(Q36557541)

English

Eukaryotic initiation factor 2B and its role in alterations in mRNA translation that occur under a number of pathophysiological and physiological conditions

scientific article published on January 2006

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scholarly article

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Europe PubMed Central

PubMed publication ID

14 August 2017

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Europe PubMed Central

Eukaryotic initiation factor 2B and its role in alterations in mRNA translation that occur under a number of pathophysiological and physiological conditions (English)

1 reference

Europe PubMed Central

PubMed publication ID

14 August 2017

pathophysiology

1 reference

based on heuristic

inferred from title

author name string

Neil Kubica

1

1 reference

Europe PubMed Central

PubMed publication ID

14 August 2017

Leonard S Jefferson

2

1 reference

Europe PubMed Central

PubMed publication ID

14 August 2017

Scot R Kimball

3

1 reference

Europe PubMed Central

PubMed publication ID

14 August 2017

publication date

1 January 2006

1 reference

Europe PubMed Central

PubMed publication ID

14 August 2017

Progress in Molecular Biology and Translational Science

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Europe PubMed Central

PubMed publication ID

14 August 2017

81

1 reference

Europe PubMed Central

PubMed publication ID

14 August 2017

271-296

1 reference

Europe PubMed Central

PubMed publication ID

14 August 2017

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Characterization of a mammalian homolog of the GCN2 eukaryotic initiation factor 2alpha kinase

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eIF2 and the control of cell physiology

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Translational control of GCN4: an in vivo barometer of initiation-factor activity

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Regulation of polypeptide-chain initiation in rat skeletal muscle. Starvation does not alter the activity or phosphorylation state of initiation factor eIF-2

1 reference

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Effect of starvation and diabetes on the activity of the eukaryotic initiation factor eIF-2 in rat skeletal muscle

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6603%2806%2981007-X

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Effect of diabetes on guanine nucleotide exchange factor activity in skeletal muscle and heart

1 reference

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Regulation of protein synthesis in Swiss 3T3 fibroblasts. Rapid activation of the guanine-nucleotide-exchange factor by insulin and growth factors

1 reference

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7 January 2021

based on heuristic

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Evidence that the dephosphorylation of Ser(535) in the epsilon-subunit of eukaryotic initiation factor (eIF) 2B is insufficient for the activation of eIF2B by insulin

1 reference

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7 January 2021

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Regulation of eukaryotic initiation factor eIF2B: glycogen synthase kinase-3 phosphorylates a conserved serine which undergoes dephosphorylation in response to insulin

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6603%2806%2981007-X

7 January 2021

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The kinase DYRK phosphorylates protein-synthesis initiation factor eIF2Bepsilon at Ser539 and the microtubule-associated protein tau at Thr212: potential role for DYRK as a glycogen synthase kinase 3-priming kinase

1 reference

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7 January 2021

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The association of NADPH with the guanine nucleotide exchange factor from rabbit reticulocytes: a role of pyridine dinucleotides in eukaryotic polypeptide chain initiation

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6603%2806%2981007-X

7 January 2021

based on heuristic

inferred from DOI database lookup

Role of translation initiation factor eIF-2B in the regulation of protein synthesis in mammalian cells

1 reference

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The distribution of hepatic metabolites and the control of the pathways of carbohydrate metabolism in animals of different dietary and hormonal status.

1 reference

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Translation factors: in sickness and in health

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6603%2806%2981007-X

7 January 2021

based on heuristic

inferred from DOI database lookup

Homologous segments in three subunits of the guanine nucleotide exchange factor eIF2B mediate translational regulation by phosphorylation of eIF2.

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6603%2806%2981007-X

7 January 2021

based on heuristic

inferred from DOI database lookup

eIF2 independently binds two distinct eIF2B subcomplexes that catalyze and regulate guanine-nucleotide exchange.

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6603%2806%2981007-X

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Subunit assembly and guanine nucleotide exchange activity of eukaryotic initiation factor-2B expressed in Sf9 cells

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The alpha-subunit of the mammalian guanine nucleotide-exchange factor eIF-2B is essential for catalytic activity in vitro

1 reference

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inferred from DOI database lookup

Characterization of the initiation factor eIF2B and its regulation in Drosophila melanogaster

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7 January 2021

based on heuristic

inferred from DOI database lookup

Characterization of the minimal catalytic domain within eIF2B: the guanine-nucleotide exchange factor for translation initiation

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6603%2806%2981007-X

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based on heuristic

inferred from DOI database lookup

Identification of domains within the epsilon-subunit of the translation initiation factor eIF2B that are necessary for guanine nucleotide exchange activity and eIF2B holoprotein formation

1 reference

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based on heuristic

inferred from DOI database lookup

Structure of the catalytic fragment of translation initiation factor 2B and identification of a critically important catalytic residue

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inferred from DOI database lookup

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1 reference

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inferred from DOI database lookup

Identification of interprotein interactions between the subunits of eukaryotic initiation factors eIF2 and eIF2B

1 reference

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based on heuristic

inferred from DOI database lookup

Conserved bipartite motifs in yeast eIF5 and eIF2Bepsilon, GTPase-activating and GDP-GTP exchange factors in translation initiation, mediate binding to their common substrate eIF2.

