(Q36597940)

15 August 2017

1 reference

title

Intracellular targeting of phosphodiesterase-4 underpins compartmentalized cAMP signaling (English)

1 reference

15 August 2017

Miles D Houslay

3

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author name string

Martin J Lynch

series ordinal

1

1 reference

PubMed ID

16984814

15 August 2017

Elaine V Hill

series ordinal

2

1 reference

15 August 2017

1 January 2006

1 reference

Current Topics in Developmental Biology

15 August 2017

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15 August 2017

75

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15 August 2017

225-259

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TCR- and CD28-mediated recruitment of phosphodiesterase 4 to lipid rafts potentiates TCR signaling

15 August 2017

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2975007-4

7 January 2021

Cyclic nucleotide phosphodiesterase 3B is a downstream target of protein kinase B and may be involved in regulation of effects of protein kinase B on thymidine incorporation in FDCP2 cells

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2975007-4

7 January 2021

The GAF domain: an evolutionary link between diverse phototransducing proteins.

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2975007-4

7 January 2021

Nonredundant function of phosphodiesterases 4D and 4B in neutrophil recruitment to the site of inflammation

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2975007-4

7 January 2021

A-kinase anchoring proteins interact with phosphodiesterases in T lymphocyte cell lines

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2975007-4

7 January 2021

Sub-family selective actions in the ability of Erk2 MAP kinase to phosphorylate and regulate the activity of PDE4 cyclic AMP-specific phosphodiesterases

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2975007-4

7 January 2021

Phorbol 12-myristate 13-acetate triggers the protein kinase A-mediated phosphorylation and activation of the PDE4D5 cAMP phosphodiesterase in human aortic smooth muscle cells through a route involving extracellular signal regulated kinase (ERK).

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2975007-4

7 January 2021

Arrestin times for compartmentalised cAMP signalling and phosphodiesterase-4 enzymes

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2975007-4

7 January 2021

TAPAS-1, a novel microdomain within the unique N-terminal region of the PDE4A1 cAMP-specific phosphodiesterase that allows rapid, Ca2+-triggered membrane association with selectivity for interaction with phosphatidic acid

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2975007-4

7 January 2021

beta-Arrestin-mediated PDE4 cAMP phosphodiesterase recruitment regulates beta-adrenoceptor switching from Gs to Gi

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2975007-4

7 January 2021

Compartmentalisation of phosphodiesterases and protein kinase A: opposites attract

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2975007-4

7 January 2021

Possible Contribution of Prostaglandin E2 to the antiproliferative effect of phosphodiesterase 4 inhibitors in human mononuclear cells

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2975007-4

7 January 2021

Phosphodiesterase 4D forms a cAMP diffusion barrier at the apical membrane of the airway epithelium.

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2975007-4

7 January 2021

The unique N-terminal domain of the cAMP phosphodiesterase PDE4D4 allows for interaction with specific SH3 domains

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2975007-4

7 January 2021

UCR1 and UCR2 domains unique to the cAMP-specific phosphodiesterase family form a discrete module via electrostatic interactions.

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2975007-4

7 January 2021

Cyclic nucleotide phosphodiesterases: functional implications of multiple isoforms

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2975007-4

7 January 2021

Delineation of RAID1, the RACK1 interaction domain located within the unique N-terminal region of the cAMP-specific phosphodiesterase, PDE4D5.

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2975007-4

7 January 2021

Alternative splicing of cAMP-specific phosphodiesterase mRNA transcripts. Characterization of a novel tissue-specific isoform, RNPDE4A8.

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2975007-4

7 January 2021

Attenuation of the activity of the cAMP-specific phosphodiesterase PDE4A5 by interaction with the immunophilin XAP2

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2975007-4

7 January 2021

Apoptosis in the developing visual system

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2975007-4

7 January 2021

RACK1, a receptor for activated C kinase and a homolog of the beta subunit of G proteins, inhibits activity of src tyrosine kinases and growth of NIH 3T3 cells

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2975007-4

7 January 2021

RACK1: a novel substrate for the Src protein-tyrosine kinase

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2975007-4

7 January 2021

RACK1 regulates specific functions of Gbetagamma

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2975007-4

7 January 2021

RACK1 binds to a signal transfer region of G betagamma and inhibits phospholipase C beta2 activation

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2975007-4

7 January 2021

AKAPs: from structure to function

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2975007-4

7 January 2021

Regulation and organization of adenylyl cyclases and cAMP.

