(Q36599926)

15 August 2017

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title

Histone deacetylase inhibitors as therapeutics for polyglutamine disorders (English)

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15 August 2017

2

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15 August 2017

Rachel Butler

1

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PubMed ID

16988654

15 August 2017

language of work or name

English

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publication date

1 October 2006

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Nature Reviews Neuroscience

15 August 2017

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15 August 2017

7

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15 August 2017

10

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15 August 2017

784-796

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https://scigraph.springernature.com/pub.10.1038/nrn1989

15 August 2017

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cites work

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Hsp70 and Hsp40 attenuate formation of spherical and annular polyglutamine oligomers by partitioning monomer

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Insoluble detergent-resistant aggregates form between pathological and nonpathological lengths of polyglutamine in mammalian cells

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A direct link between core histone acetylation and transcriptionally active chromatin

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Histone deacetylase 3 localizes to the plasma membrane and is a substrate of Src.

31 March 2020

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Histone deacetylases: transcriptional repression with SINers and NuRDs

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HDA1 and HDA3 are components of a yeast histone deacetylase (HDA) complex

31 March 2020

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Enzymatic activity associated with class II HDACs is dependent on a multiprotein complex containing HDAC3 and SMRT/N-CoR

31 March 2020

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Identification of components of the murine histone deacetylase 6 complex: link between acetylation and ubiquitination signaling pathways

31 March 2020

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HDAC-6 interacts with and deacetylates tubulin and microtubules in vivo

31 March 2020

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Isolation and characterization of a novel class II histone deacetylase, HDAC10

31 March 2020

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Molecular cloning and characterization of a novel histone deacetylase HDAC10

31 March 2020

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Isolation and characterization of mammalian HDAC10, a novel histone deacetylase

31 March 2020

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Identification of HDAC10, a novel class II human histone deacetylase containing a leucine-rich domain

31 March 2020

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Phylogenetic classification of prokaryotic and eukaryotic Sir2-like proteins

31 March 2020

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The SIR2/3/4 complex and SIR2 alone promote longevity in Saccharomyces cerevisiae by two different mechanisms

31 March 2020

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Chemistry of gene silencing: the mechanism of NAD+-dependent deacetylation reactions

31 March 2020

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31 March 2020

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31 March 2020

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Neuronal protection by sirtuins in Alzheimer's disease

31 March 2020

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Cloning and functional characterization of HDAC11, a novel member of the human histone deacetylase family

31 March 2020

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Regulation of histone deacetylase activities

31 March 2020

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Identification of a signal-responsive nuclear export sequence in class II histone deacetylases

31 March 2020

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Functional domains of histone deacetylase-3

31 March 2020

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Signal-dependent activation of the MEF2 transcription factor by dissociation from histone deacetylases

31 March 2020

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HDAC4 deacetylase associates with and represses the MEF2 transcription factor

31 March 2020

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Neuronal activity-dependent cell survival mediated by transcription factor MEF2

31 March 2020

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RNA interference reveals a requirement for myocyte enhancer factor 2A in activity-dependent neuronal survival

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Differential localization of HDAC4 orchestrates muscle differentiation

31 March 2020

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Mechanism for nucleocytoplasmic shuttling of histone deacetylase 7

31 March 2020

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Regulation of histone deacetylase 4 and 5 and transcriptional activity by 14-3-3-dependent cellular localization

31 March 2020

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Intracellular trafficking of histone deacetylase 4 regulates neuronal cell death.

31 March 2020

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Neuronal activity-dependent nucleocytoplasmic shuttling of HDAC4 and HDAC5.

31 March 2020

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Biphasic developmental changes in Ca2+/calmodulin-dependent proteins in R6/2 Huntington's disease mice

31 March 2020

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Histone deacetylase activity is retained in primary neurons expressing mutant huntingtin protein

31 March 2020

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Predominant expression of Sir2alpha, an NAD-dependent histone deacetylase, in the embryonic mouse heart and brain.

31 March 2020

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Transcriptional regulation of neuronal genes and its effect on neural functions: NAD-dependent histone deacetylase SIRT1 (Sir2alpha).

31 March 2020

1 reference

Transcriptional dysregulation in Huntington's disease

31 March 2020

1 reference

Dysregulation of gene expression in the R6/2 model of polyglutamine disease: parallel changes in muscle and brain

31 March 2020

1 reference

Polyglutamine and transcription: gene expression changes shared by DRPLA and Huntington's disease mouse models reveal context-independent effects

31 March 2020

1 reference

Regional and cellular gene expression changes in human Huntington's disease brain

31 March 2020

1 reference

The Huntington's disease protein interacts with p53 and CREB-binding protein and represses transcription

31 March 2020

1 reference

Interference by huntingtin and atrophin-1 with cbp-mediated transcription leading to cellular toxicity

31 March 2020

1 reference

CREB-binding protein sequestration by expanded polyglutamine

31 March 2020

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Polyglutamine and CBP: fatal attraction?

