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BCL-2 in the crosshairs: tipping the balance of life and death
scientific article published on 9 June 2006
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scholarly article
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Europe PubMed Central
PubMed ID
16763614
retrieved
14 August 2017
review article
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Europe PubMed Central
title
BCL-2 in the crosshairs: tipping the balance of life and death
(English)
1 reference
stated in
Europe PubMed Central
PubMed ID
16763614
retrieved
14 August 2017
author
Loren D. Walensky
series ordinal
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object named as
Walensky LD
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Europe PubMed Central
PubMed ID
16763614
retrieved
14 August 2017
language of work or name
English
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publication date
9 June 2006
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Europe PubMed Central
PubMed ID
16763614
retrieved
14 August 2017
published in
Cell Death & Differentiation
1 reference
stated in
Europe PubMed Central
PubMed ID
16763614
retrieved
14 August 2017
volume
13
1 reference
stated in
Europe PubMed Central
PubMed ID
16763614
retrieved
14 August 2017
page(s)
1339-1350
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stated in
Europe PubMed Central
PubMed ID
16763614
retrieved
14 August 2017
issue
8
1 reference
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Europe PubMed Central
PubMed ID
16763614
retrieved
14 August 2017
exact match
https://scigraph.springernature.com/pub.10.1038/sj.cdd.4401992
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Nucleotide sequence of a t(14;18) chromosomal breakpoint in follicular lymphoma and demonstration of a breakpoint-cluster region near a transcriptionally active locus on chromosome 18.
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Cloning the chromosomal breakpoint of t(14;18) human lymphomas: clustering around JH on chromosome 14 and near a transcriptional unit on 18.
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bcl-2-immunoglobulin transgenic mice demonstrate extended B cell survival and follicular lymphoproliferation
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Bcl-2 gene promotes haemopoietic cell survival and cooperates with c-myc to immortalize pre-B cells
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Growth- and tumor-promoting effects of deregulated BCL2 in human B-lymphoblastoid cells
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Bcl-2 is an inner mitochondrial membrane protein that blocks programmed cell death
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Deregulated Bcl-2-immunoglobulin transgene expands a resting but responsive immunoglobulin M and D-expressing B-cell population
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Progression from lymphoid hyperplasia to high-grade malignant lymphoma in mice transgenic for the t(14;18)
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Novel primitive lymphoid tumours induced in transgenic mice by cooperation between myc and bcl-2.
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Antiapoptotic BCL-2 is required for maintenance of a model leukemia
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The Bcl2 family: regulators of the cellular life-or-death switch
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Cell death: critical control points
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Axonal self-destruction and neurodegeneration
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Role of Bcl-2 family of proteins in malignancy
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Structural biology of the Bcl-2 family of proteins
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Granzyme B short-circuits the need for caspase 8 activity during granule-mediated cytotoxic T-lymphocyte killing by directly cleaving Bid.
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Expression of the gene encoding the proapoptotic Nip3 protein is induced by hypoxia
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BAD and glucokinase reside in a mitochondrial complex that integrates glycolysis and apoptosis
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Survival factor-induced extracellular signal-regulated kinase phosphorylates BIM, inhibiting its association with BAX and proapoptotic activity.
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Puma is an essential mediator of p53-dependent and -independent apoptotic pathways
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Proapoptotic BID is an ATM effector in the DNA-damage response
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BH3-only protein Noxa is a mediator of hypoxic cell death induced by hypoxia-inducible factor 1alpha
1 reference
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7 January 2021
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Roles of Bim in apoptosis of normal and Bcr-Abl-expressing hematopoietic progenitors
1 reference
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7 January 2021
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JNK phosphorylation of Bim-related members of the Bcl2 family induces Bax-dependent apoptosis
1 reference
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7 January 2021
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Endoplasmic reticulum stress-induced apoptosis: multiple pathways and activation of p53-up-regulated modulator of apoptosis (PUMA) and NOXA by p53
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BH3-only BIK regulates BAX,BAK-dependent release of Ca2+ from endoplasmic reticulum stores and mitochondrial apoptosis during stress-induced cell death.