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2975007-4

7 January 2021

Cyclic GMP phosphodiesterase-5: target of sildenafil

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2975007-4

7 January 2021

Phosphorylation of phosphodiesterase-5 by cyclic nucleotide-dependent protein kinase alters its catalytic and allosteric cGMP-binding activities

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2975007-4

7 January 2021

Switching of the coupling of the beta2-adrenergic receptor to different G proteins by protein kinase A.

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2975007-4

7 January 2021

cGMP-inhibited phosphodiesterases (PDE3 gene family).

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2975007-4

7 January 2021

Fluorescent indicators of cAMP and Epac activation reveal differential dynamics of cAMP signaling within discrete subcellular compartments

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2975007-4

7 January 2021

mAKAP assembles a protein kinase A/PDE4 phosphodiesterase cAMP signaling module

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2975007-4

7 January 2021

The protein kinase A anchoring protein mAKAP coordinates two integrated cAMP effector pathways.

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2975007-4

7 January 2021

Integrating signals between cAMP and the RAS/RAF/MEK/ERK signalling pathways. Based on the anniversary prize of the Gesellschaft für Biochemie und Molekularbiologie Lecture delivered on 5 July 2003 at the Special FEBS Meeting in Brussels

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2975007-4

7 January 2021

Anti-inflammatory activities of cAMP-elevating agents: enhancement of IL-10 synthesis and concurrent suppression of TNF production.

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2975007-4

7 January 2021

Selective stimulation of a cAMP-specific phosphodiesterase (PDE4A5) isoform by phosphatidic acid molecular species endogenously formed in rat thymocytes

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2975007-4

7 January 2021

Challenge of human Jurkat T-cells with the adenylate cyclase activator forskolin elicits major changes in cAMP phosphodiesterase (PDE) expression by up-regulating PDE3 and inducing PDE4D1 and PDE4D2 splice variants as well as down-regulating a novel

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2975007-4

7 January 2021

Isolation and characterization of PDE8A, a novel human cAMP-specific phosphodiesterase

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2975007-4

7 January 2021

A multicenter double-blind study of three different doses of the new cAMP-phosphodiesterase inhibitor rolipram in patients with major depressive disorder

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2975007-4

7 January 2021

Cyclic nucleotide phosphodiesterases: relating structure and function

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2975007-4

7 January 2021

Cloning and characterization of a novel human phosphodiesterase that hydrolyzes both cAMP and cGMP (PDE10A)

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2975007-4

7 January 2021

The human phosphodiesterase PDE10A gene genomic organization and evolutionary relatedness with other PDEs containing GAF domains

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2975007-4

7 January 2021

Comparison of enzymatic characterization and gene organization of cyclic nucleotide phosphodiesterase 8 family in humans

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2975007-4

7 January 2021

Neurotrophins elevate cAMP to reach a threshold required to overcome inhibition by MAG through extracellular signal-regulated kinase-dependent inhibition of phosphodiesterase.

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2975007-4

7 January 2021

Identification of cyclic AMP phosphodiesterases 3, 4 and 7 in human CD4+ and CD8+ T-lymphocytes: role in regulating proliferation and the biosynthesis of interleukin-2

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2975007-4

7 January 2021

The cAMP-specific phosphodiesterase PDE4D3 is regulated by phosphatidic acid binding. Consequences for cAMP signaling pathway and characterization of a phosphatidic acid binding site

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2975007-4

7 January 2021

Identification and characterization of a novel cyclic nucleotide phosphodiesterase gene (PDE9A) that maps to 21q22.3: alternative splicing of mRNA transcripts, genomic structure and sequence

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2975007-4

7 January 2021

The calcium/calmodulin-dependent phosphodiesterase PDE1C down-regulates glucose-induced insulin secretion

