(Q36579583)

15 August 2017

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title

Structure and function of ABC transporters: the ATP switch provides flexible control (English)

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15 August 2017

Kenneth J Linton

1

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15 August 2017

Christopher F Higgins

series ordinal

2

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15 August 2017

publication date

26 August 2006

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15 August 2017

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15 August 2017

volume

453

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15 August 2017

issue

5

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15 August 2017

page(s)

555-567

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https://scigraph.springernature.com/pub.10.1007/s00424-006-0126-x

15 August 2017

exact match

0 references

cites work

Crystal structure of the nucleotide-binding domain of the ABC-transporter haemolysin B: identification of a variable region within ABC helical domains

1 reference

12 December 2020

ATP-binding sites in the membrane components of histidine permease, a periplasmic transport system

1 reference

12 December 2020

Mechanism of action of human P-glycoprotein ATPase activity. Photochemical cleavage during a catalytic transition state using orthovanadate reveals cross-talk between the two ATP sites

1 reference

12 December 2020

Subunit interactions in ABC transporters: a conserved sequence in hydrophobic membrane proteins of periplasmic permeases defines an important site of interaction with the ATPase subunits

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12 December 2020

The E. coli BtuCD structure: a framework for ABC transporter architecture and mechanism

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12 December 2020

Drug binding sites on P-glycoprotein are altered by ATP binding prior to nucleotide hydrolysis

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12 December 2020

Synergy between conserved ABC signature Ser residues in P-glycoprotein catalysis

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12 December 2020

ATP binding to the first nucleotide binding domain of multidrug resistance-associated protein plays a regulatory role at low nucleotide concentration, whereas ATP hydrolysis at the second plays a dominant role in ATP-dependent leukotriene C4 transpo

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12 December 2020

Cotransport of reduced glutathione with bile salts by MRP4 (ABCC4) localized to the basolateral hepatocyte membrane

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12 December 2020

ATP binding to the motor domain from an ABC transporter drives formation of a nucleotide sandwich dimer

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12 December 2020

Complete nucleotide sequence and identification of membrane components of the histidine transport operon of S. typhimurium

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12 December 2020

Crystal structure of the ATP-binding subunit of an ABC transporter

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12 December 2020

Drug-stimulated nucleotide trapping in the human multidrug transporter MDR1. Cooperation of the nucleotide binding domains

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12 December 2020

Crystal structures of mismatch repair protein MutS and its complex with a substrate DNA

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12 December 2020

Stoichiometry and affinity of nucleotide binding to P-glycoprotein during the catalytic cycle

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12 December 2020

Structure of MsbA from Vibrio cholera: a multidrug resistance ABC transporter homolog in a closed conformation

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12 December 2020

Thermodynamics of peptide binding to the transporter associated with antigen processing (TAP)

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12 December 2020

Evidence for two interacting ligand binding sites in human multidrug resistance protein 2 (ATP binding cassette C2).

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12 December 2020

Correlation between steady-state ATP hydrolysis and vanadate-induced ADP trapping in Human P-glycoprotein. Evidence for ADP release as the rate-limiting step in the catalytic cycle and its modulation by substrates

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12 December 2020

Secondary and tertiary structure changes of reconstituted LmrA induced by nucleotide binding or hydrolysis. A fourier transform attenuated total reflection infrared spectroscopy and tryptophan fluorescence quenching analysis.

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12 December 2020

A structural analysis of asymmetry required for catalytic activity of an ABC-ATPase domain dimer

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12 December 2020

The ATP switch model for ABC transporters

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12 December 2020

Three-dimensional structures of the mammalian multidrug resistance P-glycoprotein demonstrate major conformational changes in the transmembrane domains upon nucleotide binding

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12 December 2020

Crystal structures of the ATPase subunit of the glucose ABC transporter from Sulfolobus solfataricus: nucleotide-free and nucleotide-bound conformations

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12 December 2020

The homodimeric ATP-binding cassette transporter LmrA mediates multidrug transport by an alternating two-site (two-cylinder engine) mechanism

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12 December 2020

Reconstitution of a bacterial periplasmic permease in proteoliposomes and demonstration of ATP hydrolysis concomitant with transport

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12 December 2020

Characterization of vincristine transport by the M(r) 190,000 multidrug resistance protein (MRP): evidence for cotransport with reduced glutathione

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12 December 2020

Demonstration of conformational changes associated with activation of the maltose transport complex

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12 December 2020

Human P-glycoprotein exhibits reduced affinity for substrates during a catalytic transition state

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12 December 2020

The alternating ATPase domains of MutS control DNA mismatch repair

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12 December 2020

P-glycoprotein catalytic mechanism: studies of the ADP-vanadate inhibited state

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12 December 2020

Both ATP sites of human P-glycoprotein are essential but not symmetric

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12 December 2020

Drug-stimulated ATPase activity of human P-glycoprotein is blocked by disulfide cross-linking between the nucleotide-binding sites.

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12 December 2020

Extending the structure of an ABC transporter to atomic resolution: modeling and simulation studies of MsbA.

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12 December 2020

Fluorescence studies on the nucleotide binding domains of the P-glycoprotein multidrug transporter

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12 December 2020

Peptides induce ATP hydrolysis at both subunits of the transporter associated with antigen processing

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12 December 2020

Comparison of the functional characteristics of the nucleotide binding domains of multidrug resistance protein 1.

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12 December 2020

ATP increases the affinity between MutS ATPase domains. Implications for ATP hydrolysis and conformational changes.