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Bmf: a proapoptotic BH3-only protein regulated by interaction with the myosin V actin motor complex, activated by anoikis
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7 January 2021
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Proteasome inhibitors trigger NOXA-mediated apoptosis in melanoma and myeloma cells
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Bad-deficient mice develop diffuse large B cell lymphoma
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7 January 2021
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Integrins and EGFR coordinately regulate the pro-apoptotic protein Bim to prevent anoikis
1 reference
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7 January 2021
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The histone deacetylase inhibitor and chemotherapeutic agent suberoylanilide hydroxamic acid (SAHA) induces a cell-death pathway characterized by cleavage of Bid and production of reactive oxygen species
1 reference
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7 January 2021
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Translocation of full-length Bid to mitochondria during anoikis
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7 January 2021
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inferred from DOI database lookup
p53- and drug-induced apoptotic responses mediated by BH3-only proteins puma and noxa
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7 January 2021
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inferred from DOI database lookup
PUMA mediates the apoptotic response to p53 in colorectal cancer cells
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https://api.crossref.org/works/10.1038%2FSJ.CDD.4401992
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7 January 2021
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Bmf is a possible mediator in histone deacetylase inhibitors FK228 and CBHA-induced apoptosis
1 reference
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reference URL
https://api.crossref.org/works/10.1038%2FSJ.CDD.4401992
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7 January 2021
based on heuristic
inferred from DOI database lookup
A role for proapoptotic BID in the DNA-damage response
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.CDD.4401992
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Life in the balance: how BH3-only proteins induce apoptosis.
1 reference
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reference URL
https://api.crossref.org/works/10.1038%2FSJ.CDD.4401992
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7 January 2021
based on heuristic
inferred from DOI database lookup
BH3-Only proteins-essential initiators of apoptotic cell death
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.CDD.4401992
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7 January 2021
based on heuristic
inferred from DOI database lookup
Cleavage of BID by caspase 8 mediates the mitochondrial damage in the Fas pathway of apoptosis
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.CDD.4401992
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Bid, a Bcl2 interacting protein, mediates cytochrome c release from mitochondria in response to activation of cell surface death receptors
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.CDD.4401992
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7 January 2021
based on heuristic
inferred from DOI database lookup
Posttranslational N-myristoylation of BID as a molecular switch for targeting mitochondria and apoptosis
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.CDD.4401992
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
PUMA, a novel proapoptotic gene, is induced by p53
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.CDD.4401992
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Direct activation of Bax by p53 mediates mitochondrial membrane permeabilization and apoptosis
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.CDD.4401992
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
PUMA couples the nuclear and cytoplasmic proapoptotic function of p53
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.CDD.4401992
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7 January 2021
based on heuristic
inferred from DOI database lookup
Differential targeting of prosurvival Bcl-2 proteins by their BH3-only ligands allows complementary apoptotic function
1 reference
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https://api.crossref.org/works/10.1038%2FSJ.CDD.4401992
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7 January 2021
based on heuristic
inferred from DOI database lookup
A common binding site mediates heterodimerization and homodimerization of Bcl-2 family members
1 reference
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https://api.crossref.org/works/10.1038%2FSJ.CDD.4401992
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7 January 2021
based on heuristic
inferred from DOI database lookup
Enforced dimerization of BAX results in its translocation, mitochondrial dysfunction and apoptosis
1 reference
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https://api.crossref.org/works/10.1038%2FSJ.CDD.4401992
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Structure of Bax: coregulation of dimer formation and intracellular localization
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.CDD.4401992
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7 January 2021
based on heuristic
inferred from DOI database lookup
Structure of Bcl-xL-Bak peptide complex: recognition between regulators of apoptosis
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.CDD.4401992
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Multiple Bcl-2 family members demonstrate selective dimerizations with Bax
1 reference
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reference URL
https://api.crossref.org/works/10.1038%2FSJ.CDD.4401992
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7 January 2021
based on heuristic
inferred from DOI database lookup
Bcl-2 heterodimerizes in vivo with a conserved homolog, Bax, that accelerates programmed cell death
1 reference
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reference URL
https://api.crossref.org/works/10.1038%2FSJ.CDD.4401992
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7 January 2021
based on heuristic
inferred from DOI database lookup
Mutagenesis of the BH3 domain of BAX identifies residues critical for dimerization and killing
1 reference
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reference URL
https://api.crossref.org/works/10.1038%2FSJ.CDD.4401992
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7 January 2021
based on heuristic
inferred from DOI database lookup
Distinct BH3 domains either sensitize or activate mitochondrial apoptosis, serving as prototype cancer therapeutics
1 reference
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https://api.crossref.org/works/10.1038%2FSJ.CDD.4401992
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7 January 2021
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BH3 domains of BH3-only proteins differentially regulate Bax-mediated mitochondrial membrane permeabilization both directly and indirectly
1 reference
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reference URL
https://api.crossref.org/works/10.1038%2FSJ.CDD.4401992
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7 January 2021
based on heuristic
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The first alpha helix of Bax plays a necessary role in its ligand-induced activation by the BH3-only proteins Bid and PUMA.