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2975007-4

7 January 2021

Absence of muscarinic cholinergic airway responses in mice deficient in the cyclic nucleotide phosphodiesterase PDE4D

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2975007-4

7 January 2021

Molecular cloning and characterization of human PDE8B, a novel thyroid-specific isozyme of 3',5'-cyclic nucleotide phosphodiesterase

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2975007-4

7 January 2021

Genomic organization, chromosomal localization, and alternative splicing of the human phosphodiesterase 8B gene

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2975007-4

7 January 2021

Cloning and characterization of two splice variants of human phosphodiesterase 11A

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2975007-4

7 January 2021

cAMP-specific phosphodiesterase HSPDE4D3 mutants which mimic activation and changes in rolipram inhibition triggered by protein kinase A phosphorylation of Ser-54: generation of a molecular model.

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2975007-4

7 January 2021

The MAP kinase ERK2 inhibits the cyclic AMP-specific phosphodiesterase HSPDE4D3 by phosphorylating it at Ser579.

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2975007-4

7 January 2021

The N-terminal alternately spliced regions of PDE4A cAMP-specific phosphodiesterases determine intracellular targeting and regulation of catalytic activity

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2975007-4

7 January 2021

PDE4 cAMP phosphodiesterases: modular enzymes that orchestrate signalling cross-talk, desensitization and compartmentalization

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2975007-4

7 January 2021

Tailoring cAMP-signalling responses through isoform multiplicity

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2975007-4

7 January 2021

The Crystal Structure of AMP-Bound PDE4 Suggests a Mechanism for Phosphodiesterase Catalysis,

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2975007-4

7 January 2021

Organization of G proteins and adenylyl cyclase at the plasma membrane

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2975007-4

7 January 2021

The human cyclic AMP-specific phosphodiesterase PDE-46 (HSPDE4A4B) expressed in transfected COS7 cells occurs as both particulate and cytosolic species that exhibit distinct kinetics of inhibition by the antidepressant rolipram

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2975007-4

7 January 2021

Induction of the cyclic nucleotide phosphodiesterase PDE4B is essential for LPS-activated TNF-alpha responses

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2975007-4

7 January 2021

Impaired growth and fertility of cAMP-specific phosphodiesterase PDE4D-deficient mice

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2975007-4

7 January 2021

Specific role of phosphodiesterase 4B in lipopolysaccharide-induced signaling in mouse macrophages

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2975007-4

7 January 2021

A subset of olfactory neurons that selectively express cGMP-stimulated phosphodiesterase (PDE2) and guanylyl cyclase-D define a unique olfactory signal transduction pathway

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2975007-4

7 January 2021

RACK1-mediated integration of adhesion and insulin-like growth factor I (IGF-I) signaling and cell migration are defective in cells expressing an IGF-I receptor mutated at tyrosines 1250 and 1251.

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2975007-4

7 January 2021

Upregulation of phosphodiesterase 1A1 expression is associated with the development of nitrate tolerance

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2975007-4

7 January 2021

Epac1 regulates integrity of endothelial cell junctions through VE-cadherin

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2975007-4

7 January 2021

Novel alternative splice variants of cGMP-binding cGMP-specific phosphodiesterase

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2975007-4

7 January 2021

Genomic origin and transcriptional regulation of two variants of cGMP-binding cGMP-specific phosphodiesterases.

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2975007-4

7 January 2021

Characterization and phosphorylation of PDE10A2, a novel alternative splice variant of human phosphodiesterase that hydrolyzes cAMP and cGMP.

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2975007-4

7 January 2021

Subcellular localization of cyclic nucleotide phosphodiesterase type 10A variants, and alteration of the localization by cAMP-dependent protein kinase-dependent phosphorylation

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2975007-4

7 January 2021

Intravenous sildenafil as an effective treatment of pulmonary hypertensive crises during acute intestinal malabsorption

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2975007-4

7 January 2021

Crystal structure of phosphodiesterase 4D and inhibitor complex(1)

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2975007-4

7 January 2021

Phosphodiesterase 4D deficiency in the ryanodine-receptor complex promotes heart failure and arrhythmias