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The antidiabetic action of insulin on nitrogen metabolism

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inferred from DOI database lookup

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1 reference

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1 reference

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inferred from DOI database lookup

An Effect of Insulin on Peptide Synthesis independent of Glucose or Amino-Acid Transport

1 reference

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based on heuristic

inferred from DOI database lookup

Protein synthesis by heart muscle ribosomes: an effect of insulin independent of substrate transport

1 reference

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based on heuristic

inferred from DOI database lookup

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1 reference

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based on heuristic

inferred from DOI database lookup

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1 reference

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based on heuristic

inferred from DOI database lookup

The effect of diabetes and insulin on the polyadenylic acid-containing RNA of rat skeletal muscle

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6603%2806%2981007-X

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based on heuristic

inferred from DOI database lookup

The relation of RNA and protein synthesis to the sedimentation of muscle ribosomes: effect of diabetes and insulin

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6603%2806%2981007-X

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based on heuristic

inferred from DOI database lookup

Tissue-specific regulation of protein synthesis by insulin and free fatty acids

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6603%2806%2981007-X

7 January 2021

based on heuristic

inferred from DOI database lookup

Glycogen synthase kinase-3 is rapidly inactivated in response to insulin and phosphorylates eukaryotic initiation factor eIF-2B.

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6603%2806%2981007-X

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based on heuristic

inferred from DOI database lookup

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1 reference

https://api.crossref.org/works/10.1016%2FS0079-6603%2806%2981007-X

7 January 2021

based on heuristic

inferred from DOI database lookup

Inactivation of glycogen synthase kinase-3 beta by phosphorylation: new kinase connections in insulin and growth-factor signalling

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6603%2806%2981007-X

7 January 2021

based on heuristic

inferred from DOI database lookup

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1 reference

https://api.crossref.org/works/10.1016%2FS0079-6603%2806%2981007-X

7 January 2021

based on heuristic

inferred from DOI database lookup

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1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

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1 reference

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based on heuristic

inferred from DOI database lookup

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1 reference

https://api.crossref.org/works/10.1016%2FS0079-6603%2806%2981007-X

7 January 2021

based on heuristic

inferred from DOI database lookup

Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase B

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6603%2806%2981007-X

7 January 2021

based on heuristic

inferred from DOI database lookup

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1 reference

https://api.crossref.org/works/10.1016%2FS0079-6603%2806%2981007-X

7 January 2021

based on heuristic

inferred from DOI database lookup

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1 reference

https://api.crossref.org/works/10.1016%2FS0079-6603%2806%2981007-X

7 January 2021

based on heuristic

inferred from DOI database lookup

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1 reference

https://api.crossref.org/works/10.1016%2FS0079-6603%2806%2981007-X

7 January 2021

based on heuristic

inferred from DOI database lookup

Activation of translation initiation factor eIF2B by insulin requires phosphatidyl inositol 3-kinase

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6603%2806%2981007-X

7 January 2021

based on heuristic

inferred from DOI database lookup

Glycogen synthase kinase-3 is the predominant insulin-regulated eukaryotic initiation factor 2B kinase in skeletal muscle.

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6603%2806%2981007-X

7 January 2021

based on heuristic

inferred from DOI database lookup

Signaling pathways: the benefits of good communication

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

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1 reference

https://api.crossref.org/works/10.1016%2FS0079-6603%2806%2981007-X

7 January 2021

based on heuristic

inferred from DOI database lookup

The TSC1-2 tumor suppressor controls insulin-PI3K signaling via regulation of IRS proteins

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6603%2806%2981007-X

7 January 2021

based on heuristic

inferred from DOI database lookup

Phosphorylation of insulin receptor substrate-1 on multiple serine residues, 612, 632, 662, and 731, modulates insulin action

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6603%2806%2981007-X

7 January 2021

based on heuristic

inferred from DOI database lookup

Regulation of insulin/insulin-like growth factor-1 signaling by proteasome-mediated degradation of insulin receptor substrate-2.

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6603%2806%2981007-X

7 January 2021

based on heuristic

inferred from DOI database lookup

Absence of S6K1 protects against age- and diet-induced obesity while enhancing insulin sensitivity

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6603%2806%2981007-X

7 January 2021

based on heuristic

inferred from DOI database lookup

Effects of intensity of acute-resistance exercise on rates of protein synthesis in moderately diabetic rats.

