(Q36527942)

English

Nordihydroguaiaretic acid improves metabolic dysregulation and aberrant hepatic lipid metabolism in mice by both PPARα-dependent and -independent pathways

scientific article published on 25 October 2012

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scholarly article

1 reference

Europe PubMed Central

PMC publication ID

14 August 2017

Nordihydroguaiaretic acid improves metabolic dysregulation and aberrant hepatic lipid metabolism in mice by both PPARα-dependent and -independent pathways (English)

1 reference

Europe PubMed Central

PMC publication ID

14 August 2017

object named as

Wen-Jun Shen

1 reference

Europe PubMed Central

PMC publication ID

14 August 2017

Fredric B Kraemer

4

object named as

Fredric B Kraemer

1 reference

Europe PubMed Central

PMC publication ID

14 August 2017

author name string

Haiyan Zhang

1

1 reference

Europe PubMed Central

PMC publication ID

14 August 2017

Yuan Cortez

3

1 reference

Europe PubMed Central

PMC publication ID

14 August 2017

Salman Azhar

5

1 reference

Europe PubMed Central

PMC publication ID

14 August 2017

publication date

25 October 2012

1 reference

Europe PubMed Central

PMC publication ID

14 August 2017

American Journal of Physiology - Gastrointestinal and Liver Physiology

1 reference

Europe PubMed Central

PMC publication ID

14 August 2017

304

1 reference

Europe PubMed Central

PMC publication ID

14 August 2017

1

1 reference

Europe PubMed Central

PMC publication ID

14 August 2017

G72-86

1 reference

Europe PubMed Central

PMC publication ID

14 August 2017

Liver-specific expression of transcriptionally active SREBP-1c is associated with fatty liver and increased visceral fat mass

1 reference

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Differing endoplasmic reticulum stress response to excess lipogenesis versus lipid oversupply in relation to hepatic steatosis and insulin resistance.

1 reference

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The Scap/SREBP pathway is essential for developing diabetic fatty liver and carbohydrate-induced hypertriglyceridemia in animals

1 reference

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Genome-wide profiling of liver X receptor, retinoid X receptor, and peroxisome proliferator-activated receptor α in mouse liver reveals extensive sharing of binding sites

1 reference

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Dissociation of inositol-requiring enzyme (IRE1α)-mediated c-Jun N-terminal kinase activation from hepatic insulin resistance in conditional X-box-binding protein-1 (XBP1) knock-out mice

1 reference

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Sustained activation of PPARα by endogenous ligands increases hepatic fatty acid oxidation and prevents obesity in ob/ob mice

1 reference

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Nonalcoholic fatty liver disease: a review of the spectrum of disease, diagnosis, and therapy

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30 September 2017

Integrated expression profiling and genome-wide analysis of ChREBP targets reveals the dual role for ChREBP in glucose-regulated gene expression.

1 reference

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The role of insulin-sensitizing agents in the treatment of nonalcoholic steatohepatitis.

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Lifestyle interventions for the treatment of non-alcoholic fatty liver disease in adults: a systematic review.

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Nonalcoholic fatty liver disease and diabetes mellitus: pathogenesis and treatment

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Human SREBP1c expression in liver is directly regulated by peroxisome proliferator-activated receptor alpha (PPARalpha)

1 reference

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30 September 2017

AMPK phosphorylates and inhibits SREBP activity to attenuate hepatic steatosis and atherosclerosis in diet-induced insulin-resistant mice

1 reference

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30 September 2017

Current therapeutic strategies in non-alcoholic fatty liver disease.

1 reference

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30 September 2017

Non-alcoholic fatty liver disease (NAFLD): why you should care, when you should worry, what you should do.

1 reference

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30 September 2017

Fatty acid regulation of hepatic lipid metabolism

1 reference

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30 September 2017

Recent insights into fatty liver, metabolic dyslipidaemia and their links to insulin resistance

1 reference

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30 September 2017

PPARalpha: energy combustion, hypolipidemia, inflammation and cancer

1 reference

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Genetic control of de novo lipogenesis: role in diet-induced obesity

1 reference

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30 September 2017

Non-alcoholic fatty liver disease: the hepatic consequence of obesity and the metabolic syndrome

1 reference

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30 September 2017

Palmitoylation of ketogenic enzyme HMGCS2 enhances its interaction with PPARalpha and transcription at the Hmgcs2 PPRE.