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2975007-4

7 January 2021

CD3- and CD28-dependent induction of PDE7 required for T cell activation

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2975007-4

7 January 2021

The RAP1 guanine nucleotide exchange factor Epac2 couples cyclic AMP and Ras signals at the plasma membrane

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2975007-4

7 January 2021

Rack1, a receptor for activated protein kinase C, interacts with integrin beta subunit

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2975007-4

7 January 2021

Activation of the cAMP-specific phosphodiesterase PDE4D3 by phosphorylation. Identification and function of an inhibitory domain

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2975007-4

7 January 2021

Recent Advances in Zinc Enzymology

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2975007-4

7 January 2021

Phosphodiesterase-4 inhibitors for asthma and chronic obstructive pulmonary disease

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2975007-4

7 January 2021

RNA silencing identifies PDE4D5 as the functionally relevant cAMP phosphodiesterase interacting with beta arrestin to control the protein kinase A/AKAP79-mediated switching of the beta2-adrenergic receptor to activation of ERK in HEK293B2 cells.

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2975007-4

7 January 2021

ERK2 mitogen-activated protein kinase binding, phosphorylation, and regulation of the PDE4D cAMP-specific phosphodiesterases. The involvement of COOH-terminal docking sites and NH2-terminal UCR regions

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2975007-4

7 January 2021

Long PDE4 cAMP specific phosphodiesterases are activated by protein kinase A-mediated phosphorylation of a single serine residue in Upstream Conserved Region 1 (UCR1)

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2975007-4

7 January 2021

Type III cGMP-inhibited cyclic nucleotide phosphodiesterases (PDE3 gene family)

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2975007-4

7 January 2021

Suppression of human inflammatory cell function by subtype-selective PDE4 inhibitors correlates with inhibition of PDE4A and PDE4B.

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2975007-4

7 January 2021

Cellular functions of immunophilins

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2975007-4

7 January 2021

The two GAF domains in phosphodiesterase 2A have distinct roles in dimerization and in cGMP binding

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2975007-4

7 January 2021

Cyclic nucleotide phosphodiesterase activity, expression, and targeting in cells of the cardiovascular system

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2975007-4

7 January 2021

An essential aspartic acid at each of two allosteric cGMP-binding sites of a cGMP-specific phosphodiesterase

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2975007-4

7 January 2021

The RACK1 scaffold protein: a dynamic cog in cell response mechanisms

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2975007-4

7 January 2021

In resting COS1 cells a dominant negative approach shows that specific, anchored PDE4 cAMP phosphodiesterase isoforms gate the activation, by basal cyclic AMP production, of AKAP-tethered protein kinase A type II located in the centrosomal region

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2975007-4

7 January 2021

Identification, characterization and regional distribution in brain of RPDE-6 (RNPDE4A5), a novel splice variant of the PDE4A cyclic AMP phosphodiesterase family

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2975007-4

7 January 2021

Association with the SRC family tyrosyl kinase LYN triggers a conformational change in the catalytic region of human cAMP-specific phosphodiesterase HSPDE4A4B. Consequences for rolipram inhibition

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2975007-4

7 January 2021

PDE4D plays a critical role in the control of airway smooth muscle contraction

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2975007-4

7 January 2021

DISC1 and DISC2: discovering and dissecting molecular mechanisms underlying psychiatric illness

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2975007-4

7 January 2021

DISC1 and PDE4B are interacting genetic factors in schizophrenia that regulate cAMP signaling

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2975007-4

7 January 2021

cGMP binding to noncatalytic sites on mammalian rod photoreceptor phosphodiesterase is regulated by binding of its gamma and delta subunits

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2975007-4

7 January 2021

PKA-dependent activation of PDE3A and PDE4 and inhibition of adenylyl cyclase V/VI in smooth muscle

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2975007-4

7 January 2021

A fluorescent indicator for visualizing cAMP-induced phosphorylation in vivo

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2975007-4

7 January 2021

Regulation of eukaryotic translation by the RACK1 protein: a platform for signalling molecules on the ribosome

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2975007-4

7 January 2021

The SH3 domain of Src tyrosyl protein kinase interacts with the N-terminal splice region of the PDE4A cAMP-specific phosphodiesterase RPDE-6 (RNPDE4A5)

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2975007-4

7 January 2021

Antidepressant effects of inhibitors of cAMP phosphodiesterase (PDE4).