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6603%2806%2981007-X

7 January 2021

based on heuristic

inferred from DOI database lookup

Severe diabetes prohibits elevations in muscle protein synthesis after acute resistance exercise in rats

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6603%2806%2981007-X

7 January 2021

based on heuristic

inferred from DOI database lookup

Severe diabetes inhibits resistance exercise-induced increase in eukaryotic initiation factor 2B activity

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6603%2806%2981007-X

7 January 2021

based on heuristic

inferred from DOI database lookup

Resistance exercise increases muscle protein synthesis and translation of eukaryotic initiation factor 2Bepsilon mRNA in a mammalian target of rapamycin-dependent manner

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6603%2806%2981007-X

7 January 2021

based on heuristic

inferred from DOI database lookup

Eukaryotic initiation factors and protein synthesis after resistance exercise in rats.

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6603%2806%2981007-X

7 January 2021

based on heuristic

inferred from DOI database lookup

Insulin and exercise decrease glycogen synthase kinase-3 activity by different mechanisms in rat skeletal muscle

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6603%2806%2981007-X

7 January 2021

based on heuristic

inferred from DOI database lookup

Immediate response of mammalian target of rapamycin (mTOR)-mediated signalling following acute resistance exercise in rat skeletal muscle

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6603%2806%2981007-X

7 January 2021

based on heuristic

inferred from DOI database lookup

Selective activation of AMPK-PGC-1alpha or PKB-TSC2-mTOR signaling can explain specific adaptive responses to endurance or resistance training-like electrical muscle stimulation

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6603%2806%2981007-X

7 January 2021

based on heuristic

inferred from DOI database lookup

Alterations in the expression of mRNAs and proteins that code for species relevant to eIF2B activity after an acute bout of resistance exercise

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6603%2806%2981007-X

7 January 2021

based on heuristic

inferred from DOI database lookup

Time course evaluation of protein synthesis and glucose uptake after acute resistance exercise in rats.

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6603%2806%2981007-X

7 January 2021

based on heuristic

inferred from DOI database lookup

Intracellular signaling specificity in skeletal muscle in response to different modes of exercise

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6603%2806%2981007-X

7 January 2021

based on heuristic

inferred from DOI database lookup

Akt/mTOR pathway is a crucial regulator of skeletal muscle hypertrophy and can prevent muscle atrophy in vivo

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6603%2806%2981007-X

7 January 2021

based on heuristic

inferred from DOI database lookup

A protein kinase B-dependent and rapamycin-sensitive pathway controls skeletal muscle growth but not fiber type specification

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6603%2806%2981007-X

7 January 2021

based on heuristic

inferred from DOI database lookup

Conditional activation of akt in adult skeletal muscle induces rapid hypertrophy

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6603%2806%2981007-X

7 January 2021

based on heuristic

inferred from DOI database lookup

Identification of domains and residues within the epsilon subunit of eukaryotic translation initiation factor 2B (eIF2Bepsilon) required for guanine nucleotide exchange reveals a novel activation function promoted by eIF2B complex formation

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6603%2806%2981007-X

7 January 2021

based on heuristic

inferred from DOI database lookup

Phosphorylation of eukaryotic translation initiation factor 2Bepsilon by glycogen synthase kinase-3beta regulates beta-adrenergic cardiac myocyte hypertrophy.

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6603%2806%2981007-X

7 January 2021

based on heuristic

inferred from DOI database lookup

Does the ribosome translate cancer?

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6603%2806%2981007-X

7 January 2021

based on heuristic

inferred from DOI database lookup

Malignant transformation by a eukaryotic initiation factor subunit that binds to mRNA 5' cap

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6603%2806%2981007-X

7 January 2021

based on heuristic

inferred from DOI database lookup

eIF-4E expression and its role in malignancies and metastases.

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6603%2806%2981007-X

7 January 2021

based on heuristic

inferred from DOI database lookup

The translation factor eIF-4E promotes tumor formation and cooperates with c-Myc in lymphomagenesis

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6603%2806%2981007-X

7 January 2021

based on heuristic

inferred from DOI database lookup

Human breast cancer cells contain elevated levels and activity of the protein kinase, PKR.

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6603%2806%2981007-X

7 January 2021

based on heuristic

inferred from DOI database lookup

Defective translational control facilitates vesicular stomatitis virus oncolysis

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6603%2806%2981007-X

7 January 2021

based on heuristic

inferred from DOI database lookup

Initiation factor eIF2B not p70 S6 kinase is involved in the activation of the PI‐3K signalling pathway induced by the v‐src oncogene

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6603%2806%2981007-X

7 January 2021

based on heuristic

inferred from DOI database lookup

The lipid phosphatase activity of PTEN is critical for its tumor supressor function

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6603%2806%2981007-X

7 January 2021

based on heuristic

inferred from DOI database lookup

The tumor suppressor, PTEN/MMAC1, dephosphorylates the lipid second messenger, phosphatidylinositol 3,4,5-trisphosphate