31 March 2020

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Sp1 and TAFII130 transcriptional activity disrupted in early Huntington's disease

31 March 2020

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Insoluble TATA-binding protein accumulation in Huntington's disease cortex.

31 March 2020

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Inducible PC12 cell model of Huntington's disease shows toxicity and decreased histone acetylation

31 March 2020

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Ultrastructure of nuclear aggregates formed by expressing an expanded polyglutamine

31 March 2020

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A common silencer element in the SCG10 and type II Na+ channel genes binds a factor present in nonneuronal cells but not in neuronal cells

31 March 2020

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Identification of potential target genes for the neuron-restrictive silencer factor

31 March 2020

1 reference

NRSF/REST is required in vivo for repression of multiple neuronal target genes during embryogenesis

31 March 2020

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Loss of huntingtin-mediated BDNF gene transcription in Huntington's disease

31 March 2020

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Differential contributions of Caenorhabditis elegans histone deacetylases to huntingtin polyglutamine toxicity.

31 March 2020

1 reference

HDAC6 is a microtubule-associated deacetylase

31 March 2020

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Inhibition of histone deacetylase 6 acetylates and disrupts the chaperone function of heat shock protein 90: a novel basis for antileukemia activity of histone deacetylase inhibitors.

31 March 2020

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HDAC6 regulates Hsp90 acetylation and chaperone-dependent activation of glucocorticoid receptor

31 March 2020

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Histone deacetylase 6 binds polyubiquitin through its zinc finger (PAZ domain) and copurifies with deubiquitinating enzymes

31 March 2020

1 reference

Small-molecule inhibition of proteasome and aggresome function induces synergistic antitumor activity in multiple myeloma

31 March 2020

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HDAC6 and microtubules are required for autophagic degradation of aggregated huntingtin

31 March 2020

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The deacetylase HDAC6 regulates aggresome formation and cell viability in response to misfolded protein stress

31 March 2020

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Small molecule regulation of Sir2 protein deacetylases

31 March 2020

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Comparison of pathways controlling toxicity in the eye and brain in Drosophila models of human neurodegenerative diseases

31 March 2020

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Resveratrol rescues mutant polyglutamine cytotoxicity in nematode and mammalian neurons.

31 March 2020

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Sirtuins for healthy neurons

31 March 2020

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p53, the cellular gatekeeper for growth and division

31 March 2020

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Cycloheximide phase-shifts, but does not prevent, de novo Krox-24 protein expression

31 March 2020

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Activation of p53 sequence-specific DNA binding by acetylation of the p53 C-terminal domain

31 March 2020

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MDM2-HDAC1-mediated deacetylation of p53 is required for its degradation

31 March 2020

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Regulation of the p53 transcriptional activity.

31 March 2020

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Acetylation of p53 augments its site-specific DNA binding both in vitro and in vivo

31 March 2020

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p53 mediates cellular dysfunction and behavioral abnormalities in Huntington's disease

31 March 2020

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The binding of the ubiquitous transcription factor Sp1 at the locus control region represses the expression of beta-like globin genes

31 March 2020

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Transcriptional repression by wild-type p53 utilizes histone deacetylases, mediated by interaction with mSin3a.

31 March 2020

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Deacetylation of p53 modulates its effect on cell growth and apoptosis

31 March 2020

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Histone deacetylases specifically down-regulate p53-dependent gene activation

31 March 2020

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Regulation of signaling protein function and trafficking by the hsp90/hsp70-based chaperone machinery

31 March 2020

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17-AAG, an Hsp90 inhibitor, ameliorates polyglutamine-mediated motor neuron degeneration

31 March 2020

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Modulating molecular chaperone Hsp90 functions through reversible acetylation.

31 March 2020

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Chemical ablation of androgen receptor in prostate cancer cells by the histone deacetylase inhibitor LAQ824.

