(Q36544885)

14 August 2017

1 reference

title

CYP2E1-dependent oxidative stress and toxicity: role in ethanol-induced liver injury (English)

1 reference

14 August 2017

2

Arthur I Cederbaum

1 reference

14 August 2017

Jose M Jimenez-Lopez

1

1 reference

14 August 2017

language of work or name

English

0 references

publication date

1 December 2005

1 reference

Expert Opinion on Drug Metabolism & Toxicology

14 August 2017

published in

1 reference

14 August 2017

volume

1

1 reference

14 August 2017

issue

4

1 reference

14 August 2017

page(s)

671-685

1 reference

P450 superfamily: update on new sequences, gene mapping, accession numbers and nomenclature.

14 August 2017

cites work

1 reference

https://api.crossref.org/works/10.1517%2F17425255.1.4.671

Common and uncommon cytochrome P450 reactions related to metabolism and chemical toxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.1.4.671

Oxygen and xenobiotic reductase activities of cytochrome P450.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.1.4.671

Molecular recognition in cytochrome P-450: mechanism for the control of uncoupling reactions.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.1.4.671

Generation of superoxide anion as a source of hydrogen peroxide in a reconstituted monooxygenase system

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.1.4.671

Oxygen activation by cytochrome P-450.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.1.4.671

Mechanisms that regulate production of reactive oxygen species by cytochrome P450.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.1.4.671

Free radicals as mediators of tissue injury and disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.1.4.671

Implication of free radical mechanisms in ethanol-induced cellular injury

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.1.4.671

Antioxidant defence mechanisms: from the beginning to the end (of the beginning).

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.1.4.671

Introduction-serial review: alcohol, oxidative stress and cell injury

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.1.4.671

Markedly enhanced cytochrome P450 2E1 induction and lipid peroxidation is associated with severe liver injury in fish oil-ethanol-fed rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.1.4.671

The glutathione precursor L-2-oxothiazolidine-4-carboxylic acid protects against liver injury due to chronic enteral ethanol exposure in the rat.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.1.4.671

Experimental liver cirrhosis induced by alcohol and iron

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.1.4.671

Molecular Basis for the Transport of Cytochrome P450 2E1 to the Plasma Membrane

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.1.4.671

Mitochondrial targeted cytochrome P450 2E1 (P450 MT5) contains an intact N terminus and requires mitochondrial specific electron transfer proteins for activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.1.4.671

Acetone catabolism by cytochrome P450 2E1: studies with CYP2E1-null mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.1.4.671

Bioactivation of halogenated hydrocarbons by cytochrome P4502E1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.1.4.671

Cytochrome P450 2E1: its clinical and toxicological role

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.1.4.671

Assessment of cytochrome P4502E1 induction in alcoholic patients by chlorzoxazone pharmacokinetics.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.1.4.671

Homology modelling of human CYP2E1 based on the CYP2C5 crystal structure: investigation of enzyme-substrate and enzyme-inhibitor interactions

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.1.4.671

Mutagenesis at a highly conserved phenylalanine in cytochrome P450 2E1 affects heme incorporation and catalytic activity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.1.4.671

Analysis of differential substrate selectivities of CYP2B6 and CYP2E1 by site-directed mutagenesis and molecular modeling

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.1.4.671

DNA strand cleavage as a sensitive assay for the production of hydroxyl radicals by microsomes: role of cytochrome P4502E1 in the increased activity after ethanol treatment

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.1.4.671

Role of ethanol-inducible cytochrome P450 (P450IIE1) in catalysing the free radical activation of aliphatic alcohols

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.1.4.671

Reactive free radical generation in vivo in heart and liver of ethanol-fed rats: correlation with radical formation in vitro

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.1.4.671

Mutations in the exons and exon-intron junction regions of human cytochrome P-4502E1 gene and alcoholism

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.1.4.671

Alcohol metabolism: role in toxicity and carcinogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.1.4.671

The induction of a specific form of cytochrome P-450 (P-450j) by fasting

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.1.4.671

Insulin signaling in the transcriptional and posttranscriptional regulation of CYP2E1 expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.1.4.671

Roles of pituitary hormones in the regulation of hepatic cytochrome P450IIE1 in rats and mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.1.4.671

CYP2E1 and CYP4A as microsomal catalysts of lipid peroxides in murine nonalcoholic steatohepatitis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.1.4.671

Multiple mechanisms in the regulation of ethanol-inducible cytochrome P450IIE1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.1.4.671

Ligand-dependent maintenance of ethanol-inducible cytochrome P-450 in primary rat hepatocyte cell cultures

