(Q40484912)

English

A Rac1/phosphatidylinositol 3-kinase/Akt3 anti-apoptotic pathway, triggered by AlsinLF, the product of the ALS2 gene, antagonizes Cu/Zn-superoxide dismutase (SOD1) mutant-induced motoneuronal cell death

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scholarly article

1 reference

Europe PubMed Central

20 September 2017

A Rac1/phosphatidylinositol 3-kinase/Akt3 anti-apoptotic pathway, triggered by AlsinLF, the product of the ALS2 gene, antagonizes Cu/Zn-superoxide dismutase (SOD1) mutant-induced motoneuronal cell death (English)

1 reference

Europe PubMed Central

20 September 2017

apoptotic process

0 references

Alsin Rho guanine nucleotide exchange factor ALS2

1 reference

GOA release 2020-03-11

small GTPase binding

1 reference

GOA release 2020-03-11

Masaaki Matsuoka

7

object named as

Masaaki Matsuoka

1 reference

Europe PubMed Central

20 September 2017

author name string

Kohsuke Kanekura

1

1 reference

Europe PubMed Central

20 September 2017

Yuichi Hashimoto

2

1 reference

Europe PubMed Central

20 September 2017

Yoshiko Kita

3

1 reference

Europe PubMed Central

20 September 2017

Jumpei Sasabe

4

1 reference

Europe PubMed Central

20 September 2017

Sadakazu Aiso

5

1 reference

Europe PubMed Central

20 September 2017

Ikuo Nishimoto

6

1 reference

Europe PubMed Central

20 September 2017

language of work or name

0 references

publication date

3 December 2004

1 reference

Europe PubMed Central

20 September 2017

Journal of Biological Chemistry

1 reference

Europe PubMed Central

20 September 2017

280

1 reference

Europe PubMed Central

20 September 2017

6

1 reference

Europe PubMed Central

20 September 2017

4532-4543

1 reference

Europe PubMed Central

20 September 2017

Mutations in Cu/Zn superoxide dismutase gene are associated with familial amyotrophic lateral sclerosis

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M410508200

21 January 2018

Motor neuron degeneration in mice that express a human Cu,Zn superoxide dismutase mutation

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M410508200

21 January 2018

A gene encoding a putative GTPase regulator is mutated in familial amyotrophic lateral sclerosis 2

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M410508200

21 January 2018

The gene encoding alsin, a protein with three guanine-nucleotide exchange factor domains, is mutated in a form of recessive amyotrophic lateral sclerosis

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M410508200

21 January 2018

Infantile-onset ascending hereditary spastic paralysis is associated with mutations in the alsin gene

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M410508200

21 January 2018

Infantile ascending hereditary spastic paralysis (IAHSP): clinical features in 11 families

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M410508200

21 January 2018

AnALS2gene mutation causes hereditary spastic paraplegia in a Pakistani kindred

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M410508200

21 January 2018

The first nonsense mutation in alsin results in a homogeneous phenotype of infantile-onset ascending spastic paralysis with bulbar involvement in two siblings

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M410508200

21 January 2018

Alsin, the product of ALS2 gene, suppresses SOD1 mutant neurotoxicity through RhoGEF domain by interacting with SOD1 mutants

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M410508200

21 January 2018

Rho signals to cell growth and apoptosis

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M410508200

21 January 2018

Rho family proteins modulate rapid apoptosis induced by cytotoxic T lymphocytes and Fas.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M410508200

21 January 2018

Apoptosis induced by Rac GTPase correlates with induction of FasL and ceramides production

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M410508200

21 January 2018

Anti-apoptotic function of Rac in hematopoietic cells.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M410508200

21 January 2018

Activation of the RacGTPase inhibits apoptosis in human tumor cells

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M410508200

21 January 2018

Rac1 inhibits TNF-alpha-induced endothelial cell apoptosis: dual regulation by reactive oxygen species

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M410508200

21 January 2018

Rac1 and RhoG promote cell survival by the activation of PI3K and Akt, independently of their ability to stimulate JNK and NF-kappaB

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M410508200

21 January 2018

Rac1 inhibits apoptosis in human lymphoma cells by stimulating Bad phosphorylation on Ser-75.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M410508200

