(Q36538982)

14 August 2017

1 reference

title

Clinical pharmacokinetics of anxiolytics and hypnotics in the elderly. Therapeutic considerations (Part II). (English)

1 reference

14 August 2017

1 reference

2

Harmatz JS

1 reference

14 August 2017

1

Greenblatt DJ

1 reference

14 August 2017

3

Shader RI

1 reference

14 August 2017

1 October 1991

1 reference

Clinical Pharmacokinetics

14 August 2017

1 reference

14 August 2017

21

1 reference

14 August 2017

262-273

1 reference

14 August 2017

4

1 reference

https://scigraph.springernature.com/pub.10.2165/00003088-199121040-00003

14 August 2017

0 references

cites work

Benzodiazepine kinetics: implications for therapeutics and pharmacogeriatrics

1 reference

12 December 2020

Metabolites of Bromazepam, a Benzodiazepine, in the Human, Dog, Rat, and Mouse

1 reference

12 December 2020

Renal disease, age, and oxazepam kinetics

1 reference

12 December 2020

Effect of age and gender on disposition of temazepam

1 reference

12 December 2020

Benzodiazepine receptor binding in young, mature and senescent rat brain and kidney

1 reference

12 December 2020

Pharmacokinetics of buspirone in elderly subjects

1 reference

12 December 2020

Absolute bioavailability of oral and intramuscular diazepam: effects of age and sex.

1 reference

12 December 2020

Alprazolam in the elderly: pharmacokinetics and pharmacodynamics during multiple dosing

1 reference

12 December 2020

Influence of age and previous use of diazepam dosage required for endoscopy

1 reference

12 December 2020

Age, sex, and nitrazepam kinetics: relation to antipyrine disposition.

1 reference

12 December 2020

Comparative Single-Dose Kinetics of Oxazolam, Prazepam, and Clorazepate: Three Precursors of Desmethyldiazepam

1 reference

12 December 2020

Pharmacokinetic investigations in elderly patients. Clinical and ethical considerations

1 reference

12 December 2020

Antipyrine kinetics in the elderly: prediction of age-related changes in benzodiazepine oxidizing capacity

1 reference

12 December 2020

Implications of altered drug disposition in the elderly: studies of benzodiazepines

1 reference

12 December 2020

Prescribing of psychotropic medication by primary care physicians and psychiatrists

1 reference

12 December 2020

Effect of age and liver cirrhosis on the pharmacokinetics of nitrazepam

1 reference

12 December 2020

Effects of diazepam on recall memory: relationship to aging, dose, and duration of treatment.

1 reference

12 December 2020

Risk factors for falls among elderly persons living in the community

1 reference

12 December 2020

Low doses of brotizolam and nitrazepam as hypnotics in the elderly.

1 reference

12 December 2020

Effect of Age on the Pharmacokinetics of Diazepam Given in Conjunction with Spinal Anesthesia

1 reference

12 December 2020

Clinical Pharmacokinetics of Diazepam

1 reference

12 December 2020

1 reference

12 December 2020

Benzodiazepine sedatives and the risk of falling in a community-dwelling elderly cohort

1 reference

12 December 2020

Predictors of falls among elderly people. Results of two population-based studies

1 reference

12 December 2020

Diazepam disposition in mature and aged rabbits and rats

1 reference

12 December 2020

Patterns of benzodiazepine use in Great Britain as measured by a general population survey.

1 reference

12 December 2020

Triazolam disposition

1 reference

12 December 2020

Pharmacokinetics of drugs in obesity

1 reference

12 December 2020

Single dose pharmacokinetics and pharmacodynamics of oral loprazolam in the elderly

1 reference

12 December 2020

Insomnia in the Elderly: Treatment with Flurazepam Hydrochloride

1 reference

12 December 2020

Clinical pharmacokinetics of nitrazepam

1 reference

12 December 2020

Aging: changes in a passive-avoidance response with brain levels of temazepam.