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6603%2806%2981007-X

7 January 2021

based on heuristic

inferred from DOI database lookup

New insights into tumor suppression: PTEN suppresses tumor formation by restraining the phosphoinositide 3-kinase/AKT pathway

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6603%2806%2981007-X

7 January 2021

based on heuristic

inferred from DOI database lookup

PTEN, a putative protein tyrosine phosphatase gene mutated in human brain, breast, and prostate cancer

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6603%2806%2981007-X

7 January 2021

based on heuristic

inferred from DOI database lookup

Germline mutations of the PTEN gene in Cowden disease, an inherited breast and thyroid cancer syndrome

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6603%2806%2981007-X

7 January 2021

based on heuristic

inferred from DOI database lookup

Feedback inhibition of Akt signaling limits the growth of tumors lacking Tsc2

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6603%2806%2981007-X

7 January 2021

based on heuristic

inferred from DOI database lookup

Pathogenetic mechanisms of septic shock

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6603%2806%2981007-X

7 January 2021

based on heuristic

inferred from DOI database lookup

The pathophysiology and treatment of sepsis

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6603%2806%2981007-X

7 January 2021

based on heuristic

inferred from DOI database lookup

Inhibition of Skeletal Muscle Protein Synthesis in Septic Intra-abdominal Abscess

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6603%2806%2981007-X

7 January 2021

based on heuristic

inferred from DOI database lookup

Sepsis-induced changes in protein synthesis: differential effects on fast- and slow-twitch muscles

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6603%2806%2981007-X

7 January 2021

based on heuristic

inferred from DOI database lookup

Magnetic resonance imaging in classification of congenital muscular dystrophies with brain abnormalities.

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6603%2806%2981007-X

7 January 2021

based on heuristic

inferred from DOI database lookup

Phenotypic variation in leukoencephalopathy with vanishing white matter

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6603%2806%2981007-X

7 January 2021

based on heuristic

inferred from DOI database lookup

The gene for leukoencephalopathy with vanishing white matter is located on chromosome 3q27

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6603%2806%2981007-X

7 January 2021

based on heuristic

inferred from DOI database lookup

Subunits of the translation initiation factor eIF2B are mutant in leukoencephalopathy with vanishing white matter

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6603%2806%2981007-X

7 January 2021

based on heuristic

inferred from DOI database lookup

Magnetic resonance in childhood white-matter disorders

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6603%2806%2981007-X

7 January 2021

based on heuristic

inferred from DOI database lookup

The large spectrum of eIF2B-related diseases

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6603%2806%2981007-X

7 January 2021

based on heuristic

inferred from DOI database lookup

A severe variant of childhood ataxia with central hypomyelination/vanishing white matter leukoencephalopathy related to EIF21B5 mutation

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6603%2806%2981007-X

7 January 2021

based on heuristic

inferred from DOI database lookup

Cree leukoencephalopathy and CACH/VWM disease are allelic at the EIF2B5 locus

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6603%2806%2981007-X

7 January 2021

based on heuristic

inferred from DOI database lookup

Mutations causing childhood ataxia with central nervous system hypomyelination reduce eukaryotic initiation factor 2B complex formation and activity

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6603%2806%2981007-X

7 January 2021

based on heuristic

inferred from DOI database lookup

Mutations linked to leukoencephalopathy with vanishing white matter impair the function of the eukaryotic initiation factor 2B complex in diverse ways

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6603%2806%2981007-X

7 January 2021

based on heuristic

inferred from DOI database lookup

Decreased guanine nucleotide exchange factor activity in eIF2B-mutated patients

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6603%2806%2981007-X

7 January 2021

based on heuristic

inferred from DOI database lookup

Regulated translation initiation controls stress-induced gene expression in mammalian cells

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6603%2806%2981007-X

7 January 2021

based on heuristic

inferred from DOI database lookup

Heightened stress response in primary fibroblasts expressing mutant eIF2B genes from CACH/VWM leukodystrophy patients

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6603%2806%2981007-X

7 January 2021

based on heuristic

inferred from DOI database lookup

The unfolded protein response in vanishing white matter disease.

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6603%2806%2981007-X

7 January 2021

based on heuristic

inferred from DOI database lookup

Developmental changes of eukaryotic initiation factor 2B subunits in rat hippocampus

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6603%2806%2981007-X

7 January 2021

based on heuristic

inferred from DOI database lookup

EIF2B5 mutations compromise GFAP+ astrocyte generation in vanishing white matter leukodystrophy

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6603%2806%2981007-X

7 January 2021

based on heuristic

inferred from DOI database lookup

Identifiers

10.1016/S0079-6603(06)81007-X

1 reference

Europe PubMed Central

PubMed publication ID

14 August 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

14 August 2017

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