(Q36504175)

14 August 2017

Small changes in enzyme function can lead to surprisingly large fitness effects during adaptive evolution of antibiotic resistance (English)

1 reference

14 August 2017

0 references

antibiotic resistance

1 reference

1 reference

1

Katarzyna Walkiewicz

1 reference

14 August 2017

Andres S Benitez Cardenas

2

1 reference

14 August 2017

Christine Sun

3

1 reference

14 August 2017

Colin Bacorn

4

1 reference

14 August 2017

Gerda Saxer

5

1 reference

14 August 2017

Yousif Shamoo

6

1 reference

14 August 2017

language of work or name

English

0 references

publication date

10 December 2012

1 reference

Proceedings of the National Academy of Sciences of the United States of America

14 August 2017

1 reference

14 August 2017

109

1 reference

14 August 2017

52

1 reference

14 August 2017

21408-21413

1 reference

FREQ-Seq: a rapid, cost-effective, sequencing-based method to determine allele frequencies directly from mixed populations

14 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3535585

Diminishing returns epistasis among beneficial mutations decelerates adaptation

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3535585

Crystal structure of Bacteroides thetaiotaomicron TetX2: A tetracycline degrading monooxygenase at 2.8 Å resolution

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3535585

Genetic variation and the fate of beneficial mutations in asexual populations

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3535585

Structural basis for a new tetracycline resistance mechanism relying on the TetX monooxygenase

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3535585

The repeatability of adaptive radiation during long-term experimental evolution of Escherichia coli in a multiple nutrient environment

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3535585

Mutational effects and the evolution of new protein functions.

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3535585

Evolutionary fates within a microbial population highlight an essential role for protein folding during natural selection

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3535585

Exploring protein fitness landscapes by directed evolution

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3535585

Absolute metabolite concentrations and implied enzyme active site occupancy in Escherichia coli

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3535585

Mechanistic approaches to the study of evolution: the functional synthesis

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3535585

Microbial genetics: Evolution experiments with microorganisms: the dynamics and genetic bases of adaptation

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3535585

One-step inactivation of chromosomal genes in Escherichia coli K-12 using PCR products

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3535585

The SOS response regulates adaptive mutation

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3535585

Evolution of high mutation rates in experimental populations of E. coli

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3535585

Metabolic flux and fitness

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3535585

The kinetics of enzyme-catalyzed reactions with two or more substrates or products. I. Nomenclature and rate equations. 1963.

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3535585

The molecular diversity of adaptive convergence.

28 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3535585

Negative epistasis between beneficial mutations in an evolving bacterial population

21 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3535585

TetX is a flavin-dependent monooxygenase conferring resistance to tetracycline antibiotics

21 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3535585

In vivo molecular evolution reveals biophysical origins of organismal fitness

21 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3535585

ANALYZING TABLES OF STATISTICAL TESTS

21 October 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/23236139

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1073/PNAS.1209335110

1 reference

release_ltzsvjxwy5fu7cq63atiq62xza

14 August 2017

0 references

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/ltzsvjxwy5fu7cq63atiq62xza

mapped directly with Wikidata item

24 November 2022

based on heuristic

1 reference

14 August 2017

1 reference