1 reference

12 December 2020

Clinical pharmacokinetics of lorazepam. I. Absorption and disposition of oral 14C-lorazepam

1 reference

12 December 2020

Drug therapy in the elderly

1 reference

12 December 2020

Adverse effects of single therapeutic doses of diazepam on performance in normal geriatric subjects: relationship to plasma concentrations.

1 reference

12 December 2020

Relationship between diazepam dose, plasma level, age, and central nervous system depression

1 reference

12 December 2020

Clinical Depression of the Central Nervous System Due to Diazepam and Chlordiazepoxide in Relation to Cigarette Smoking and Age

1 reference

12 December 2020

Symptom checklist syndromes in the general population. Correlations with psychotherapeutic drug use.

1 reference

12 December 2020

Kinetics, brain uptake, and receptor binding characteristics of flurazepam and its metabolites.

1 reference

12 December 2020

Effect of age on levels of diazepam in plasma and brain of rats

1 reference

12 December 2020

Responsiveness to oral diazepam in the elderly: relationship to total and free plasma concentrations

1 reference

12 December 2020

Midazolam kinetics in women of two age groups

1 reference

12 December 2020

Clinical Pharmacokinetics of Oxazepam and Lorazepam

1 reference

12 December 2020

Effects of aging and liver disease on disposition of lorazepam

1 reference

12 December 2020

Effect on neuronal and non-neuronal benzodiazepine binding sites.

1 reference

12 December 2020

Kinetics and biotransformation of lormetazepam. II. Radioimmunologic determinations in plasma and urine of young and elderly subjects: first-pass effect

1 reference

12 December 2020

Increased sensitivity to nitrazepam in old age

1 reference

12 December 2020

Bromazepam pharmacokinetics: influence of age, gender, oral contraceptives, cimetidine, and propranolol

1 reference

12 December 2020

Disposition of oxazepam in relation to age, sex, and cigarette smoking

1 reference

12 December 2020

Sensitivity to triazolam in the elderly.

1 reference

12 December 2020

Effect of age, gender, and obesity on midazolam kinetics.

1 reference

12 December 2020

Incidence of depression and anxiety: the Stirling County Study

1 reference

12 December 2020

Toxicity of nitrazepam in the elderly: a report from the Boston Collaborative Drug Surveillance Program

1 reference

12 December 2020

Aging: effect on the interaction of ethanol and pentobarbital with the benzodiazepine-GABA receptor-ionophore complex

1 reference

12 December 2020

Oxazepam kinetics: effects of age and sex.

1 reference

12 December 2020

Diazepam kinetics in relation to age and sex.

1 reference

12 December 2020

Reduced single-dose clearance of clobazam in elderly men predicts increased multiple-dose accumulation

1 reference

12 December 2020

Pharmacokinetics of brotizolam in the elderly

1 reference

12 December 2020

The pharmacokinetics and biotransformation of the new benzodiazepine lormetazepam in humans I. Absorption, distribution, elimination and metabolism of lormetazepam-5-14C

1 reference

12 December 2020

Drug therapy. Current status of benzodiazepines

1 reference

12 December 2020

Hepatic drug metabolism and aging

1 reference

12 December 2020

Long v short half-life benzodiazepines in the elderly. Kinetics and clinical effects of diazepam and oxazepam.

1 reference

12 December 2020

Drug disposition in obese humans. An update

1 reference

12 December 2020

Efficacy of a reduced triazolam dose in elderly insomniacs

1 reference

12 December 2020

Quazepam kinetics in the elderly

1 reference

12 December 2020

No evidence of a genetic polymorphism in the oxidative metabolism of midazolam.

1 reference

12 December 2020

Effects of single doses of alpidem, lorazepam, and placebo on memory and attention in healthy young and elderly volunteers

1 reference

12 December 2020

Management of drug therapy in the elderly

1 reference

12 December 2020

Aging and benzodiazepine binding in the rat cerebral cortex

1 reference

12 December 2020

GABA stimulation of 3H-diazepam binding in aged mice.

1 reference

12 December 2020

Differential CNS effects of diazepam in elderly adults.

