(Q36510891)

14 August 2017

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title

ABC drug transporter at the blood-brain barrier: effects on drug metabolism and drug response (English)

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14 August 2017

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2

Manfred Uhr

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author name string

Martin Ebinger

series ordinal

1

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14 August 2017

publication date

1 August 2006

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European Archives of Psychiatry and Clinical Neuroscience

14 August 2017

published in

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14 August 2017

volume

256

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14 August 2017

issue

5

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14 August 2017

page(s)

294-298

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Confocal imaging of xenobiotic transport across the blood‐brain barrier

14 August 2017

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Neurotrophic and neuroprotective actions of estrogens and their therapeutic implications

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Two members of the mouse mdr gene family confer multidrug resistance with overlapping but distinct drug specificities

21 January 2018

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Immunohistochemical localization in normal tissues of different epitopes in the multidrug transport protein P170: evidence for localization in brain capillaries and crossreactivity of one antibody with a muscle protein

21 January 2018

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Functional expression and localization of P-glycoprotein at the blood brain barrier

21 January 2018

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12 December 2020

Pegylated liposomal doxorubicin-efficacy in patients with recurrent high-grade glioma

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12 December 2020

Drug transporters in the central nervous system: brain barriers and brain parenchyma considerations

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12 December 2020

Emerging significance of P-glycoprotein in understanding drug disposition and drug interactions in psychopharmacology

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12 December 2020

P-glycoprotein is a factor in the uptake of dextromethorphan, but not of melperone, into the mouse brain: evidence for an overlap in substrate specificity between P-gp and CYP2D6.

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12 December 2020

Contribution of cholesterol and phospholipids to inhibitory effect of dimethyl-beta-cyclodextrin on efflux function of P-glycoprotein and multidrug resistance-associated protein 2 in vinblastine-resistant Caco-2 cell monolayers

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12 December 2020

Vascular and Parenchymal Mechanisms in Multiple Drug Resistance: a Lesson from Human Epilepsy

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12 December 2020

Expression of the mdr (P-glycoprotein) gene in Chinese hamster digestive tracts

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12 December 2020

Penetration of endogenous steroid hormones corticosterone, cortisol, aldosterone and progesterone into the brain is enhanced in mice deficient for both mdr1a and mdr1b P-glycoproteins

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12 December 2020

ABC transporters and the blood-brain barrier

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12 December 2020

Genetic analysis of the multidrug transporter

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12 December 2020

Investigation of polymorphism in the MDR1 gene and antidepressant-induced mania

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12 December 2020

Drug transport to the brain: key roles for the efflux pump P-glycoprotein in the blood-brain barrier

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12 December 2020

Polymorphism in the P-glycoprotein drug transporter MDR1 gene: a possible link between environmental and genetic factors in Parkinson's disease

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12 December 2020

A Role for P-Glycoprotein in Environmental Toxicology

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12 December 2020

ABC drug transporters: hereditary polymorphisms and pharmacological impact in MDR1, MRP1 and MRP2.

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12 December 2020

MDR1 genetic polymorphism does not modify either cell permissiveness to HIV-1 or disease progression before treatment

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12 December 2020

Differential enhancement of antidepressant penetration into the brain in mice with abcb1ab (mdr1ab) P-Glycoprotein gene disruption

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12 December 2020

How significant is the role of P-glycoprotein in drug absorption and brain uptake?

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12 December 2020

P-glycoprotein inhibitors and their screening: a perspective from bioavailability enhancement

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12 December 2020

Polymorphisms in human MDR1 (P-glycoprotein): recent advances and clinical relevance

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12 December 2020

Do antidepressants regulate how cortisol affects the brain?

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12 December 2020

Transporter-mediated permeation of drugs across the blood-brain barrier

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12 December 2020

Is the multidrug transporter a flippase?

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12 December 2020

Bidirectional transport of rhodamine 123 and Hoechst 33342, fluorescence probes of the binding sites on P-glycoprotein, across MDCK-MDR1 cell monolayers

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12 December 2020

CYP3A5 and MDR1 genetic polymorphisms and cyclosporine pharmacokinetics after renal transplantation

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12 December 2020

Utility of Mdr1-gene deficient mice in assessing the impact of P-glycoprotein on pharmacokinetics and pharmacodynamics in drug discovery and development

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12 December 2020

The pharmacogenetics of immunosuppression for organ transplantation: a route to individualization of drug administration.

