(Q36508071)

14 August 2017

1 reference

title

Lipids and the pathogenesis of Alzheimer's disease: is there a link? (English)

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14 August 2017

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1 reference

1

Michelle M Mielke

1 reference

14 August 2017

C G Lyketsos

2

1 reference

14 August 2017

1 April 2006

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International Review of Psychiatry

14 August 2017

1 reference

14 August 2017

18

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14 August 2017

2

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14 August 2017

173-186

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Neuronal membrane cholesterol loss enhances amyloid peptide generation

14 August 2017

1 reference

https://api.crossref.org/works/10.1080%2F09540260600583007

Ceramide in apoptosis signaling: relationship with oxidative stress

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F09540260600583007

Infant nutrition--brain development--disease in later life. An introduction.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F09540260600583007

Increased glycerol-3-phosphorylcholine in post-mortem Alzheimer's brain.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F09540260600583007

Cholesterol and other membrane active sterols: from membrane evolution to "rafts".

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F09540260600583007

Apolipoprotein E, plaques, tangles and cholinergic dysfunction in Alzheimer's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F09540260600583007

Brain cholesterol: long secret life behind a barrier.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F09540260600583007

A role for apolipoprotein E, apolipoprotein A-I, and low density lipoprotein receptors in cholesterol transport during regeneration and remyelination of the rat sciatic nerve

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F09540260600583007

Plasma levels of 24S-hydroxycholesterol in patients with neurological diseases.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F09540260600583007

Projections of Alzheimer's disease in the United States and the public health impact of delaying disease onset.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F09540260600583007

Structure and function of sphingolipid- and cholesterol-rich membrane rafts

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F09540260600583007

Apoptosis and increased generation of reactive oxygen species in Down's syndrome neurons in vitro.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F09540260600583007

Genetic association of CYP46 and risk for Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F09540260600583007

Fatty acid analysis of blood plasma of patients with Alzheimer's disease, other types of dementia, and cognitive impairment

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F09540260600583007

Alzheimer's disease: etiologies, pathophysiology, cognitive reserve, and treatment opportunities

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F09540260600583007

Dysregulation of sphingolipid and sterol metabolism by ApoE4 in HIV dementia

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F09540260600583007

Sphingomyelin and ceramide as regulators of development and lifespan

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F09540260600583007

Genetic variation in the cholesterol 24-hydroxylase (CYP46) gene and the risk of Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F09540260600583007

Cholesterol metabolism in the brain

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F09540260600583007

Amyloidogenic processing of the Alzheimer beta-amyloid precursor protein depends on lipid rafts

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F09540260600583007

Chemistry and biochemistry of 4-hydroxynonenal, malonaldehyde and related aldehydes

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F09540260600583007

Cholesterol-dependent modulation of tau phosphorylation in cultured neurons

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F09540260600583007

Biochemical aspects of neurodegeneration in human brain: involvement of neural membrane phospholipids and phospholipases A2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F09540260600583007

Simvastatin strongly reduces levels of Alzheimer's disease beta -amyloid peptides Abeta 42 and Abeta 40 in vitro and in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F09540260600583007

Plasma levels of 8-epiPGF2alpha, an in vivo marker of oxidative stress, are not affected by aging or Alzheimer's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F09540260600583007

Global prevalence of dementia: a Delphi consensus study

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F09540260600583007

Antioxidants, oxidative stress, and degenerative neurological disorders

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F09540260600583007

Effects of aging on the content, composition and synthesis of sphingomyelin in the central nervous system

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F09540260600583007

An 18-year follow-up of overweight and risk of Alzheimer disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F09540260600583007

Enzymes of sphingolipid metabolism: from modular to integrative signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F09540260600583007

n-3 fatty acids and lipoproteins: comparison of results from human and animal studies

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F09540260600583007

Alzheimer Disease in the US Population

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F09540260600583007

Stroke and the risk of Alzheimer disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F09540260600583007

Lack of association of the cholesterol 24-hydroxylase (CYP46) intron 2 polymorphism with Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F09540260600583007

Application of exogenous ceramide to cultured rat spinal motoneurons promotes survival or death by regulation of apoptosis depending on its concentrations

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F09540260600583007

Induction of apoptotic DNA damage and cell death by activation of the sphingomyelin pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F09540260600583007