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12 December 2020

A Tweezers-like Motion of the ATP-Binding Cassette Dimer in an ABC Transport Cycle

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12 December 2020

The catalytic cycle of P-glycoprotein

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12 December 2020

P-glycoprotein misfolds in Escherichia coli: evidence against alternating-topology models of the transport cycle

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12 December 2020

P-glycoprotein is stably inhibited by vanadate-induced trapping of nucleotide at a single catalytic site

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12 December 2020

Evidence for a requirement for ATP hydrolysis at two distinct steps during a single turnover of the catalytic cycle of human P-glycoprotein

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12 December 2020

On the mechanism of MgATP-dependent gating of CFTR Cl- channels

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12 December 2020

The human mismatch recognition complex hMSH2-hMSH6 functions as a novel molecular switch

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12 December 2020

Vanadate-induced trapping of nucleotides by purified maltose transport complex requires ATP hydrolysis

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12 December 2020

CFTR channel opening by ATP-driven tight dimerization of its nucleotide-binding domains

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12 December 2020

A General Theory of Membrane Transport From Studies of Bacteria

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12 December 2020

The ATP hydrolysis cycle of the nucleotide-binding domain of the mitochondrial ATP-binding cassette transporter Mdl1p.

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12 December 2020

Ligand-mediated tertiary structure changes of reconstituted P-glycoprotein. A tryptophan fluorescence quenching analysis

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12 December 2020

The vinblastine binding site adopts high- and low-affinity conformations during a transport cycle of P-glycoprotein

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12 December 2020

RETRACTED: Structure of the ABC transporter MsbA in complex with ADP.vanadate and lipopolysaccharide

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12 December 2020

Nucleotide binding by membrane components of bacterial periplasmic binding protein-dependent transport systems

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12 December 2020

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12 December 2020

Repacking of the transmembrane domains of P-glycoprotein during the transport ATPase cycle

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12 December 2020

Interaction of LDS-751 and rhodamine 123 with P-glycoprotein: evidence for simultaneous binding of both drugs

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12 December 2020

Binding protein-independent histidine permease mutants. Uncoupling of ATP hydrolysis from transmembrane signaling

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12 December 2020

Energy coupling to periplasmic binding protein-dependent transport systems: stoichiometry of ATP hydrolysis during transport in vivo

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12 December 2020

Mutations in either nucleotide-binding site of P-glycoprotein (Mdr3) prevent vanadate trapping of nucleotide at both sites.

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12 December 2020

Site-directed fluorescence labeling of P-glycoprotein on cysteine residues in the nucleotide binding domains.

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12 December 2020

Maltose-binding protein is open in the catalytic transition state for ATP hydrolysis during maltose transport

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12 December 2020

Expression of the human multidrug resistance cDNA in insect cells generates a high activity drug-stimulated membrane ATPase

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12 December 2020

The non-hydrolytic pathway of cystic fibrosis transmembrane conductance regulator ion channel gating

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12 December 2020

Purification and characterization of HisP, the ATP-binding subunit of a traffic ATPase (ABC transporter), the histidine permease of Salmonella typhimurium. Solubility, dimerization, and ATPase activity

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12 December 2020

hMSH2-hMSH6 forms a hydrolysis-independent sliding clamp on mismatched DNA

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12 December 2020

Requirements for peptide binding to the human transporter associated with antigen processing revealed by peptide scans and complex peptide libraries

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12 December 2020

An atomic detail model for the human ATP binding cassette transporter P‐glycoprotein derived from disulphide cross‐ linking and homology modeling

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12 December 2020

RETRACTED: Structure of MsbA from E. coli: a homolog of the multidrug resistance ATP binding cassette (ABC) transporters

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12 December 2020

The maltose transport system of Escherichia coli displays positive cooperativity in ATP hydrolysis

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12 December 2020

Positively cooperative sites for drug transport by P-glycoprotein with distinct drug specificities

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12 December 2020

Cooperative binding of ATP and MgADP in the sulfonylurea receptor is modulated by glibenclamide

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12 December 2020

Mechanism of maltose transport in Escherichia coli: transmembrane signaling by periplasmic binding proteins

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12 December 2020

Structural biology of Rad50 ATPase: ATP-driven conformational control in DNA double-strand break repair and the ABC-ATPase superfamily

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12 December 2020

Structure of the multidrug resistance P-glycoprotein to 2.5 nm resolution determined by electron microscopy and image analysis.

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12 December 2020

One intact ATP-binding subunit is sufficient to support ATP hydrolysis and translocation in an ABC transporter, the histidine permease

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12 December 2020

Characterization of the adenosine triphosphatase activity of the periplasmic histidine permease, a traffic ATPase (ABC transporter).

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12 December 2020

Mutation of a single MalK subunit severely impairs maltose transport activity in Escherichia coli

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12 December 2020

H662 is the linchpin of ATP hydrolysis in the nucleotide-binding domain of the ABC transporter HlyB

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12 December 2020

Nonequivalence of the nucleotide-binding subunits of an ABC transporter, the histidine permease, and conformational changes in the membrane complex

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12 December 2020

Intermediate structural states involved in MRP1-mediated drug transport. Role of glutathione

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12 December 2020

The multi-drug resistance reversal agent SR33557 and modulation of vinca alkaloid binding to P-glycoprotein by an allosteric interaction.

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12 December 2020

Communication between multiple drug binding sites on P-glycoprotein

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12 December 2020

10.1007/S00424-006-0126-X

Identifiers

DOI

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15 August 2017

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