(Q36516918)

14 August 2017

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title

Parkinson's disease: the genetics of a heterogeneous disorder (English)

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14 August 2017

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D Gosal

1

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14 August 2017

O A Ross

series ordinal

2

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14 August 2017

M Toft

series ordinal

3

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14 August 2017

publication date

1 June 2006

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European Journal of Neurology

14 August 2017

published in

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14 August 2017

volume

13

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14 August 2017

issue

6

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14 August 2017

page(s)

616-627

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Parkinson's disease. First of two parts

14 August 2017

cites work

1 reference

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No evidence for heritability of Parkinson disease in Swedish twins.

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The environment and Parkinson's disease: is the nigrostriatal system preferentially targeted by neurotoxins?

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21 January 2018

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Mechanism of the neurotoxicity of MPTP. An update

21 January 2018

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Cloning of the gene containing mutations that cause PARK8-linked Parkinson's disease

21 January 2018

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Mutations in LRRK2 cause autosomal-dominant parkinsonism with pleomorphic pathology

21 January 2018

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Identification of a novel LRRK2 mutation linked to autosomal dominant parkinsonism: evidence of a common founder across European populations

21 January 2018

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Clinical features of LRRK2-associated Parkinson's disease in central Norway

21 January 2018

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A new locus for Parkinson's disease (PARK8) maps to chromosome 12p11.2-q13.1.

21 January 2018

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The PARK8 locus in autosomal dominant parkinsonism: confirmation of linkage and further delineation of the disease-containing interval

21 January 2018

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Familial Parkinson's disease: clinical and genetic analysis of four Basque families.

21 January 2018

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A frequent LRRK2 gene mutation associated with autosomal dominant Parkinson's disease.

21 January 2018

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Clinical and positron emission tomography of Parkinson's disease caused by LRRK2.

21 January 2018

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G2019S LRRK2 mutation in French and North African families with Parkinson's disease

21 January 2018

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The G2019S LRRK2 mutation is uncommon in an Asian cohort of Parkinson's disease patients.

21 January 2018

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LRRK2 R1441G in Spanish patients with Parkinson's disease.

21 January 2018

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An LRRK2 mutation as a cause for the parkinsonism in the original PARK8 family.

21 January 2018

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Autosomal dominant parkinsonism associated with variable synuclein and tau pathology

21 January 2018

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Clinical traits of LRRK2-associated Parkinson's disease in Ireland: a link between familial and idiopathic PD.

21 January 2018

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Roc, a Ras/GTPase domain in complex proteins

21 January 2018

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Mutations of the BRAF gene in human cancer

21 January 2018

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Alpha-synuclein phosphorylation controls neurotoxicity and inclusion formation in a Drosophila model of Parkinson disease

21 January 2018

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Hereditary early-onset Parkinson's disease caused by mutations in PINK1

21 January 2018

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Novel PINK1 mutations in early-onset parkinsonism

21 January 2018

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https://api.crossref.org/works/10.1111%2FJ.1468-1331.2006.01336.X

Analysis of the PINK1 gene in a large cohort of cases with Parkinson disease

21 January 2018

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PINK1 mutations are associated with sporadic early-onset parkinsonism

21 January 2018

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Phenotypic characterisation of autosomal recessive PARK6-linked parkinsonism in three unrelated Italian families

21 January 2018

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Clinical and subclinical dopaminergic dysfunction in PARK6-linked parkinsonism: an 18F-dopa PET study

21 January 2018

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PINK1 (PARK6) associated Parkinson disease in Ireland

21 January 2018

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Genetic association study of PINK1 coding polymorphisms in Parkinson's disease.

21 January 2018

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The gene responsible for PARK6 Parkinson's disease, PINK1, does not influence common forms of parkinsonism

21 January 2018

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Mutations in PTEN-induced putative kinase 1 associated with recessive parkinsonism have differential effects on protein stability

21 January 2018

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https://api.crossref.org/works/10.1111%2FJ.1468-1331.2006.01336.X

Molecular Pathways of Neurodegeneration in Parkinson's Disease

21 January 2018

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Mutations in the DJ-1 gene associated with autosomal recessive early-onset parkinsonism

21 January 2018

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The role of pathogenic DJ-1 mutations in Parkinson's disease.

21 January 2018

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Analysis of an early-onset Parkinson's disease cohort for DJ-1 mutations.

21 January 2018

1 reference

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DJ-1 mutations are a rare cause of recessively inherited early onset parkinsonism mediated by loss of protein function

21 January 2018

1 reference

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Genetic analysis of DJ-1 in a cohort Parkinson's disease patients of different ethnicity.

21 January 2018

1 reference

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Park7, a novel locus for autosomal recessive early-onset parkinsonism, on chromosome 1p36.

