(Q36543763)

English

The four and a half LIM-only protein 2 (FHL2) activates transforming growth factor β (TGF-β) signaling by regulating ubiquitination of the E3 ligase Arkadia.

scientific article published on 4 December 2012

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scholarly article

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19 February 2020

The four and a half LIM-only protein 2 (FHL2) activates transforming growth factor β (TGF-β) signaling by regulating ubiquitination of the E3 ligase Arkadia (English)

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19 February 2020

protein ubiquitination

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inferred from title

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19 February 2020

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Laurence Lévy

2

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19 February 2020

Florence Levillayer

3

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19 February 2020

Baosen Jia

4

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19 February 2020

Gaiyun Li

5

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19 February 2020

Christine Neuveut

6

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19 February 2020

Marie-Annick Buendia

7

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19 February 2020

Ke Lan

8

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19 February 2020

Yu Wei

9

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19 February 2020

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4 December 2012

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19 February 2020

number of pages

10

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Journal of Biological Chemistry

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19 February 2020

288

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19 February 2020

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19 February 2020

1785-1794

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19 February 2020

The predator becomes the prey: regulating the ubiquitin system by ubiquitylation and degradation

1 reference

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30 September 2017

RING domain E3 ubiquitin ligases

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3548488

30 September 2017

Nonproteolytic functions of ubiquitin in cell signaling

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Human four-and-a-half LIM family members suppress tumor cell growth through a TGF-beta-like signaling pathway.

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Nuclear signalling by tumour-associated antigen EpCAM

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Tumor necrosis factor receptor-associated factor 6 is an intranuclear transcriptional coactivator in osteoclasts

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Atypical ubiquitin chains: new molecular signals. 'Protein Modifications: Beyond the Usual Suspects' review series

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30 September 2017

The LIM-only protein FHL2 regulates cyclin D1 expression and cell proliferation.

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30 September 2017

Arkadia activates Smad3/Smad4-dependent transcription by triggering signal-induced SnoN degradation

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30 September 2017

Arkadia induces degradation of SnoN and c-Ski to enhance transforming growth factor-beta signaling

1 reference

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30 September 2017

Arkadia enhances Nodal/TGF-beta signaling by coupling phospho-Smad2/3 activity and turnover

1 reference

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30 September 2017

Genome-scale loss-of-function screening with a lentiviral RNAi library

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30 September 2017

The LIM-only protein FHL2 is a negative regulator of E4F1

1 reference

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30 September 2017

Axin is a scaffold protein in TGF-beta signaling that promotes degradation of Smad7 by Arkadia

1 reference

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30 September 2017

FHL2 inhibits the activated osteoclast in a TRAF6-dependent manner

1 reference

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30 September 2017

Smad4 dependency defines two classes of transforming growth factor {beta} (TGF-{beta}) target genes and distinguishes TGF-{beta}-induced epithelial-mesenchymal transition from its antiproliferative and migratory responses

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30 September 2017

The LIM-only proteins FHL2 and FHL3 interact with alpha- and beta-subunits of the muscle alpha7beta1 integrin receptor

1 reference

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30 September 2017

Extracellular signal-regulated kinase 2 interacts with and is negatively regulated by the LIM-only protein FHL2 in cardiomyocytes

1 reference

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30 September 2017

Arkadia amplifies TGF-beta superfamily signalling through degradation of Smad7

1 reference

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SKI activates Wnt/beta-catenin signaling in human melanoma

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BRCA1 interacts with FHL2 and enhances FHL2 transactivation function

1 reference

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30 September 2017

A proteomics approach to understanding protein ubiquitination

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30 September 2017

The LIM-only protein FHL2 is a serum-inducible transcriptional coactivator of AP-1.

1 reference

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30 September 2017

CAND1 binds to unneddylated CUL1 and regulates the formation of SCF ubiquitin E3 ligase complex

1 reference

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NEDD8 modification of CUL1 dissociates p120(CAND1), an inhibitor of CUL1-SKP1 binding and SCF ligases

1 reference

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Identification of the LIM protein FHL2 as a coactivator of beta-catenin

1 reference

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The LIM-only protein FHL2 interacts with beta-catenin and promotes differentiation of mouse myoblasts

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A family of LIM-only transcriptional coactivators: tissue-specific expression and selective activation of CREB and CREM

1 reference

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30 September 2017

The LIM-only protein DRAL/FHL2 binds to the cytoplasmic domain of several alpha and beta integrin chains and is recruited to adhesion complexes

1 reference

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Degradation of CFTR by the ubiquitin-proteasome pathway

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Lysosomal localization of ubiquitinated Jun requires multiple determinants in a lysine-27-linked polyubiquitin conjugate

1 reference

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Analysis of protein ubiquitination.

1 reference

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21 September 2018

Deficiency in the LIM-only protein FHL2 impairs assembly of extracellular matrix proteins

1 reference

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21 September 2018

Identifiers

10.1074/JBC.M112.439760

1 reference

Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23212909%20AND%20SRC:MED&resulttype=core&format=json

19 February 2020

PMC publication ID

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23212909%20AND%20SRC:MED&resulttype=core&format=json

19 February 2020

PubMed publication ID

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23212909%20AND%20SRC:MED&resulttype=core&format=json

19 February 2020

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