1 reference

12 December 2020

Drug metabolism in the elderly

1 reference

12 December 2020

Midazolam: pharmacology and uses

1 reference

12 December 2020

Oxidative versus conjugative biotransformation of temazepam

1 reference

12 December 2020

Altered elimination of desmethyldiazepam in the elderly

1 reference

12 December 2020

Effect of age, body composition, and lipid solubility on benzodiazepine tissue distribution in rats.

1 reference

12 December 2020

Benzodiazepines of long and short elimination half-life and the risk of hip fracture

1 reference

12 December 2020

Human pharmacokinetics of nitrazepam: Effect of age and diseases

1 reference

12 December 2020

Desmethyldiazepam pharmacokinetics: studies following intravenous and oral desmethyldiazepam, oral clorazepate, and intravenous diazepam.

1 reference

12 December 2020

Sedative-hypnotic drug use and ageing

1 reference

12 December 2020

Absorption and disposition of chlordiazepoxide in young and elderly male volunteers

1 reference

12 December 2020

Increased sensitivity of the elderly to the central depressant effects of diazepam.

1 reference

12 December 2020

Reduced clearance of triazolam in old age: relation to antipyrine oxidizing capacity

1 reference

12 December 2020

Effects of age, gender and oral contraceptives on intramuscular midazolam pharmacokinetics.

1 reference

12 December 2020

First-pass elimination. Basic concepts and clinical consequences

1 reference

12 December 2020

Pharmacology and aging

1 reference

12 December 2020

Effect of age and sex on lorazepam protein binding

1 reference

12 December 2020

Aging: changes in distribution of diazepam and metabolites in the rat.

1 reference

12 December 2020

Hypnotics in the elderly. What cause for concern?

1 reference

12 December 2020

Prevalence and Correlates of the Long-term Regular Use of Anxiolytics

1 reference

12 December 2020

Aging, diazepam exposure and benzodiazepine receptors in rat cortex

1 reference

12 December 2020

Clearance approaches in pharmacology.

1 reference

12 December 2020

Buspirone hydrochloride: a unique new anxiolytic agent. Pharmacokinetics, clinical pharmacology, abuse potential and clinical efficacy

1 reference

12 December 2020

Age-associated alterations in diazepam metabolizing enzyme activities in male and female rats.

1 reference

12 December 2020

Influence of dosing regimen on alprazolam and metabolite serum concentrations and tolerance to sedative and psychomotor effects

1 reference

12 December 2020

Failure to limit quantities of benzodiazepine hypnotic drugs for outpatients: placing the elderly at risk

1 reference

12 December 2020

Pharmacokinetics and metabolism of temazepam in man and several animal species

1 reference

12 December 2020

Insomnia and its treatment. Prevalence and correlates.

1 reference

12 December 2020

Psychotropic drug use in the Boston area. A report from the Boston Collaborative Drug Surveillance Program

1 reference

12 December 2020

Age- and gender-related differences in diazepam pharmacokinetics.

1 reference

12 December 2020

The neuropsychiatric effects of aspartame in normal volunteers

1 reference

12 December 2020

Toxicity of high-dose flurazepam in the elderly

1 reference

12 December 2020

The effects of age and liver disease on the disposition and elimination of diazepam in adult man

1 reference

12 December 2020

Determination of biological activity of alprazolam, triazolam and their metabolites

1 reference

12 December 2020

One-month prevalence of mental disorders in the United States. Based on five Epidemiologic Catchment Area sites.

1 reference

12 December 2020

Disposition and metabolic fate of 14C-quazepam in man

1 reference

12 December 2020

Effect of age and parenchymal liver disease on the disposition and elimination of chlordiazepoxide (librium).

1 reference

12 December 2020

Aging and drug disposition: an update

1 reference

12 December 2020

Drug therapy: drug disposition in old age.

1 reference

12 December 2020

Aging and determinants of hepatic drug clearance

1 reference

12 December 2020

Plasma diazepam and desmethyldiazepam concentrations during long-term diazepam therapy

1 reference

12 December 2020

Pharmacokinetic aspects of drug therapy in the elderly

1 reference

12 December 2020

Diazepam disposition determinants.