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12 December 2020

ABCB1 (MDR1)-type P-glycoproteins at the blood-brain barrier modulate the activity of the hypothalamic-pituitary-adrenocortical system: implications for affective disorder

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12 December 2020

The role of drug transporters at the blood-brain barrier

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12 December 2020

Multidrug-resistance gene (P-glycoprotein) is expressed by endothelial cells at blood-brain barrier sites

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12 December 2020

Characterisation of the brain multidrug resistance protein (BMDP/ABCG2/BCRP) expressed at the blood–brain barrier

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12 December 2020

A family of drug transporters: the multidrug resistance-associated proteins.

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12 December 2020

Transport mechanisms for the antidepressant citalopram in brain microvessel endothelium

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12 December 2020

Deposition of Alzheimer's beta-amyloid is inversely correlated with P-glycoprotein expression in the brains of elderly non-demented humans

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12 December 2020

Association of Multidrug Resistance in Epilepsy with a Polymorphism in the Drug-Transporter GeneABCB1

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12 December 2020

Pharmacokinetics of erythromycin in rabbit corneas after single-dose infusion: role of P-glycoprotein as a barrier to in vivo ocular drug absorption

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12 December 2020

The Role of ABC Transporters in Clinical Practice

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12 December 2020

Glutamate up-regulates P-glycoprotein expression in rat brain microvessel endothelial cells by an NMDA receptor-mediated mechanism

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12 December 2020

Response to antiretroviral treatment in HIV-1-infected individuals with allelic variants of the multidrug resistance transporter 1: a pharmacogenetics study

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12 December 2020

A new multidrug resistance protein at the blood-brain barrier

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12 December 2020

PET Studies on P-glycoprotein function in the blood-brain barrier: how it affects uptake and binding of drugs within the CNS.

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12 December 2020

No effect of MDR1 C3435T variant on loperamide disposition and central nervous system effects

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12 December 2020

Mammalian drug efflux transporters of the ATP binding cassette (ABC) family: an overview.

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12 December 2020

Multidrug resistance P-glycoprotein: crucial significance in drug disposition and interaction.

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12 December 2020

Multidrug resistance proteins in rheumatoid arthritis, role in disease-modifying antirheumatic drug efficacy and inflammatory processes: an overview

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12 December 2020

Multidrug resistance protein 1 protects the choroid plexus epithelium and contributes to the blood-cerebrospinal fluid barrier

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12 December 2020

Transport of HIV protease inhibitors through the blood-brain barrier and interactions with the efflux proteins, P-glycoprotein and multidrug resistance proteins

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12 December 2020

The role of MDR1 genetic polymorphisms in interindividual variability in P-glycoprotein expression and function

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12 December 2020

Effects of ABCB1 (multidrug resistance transporter) gene mutations on disposition and central nervous effects of loperamide in healthy volunteers

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12 December 2020

abcb1ab P-glycoprotein is involved in the uptake of citalopram and trimipramine into the brain of mice

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12 December 2020

Ritonavir and dexamethasone induce expression of CYP3A and P-glycoprotein in rats

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12 December 2020

P-glycoprotein: a defense mechanism limiting oral bioavailability and CNS accumulation of drugs

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12 December 2020

The blood-brain barrier: an overview: structure, regulation, and clinical implications

1 reference

12 December 2020

Isolation of endothelial cells from brain, lung, and kidney: expression of the multidrug resistance P-glycoprotein isoforms

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12 December 2020

Impact of drug transporter studies on drug discovery and development

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12 December 2020

Disruption of the mouse mdr1a P-glycoprotein gene leads to a deficiency in the blood-brain barrier and to increased sensitivity to drugs

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12 December 2020

Stress, hypercortisolism and corticosteroid receptors in depression: implications for therapy

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12 December 2020

P-glycoprotein reduces the ability of amitriptyline metabolites to cross the blood brain barrier in mice after a 10-day administration of amitriptyline

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12 December 2020

10.1007/S00406-006-0664-4

Identifiers

DOI

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14 August 2017

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