Smith-Lemli-Opitz syndrome and the DHCR7 gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F09540260600583007

The incidence of dementia: a meta-analysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F09540260600583007

Dietary fat intake and the risk of incident dementia in the Rotterdam Study

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F09540260600583007

The role of n-3 polyunsaturated fatty acids in brain: modulation of rat brain gene expression by dietary n-3 fatty acids

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F09540260600583007

Midlife vascular risk factors and Alzheimer's disease in later life: longitudinal, population based study

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F09540260600583007

Membrane breakdown in acute and chronic neurodegeneration: focus on choline-containing phospholipids

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F09540260600583007

Altered levels of plasma 24S- and 27-hydroxycholesterol in demented patients

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F09540260600583007

Low serum docosahexaenoic acid is a significant risk factor for Alzheimer's dementia.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F09540260600583007

Risk of dementia among persons with diabetes mellitus: a population-based cohort study

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F09540260600583007

Two types of hydrocarbon chain interdigitation in sphingomyelin bilayers.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F09540260600583007

Serum cholesterol and risk of Alzheimer disease: a community-based cohort study.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F09540260600583007

Elevated 4-hydroxynonenal in ventricular fluid in Alzheimer's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F09540260600583007

Cholesterol homeostasis in human brain: evidence for an age-dependent flux of 24S-hydroxycholesterol from the brain into the circulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F09540260600583007

Four-hydroxynonenal, a product of lipid peroxidation, is increased in the brain in Alzheimer's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F09540260600583007

CNS synaptogenesis promoted by glia-derived cholesterol

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F09540260600583007

Increased oxidative stress in Alzheimer's disease as assessed with 4-hydroxynonenal but not malondialdehyde

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F09540260600583007

An update of the enzymology and regulation of sphingomyelin metabolism

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F09540260600583007

Sphingolipids--the enigmatic lipid class: biochemistry, physiology, and pathophysiology

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F09540260600583007

High total cholesterol levels in late life associated with a reduced risk of dementia.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F09540260600583007

Increased CSF F2-isoprostane concentration in probable AD.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F09540260600583007

The magnitude of brain lipid peroxidation correlates with the extent of degeneration but not with density of neuritic plaques or neurofibrillary tangles or with APOE genotype in Alzheimer's disease patients

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F09540260600583007

Peripheral F2-isoprostanes and F4-neuroprostanes are not increased in Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F09540260600583007

Consumption of fish and n-3 fatty acids and risk of incident Alzheimer disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F09540260600583007

Decreased lysophosphatidylcholine/phosphatidylcholine ratio in cerebrospinal fluid in Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F09540260600583007

Differential effects of apolipoproteins E3 and E4 on neuronal growth in vitro

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F09540260600583007

Elastic deformation and failure of lipid bilayer membranes containing cholesterol

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F09540260600583007

Evidence for a membrane defect in Alzheimer disease brain

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F09540260600583007

Serum total cholesterol, apolipoprotein E epsilon 4 allele, and Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F09540260600583007

Atrial fibrillation and dementia in a population-based study. The Rotterdam Study.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F09540260600583007

Diabetes mellitus and the risk of dementia: The Rotterdam Study.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F09540260600583007

24S-hydroxycholesterol in cerebrospinal fluid is elevated in early stages of dementia

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F09540260600583007

Plasma 24S-hydroxycholesterol: a peripheral indicator of neuronal degeneration and potential state marker for Alzheimer's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F09540260600583007

Increased brain beta-amyloid load, phosphorylated tau, and risk of Alzheimer disease associated with an intronic CYP46 polymorphism

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F09540260600583007

Lovastatin enhances Abeta production and senile plaque deposition in female Tg2576 mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F09540260600583007

Brain membrane phospholipid alterations in Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F09540260600583007

Correlation of phosphorus-31 magnetic resonance spectroscopy and morphologic findings in Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F09540260600583007

Apolipoprotein E polymorphism and Alzheimer's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F09540260600583007

Mechanisms of free radical oxidation of unsaturated lipids

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F09540260600583007

Increase of brain oxidative stress in mild cognitive impairment: a possible predictor of Alzheimer disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F09540260600583007

Oxidative injury in diseases of the central nervous system: focus on Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F09540260600583007

Short-term administration of omega 3 fatty acids from fish oil results in increased transthyretin transcription in old rat hippocampus.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F09540260600583007