1 reference

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30 September 2017

Nonalcoholic fatty liver disease: pathology and pathogenesis

1 reference

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30 September 2017

Fenofibrate simultaneously induces hepatic fatty acid oxidation, synthesis, and elongation in mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3543637

30 September 2017

AMPK: an emerging drug target for diabetes and the metabolic syndrome

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3543637

30 September 2017

GRP78 expression inhibits insulin and ER stress-induced SREBP-1c activation and reduces hepatic steatosis in mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3543637

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AMP-activated protein kinase in the regulation of hepatic energy metabolism: from physiology to therapeutic perspectives.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3543637

30 September 2017

Current and emerging therapies in nonalcoholic fatty liver disease

1 reference

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30 September 2017

Nonalcoholic fatty liver disease: a manifestation of the metabolic syndrome.

1 reference

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30 September 2017

Causes and metabolic consequences of Fatty liver

1 reference

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30 September 2017

Regulation of hepatic lipogenesis by the transcription factor XBP1

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3543637

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Dephosphorylation of translation initiation factor 2alpha enhances glucose tolerance and attenuates hepatosteatosis in mice

1 reference

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30 September 2017

Nonalcoholic fatty liver disease as a component of the metabolic syndrome

1 reference

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30 September 2017

Recent advances in nonalcholic fatty liver disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3543637

30 September 2017

Contribution of de novo fatty acid synthesis to hepatic steatosis and insulin resistance: lessons from genetically engineered mice

1 reference

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30 September 2017

Carbohydrate-response element-binding protein deletion alters substrate utilization producing an energy-deficient liver

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3543637

30 September 2017

Fatty liver: a novel component of the metabolic syndrome

1 reference

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30 September 2017

ChREBP, a transcriptional regulator of glucose and lipid metabolism

1 reference

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30 September 2017

The liver X receptor (LXR) and hepatic lipogenesis. The carbohydrate-response element-binding protein is a target gene of LXR

1 reference

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Ablation of PGC-1beta results in defective mitochondrial activity, thermogenesis, hepatic function, and cardiac performance

1 reference

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30 September 2017

Carbohydrate response element binding protein, ChREBP, a transcription factor coupling hepatic glucose utilization and lipid synthesis

1 reference

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30 September 2017

Deficiency of carbohydrate-activated transcription factor ChREBP prevents obesity and improves plasma glucose control in leptin-deficient (ob/ob) mice.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3543637

30 September 2017

PGC-1 coactivators: inducible regulators of energy metabolism in health and disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3543637

30 September 2017

Metabolic control through the PGC-1 family of transcription coactivators

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3543637

30 September 2017

PGC-1alpha deficiency causes multi-system energy metabolic derangements: muscle dysfunction, abnormal weight control and hepatic steatosis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3543637

30 September 2017

Hepatic insig-1 or -2 overexpression reduces lipogenesis in obese Zucker diabetic fatty rats and in fasted/refed normal rats

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3543637

30 September 2017

Overexpression of Insig-1 in the livers of transgenic mice inhibits SREBP processing and reduces insulin-stimulated lipogenesis

1 reference

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Peroxisomal-proliferator-activated receptor alpha activates transcription of the rat hepatic malonyl-CoA decarboxylase gene: a key regulation of malonyl-CoA level

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A simple method for the isolation and purification of total lipides from animal tissues

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30 September 2017

Liver-specific disruption of PPARgamma in leptin-deficient mice improves fatty liver but aggravates diabetic phenotypes

1 reference

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30 September 2017

Peroxisome-proliferator-activated receptor-alpha (PPARalpha) deficiency leads to dysregulation of hepatic lipid and carbohydrate metabolism by fatty acids and insulin

1 reference

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30 September 2017

SREBPs: activators of the complete program of cholesterol and fatty acid synthesis in the liver

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Nonalcoholic fatty liver disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3543637

30 September 2017

Absence of sterol regulatory element-binding protein-1 (SREBP-1) ameliorates fatty livers but not obesity or insulin resistance in Lep(ob)/Lep(ob) mice

