an investigational nucleoside analogue for chronic hepatitis B.

1 reference

7 January 2021

3'-Azido-3'-deoxythymidine (BW A509U): an antiviral agent that inhibits the infectivity and cytopathic effect of human T-lymphotropic virus type III/lymphadenopathy-associated virus in vitro

1 reference

7 January 2021

Molecular targets for AIDS therapy

1 reference

7 January 2021

Mitochondrial toxicity in the era of HAART: evaluating venous lactate and peripheral blood mitochondrial DNA in HIV-infected patients taking antiretroviral therapy

1 reference

7 January 2021

1 reference

7 January 2021

Mitochondrial and metabolic effects of nucleoside reverse transcriptase inhibitors (NRTIs) in mice receiving one of five single- and three dual-NRTI treatments

1 reference

7 January 2021

Mitochondrial carrier proteins

1 reference

7 January 2021

Active site mutation in DNA polymerase gamma associated with progressive external ophthalmoplegia causes error-prone DNA synthesis

1 reference

7 January 2021

Disorders associated with depletion of mitochondrial DNA

1 reference

7 January 2021

The adenine nucleotide translocase type 1 (ANT1): a new factor in mitochondrial disease

1 reference

7 January 2021

Insulin resistance in the HIV-infected population: the potential role of mitochondrial dysfunction.

1 reference

7 January 2021

Studies on the inhibition of mitochondrial DNA replication by 3'-azido-3'-deoxythymidine and other dideoxynucleoside analogs which inhibit HIV-1 replication

1 reference

7 January 2021

Disorders of nuclear-mitochondrial intergenomic signaling

1 reference

7 January 2021

Diseases caused by nuclear genes affecting mtDNA stability

1 reference

7 January 2021

Mitochondrial toxicity--new adverse drug effects

1 reference

7 January 2021

Role of reactive oxygen species and poly-ADP-ribose polymerase in the development of AZT-induced cardiomyopathy in rat.

1 reference

7 January 2021

In-vitro genetic modification of mitochondrial function

1 reference

7 January 2021

The determination of complete human mitochondrial DNA sequences in single cells: implications for the study of somatic mitochondrial DNA point mutations

1 reference

7 January 2021

Serum L-lactate and pyruvate in HIV-infected patients with and without presumed NRTI-related adverse events compared to healthy volunteers

1 reference

7 January 2021

The enzymatic termination of polydeoxynucleotides by 2',3'-dideoxyadenosine triphosphate

1 reference

7 January 2021

Disorders of the mitochondria

1 reference

7 January 2021

Hyperoxia increases H2O2 release by lung mitochondria and microsomes

1 reference

7 January 2021

Evidence of nucleoside analogue reverse transcriptase inhibitor--associated genetic and structural defects of mitochondria in adipose tissue of HIV-infected patients

1 reference

7 January 2021

Mitochondrial DNA mutations in diseases of energy metabolism

1 reference

7 January 2021

Mitochondrial diseases in man and mouse

1 reference

7 January 2021

Mouse models for mitochondrial disease

1 reference

7 January 2021

Deoxyribonucleotide analogs as inhibitors and substrates of DNA polymerases

1 reference

7 January 2021

Azidothymidine causes functional and structural destruction of mitochondria, glutathione deficiency and HIV-1 promoter sensitization

1 reference

7 January 2021

The expanding spectrum of nuclear gene mutations in mitochondrial disorders

1 reference

7 January 2021

Mitochondrial disorders

1 reference

7 January 2021

Construction of transgenic mice with tissue-specific acceleration of mitochondrial DNA mutagenesis

1 reference

7 January 2021

Identifiers

DOI

10.1002/EM.20223

1 reference

14 August 2017

1 reference

PubMed ID

16758472