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.CDD.4401992
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7 January 2021
based on heuristic
inferred from DOI database lookup
Bid, Bax, and lipids cooperate to form supramolecular openings in the outer mitochondrial membrane
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.CDD.4401992
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Lipidic pore formation by the concerted action of proapoptotic BAX and tBID.
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.CDD.4401992
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Identification of novel isoforms of the BH3 domain protein Bim which directly activate Bax to trigger apoptosis
1 reference
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reference URL
https://api.crossref.org/works/10.1038%2FSJ.CDD.4401992
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Humanin peptide suppresses apoptosis by interfering with Bax activation
1 reference
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reference URL
https://api.crossref.org/works/10.1038%2FSJ.CDD.4401992
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
VDAC2 inhibits BAK activation and mitochondrial apoptosis
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.CDD.4401992
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
ASC is a Bax adaptor and regulates the p53-Bax mitochondrial apoptosis pathway
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.CDD.4401992
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Ku70 suppresses the apoptotic translocation of Bax to mitochondria.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.CDD.4401992
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Bax inhibitor-1, a mammalian apoptosis suppressor identified by functional screening in yeast
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.CDD.4401992
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Mitochondrial p53 activates Bak and causes disruption of a Bak-Mcl1 complex.
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.CDD.4401992
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Clusterin inhibits apoptosis by interacting with activated Bax
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.CDD.4401992
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7 January 2021
based on heuristic
inferred from DOI database lookup
The proapoptotic activity of the Bcl-2 family member Bim is regulated by interaction with the dynein motor complex
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.CDD.4401992
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Serine phosphorylation of death agonist BAD in response to survival factor results in binding to 14-3-3 not BCL-X(L)
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.CDD.4401992
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
X-ray and NMR structure of human Bcl-xL, an inhibitor of programmed cell death
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.CDD.4401992
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
BAX-dependent transport of cytochrome c reconstituted in pure liposomes
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.CDD.4401992
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Bax interacts with the permeability transition pore to induce permeability transition and cytochrome c release in isolated mitochondria
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.CDD.4401992
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The putative pore-forming domain of Bax regulates mitochondrial localization and interaction with Bcl-X(L).
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.CDD.4401992
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Channel formation by antiapoptotic protein Bcl-2.