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.1.4.671

Characterization of cytochrome P450 2E1 induction in a rat hepatoma FGC-4 cell model by ethanol

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.1.4.671

Characterization of cytochrome P4502E1 turnover in transfected HepG2 cells expressing human CYP2E1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.1.4.671

Ethanol withdrawal induced CYP2E1 degradation in vivo, blocked by proteasomal inhibitor PS-341.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.1.4.671

Cytochrome P450 2E1 (CYP2E1) is essential for acrylonitrile metabolism to cyanide: comparative studies using CYP2E1-null and wild-type mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.1.4.671

Comparison of the susceptibility of wild-type and CYP2E1 knockout mice to the hepatotoxic and pneumotoxic effects of styrene and styrene oxide

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.1.4.671

Role of mouse CYP2E1 in the O-hydroxylation of p-nitrophenol: comparison of activities in hepatic microsomes from Cyp2e1(-/-) and wild-type mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.1.4.671

The effect of ethanol-induced cytochrome p4502E1 on the inhibition of proteasome activity by alcohol.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.1.4.671

The cyp2e1-humanized transgenic mouse: role of cyp2e1 in acetaminophen hepatotoxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.1.4.671

Role of cytochrome P-450 2E1 in ethanol-, carbon tetrachloride- and iron-dependent microsomal lipid peroxidation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.1.4.671

Inhibition of ethanol-induced liver disease in the intragastric feeding rat model by chlormethiazole

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.1.4.671

Production of a cytochrome P450 2E1 transgenic mouse and initial evaluation of alcoholic liver damage

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.1.4.671

The role of Kupffer cell oxidant production in early ethanol-induced liver disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.1.4.671

Essential role of tumor necrosis factor alpha in alcohol-induced liver injury in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.1.4.671

Cytochrome P450 CYP2E1, but not nicotinamide adenine dinucleotide phosphate oxidase, is required for ethanol-induced oxidative DNA damage in rodent liver

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.1.4.671

Stable expression of human cytochrome P4502E1 in HepG2 cells: characterization of catalytic activities and production of reactive oxygen intermediates

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.1.4.671

Cytotoxicity and apoptosis produced by arachidonic acid in Hep G2 cells overexpressing human cytochrome P4502E1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.1.4.671

Ethanol cytotoxicity to a transfected HepG2 cell line expressing human cytochrome P4502E1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.1.4.671

Removal of glutathione produces apoptosis and necrosis in HepG2 cells overexpressing CYP2E1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.1.4.671

CYP2E1 overexpression in HepG2 cells induces glutathione synthesis by transcriptional activation of gamma-glutamylcysteine synthetase.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.1.4.671

Cytochrome P450 2E1 responsiveness in the promoter of glutamate-cysteine ligase catalytic subunit

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.1.4.671

Induction of catalase, alpha, and microsomal glutathione S-transferase in CYP2E1 overexpressing HepG2 cells and protection against short-term oxidative stress.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.1.4.671

Adenovirus-mediated overexpression of catalase in the cytosolic or mitochondrial compartment protects against toxicity caused by glutathione depletion in HepG2 cells expressing CYP2E1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.1.4.671

Spin trapping agents (Tempol and POBN) protect HepG2 cells overexpressing CYP2E1 against arachidonic acid toxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.1.4.671

Adenovirus-mediated overexpression of catalase in the cytosolic or mitochondrial compartment protects against cytochrome P450 2E1-dependent toxicity in HepG2 cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.1.4.671

Cyclosporine A protects against arachidonic acid toxicity in rat hepatocytes: role of CYP2E1 and mitochondria

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.1.4.671

Diallyl sulfide induces heme oxygenase-1 through MAPK pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.1.4.671

Inhibition of CYP2E1 catalytic activity in vitro by S-adenosyl-L-methionine

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.1.4.671

CYP2E1-mediated mechanism of anti-genotoxicity of the broccoli constituent sulforaphane.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.1.4.671

Inactivation of cytochrome P450 3A4 by bergamottin, a component of grapefruit juice

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.1.4.671

Inhibition of CYP2E1 with natural agents may be a feasible strategy for minimizing the hepatotoxicity of ethanol

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.1.4.671

Peptidase activities of the multicatalytic protease in rat liver after voluntary and intragastric ethanol administration

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.1.4.671

Proteasome-dependent degradation of cytochromes P450 2E1 and 2B1 expressed in tetracycline-regulated HeLa cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.1.4.671

Increased prooxidant production and enhanced susceptibility to glutathione depletion in HepG2 cells co-expressing HCV core protein and CYP2E1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.1.4.671

21 January 2018

Identifiers

DOI

10.1517/17425255.1.4.671

1 reference

14 August 2017

1 reference