21 January 2018

Alsin is a Rab5 and Rac1 guanine nucleotide exchange factor

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M410508200

21 January 2018

A DNA vector-based RNAi technology to suppress gene expression in mammalian cells

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M410508200

21 January 2018

Neuroblastoma x spinal cord (NSC) hybrid cell lines resemble developing motor neurons

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M410508200

21 January 2018

Deletion of the hypoxia-response element in the vascular endothelial growth factor promoter causes motor neuron degeneration.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M410508200

21 January 2018

VEGF-induced activation of the PI3-K/Akt pathway reduces mutant SOD1-mediated motor neuron cell death.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M410508200

21 January 2018

Structure and mutagenesis of the Dbl homology domain

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M410508200

21 January 2018

Identification of Rho GTPase-dependent sites in the Dbl homology domain of oncogenic Dbl that are required for transformation

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M410508200

21 January 2018

Structural basis for the signaling specificity of RhoG and Rac1 GTPases

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M410508200

21 January 2018

Mechanisms of guanine nucleotide exchange and Rac-mediated signaling revealed by a dominant negative trio mutant

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M410508200

21 January 2018

Analysis of G-protein-coupled receptor dimerization following chemokine signaling

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M410508200

21 January 2018

Determination of GTP loading on Rho

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M410508200

21 January 2018

Involvement of NADPH oxidase-mediated generation of reactive oxygen species in the apototic cell death by capsaicin in HepG2 human hepatoma cells

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M410508200

21 January 2018

Assays for Akt.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M410508200

21 January 2018

Retrograde viral delivery of IGF-1 prolongs survival in a mouse ALS model.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M410508200

21 January 2018

Adenovirus-mediated gene transfer of glial cell line-derived neurotrophic factor prevents motor neuron loss of transgenic model mice for amyotrophic lateral sclerosis

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M410508200

21 January 2018

VEGF delivery with retrogradely transported lentivector prolongs survival in a mouse ALS model.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M410508200

21 January 2018

The protein kinase B/Akt signalling pathway in human malignancy

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M410508200

21 January 2018

PI3K/Akt and apoptosis: size matters

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M410508200

21 January 2018

Identification of a PKB/Akt hydrophobic motif Ser-473 kinase as DNA-dependent protein kinase

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M410508200

21 January 2018

Akt, a pleckstrin homology domain containing kinase, is activated primarily by phosphorylation

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M410508200

21 January 2018

Rho-regulated signals induce apoptosis in vitro and in vivo by a p53-independent, but Bcl2 dependent pathway.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M410508200

21 January 2018

Guanine nucleotide exchange factors regulate specificity of downstream signaling from Rac and Cdc42.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M410508200

21 January 2018

Rac activation induces NADPH oxidase activity in transgenic COSphox cells, and the level of superoxide production is exchange factor-dependent.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M410508200

21 January 2018

Cell migration: Rho GTPases lead the way

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M410508200

21 January 2018

Growth retardation and increased apoptosis in mice with homozygous disruption of the Akt1 gene

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M410508200

21 January 2018

Akt1/PKBalpha is required for normal growth but dispensable for maintenance of glucose homeostasis in mice

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M410508200

21 January 2018

Insulin resistance and a diabetes mellitus-like syndrome in mice lacking the protein kinase Akt2 (PKB beta)

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M410508200

21 January 2018

Dwarfism, impaired skin development, skeletal muscle atrophy, delayed bone development, and impeded adipogenesis in mice lacking Akt1 and Akt2.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M410508200

21 January 2018

Differential regulation of Akt kinase isoforms by the members of the TCL1 oncogene family

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M410508200

21 January 2018

Akt1 regulates a JNK scaffold during excitotoxic apoptosis

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M410508200

21 January 2018

PKB binding proteins. Getting in on the Akt.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M410508200

21 January 2018

Amino- and carboxyl-terminal mutants of presenilin 1 cause neuronal cell death through distinct toxic mechanisms: Study of 27 different presenilin 1 mutants

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M410508200

21 January 2018

Neurotoxic mechanisms by Alzheimer's disease-linked N141I mutant presenilin 2.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M410508200

21 January 2018

Identifiers

10.1074/JBC.M410508200

1 reference

Europe PubMed Central

20 September 2017

1 reference

Europe PubMed Central

20 September 2017

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