31 March 2020

1 reference

Valproic acid reduces brain damage induced by transient focal cerebral ischemia in rats: potential roles of histone deacetylase inhibition and heat shock protein induction

31 March 2020

1 reference

Lifespan extension and elevated hsp gene expression in Drosophila caused by histone deacetylase inhibitors

31 March 2020

1 reference

Progressive decrease in chaperone protein levels in a mouse model of Huntington's disease and induction of stress proteins as a therapeutic approach

31 March 2020

1 reference

The Hdh(Q150/Q150) knock-in mouse model of HD and the R6/2 exon 1 model develop comparable and widespread molecular phenotypes

31 March 2020

1 reference

Ataxin-3 is a histone-binding protein with two independent transcriptional corepressor activities

31 March 2020

1 reference

Diseases of unstable repeat expansion: mechanisms and common principles

31 March 2020

1 reference

Ataxin 1, a SCA1 neurodegenerative disorder protein, is functionally linked to the silencing mediator of retinoid and thyroid hormone receptors

31 March 2020

1 reference

The cerebellar leucine-rich acidic nuclear protein interacts with ataxin-1

31 March 2020

1 reference

Regulation of histone acetylation and transcription by INHAT, a human cellular complex containing the set oncoprotein

31 March 2020

1 reference

Interaction of Akt-phosphorylated ataxin-1 with 14-3-3 mediates neurodegeneration in spinocerebellar ataxia type 1.

31 March 2020

1 reference

The polyglutamine neurodegenerative protein ataxin-3 binds polyubiquitylated proteins and has ubiquitin protease activity

31 March 2020

1 reference

The polyglutamine neurodegenerative protein ataxin 3 regulates aggresome formation

31 March 2020

1 reference

Polyglutamine-expanded ataxin-7 inhibits STAGA histone acetyltransferase activity to produce retinal degeneration

31 March 2020

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Polyglutamine-expanded spinocerebellar ataxia-7 protein disrupts normal SAGA and SLIK histone acetyltransferase activity

31 March 2020

1 reference

SALSA, a variant of yeast SAGA, contains truncated Spt7, which correlates with activated transcription

31 March 2020

1 reference

The novel SLIK histone acetyltransferase complex functions in the yeast retrograde response pathway.

31 March 2020

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Glutamine-expanded ataxin-7 alters TFTC/STAGA recruitment and chromatin structure leading to photoreceptor dysfunction.

31 March 2020

1 reference

Nuclear accumulation of truncated atrophin-1 fragments in a transgenic mouse model of DRPLA.

31 March 2020

1 reference

Atrophin-1, the dentato-rubral and pallido-luysian atrophy gene product, interacts with ETO/MTG8 in the nuclear matrix and represses transcription

31 March 2020

1 reference

Aberrant recruitment of the nuclear receptor corepressor-histone deacetylase complex by the acute myeloid leukemia fusion partner ETO.

31 March 2020

1 reference

ETO, a target of t(8;21) in acute leukemia, interacts with the N-CoR and mSin3 corepressors

31 March 2020

1 reference

ETO, fusion partner in t(8;21) acute myeloid leukemia, represses transcription by interaction with the human N-CoR/mSin3/HDAC1 complex

31 March 2020

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Sodium butyrate ameliorates histone hypoacetylation and neurodegenerative phenotypes in a mouse model for DRPLA.

31 March 2020

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Histone deacetylase-associating Atrophin proteins are nuclear receptor corepressors

31 March 2020

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Histone deacetylase inhibitors reduce polyglutamine toxicity

31 March 2020

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Histone deacetylase inhibitors arrest polyglutamine-dependent neurodegeneration in Drosophila

31 March 2020

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Suberoylanilide hydroxamic acid, a histone deacetylase inhibitor, ameliorates motor deficits in a mouse model of Huntington's disease

31 March 2020

1 reference

Histone Deacetylase Inhibition by Sodium Butyrate Chemotherapy Ameliorates the Neurodegenerative Phenotype in Huntington's Disease Mice

31 March 2020

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Neuroprotective effects of phenylbutyrate in the N171-82Q transgenic mouse model of Huntington's disease

31 March 2020

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Clinical development of histone deacetylase inhibitors as anticancer agents

31 March 2020

1 reference

Histone Deacetylase Inhibitors

31 March 2020

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Deacetylase enzymes: biological functions and the use of small-molecule inhibitors

31 March 2020

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Crystal structure of a eukaryotic zinc-dependent histone deacetylase, human HDAC8, complexed with a hydroxamic acid inhibitor

31 March 2020

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Sodium butyrate ameliorates phenotypic expression in a transgenic mouse model of spinal and bulbar muscular atrophy

31 March 2020

1 reference

Genome-wide expression profiling of human blood reveals biomarkers for Huntington's disease.

31 March 2020

1 reference

Identification of combinatorial drug regimens for treatment of Huntington's disease using Drosophila.