1 reference

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Mechanism for fatty acid "sparing" effect on glucose-induced transcription: regulation of carbohydrate-responsive element-binding protein by AMP-activated protein kinase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3543637

30 September 2017

Role of LXRs in control of lipogenesis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3543637

30 September 2017

Regulation of mouse sterol regulatory element-binding protein-1c gene (SREBP-1c) by oxysterol receptors, LXRalpha and LXRbeta

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3543637

30 September 2017

Masoprocol decreases rat lipolytic activity by decreasing the phosphorylation of HSL

1 reference

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30 September 2017

Increased levels of nuclear SREBP-1c associated with fatty livers in two mouse models of diabetes mellitus

1 reference

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30 September 2017

A critical role for the peroxisome proliferator-activated receptor alpha (PPARalpha) in the cellular fasting response: the PPARalpha-null mouse as a model of fatty acid oxidation disorders

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3543637

30 September 2017

Peroxisome proliferator-activated receptor alpha mediates the adaptive response to fasting

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3543637

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The mitochondrial carnitine palmitoyltransferase system. From concept to molecular analysis

1 reference

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30 September 2017

Effects of the obese gene product on body weight regulation in ob/ob mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3543637

30 September 2017

The unfolded protein response transducer IRE1α prevents ER stress-induced hepatic steatosis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3543637

28 June 2018

UPR pathways combine to prevent hepatic steatosis caused by ER stress-mediated suppression of transcriptional master regulators.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3543637

28 June 2018

A role for PPARalpha in the control of SREBP activity and lipid synthesis in the liver

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3543637

28 June 2018

Defect in peroxisome proliferator-activated receptor alpha-inducible fatty acid oxidation determines the severity of hepatic steatosis in response to fasting.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3543637

28 June 2018

Effect of masoprocol on carbohydrate and lipid metabolism in a rat model of Type II diabetes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3543637

28 June 2018

Mitochondrial and peroxisomal fatty acid oxidation in liver homogenates and isolated hepatocytes from control and clofibrate-treated rats

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3543637

28 June 2018

Peroxisome proliferator-activated receptor-α agonist, Wy 14,643, improves metabolic indices, steatosis and ballooning in diabetic mice with non-alcoholic steatohepatitis.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3543637

21 September 2018

Peroxisome proliferator-activated receptor alpha target genes.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3543637

21 September 2018

Nordihydroguaiaretic acid protects against high-fat diet-induced fatty liver by activating AMP-activated protein kinase in obese mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3543637

21 September 2018

Role of adenosine monophosphate-activated protein kinase-p70 ribosomal S6 kinase-1 pathway in repression of liver X receptor-alpha-dependent lipogenic gene induction and hepatic steatosis by a novel class of dithiolethiones

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3543637

21 September 2018

Peroxisome proliferator-activated receptor alpha deficiency abolishes the response of lipogenic gene expression to re-feeding: restoration of the normal response by activation of liver X receptor alpha

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3543637

21 September 2018

ChREBP*Mlx is the principal mediator of glucose-induced gene expression in the liver.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3543637

21 September 2018

"New" hepatic fat activates PPARalpha to maintain glucose, lipid, and cholesterol homeostasis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3543637

21 September 2018

High dietary fructose induces a hepatic stress response resulting in cholesterol and lipid dysregulation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3543637

21 September 2018

Peroxisome proliferator-activated receptor-alpha regulates lipid homeostasis, but is not associated with obesity: studies with congenic mouse lines

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3543637

21 September 2018

Nonalcoholic fatty liver disease in children

1 reference

https://pubmed.ncbi.nlm.nih.gov/23104557

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Fenofibrate, a peroxisome proliferator-activated receptor alpha agonist, reduces hepatic steatosis and lipid peroxidation in fatty liver Shionogi mice with hereditary fatty liver

1 reference

https://pubmed.ncbi.nlm.nih.gov/23104557

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Non-alcoholic fatty liver disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/23104557

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1152/AJPGI.00328.2012

1 reference

Europe PubMed Central

PMC publication ID

14 August 2017

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

14 August 2017

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

14 August 2017

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