1 reference
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reference URL
https://api.crossref.org/works/10.1038%2FSJ.CDD.4401992
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7 January 2021
based on heuristic
inferred from DOI database lookup
Bax-induced cytochrome c release from mitochondria depends on alpha-helices-5 and -6
1 reference
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reference URL
https://api.crossref.org/works/10.1038%2FSJ.CDD.4401992
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7 January 2021
based on heuristic
inferred from DOI database lookup
Peptides corresponding to helices 5 and 6 of Bax can independently form large lipid pores
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.CDD.4401992
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Solution structure of the antiapoptotic protein bcl-2
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.CDD.4401992
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Rationale for Bcl-xL/Bad peptide complex formation from structure, mutagenesis, and biophysical studies
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.CDD.4401992
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Structural model of the BCL-w-BID peptide complex and its interactions with phospholipid micelles
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.CDD.4401992
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Solution structure of human BCL-w: modulation of ligand binding by the C-terminal helix
1 reference
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reference URL
https://api.crossref.org/works/10.1038%2FSJ.CDD.4401992
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7 January 2021
based on heuristic
inferred from DOI database lookup
The structure of Bcl-w reveals a role for the C-terminal residues in modulating biological activity
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.CDD.4401992
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Solution structure of prosurvival Mcl-1 and characterization of its binding by proapoptotic BH3-only ligands.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.CDD.4401992
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Solution structure of the proapoptotic molecule BID: a structural basis for apoptotic agonists and antagonists
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.CDD.4401992
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Solution structure of BID, an intracellular amplifier of apoptotic signaling
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.CDD.4401992
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7 January 2021
based on heuristic
inferred from DOI database lookup
Bcl-2 phosphorylation required for anti-apoptosis function
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.CDD.4401992
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7 January 2021
based on heuristic
inferred from DOI database lookup
Deletion of the loop region of Bcl-2 completely blocks paclitaxel-induced apoptosis
1 reference
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reference URL
https://api.crossref.org/works/10.1038%2FSJ.CDD.4401992
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7 January 2021
based on heuristic
inferred from DOI database lookup
The N-terminal end of Bax contains a mitochondrial-targeting signal.
1 reference
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reference URL
https://api.crossref.org/works/10.1038%2FSJ.CDD.4401992
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7 January 2021
based on heuristic
inferred from DOI database lookup
Involvement of the N-terminus of Bax in its intracellular localization and function.
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reference URL
https://api.crossref.org/works/10.1038%2FSJ.CDD.4401992
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7 January 2021
based on heuristic
inferred from DOI database lookup
Regulated targeting of BAX to mitochondria.
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Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.CDD.4401992
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7 January 2021
based on heuristic
inferred from DOI database lookup
The Bax N terminus is required for negative regulation by the mitogen-activated protein kinase kinase and Akt signaling pathways in T cells
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Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.CDD.4401992
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7 January 2021
based on heuristic
inferred from DOI database lookup
N-terminal cleavage of bax by calpain generates a potent proapoptotic 18-kDa fragment that promotes bcl-2-independent cytochrome C release and apoptotic cell death.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.CDD.4401992
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Bax cleavage is mediated by calpain during drug-induced apoptosis
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.CDD.4401992
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Cleavage of Bax enhances its cell death function
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.CDD.4401992
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The p18 truncated form of Bax behaves like a Bcl-2 homology domain 3-only protein
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.CDD.4401992
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Conformation of membrane-associated proapoptotic tBid
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.CDD.4401992
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Conformational changes in BID, a pro-apoptotic BCL-2 family member, upon membrane binding. A site-directed spin labeling study
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.CDD.4401992
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Proapoptotic BH3-only proteins trigger membrane integration of prosurvival Bcl-w and neutralize its activity
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.CDD.4401992
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
NMR studies of the anti-apoptotic protein Bcl-xL in micelles
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.CDD.4401992
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Interaction with a membrane surface triggers a reversible conformational change in Bax normally associated with induction of apoptosis
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.CDD.4401992
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Structure-based discovery of an organic compound that binds Bcl-2 protein and induces apoptosis of tumor cells
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.CDD.4401992
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Discovery of small-molecule inhibitors of Bcl-2 through structure-based computer screening
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.CDD.4401992
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Breast cancer cells can evade apoptosis-mediated selective killing by a novel small molecule inhibitor of Bcl-2
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.CDD.4401992
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Biophysical characterization of recombinant human Bcl-2 and its interactions with an inhibitory ligand, antimycin A.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.CDD.4401992
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Antimycin A mimics a cell-death-inducing Bcl-2 homology domain 3.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.CDD.4401992
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Identification of small-molecule inhibitors of interaction between the BH3 domain and Bcl-xL
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.CDD.4401992
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Identification of chelerythrine as an inhibitor of BclXL function
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.CDD.4401992
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Discovery, characterization, and structure-activity relationships studies of proapoptotic polyphenols targeting B-cell lymphocyte/leukemia-2 proteins
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.CDD.4401992
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Rational design and real time, in-cell detection of the proapoptotic activity of a novel compound targeting Bcl-X(L).