31 March 2020

1 reference

Infantile muscular atrophy

31 March 2020

1 reference

Genetic mapping of chronic childhood-onset spinal muscular atrophy to chromosome 5q11.2-13.3

31 March 2020

1 reference

Gene for chronic proximal spinal muscular atrophies maps to chromosome 5q

31 March 2020

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Genetic homogeneity between acute and chronic forms of spinal muscular atrophy

31 March 2020

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Correlation between severity and SMN protein level in spinal muscular atrophy

31 March 2020

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31 March 2020

Spinal muscular atrophy

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Treatment of spinal muscular atrophy by sodium butyrate

31 March 2020

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Valproic acid increases SMN levels in spinal muscular atrophy patient cells.

31 March 2020

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Valproic acid increases the SMN2 protein level: a well-known drug as a potential therapy for spinal muscular atrophy

31 March 2020

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Phenylbutyrate increases SMN expression in vitro: relevance for treatment of spinal muscular atrophy

31 March 2020

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The benzamide M344, a novel histone deacetylase inhibitor, significantly increases SMN2 RNA/protein levels in spinal muscular atrophy cells

31 March 2020

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The role of histone acetylation in SMN gene expression.

31 March 2020

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Amide Analogues of Trichostatin A as Inhibitors of Histone Deacetylase and Inducers of Terminal Cell Differentiation

31 March 2020

1 reference

Transcriptional repression by neuron-restrictive silencer factor is mediated via the Sin3-histone deacetylase complex

31 March 2020

1 reference

A histone deacetylase corepressor complex regulates the Notch signal transduction pathway

31 March 2020

1 reference

Analysis of the NuRD subunits reveals a histone deacetylase core complex and a connection with DNA methylation

31 March 2020

1 reference

ETO, a target of t(8;21) in acute leukemia, makes distinct contacts with multiple histone deacetylases and binds mSin3A through its oligomerization domain

31 March 2020

1 reference

The histone deacetylase-3 complex contains nuclear receptor corepressors

31 March 2020

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Both corepressor proteins SMRT and N-CoR exist in large protein complexes containing HDAC3

31 March 2020

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Three proteins define a class of human histone deacetylases related to yeast Hda1p

31 March 2020

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Histone deacetylase HDAC8 associates with smooth muscle alpha-actin and is essential for smooth muscle cell contractility.

31 March 2020

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mHDA1/HDAC5 histone deacetylase interacts with and represses MEF2A transcriptional activity

31 March 2020

1 reference

A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington's disease chromosomes.

31 March 2020

1 reference

Androgen receptor gene mutations in X-linked spinal and bulbar muscular atrophy

31 March 2020

1 reference

Unstable expansion of CAG repeat in hereditary dentatorubral-pallidoluysian atrophy (DRPLA)

31 March 2020

1 reference

Dentatorubral and pallidoluysian atrophy expansion of an unstable CAG trinucleotide on chromosome 12p

31 March 2020

1 reference

Expansion of an unstable trinucleotide CAG repeat in spinocerebellar ataxia type 1.

31 March 2020

1 reference

Presymptomatic analysis of spinocerebellar ataxia type 1 (SCA1) via the expansion of the SCA1 CAG-repeat in a large pedigree displaying anticipation and parental male bias.

31 March 2020

1 reference

Cloning of the gene for spinocerebellar ataxia 2 reveals a locus with high sensitivity to expanded CAG/glutamine repeats

31 March 2020

1 reference

Identification of the spinocerebellar ataxia type 2 gene using a direct identification of repeat expansion and cloning technique, DIRECT.

31 March 2020

1 reference

Moderate expansion of a normally biallelic trinucleotide repeat in spinocerebellar ataxia type 2.

31 March 2020

1 reference

CAG expansions in a novel gene for Machado-Joseph disease at chromosome 14q32.1

31 March 2020

1 reference

Autosomal dominant cerebellar ataxia (SCA6) associated with small polyglutamine expansions in the alpha 1A-voltage-dependent calcium channel

31 March 2020

1 reference

Cloning of the SCA7 gene reveals a highly unstable CAG repeat expansion

31 March 2020

1 reference

An expanded CAG repeat sequence in spinocerebellar ataxia type 7

31 March 2020

1 reference

A neurological disease caused by an expanded CAG trinucleotide repeat in the TATA-binding protein gene: a new polyglutamine disease?

31 March 2020

1 reference

Cellular toxicity of polyglutamine expansion proteins: mechanism of transcription factor deactivation

31 March 2020

1 reference

31 March 2020

Identifiers

DOI

10.1038/NRN1989

1 reference

PubMed ID

16988654

Dimensions Publication ID

15 August 2017

0 references

1 reference

PubMed ID

16988654