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2975007-4

7 January 2021

Short term feedback regulation of cAMP in FRTL-5 thyroid cells. Role of PDE4D3 phosphodiesterase activation.

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2975007-4

7 January 2021

Phosphodiesterase regulation is critical for the differentiation and pattern of gene expression in granulosa cells of the ovarian follicle

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2975007-4

7 January 2021

Targeting of cyclic AMP degradation to beta 2-adrenergic receptors by beta-arrestins

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2975007-4

7 January 2021

Redefining the role of the endogenous XAP2 and C-terminal hsp70-interacting protein on the endogenous Ah receptors expressed in mouse and rat cell lines.

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2975007-4

7 January 2021

Detecting cAMP-induced Epac activation by fluorescence resonance energy transfer: Epac as a novel cAMP indicator

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2975007-4

7 January 2021

Emerging roles of caspase-3 in apoptosis

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2975007-4

7 January 2021

Potent inhibition of cytokine production from intestinal lamina propria T cells by phosphodiesterase-4 inhibitory thalidomide analogues

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2975007-4

7 January 2021

Distinctive anatomical patterns of gene expression for cGMP-inhibited cyclic nucleotide phosphodiesterases

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2975007-4

7 January 2021

Ovulation: new factors that prepare the oocyte for fertilization

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2975007-4

7 January 2021

Dimerization of the type 4 cAMP-specific phosphodiesterases is mediated by the upstream conserved regions (UCRs).

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2975007-4

7 January 2021

The oligomerization state determines regulatory properties and inhibitor sensitivity of type 4 cAMP-specific phosphodiesterases

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2975007-4

7 January 2021

Deletion of phosphodiesterase 4D in mice shortens alpha(2)-adrenoceptor-mediated anesthesia, a behavioral correlate of emesis

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2975007-4

7 January 2021

Isolation and characterization of human cDNAs encoding a cGMP-stimulated 3',5'-cyclic nucleotide phosphodiesterase

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2975007-4

7 January 2021

Calmodulin-stimulated cyclic nucleotide phosphodiesterase (PDE1C) is induced in human arterial smooth muscle cells of the synthetic, proliferative phenotype

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2975007-4

7 January 2021

Compartmentation of cyclic adenosine 3',5'-monophosphate signaling in caveolae

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2975007-4

7 January 2021

Intracellular compartmentalization of PDE4 cyclic AMP-specific phosphodiesterases.

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2975007-4

7 January 2021

Immunohistochemical localization of PDE10A in the rat brain

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2975007-4

7 January 2021

The specific type IV phosphodiesterase inhibitor rolipram suppresses tumor necrosis factor-alpha production by human mononuclear cells

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2975007-4

7 January 2021

Phosphorylation and activation of a cAMP-specific phosphodiesterase by the cAMP-dependent protein kinase. Involvement of serine 54 in the enzyme activation

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2975007-4

7 January 2021

Induction of phosphodiesterases 3B, 4A4, 4D1, 4D2, and 4D3 in Jurkat T-cells and in human peripheral blood T-lymphocytes by 8-bromo-cAMP and Gs-coupled receptor agonists. Potential role in beta2-adrenoreceptor desensitization.

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2975007-4

7 January 2021

Engineered deletion of the unique N-terminal domain of the cyclic AMP-specific phosphodiesterase RD1 prevents plasma membrane association and the attainment of enhanced thermostability without altering its sensitivity to inhibition by rolipram

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2975007-4

7 January 2021

Remodelling of the PDE4 cAMP phosphodiesterase isoform profile upon monocyte-macrophage differentiation of human U937 cells.