1 reference

12 December 2020

Desmethyldiazepam kinetics in the elderly after oral prazepam

1 reference

12 December 2020

Influence of food and of age on nitrazepam kinetics

1 reference

12 December 2020

Determinants of benzodiazepine brain uptake: lipophilicity versus binding affinity.

1 reference

12 December 2020

Lorazepam kinetics in the elderly

1 reference

12 December 2020

Diazepam, behavior, and aging: increased sensitivity or lower baseline performance?

1 reference

12 December 2020

Enhanced bioavailability of triazolam following sublingual versus oral administration

1 reference

12 December 2020

Psychotropic drug utilization patterns in a metropolitan population

1 reference

12 December 2020

Effect of age on the pharmacokinetics and sedative of flunitrazepam

1 reference

12 December 2020

Effect of subject age and gender on the pharmacokinetics of oral triazolam and temazepam

1 reference

12 December 2020

Psychotropic drug use and the risk of hip fracture

1 reference

12 December 2020

Blood level, excretion, and metabolite pattern of [14C]-brotizolam in humans

1 reference

12 December 2020

Clobazam kinetics in the elderly

1 reference

12 December 2020

Alprazolam kinetics in the elderly. Relation to antipyrine disposition

1 reference

12 December 2020

Age and gender effects on chlordiazepoxide kinetics: relation to antipyrine disposition

1 reference

12 December 2020

Diazepam tolerance: effect of age, regular sedation, and alcohol

1 reference

12 December 2020

Metabolic fate of [14C]-brotizolam in the rat, dog, monkey and man.

1 reference

12 December 2020

Kinetic and dynamic components of increased benzodiazepine sensitivity in aging animals

1 reference

12 December 2020

Prevalence, frequency, and duration of hypnotic drug use among the elderly living at home

1 reference

12 December 2020

Disposition of clotiazepam: influence of age, sex, oral contraceptives, cimetidine, isoniazid and ethanol

1 reference

12 December 2020

Drug therapy: Psychotropic drug use in the elderly (first of two parts).

1 reference

12 December 2020

Close correlation of acetaminophen clearance with that of conjugated benzodiazepines but not oxidized benzodiazepines

1 reference

12 December 2020

Improved hypnotic treatment using chlormethiazole and temazepam

1 reference

12 December 2020

Effect of Age and Cardiopulmonary Bypass on the Pharmacokinetics of Lorazepam

1 reference

12 December 2020

The effect of age on the pharmacokinetics of diazepam.

1 reference

12 December 2020

Pharmacodynamics and pharmacokinetics of ethanol, diazepam and pentobarbital in young and aged rats.

1 reference

12 December 2020

Effect of aging on anticonflict and CNS depressant activity of diazepam in rats.

1 reference

12 December 2020

Adverse drug reactions associated with global cognitive impairment in elderly persons.

1 reference

12 December 2020

Clinical Pharmacokinetics of Chlordiazepoxide

1 reference

12 December 2020

Kinetics and clinical effects of flurazepam in young and elderly noninsomniacs

1 reference

12 December 2020

Electron-capture gas chromatographic analysis of the triazolobenzodiazepines alprazolam and triazolam

1 reference

12 December 2020

Brain benzodiazepine receptor changes during ageing

1 reference

12 December 2020

Effect of age and sex on disposition of desmethyldiazepam formed from its precursor clorazepate.

1 reference

12 December 2020

Comparison of the pharmacokinetic profile of metaclazepam in old and young volunteers

1 reference

12 December 2020

Electron capture GLC analysis of the thienodiazepine clotiazepam. Preliminary pharmacokinetic studies

1 reference

12 December 2020

Normal disposition of oxazepam in acute viral hepatitis and cirrhosis

1 reference

12 December 2020

10.2165/00003088-199121040-00003

Identifiers

DOI

1 reference

PubMed ID

1684744

Dimensions Publication ID

14 August 2017

1010106193

0 references

Fatcat ID

release_gnogkfenofchxb7kicbvorwxo4

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/gnogkfenofchxb7kicbvorwxo4

24 November 2022

mapped directly with Wikidata item

PubMed ID

1684744

1 reference

PubMed ID

1684744