(Q36543087)

14 August 2017

1 reference

title

Role of innate immunity in acetaminophen-induced hepatotoxicity (English)

1 reference

14 August 2017

1 reference

Zhang-Xu Liu

1

1 reference

PubMed ID

16859400

14 August 2017

Neil Kaplowitz

series ordinal

2

1 reference

PubMed ID

16859400

14 August 2017

language of work or name

English

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publication date

1 August 2006

1 reference

Expert Opinion on Drug Metabolism & Toxicology

14 August 2017

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14 August 2017

2

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14 August 2017

4

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14 August 2017

493-503

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Acetaminophen toxicity in an urban county hospital

14 August 2017

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.4.493

Acetaminophen-induced acute liver failure: results of a United States multicenter, prospective study

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.4.493

N-acetyl-p-benzoquinone imine: a cytochrome P-450-mediated oxidation product of acetaminophen

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.4.493

Identification of the hepatic protein targets of reactive metabolites of acetaminophen in vivo in mice using two-dimensional gel electrophoresis and mass spectrometry

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.4.493

The role of oxidant stress and reactive nitrogen species in acetaminophen hepatotoxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.4.493

Role of free radicals in toxic hepatic injury. II. Are free radicals the cause of toxin-induced liver injury?

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.4.493

Selective protein covalent binding and target organ toxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.4.493

Vascular and hepatocellular peroxynitrite formation during acetaminophen toxicity: role of mitochondrial oxidant stress

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.4.493

Intracellular signaling mechanisms of acetaminophen-induced liver cell death

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.4.493

Acetaminophen-induced hepatotoxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.4.493

An important function of Nrf2 in combating oxidative stress: detoxification of acetaminophen

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.4.493

High sensitivity of Nrf2 knockout mice to acetaminophen hepatotoxicity associated with decreased expression of ARE-regulated drug metabolizing enzymes and antioxidant genes

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.4.493

Idiosyncratic drug hepatotoxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.4.493

Keap1 represses nuclear activation of antioxidant responsive elements by Nrf2 through binding to the amino-terminal Neh2 domain

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.4.493

Hepatocyte-specific deletion of the keap1 gene activates Nrf2 and confers potent resistance against acute drug toxicity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.4.493

Innate immune system plays a critical role in determining the progression and severity of acetaminophen hepatotoxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.4.493

Role of inflammation in the mechanism of acetaminophen-induced hepatotoxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.4.493

Role of CCR2 in macrophage migration into the liver during acetaminophen-induced hepatotoxicity in the mouse

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.4.493

Detoxification of reactive oxygen species by a nonpeptidyl mimic of superoxide dismutase cures acetaminophen-induced acute liver failure in the mouse

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.4.493

Hepatoimmunology: a perspective

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.4.493

Role of macrophages and inflammatory mediators in chemically induced toxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.4.493

Protective role of Kupffer cells in acetaminophen-induced hepatic injury in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.4.493

Lipopolysaccharide-binding protein modulates acetaminophen-induced liver injury in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.4.493

Liposome mediated depletion of macrophages: mechanism of action, preparation of liposomes and applications

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.4.493

Acetaminophen toxicity in mice lacking NADPH oxidase activity: role of peroxynitrite formation and mitochondrial oxidant stress

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.4.493

Hepatic T cells and liver tolerance

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.4.493

Regulation and antimetastatic functions of liver-associated natural killer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.4.493

Innate and adaptive lymphoid cells in the human liver

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.4.493

NK cells cause liver injury and facilitate the induction of T cell-mediated immunity to a viral liver infection

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.4.493

Natural killer cells in antiviral defense: function and regulation by innate cytokines

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.4.493

Natural killer cells, viruses and cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.4.493

Mouse CD1-specific NK1 T cells: development, specificity, and function

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.4.493

The regulatory role of Valpha14 NKT cells in innate and acquired immune response.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.4.493

Natural killer T cell activation inhibits hepatitis B virus replication in vivo.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.4.493

Critical contribution of liver natural killer T cells to a murine model of hepatitis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.4.493

A pivotal involvement of IFN-gamma in the pathogenesis of acetaminophen-induced acute liver injury.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.4.493

Reduction of liver Fas expression by an antisense oligonucleotide protects mice from fulminant hepatitis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.4.493

Acetaminophen-induced inhibition of Fas receptor-mediated liver cell apoptosis: mitochondrial dysfunction versus glutathione depletion

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.4.493

Genomic identification of potential risk factors during acetaminophen-induced liver disease in susceptible and resistant strains of mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.4.493

Osteopontin as a mediator of NKT cell function in T cell-mediated liver diseases.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.4.493

Effect of osteopontin alleles on beta-glucan-induced granuloma formation in the mouse liver