In vivo fatty acid incorporation into brain phosholipids in relation to plasma availability, signal transduction and membrane remodeling

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F09540260600583007

Relation of plasma lipids to Alzheimer disease and vascular dementia

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F09540260600583007

Measurement of F(2)-isoprostanes as an index of oxidative stress in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F09540260600583007

APOE genotype, plasma lipids, lipoproteins, and AD in community elderly.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F09540260600583007

Intracellular signal transduction pathways activated by ceramide and its metabolites

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F09540260600583007

Astroglial expression of ceramide in Alzheimer's disease brains: a role during neuronal apoptosis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F09540260600583007

Cerebrospinal fluid 24S-hydroxycholesterol is increased in patients with Alzheimer's disease compared to healthy controls

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F09540260600583007

How cells handle cholesterol.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F09540260600583007

Cholesterol depletion inhibits the generation of beta-amyloid in hippocampal neurons

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F09540260600583007

Reduced phosphoinositide concentrations in anterior temporal cortex of Alzheimer-diseased brains.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F09540260600583007

Apolipoprotein E: high-avidity binding to beta-amyloid and increased frequency of type 4 allele in late-onset familial Alzheimer disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F09540260600583007

Plasma total cholesterol level as a risk factor for Alzheimer disease: the Framingham Study

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F09540260600583007

Serum cholesterol, precursors and metabolites and cognitive performance in an aging population

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F09540260600583007

Aging and oxidative stress in neurodegeneration.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F09540260600583007

Glycerophosphocholine is elevated in cerebrospinal fluid of Alzheimer patients

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F09540260600583007

Generation of viable cholesterol-free mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F09540260600583007

Obesity in middle age and future risk of dementia: a 27 year longitudinal population based study

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F09540260600583007

Midlife cardiovascular risk factors and risk of dementia in late life

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F09540260600583007

The metabolic syndrome, inflammation, and risk of cognitive decline

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F09540260600583007

Incidence and risk factors of vascular dementia and Alzheimer's disease in a defined elderly Japanese population: the Hisayama Study

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F09540260600583007

Consensus Report of the Working Group on: “Molecular and Biochemical Markers of Alzheimer’s Disease” 11The names of the Working Group Members and the names of the Working Group Advisory Committee Members are listed in the Appendix A(section VI)

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F09540260600583007

Atherosclerosis, apolipoprotein E, and prevalence of dementia and Alzheimer's disease in the Rotterdam Study

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F09540260600583007

Lipid peroxidation contributes to age-related membrane rigidity

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F09540260600583007

Role of lipoproteins in the delivery of lipids to axons during axonal regeneration

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F09540260600583007

The role of glutathione, membrane sphingomyelin, and its metabolites in oxidative stress-induced calcium "dysregulation" in PC12 cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F09540260600583007

Determination of cholesterol oxidation products in human plasma by isotope dilution-mass spectrometry

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F09540260600583007

Cholesterol for synthesis of myelin is made locally, not imported into brain

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F09540260600583007

Metabolic cardiovascular syndrome and risk of dementia in Japanese-American elderly men. The Honolulu-Asia aging study

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F09540260600583007

Omega-3 fatty acids and risk of cognitive impairment and dementia

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F09540260600583007

Cholesterol and arterial distensibility in the first decade of life: a population-based study

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F09540260600583007

Activation of sphingolipid turnover and chronic generation of ceramide and sphingosine in liver during aging

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F09540260600583007

Reduced levels of cholesterol, phospholipids, and fatty acids in cerebrospinal fluid of Alzheimer disease patients are not related to apolipoprotein E4.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F09540260600583007

Programmed cell death induced by ceramide

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F09540260600583007

Increased 8,12-iso-iPF2alpha-VI in Alzheimer's disease: correlation of a noninvasive index of lipid peroxidation with disease severity

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F09540260600583007

Membrane lipids, selectively diminished in Alzheimer brains, suggest synapse loss as a primary event in early-onset form (type I) and demyelination in late-onset form (type II).

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F09540260600583007

Inhibition of atherosclerosis by cod-liver oil in a hyperlipidemic swine model

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F09540260600583007

10.1080/09540260600583007

21 January 2018

Identifiers

DOI

1 reference

14 August 2017

1 reference

PubMed ID

16777671