(Q37773157)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20634811%20AND%20SRC:MED&resulttype=core&format=json

7 February 2020

review article

1 reference

title

Mutational effects and the evolution of new protein functions (English)

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20634811%20AND%20SRC:MED&resulttype=core&format=json

7 February 2020

0 references

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20634811%20AND%20SRC:MED&resulttype=core&format=json

7 February 2020

author name string

Dan S Tawfik

series ordinal

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20634811%20AND%20SRC:MED&resulttype=core&format=json

7 February 2020

publication date

1 August 2010

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20634811%20AND%20SRC:MED&resulttype=core&format=json

7 February 2020

published in

Nature Reviews Genetics

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20634811%20AND%20SRC:MED&resulttype=core&format=json

7 February 2020

volume

11

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20634811%20AND%20SRC:MED&resulttype=core&format=json

7 February 2020

page(s)

572-582

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20634811%20AND%20SRC:MED&resulttype=core&format=json

7 February 2020

issue

8

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20634811%20AND%20SRC:MED&resulttype=core&format=json

https://scigraph.springernature.com/pub.10.1038/nrg2808

7 February 2020

exact match

0 references

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31 March 2020

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31 March 2020

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Stability effects of mutations and protein evolvability

31 March 2020

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The distribution of fitness effects of new mutations

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Genetic constraints on protein evolution

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Thermodynamic prediction of protein neutrality

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Robustness-epistasis link shapes the fitness landscape of a randomly drifting protein.

31 March 2020

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Ohno's model revisited: measuring the frequency of potentially adaptive mutations under various mutational drifts

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Structural perturbation and compensation by directed evolution at physiological temperature leads to thermostabilization of beta-lactamase.

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Identification and analysis of deleterious human SNPs.

31 March 2020

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Do viral proteins possess unique biophysical features?

31 March 2020

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Evolution of an antibiotic resistance enzyme constrained by stability and activity trade-offs

31 March 2020

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How protein stability and new functions trade off

31 March 2020

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Following evolutionary paths to protein-protein interactions with high affinity and selectivity

31 March 2020

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Asymmetric segregation of protein aggregates is associated with cellular aging and rejuvenation.

31 March 2020

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A compromise required by gene sharing enables survival: Implications for evolution of new enzyme activities

31 March 2020

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Evolutionary potential of (beta/alpha)8-barrels: in vitro enhancement of a "new" reaction in the enolase superfamily

31 March 2020

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Enzyme promiscuity: a mechanistic and evolutionary perspective

31 March 2020

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The 'evolvability' of promiscuous protein functions

31 March 2020

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Protein dynamism and evolvability.

31 March 2020

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A burst of protein sequence evolution and a prolonged period of asymmetric evolution follow gene duplication in yeast

31 March 2020

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Genetics. More than just a copy

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An expressed fgf4 retrogene is associated with breed-defining chondrodysplasia in domestic dogs

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Gene amplification and adaptive evolution in bacteria.

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Metabolic network analysis of the causes and evolution of enzyme dispensability in yeast.

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Diet and the evolution of human amylase gene copy number variation

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Evolutionary origin and functions of retrogene introns

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Preferential expression of a mutant allele of the amplified MDR1 (ABCB1) gene in drug-resistant variants of a human sarcoma

31 March 2020

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Gene dosage and gene duplicability

31 March 2020

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Potential role of phenotypic mutations in the evolution of protein expression and stability

31 March 2020

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Transferable hyperproduction of TEM-1 beta-lactamase in Shigella flexneri due to a point mutation in the pribnow box.

31 March 2020

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The EBG system of E. coli: origin and evolution of a novel beta-galactosidase for the metabolism of lactose

31 March 2020

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The cost of expression of Escherichia coli lac operon proteins is in the process, not in the products

31 March 2020

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Energy constraints on the evolution of gene expression

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Intrinsic protein disorder and interaction promiscuity are widely associated with dosage sensitivity.

31 March 2020

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Gene dosage balance: deletions, duplications and dominance

31 March 2020

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Why highly expressed proteins evolve slowly

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Endosymbiotic bacteria: groEL buffers against deleterious mutations

31 March 2020

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The Hsp90 capacitor, developmental remodeling, and evolution: the robustness of gene networks and the curious evolvability of metamorphosis

31 March 2020

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Hsp90 potentiates the rapid evolution of new traits: drug resistance in diverse fungi

31 March 2020

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A second-site suppressor of a folding defect functions via interactions with a chaperone network to improve folding and assembly in vivo.