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.4.493

Defective IgE production by SJL mice is linked to the absence of CD4+, NK1.1+ T cells that promptly produce interleukin 4

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.4.493

Variation in adenovirus transgene expression between BALB/c and C57BL/6 mice is associated with differences in interleukin-12 and gamma interferon production and NK cell activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.4.493

Neutrophils and immunity: challenges and opportunities

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.4.493

Adenoviral gene therapy leads to rapid induction of multiple chemokines and acute neutrophil-dependent hepatic injury in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.4.493

Neutrophils aggravate acute liver injury during obstructive cholestasis in bile duct-ligated mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.4.493

Essential role for neutrophil recruitment to the liver in concanavalin A-induced hepatitis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.4.493

The hepatic inflammatory response after acetaminophen overdose: role of neutrophils

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.4.493

Neutrophils are essential for early anti-Listeria defense in the liver, but not in the spleen or peritoneal cavity, as revealed by a granulocyte-depleting monoclonal antibody

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.4.493

Neutrophil depletion protects against murine acetaminophen hepatotoxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.4.493

Opposite roles of neutrophils and macrophages in the pathogenesis of acetaminophen-induced acute liver injury.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.4.493

The molecular cell biology of interferon-gamma and its receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.4.493

Reduced hepatotoxicity of acetaminophen in mice lacking inducible nitric oxide synthase: potential role of tumor necrosis factor-alpha and interleukin-10.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.4.493

Acetaminophen hepatotoxicity in tumor necrosis factor/lymphotoxin-alpha gene knockout mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.4.493

Role of tumor necrosis factor receptor 1 (p55) in hepatocyte proliferation during acetaminophen-induced toxicity in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.4.493

Exaggerated hepatotoxicity of acetaminophen in mice lacking tumor necrosis factor receptor-1 Potential role of inflammatory mediators

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.4.493

Shear stress increases expression of a KATP channel in rat and bovine pulmonary vascular endothelial cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.4.493

The pathogenic roles of tumor necrosis factor receptor p55 in acetaminophen-induced liver injury in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.4.493

Initiation of liver growth by tumor necrosis factor: deficient liver regeneration in mice lacking type I tumor necrosis factor receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.4.493

Role of interleukin-6 in hepatic heat shock protein expression and protection against acetaminophen-induced liver disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.4.493

Protection against acetaminophen-induced liver injury and lethality by interleukin 10: role of inducible nitric oxide synthase

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.4.493

Exaggerated hepatic injury due to acetaminophen challenge in mice lacking C-C chemokine receptor 2

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.4.493

IFN-gamma-inducible protein-10 (CXCL10) is hepatoprotective during acute liver injury through the induction of CXCR2 on hepatocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.4.493

Macrophage inflammatory protein-2 gene therapy attenuates adenovirus- and acetaminophen-mediated hepatic injury

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.4.493

Release of chromatin protein HMGB1 by necrotic cells triggers inflammation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.4.493

The nuclear factor HMGB1 mediates hepatic injury after murine liver ischemia-reperfusion

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.4.493

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.4.493

NK cells in innate immunity

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.4.493

Natural killer cell-mediated lysis of hepatoma cells via specific induction of NKG2D ligands by the histone deacetylase inhibitor sodium valproate

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.4.493

Differential expression of Fas (CD95) and Fas ligand on normal human phagocytes: implications for the regulation of apoptosis in neutrophils

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.4.493

Fas ligand induces cell-autonomous NF-kappaB activation and interleukin-8 production by a mechanism distinct from that of tumor necrosis factor-alpha.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.4.493

Calpain released from dying hepatocytes mediates progression of acute liver injury induced by model hepatotoxicants

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.4.493

Deoxyribonuclease 1 aggravates acetaminophen-induced liver necrosis in male CD-1 mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.4.493

Increased resistance to acetaminophen hepatotoxicity in mice lacking glutathione S-transferase Pi.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.4.493

Protective effect of rhIL-11 in a murine model of acetaminophen-induced hepatotoxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.4.493

Macrophage migration inhibitory factor in drug-induced liver injury: a role in susceptibility and stress responsiveness

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.4.493

A protective role for cyclooxygenase-2 in drug-induced liver injury in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.4.493

Subliminal Fas stimulation increases the hepatotoxicity of acetaminophen and bromobenzene in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.4.493

Increased hepatotoxicity of acetaminophen in Hsp70i knockout mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.4.493

Mechanisms for sensitization to TNF-induced apoptosis by acute glutathione depletion in murine hepatocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.4.493

21 January 2018

Identifiers

DOI

10.1517/17425255.2.4.493

1 reference

14 August 2017

1 reference

PubMed ID

16859400