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2975007-4

7 January 2021

Distinguishing the roles of the two different cGMP-binding sites for modulating phosphorylation of exogenous substrate (heterophosphorylation) and autophosphorylation of cGMP-dependent protein kinase

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2975007-4

7 January 2021

Cloning and characterization of a cAMP-specific cyclic nucleotide phosphodiesterase

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2975007-4

7 January 2021

Isolation and characterization of a dual-substrate phosphodiesterase gene family: PDE10A

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2975007-4

7 January 2021

Phosphodiesterase-4 inhibitors in the treatment of inflammatory lung disease.

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2975007-4

7 January 2021

Identification of a surface on the beta-propeller protein RACK1 that interacts with the cAMP-specific phosphodiesterase PDE4D5

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2975007-4

7 January 2021

Effect of cilostazol in patients with intermittent claudication: a randomized, double-blind, placebo-controlled study

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2975007-4

7 January 2021

Genomic organisation of the human cyclic AMP-specific phosphodiesterase PDE4C gene and its chromosomal localisation to 19p13.1, between RAB3A and JUND.

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2975007-4

7 January 2021

Structure of the catalytic domain of human phosphodiesterase 5 with bound drug molecules

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2975007-4

7 January 2021

The mRNA encoding a high-affinity cAMP phosphodiesterase is regulated by hormones and cAMP

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2975007-4

7 January 2021

Effects of 1-benzylxanthines on cyclic AMP phosphodiesterase 4 isoenzyme

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2975007-4

7 January 2021

Phosphodiesterase 4D and protein kinase a type II constitute a signaling unit in the centrosomal area

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2975007-4

7 January 2021

Spatial and temporal regulation of RACK1 function and N-methyl-D-aspartate receptor activity through WD40 motif-mediated dimerization.

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2975007-4

7 January 2021

Ariflo (SB 207499), a second generation phosphodiesterase 4 inhibitor for the treatment of asthma and COPD: from concept to clinic

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2975007-4

7 January 2021

Identification of key amino acids in a conserved cGMP-binding site of cGMP-binding phosphodiesterases. A putative NKXnD motif for cGMP binding

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2975007-4

7 January 2021

Myomegalin is a novel protein of the golgi/centrosome that interacts with a cyclic nucleotide phosphodiesterase

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2975007-4

7 January 2021

Potential antidepressant activity of rolipram and other selective cyclic adenosine 3′,5′-monophosphate phosphodiesterase inhibitors

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2975007-4

7 January 2021

Identification and characterization of a new human type 9 cGMP-specific phosphodiesterase splice variant (PDE9A5). Differential tissue distribution and subcellular localization of PDE9A variants

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2975007-4

7 January 2021

Ryanodine receptor-targeted anti-arrhythmic therapy

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2975007-4

7 January 2021

Binuclear Metallohydrolases

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2975007-4

7 January 2021

Atomic structure of PDE4: insights into phosphodiesterase mechanism and specificity

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2975007-4

7 January 2021

The calmodulin-dependent phosphodiesterase gene PDE1C encodes several functionally different splice variants in a tissue-specific manner.

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2975007-4

7 January 2021

Phosphodiesterase 7A-deficient mice have functional T cells.

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2975007-4

7 January 2021

A novel cyclic GMP stimulated phosphodiesterase from rat brain

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2975007-4

7 January 2021

The RACK1 signaling scaffold protein selectively interacts with the cAMP-specific phosphodiesterase PDE4D5 isoform

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2975007-4

7 January 2021

Isolation and characterization of two novel phosphodiesterase PDE11A variants showing unique structure and tissue-specific expression

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2975007-4

7 January 2021

A genetically encoded, fluorescent indicator for cyclic AMP in living cells

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2975007-4

7 January 2021

Results of a phase II study of the antidepressant effect of rolipram

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2975007-4

7 January 2021

Inhibition of the phosphodiesterase 4 (PDE4) enzyme reverses memory deficits produced by infusion of the MEK inhibitor U0126 into the CA1 subregion of the rat hippocampus

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2975007-4

7 January 2021

Genetically encoded reporters of protein kinase A activity reveal impact of substrate tethering

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2975007-4

7 January 2021

Phosphodiesterase-4 as a potential drug target

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2975007-4

7 January 2021

10.1016/S0070-2153(06)75007-4

Identifiers

DOI

1 reference

15 August 2017

1 reference

PubMed ID

16984814