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.CDD.4401992
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Apoptosis-based therapies for hematologic malignancies
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.CDD.4401992
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Modulating the bcl-2 family of apoptosis suppressors for potential therapeutic benefit in cancer
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.CDD.4401992
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Discovering high-affinity ligands for proteins: SAR by NMR
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.CDD.4401992
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
An inhibitor of Bcl-2 family proteins induces regression of solid tumours
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.CDD.4401992
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Discovery of a potent inhibitor of the antiapoptotic protein Bcl-xL from NMR and parallel synthesis.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.CDD.4401992
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Discovery and structure-activity relationship of antagonists of B-cell lymphoma 2 family proteins with chemopotentiation activity in vitro and in vivo
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.CDD.4401992
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The BH3 domain of BAD fused to the Antennapedia peptide induces apoptosis via its alpha helical structure and independent of Bcl-2
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.CDD.4401992
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Permeabilization of the mitochondrial inner membrane during apoptosis: impact of the adenine nucleotide translocator
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.CDD.4401992
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Paralog-selective ligands for bcl-2 proteins
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.CDD.4401992
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Design and Evolution of a Miniature Bcl-2 Binding Protein We thank the HHMI Biopolymer/Keck Foundation Biotechnology Resource Laboratory (Yale University School of Medicine, New Haven, CT) for oligonucleotide and peptide synthesis and amino acid ana
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.CDD.4401992
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Development of a potent Bcl-x(L) antagonist based on alpha-helix mimicry
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.CDD.4401992
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Terphenyl-based helical mimetics that disrupt the p53/HDM2 interaction
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.CDD.4401992
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Synthesis of a 2,3';6',3''-terpyridine scaffold as an alpha-helix mimetic
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.CDD.4401992
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Terephthalamide derivatives as mimetics of helical peptides: disruption of the Bcl-x(L)/Bak interaction
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.CDD.4401992
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Chimeric (alpha/beta + alpha)-peptide ligands for the BH3-recognition cleft of Bcl-XL: critical role of the molecular scaffold in protein surface recognition
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.CDD.4401992
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Highly Efficient Synthesis of Covalently Cross-Linked Peptide Helices by Ring-Closing Metathesis
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.CDD.4401992
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Synthesis and helical structure of lactam bridged BH3 peptides derived from pro-apoptotic Bcl-2 family proteins.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.CDD.4401992
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Activation of apoptosis in vivo by a hydrocarbon-stapled BH3 helix
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.CDD.4401992
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Targeting apoptosis via chemical design: inhibition of bid-induced cell death by small organic molecules.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.CDD.4401992
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
3,6-Dibromocarbazole Piperazine Derivatives of 2-Propanol as First Inhibitors of Cytochrome c Release via Bax Channel Modulation
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.CDD.4401992
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Bax channel inhibitors prevent mitochondrion-mediated apoptosis and protect neurons in a model of global brain ischemia.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.CDD.4401992
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Cytoprotective membrane-permeable peptides designed from the Bax-binding domain of Ku70.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.CDD.4401992
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Promoting apoptosis as a strategy for cancer drug discovery
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.CDD.4401992
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Phase II study of G3139, a Bcl-2 antisense oligonucleotide, in combination with dexamethasone and thalidomide in relapsed multiple myeloma patients
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.CDD.4401992
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Investigations of antisense oligonucleotides targeted against bcl-2 RNAs.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.CDD.4401992
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
BCL2-mediated tumorigenicity of a human T-lymphoid cell line: synergy with MYC and inhibition by BCL2 antisense
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.CDD.4401992
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Identifiers
DOI
10.1038/SJ.CDD.4401992
1 reference
stated in
Europe PubMed Central
PubMed ID
16763614
retrieved
14 August 2017
PubMed ID
16763614
1 reference
stated in
Europe PubMed Central
PubMed ID
16763614
retrieved
14 August 2017
ResearchGate publication ID
7018949
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