(Q36562466)

English

A contrast in safety, pharmacokinetics and pharmacodynamics across age groups after a single 50 mg oral dose of the γ-secretase inhibitor avagacestat

scientific article published on January 2013

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scholarly article

1 reference

Europe PubMed Central

PMC publication ID

14 August 2017

A contrast in safety, pharmacokinetics and pharmacodynamics across age groups after a single 50 mg oral dose of the γ-secretase inhibitor avagacestat (English)

1 reference

Europe PubMed Central

PMC publication ID

14 August 2017

pharmacokinetics

1 reference

based on heuristic

inferred from title

pharmacodynamics

1 reference

based on heuristic

inferred from title

author name string

Gary Tong

1

1 reference

Europe PubMed Central

PMC publication ID

14 August 2017

Jun-Sheng Wang

2

1 reference

Europe PubMed Central

PMC publication ID

14 August 2017

Oleksandr Sverdlov

3

1 reference

Europe PubMed Central

PMC publication ID

14 August 2017

Shu-Pang Huang

4

1 reference

Europe PubMed Central

PMC publication ID

14 August 2017

Randy Slemmon

5

1 reference

Europe PubMed Central

PMC publication ID

14 August 2017

Robert Croop

6

1 reference

Europe PubMed Central

PMC publication ID

14 August 2017

Lorna Castaneda

7

1 reference

Europe PubMed Central

PMC publication ID

14 August 2017

Huidong Gu

8

1 reference

Europe PubMed Central

PMC publication ID

14 August 2017

Oi Wong

9

1 reference

Europe PubMed Central

PMC publication ID

14 August 2017

Hewei Li

10

1 reference

Europe PubMed Central

PMC publication ID

14 August 2017

Robert M Berman

11

1 reference

Europe PubMed Central

PMC publication ID

14 August 2017

Christina Smith

12

1 reference

Europe PubMed Central

PMC publication ID

14 August 2017

Charles F Albright

13

1 reference

Europe PubMed Central

PMC publication ID

14 August 2017

Randy Dockens

14

1 reference

Europe PubMed Central

PMC publication ID

14 August 2017

language of work or name

0 references

publication date

1 January 2013

1 reference

Europe PubMed Central

PMC publication ID

14 August 2017

British Journal of Clinical Pharmacology

1 reference

Europe PubMed Central

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14 August 2017

75

1 reference

Europe PubMed Central

PMC publication ID

14 August 2017

1

1 reference

Europe PubMed Central

PMC publication ID

14 August 2017

136-145

1 reference

Europe PubMed Central

PMC publication ID

14 August 2017

Guide to Receptors and Channels (GRAC), 5th edition

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3555053

30 September 2017

Decreased clearance of CNS beta-amyloid in Alzheimer's disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3555053

30 September 2017

Comparison of conventional ELISA with electrochemiluminescence technology for detection of amyloid-β in plasma

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3555053

30 September 2017

Begacestat (GSI-953): a novel, selective thiophene sulfonamide inhibitor of amyloid precursor protein gamma-secretase for the treatment of Alzheimer's disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3555053

30 September 2017

Recent developments in Alzheimer's disease therapeutics

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3555053

30 September 2017

The amyloid-beta rise and gamma-secretase inhibitor potency depend on the level of substrate expression

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3555053

30 September 2017

Trefoil factors: initiators of mucosal healing

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3555053

30 September 2017

The Notch ligands, Jagged and Delta, are sequentially processed by alpha-secretase and presenilin/gamma-secretase and release signaling fragments

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3555053

30 September 2017

Analysis of Relative Gene Expression Data Using Real-Time Quantitative PCR and the 2−ΔΔCT Method

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3555053

30 September 2017

Pathologic correlates of nondemented aging, mild cognitive impairment, and early-stage Alzheimer's disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3555053

30 September 2017

Mild cognitive impairment: clinical characterization and outcome

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3555053

30 September 2017

Stool form scale as a useful guide to intestinal transit time

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3555053

30 September 2017

Clinical diagnosis of Alzheimer's disease: report of the NINCDS-ADRDA Work Group under the auspices of Department of Health and Human Services Task Force on Alzheimer's Disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3555053

30 September 2017

Long-term efficacy and safety of donepezil in the treatment of Alzheimer's disease: final analysis of a US multicentre open-label study

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3555053

28 June 2018

VBM anticipates the rate of progression of Alzheimer disease: a 3-year longitudinal study

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2125.2012.04339.X

21 January 2018

Development and validation of sensitive and selective LC-MS/MS methods for the determination of BMS-708163, a gamma-secretase inhibitor, in plasma and cerebrospinal fluid using deprotonated or formate adduct ions as precursor ions

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2125.2012.04339.X

21 January 2018

The application of statistical moment theory to the evaluation of in vivo dissolution time and absorption time.

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2125.2012.04339.X

21 January 2018

Identification of Notch target genes in uncommitted T-cell progenitors: No direct induction of a T-cell specific gene program

1 reference

https://pubmed.ncbi.nlm.nih.gov/22616739

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Multicenter, randomized, double-blind, placebo-controlled, single-ascending dose study of the oral γ-secretase inhibitor BMS-708163 (Avagacestat): tolerability profile, pharmacokinetic parameters, and pharmacodynamic markers

1 reference

https://pubmed.ncbi.nlm.nih.gov/22616739

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1111/J.1365-2125.2012.04339.X

1 reference

Europe PubMed Central

PMC publication ID

14 August 2017

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

14 August 2017

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

14 August 2017

ResearchGate publication ID

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