21 January 2018

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https://api.crossref.org/works/10.1111%2FJ.1468-1331.2006.01336.X

The expression of DJ-1 (PARK7) in normal human CNS and idiopathic Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1468-1331.2006.01336.X

The Parkinson's disease protein DJ-1 is neuroprotective due to cysteine-sulfinic acid-driven mitochondrial localization

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1468-1331.2006.01336.X

Nigrostriatal dopaminergic deficits and hypokinesia caused by inactivation of the familial Parkinsonism-linked gene DJ-1

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1468-1331.2006.01336.X

L166P mutant DJ-1, causative for recessive Parkinson's disease, is degraded through the ubiquitin-proteasome system

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1468-1331.2006.01336.X

The ubiquitin pathway in Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1468-1331.2006.01336.X

The Ile93Met mutation in the ubiquitin carboxy-terminal-hydrolase-L1 gene is not observed in European cases with familial Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1468-1331.2006.01336.X

UCHL1 is a Parkinson's disease susceptibility gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1468-1331.2006.01336.X

Ubiquitin carboxyl-terminal hydrolase (PGP 9.5) is selectively present in ubiquitinated inclusion bodies characteristic of human neurodegenerative diseases.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1468-1331.2006.01336.X

Mutations in the parkin gene cause autosomal recessive juvenile parkinsonism

21 January 2018

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https://api.crossref.org/works/10.1111%2FJ.1468-1331.2006.01336.X

Parkin genetics: one model for Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1468-1331.2006.01336.X

Association between early-onset Parkinson's disease and mutations in the parkin gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1468-1331.2006.01336.X

Parkinson's disease in Ireland: clinical presentation and genetic heterogeneity in patients with parkin mutations

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1468-1331.2006.01336.X

Frequency of parkin mutations in late-onset Parkinson's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1468-1331.2006.01336.X

Parkin deletions in a family with adult-onset, tremor-dominant parkinsonism: expanding the phenotype

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1468-1331.2006.01336.X

Lewy bodies and parkinsonism in families with parkin mutations

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1468-1331.2006.01336.X

Positron emission tomographic analysis of the nigrostriatal dopaminergic system in familial parkinsonism associated with mutations in the parkin gene.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1468-1331.2006.01336.X

Clinical findings in a large family with a parkin ex3delta40 mutation

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1468-1331.2006.01336.X

Parkin variants in North American Parkinson's disease: cases and controls.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1468-1331.2006.01336.X

Functional association of the parkin gene promoter with idiopathic Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1468-1331.2006.01336.X

How much phenotypic variation can be attributed to parkin genotype?

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1468-1331.2006.01336.X

Familial juvenile parkinsonism: clinical and pathologic study in a family

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1468-1331.2006.01336.X

Pathologic and biochemical studies of juvenile parkinsonism linked to chromosome 6q.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1468-1331.2006.01336.X

Clinical and pathologic abnormalities in a family with parkinsonism and parkin gene mutations.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1468-1331.2006.01336.X

Familial Parkinson disease gene product, parkin, is a ubiquitin-protein ligase

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1468-1331.2006.01336.X

RING finger 1 mutations in Parkin produce altered localization of the protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1468-1331.2006.01336.X

Failure of the ubiquitin-proteasome system in Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1468-1331.2006.01336.X

Mapping of a gene for Parkinson's disease to chromosome 4q21-q23

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1468-1331.2006.01336.X

Mutation in the alpha-synuclein gene identified in families with Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1468-1331.2006.01336.X

Ala30Pro mutation in the gene encoding alpha-synuclein in Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1468-1331.2006.01336.X

Low frequency of alpha-synuclein mutations in familial Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1468-1331.2006.01336.X

The new mutation, E46K, of alpha-synuclein causes Parkinson and Lewy body dementia

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1468-1331.2006.01336.X

Clinical genetic analysis of Parkinson's disease in the Contursi kindred

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1468-1331.2006.01336.X

Clinical and pathological features of a Parkinsonian syndrome in a family with an Ala53Thr alpha-synuclein mutation

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1468-1331.2006.01336.X

Familial parkinsonism with synuclein pathology: clinical and PET studies of A30P mutation carriers.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1468-1331.2006.01336.X

alpha-Synuclein locus triplication causes Parkinson's disease

21 January 2018

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https://api.crossref.org/works/10.1111%2FJ.1468-1331.2006.01336.X

Comparison of kindreds with parkinsonism and alpha-synuclein genomic multiplications

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1468-1331.2006.01336.X

Alpha-synuclein locus duplication as a cause of familial Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1468-1331.2006.01336.X

Alpha-synuclein missense and multiplication mutations in autosomal dominant Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1468-1331.2006.01336.X

SNCA multiplication is not a common cause of Parkinson disease or dementia with Lewy bodies.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1468-1331.2006.01336.X

Multiplication of the alpha-synuclein gene is not a common disease mechanism in Lewy body disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1468-1331.2006.01336.X

Hereditary form of parkinsonism--dementia

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1468-1331.2006.01336.X

Alpha-synuclein in Lewy bodies

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1468-1331.2006.01336.X

Concurrence of alpha-synuclein and tau brain pathology in the Contursi kindred

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1468-1331.2006.01336.X

Staging of brain pathology related to sporadic Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1468-1331.2006.01336.X

Accelerated in vitro fibril formation by a mutant alpha-synuclein linked to early-onset Parkinson disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1468-1331.2006.01336.X

Mutation E46K increases phospholipid binding and assembly into filaments of human alpha-synuclein

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1468-1331.2006.01336.X

alpha-Synuclein promoter confers susceptibility to Parkinson's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1468-1331.2006.01336.X

Multiple regions of alpha-synuclein are associated with Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1468-1331.2006.01336.X

Molecular pathophysiology of Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1468-1331.2006.01336.X

Challenges in Parkinson's disease: restoration of the nigrostriatal dopamine system is not enough

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1468-1331.2006.01336.X

Sequencing of the alpha-synuclein gene in a large series of cases of familial Parkinson's disease fails to reveal any further mutations. The European Consortium on Genetic Susceptibility in Parkinson's Disease (GSPD)

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1468-1331.2006.01336.X

LRRK2 mutations and Parkinsonism

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1468-1331.2006.01336.X

10.1111/J.1468-1331.2006.01336.X

21 January 2018

Identifiers

DOI

1 reference

14 August 2017

1 reference