(Q44669058)

5 December 2017

title

Synergy between conserved ABC signature Ser residues in P-glycoprotein catalysis (English)

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5 December 2017

Gregory Tombline

1

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5 December 2017

Lori Bartholomew

2

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5 December 2017

Khursheed Gimi

3

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5 December 2017

Grace A Tyndall

4

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5 December 2017

Alan E Senior

5

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5 December 2017

language of work or name

English

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publication date

24 November 2003

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Journal of Biological Chemistry

5 December 2017

published in

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5 December 2017

volume

279

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5 December 2017

issue

7

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5 December 2017

page(s)

5363-5373

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Biochemical, cellular, and pharmacological aspects of the multidrug transporter

5 December 2017

cites work

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M311964200

Determining the structure and mechanism of the human multidrug resistance P-glycoprotein using cysteine-scanning mutagenesis and thiol-modification techniques

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M311964200

Mammalian ABC transporters in health and disease

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M311964200

Multidrug resistance in cancer: role of ATP-dependent transporters

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M311964200

ABC-ATPases, adaptable energy generators fuelling transmembrane movement of a variety of molecules in organisms from bacteria to humans

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M311964200

Discrete mutations introduced in the predicted nucleotide-binding sites of the mdr1 gene abolish its ability to confer multidrug resistance

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M311964200

Mutations in either nucleotide-binding site of P-glycoprotein (Mdr3) prevent vanadate trapping of nucleotide at both sites.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M311964200

Conserved walker A Ser residues in the catalytic sites of P-glycoprotein are critical for catalysis and involved primarily at the transition state step.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M311964200

Both ATP sites of human P-glycoprotein are essential but not symmetric

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M311964200

The human ATP-binding cassette (ABC) transporter superfamily

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M311964200

Structural biology of Rad50 ATPase: ATP-driven conformational control in DNA double-strand break repair and the ABC-ATPase superfamily

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M311964200

ATP binding to the motor domain from an ABC transporter drives formation of a nucleotide sandwich dimer

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M311964200

A Tweezers-like Motion of the ATP-Binding Cassette Dimer in an ABC Transport Cycle

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M311964200

The E. coli BtuCD structure: a framework for ABC transporter architecture and mechanism

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M311964200

Vanadate-catalyzed photocleavage of the signature motif of an ATP-binding cassette (ABC) transporter

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M311964200

The "LSGGQ" motif in each nucleotide-binding domain of human P-glycoprotein is adjacent to the opposing walker A sequence

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M311964200

P-glycoprotein catalytic mechanism: studies of the ADP-vanadate inhibited state

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M311964200

Mutations within the first LSGGQ motif of Ste6p cause defects in a-factor transport and mating in Saccharomyces cerevisiae

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M311964200

Functional asymmetry of the two nucleotide binding domains in the ABC transporter Ste6.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M311964200

Large scale purification of detergent-soluble P-glycoprotein from Pichia pastoris cells and characterization of nucleotide binding properties of wild-type, Walker A, and Walker B mutant proteins.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M311964200

Investigation of the role of glutamine-471 and glutamine-1114 in the two catalytic sites of P-glycoprotein

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M311964200

ATPase activity of Chinese hamster P-glycoprotein

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M311964200

P-glycoprotein is stably inhibited by vanadate-induced trapping of nucleotide at a single catalytic site

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M311964200

Cysteines 431 and 1074 are responsible for inhibitory disulfide cross-linking between the two nucleotide-binding sites in human P-glycoprotein

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M311964200

ATP hydrolysis by multidrug-resistance protein from Chinese hamster ovary cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M311964200

X-ray structure of the magnesium(II).ADP.vanadate complex of the Dictyostelium discoideum myosin motor domain to 1.9 A resolution

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M311964200

The pentacovalent phosphorus intermediate of a phosphoryl transfer reaction

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M311964200

Covalent modification of human P-glycoprotein mutants containing a single cysteine in either nucleotide-binding fold abolishes drug-stimulated ATPase activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M311964200

The catalytic cycle of P-glycoprotein

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M311964200

X-ray structures of the myosin motor domain of Dictyostelium discoideum complexed with MgADP.BeFx and MgADP.AlF4-

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M311964200

Transition State Analysis of the Coupling of Drug Transport to ATP Hydrolysis by P-glycoprotein

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M311964200

The mechanism of action of multidrug-resistance-linked P-glycoprotein

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M311964200

The homodimeric ATP-binding cassette transporter LmrA mediates multidrug transport by an alternating two-site (two-cylinder engine) mechanism

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M311964200

21 January 2018

Identifiers

DOI

10.1074/JBC.M311964200

1 reference

5 December 2017

1 reference