31 March 2020

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Chaperonin overexpression promotes genetic variation and enzyme evolution

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Analysis of the fitness effect of compensatory mutations

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Intense neutral drifts yield robust and evolvable consensus proteins

31 March 2020

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Increased folding stability of TEM-1 beta-lactamase by in vitro selection

31 March 2020

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Genetic and Structural Characterization of an L201P Global Suppressor Substitution in TEM-1 β-Lactamase

31 March 2020

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Protein stability promotes evolvability

31 March 2020

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Mammalian Per-Arnt-Sim proteins in environmental adaptation

31 March 2020

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31 March 2020

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Copy number variants and genetic traits: closer to the resolution of phenotypic to genotypic variability

31 March 2020

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Mechanisms of change in gene copy number

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Null mutations in human and mouse orthologs frequently result in different phenotypes

31 March 2020

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On Some Principles Governing Molecular Evolution

31 March 2020

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Evolution by gene duplication: an update

31 March 2020

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Adaptive evolution after gene duplication

31 March 2020

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The altered evolutionary trajectories of gene duplicates

31 March 2020

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A common framework for understanding the origin of genetic dominance and evolutionary fates of gene duplications

31 March 2020

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Ohno's dilemma: evolution of new genes under continuous selection

31 March 2020

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In search of the limits of evolution

31 March 2020

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The role of dynamic conformational ensembles in biomolecular recognition

31 March 2020

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Gene sharing by delta-crystallin and argininosuccinate lyase

31 March 2020

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The function of lysyl-tRNA synthetase and Ap4A as signaling regulators of MITF activity in FcepsilonRI-activated mast cells

31 March 2020

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Messenger molecules and cell death: therapeutic implications.

31 March 2020

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RNase A ribonucleases and host defense: an evolving story

31 March 2020

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Enzyme recruitment in evolution of new function

31 March 2020

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Catalytic promiscuity and the evolution of new enzymatic activities

31 March 2020

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Unexpected divergence of enzyme function and sequence: "N-acylamino acid racemase" is o-succinylbenzoate synthase

31 March 2020

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The Latent Promiscuity of Newly Identified Microbial Lactonases Is Linked to a Recently Diverged Phosphotriesterase†

31 March 2020

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Evolution of efficient pathways for degradation of anthropogenic chemicals

31 March 2020

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The evolution of functionally novel proteins after gene duplication.

31 March 2020

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Evidence for escape from adaptive conflict?

31 March 2020

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Escape from adaptive conflict after duplication in an anthocyanin pathway gene

31 March 2020

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The new mutation theory of phenotypic evolution

31 March 2020

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Pathway evolution by horizontal transfer and positive selection is accommodated by relaxed negative selection upon upstream pathway genes in purple bacterial carotenoid biosynthesis

31 March 2020

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Degradation of nitroaromatic compounds: a model to study evolution of metabolic pathways

31 March 2020

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Questioning our perceptions about evolution of biodegradative enzymes

31 March 2020

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Multiple mutations and gene duplications conferring organophosphorus insecticide resistance have been selected at the Rop-1 locus of the sheep blowfly, Lucilia cuprina

31 March 2020

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A codon deletion confers resistance to herbicides inhibiting protoporphyrinogen oxidase

31 March 2020

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Quantitative exploration of the catalytic landscape separating divergent plant sesquiterpene synthases

31 March 2020

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Stepwise acquisition of pyrimethamine resistance in the malaria parasite

31 March 2020

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Empirical fitness landscapes reveal accessible evolutionary paths

31 March 2020

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Dobzhansky-Muller incompatibilities in protein evolution

31 March 2020

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Darwinian evolution can follow only very few mutational paths to fitter proteins

31 March 2020

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Preservation of duplicate genes by complementary, degenerative mutations

31 March 2020

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12 December 2020

A structural model of latent evolutionary potentials underlying neutral networks in proteins

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12 December 2020

Gene amplification in cultured cells

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12 December 2020

Catalytic and binding poly-reactivities shared by two unrelated proteins: The potential role of promiscuity in enzyme evolution

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12 December 2020

Selective neutrality of 6PGD allozymes in E. coli and the effects of genetic background.

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12 December 2020

A general method of terminal truncation, evolution, and re-elongation to generate enzymes of enhanced stability.

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12 December 2020

The probability of duplicate gene preservation by subfunctionalization

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12 December 2020

Direct estimate of the mutation rate and the distribution of fitness effects in the yeast Saccharomyces cerevisiae

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12 December 2020

Evolution of a regulated operon in the laboratory

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12 December 2020