(Q36565653)

15 August 2017

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title

Anti-ALS activity of alsin, the product of the ALS2 gene, and activity-dependent neurotrophic factor (English)

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amyotrophic lateral sclerosis

15 August 2017

main subject

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1

Masaaki Matsuoka

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15 August 2017

Ikuo Nishimoto

2

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15 August 2017

publication date

1 January 2005

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Neurodegenerative Diseases

15 August 2017

published in

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15 August 2017

volume

2

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15 August 2017

issue

3-4

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15 August 2017

page(s)

135-138

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Mutations in Cu/Zn superoxide dismutase gene are associated with familial amyotrophic lateral sclerosis

15 August 2017

cites work

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Molecular and cellular pathways of neurodegeneration in motor neurone disease

21 January 2018

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A gene encoding a putative GTPase regulator is mutated in familial amyotrophic lateral sclerosis 2

21 January 2018

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The gene encoding alsin, a protein with three guanine-nucleotide exchange factor domains, is mutated in a form of recessive amyotrophic lateral sclerosis

21 January 2018

1 reference

ALS2, a novel guanine nucleotide exchange factor for the small GTPase Rab5, is implicated in endosomal dynamics

21 January 2018

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Homo-oligomerization of ALS2 through its unique carboxyl-terminal regions is essential for the ALS2-associated Rab5 guanine nucleotide exchange activity and its regulatory function on endosome trafficking

21 January 2018

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Alsin, the product of ALS2 gene, suppresses SOD1 mutant neurotoxicity through RhoGEF domain by interacting with SOD1 mutants

21 January 2018

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Alsin is a Rab5 and Rac1 guanine nucleotide exchange factor

21 January 2018

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A Rac1/phosphatidylinositol 3-kinase/Akt3 anti-apoptotic pathway, triggered by AlsinLF, the product of the ALS2 gene, antagonizes Cu/Zn-superoxide dismutase (SOD1) mutant-induced motoneuronal cell death

21 January 2018

1 reference

Neuroprotective effect of activity-dependent neurotrophic factor against toxicity from familial amyotrophic lateral sclerosis-linked mutant SOD1 in vitro and in vivo.

21 January 2018

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Treatment of motoneuron degeneration by intracerebroventricular delivery of VEGF in a rat model of ALS.

21 January 2018

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VEGF delivery with retrogradely transported lentivector prolongs survival in a mouse ALS model

21 January 2018

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Retrograde viral delivery of IGF-1 prolongs survival in a mouse ALS model.

21 January 2018

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Minocycline inhibits cytochrome c release and delays progression of amyotrophic lateral sclerosis in mice

21 January 2018

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Treatment with arimoclomol, a coinducer of heat shock proteins, delays disease progression in ALS mice

21 January 2018

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AnALS2gene mutation causes hereditary spastic paraplegia in a Pakistani kindred

21 January 2018

1 reference

21 January 2018

Identifiers

DOI

10.1159/000089618

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15 August 2017

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