(Q36602188)

English

Targeting aurora kinases limits tumour growth through DNA damage-mediated senescence and blockade of NF-κB impairs this drug-induced senescence.

scientific article published on 25 November 2012

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18 February 2020

Targeting aurora kinases limits tumour growth through DNA damage-mediated senescence and blockade of NF-κB impairs this drug-induced senescence (English)

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18 February 2020

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Sarah Palmer Short

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18 February 2020

Sarah Palmer Short

10

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18 February 2020

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Ann Richmond

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18 February 2020

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Yan Liu

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18 February 2020

Oriana E Hawkins

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18 February 2020

Yingjun Su

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18 February 2020

Anna E Vilgelm

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18 February 2020

Tammy Sobolik

5

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18 February 2020

Yee-Mon Thu

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18 February 2020

Sara Kantrow

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18 February 2020

Ryan C Splittgerber

8

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18 February 2020

Katayoun I Amiri

11

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18 February 2020

Jeffery A Ecsedy

12

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18 February 2020

Jeffery A Sosman

13

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18 February 2020

Mark C Kelley

14

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18 February 2020

publication date

25 November 2012

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18 February 2020

number of pages

18

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EMBO Molecular Medicine

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18 February 2020

5

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18 February 2020

1

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18 February 2020

149-166

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18 February 2020

p53-mediated senescence impairs the apoptotic response to chemotherapy and clinical outcome in breast cancer.

1 reference

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RAF265 inhibits the growth of advanced human melanoma tumors

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Oncogenic RAS regulates BRIP1 expression to induce dissociation of BRCA1 from chromatin, inhibit DNA repair, and promote senescence.

1 reference

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30 September 2017

Characterization of Alisertib (MLN8237), an investigational small-molecule inhibitor of aurora A kinase using novel in vivo pharmacodynamic assays

1 reference

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30 September 2017

Control of the senescence-associated secretory phenotype by NF-κB promotes senescence and enhances chemosensitivity

1 reference

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Opposing roles of NF-κB in anti-cancer treatment outcome unveiled by cross-species investigations

1 reference

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30 September 2017

Functional analysis and molecular targeting of aurora kinases a and B in advanced melanoma

1 reference

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30 September 2017

Inhibition of Aurora-A kinase induces cell cycle arrest in epithelial ovarian cancer stem cells by affecting NFĸB pathway

1 reference

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30 September 2017

Aurora A is a repressed effector target of the chromatin remodeling protein INI1/hSNF5 required for rhabdoid tumor cell survival

1 reference

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30 September 2017

Activation of nuclear factor-kappa B signalling promotes cellular senescence

1 reference

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30 September 2017

Cellular senescence: putting the paradoxes in perspective

1 reference

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30 September 2017

The essence of senescence

1 reference

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30 September 2017

CD4(+) T cells contribute to the remodeling of the microenvironment required for sustained tumor regression upon oncogene inactivation

1 reference

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30 September 2017

A novel Aurora-A kinase inhibitor MLN8237 induces cytotoxicity and cell-cycle arrest in multiple myeloma

1 reference

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30 September 2017

MLN8054, an inhibitor of Aurora A kinase, induces senescence in human tumor cells both in vitro and in vivo

1 reference

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30 September 2017

RelA/p65 functions to maintain cellular senescence by regulating genomic stability and DNA repair

1 reference

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Monitoring NF-kappaB mediated chemokine transcription in tumorigenesis

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30 September 2017

Senescence-associated secretory phenotypes reveal cell-nonautonomous functions of oncogenic RAS and the p53 tumor suppressor

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30 September 2017

The consequences of tetraploidy and aneuploidy

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30 September 2017

Aurora kinase A inhibition leads to p73-dependent apoptosis in p53-deficient cancer cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3569660

30 September 2017

The Aurora kinase family in cell division and cancer.

1 reference

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30 September 2017

Living on a break: cellular senescence as a DNA-damage response

1 reference

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30 September 2017

Oncogene-induced senescence relayed by an interleukin-dependent inflammatory network

1 reference

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30 September 2017

Chemokine signaling via the CXCR2 receptor reinforces senescence

1 reference

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30 September 2017

Mechanism of action of the Aurora kinase inhibitor CCT129202 and in vivo quantification of biological activity

1 reference

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30 September 2017

Cellular senescence: when bad things happen to good cells

1 reference

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30 September 2017

Senescent human fibroblasts increase the early growth of xenograft tumors via matrix metalloproteinase secretion

1 reference

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Antitumor activity of MLN8054, an orally active small-molecule inhibitor of Aurora A kinase

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30 September 2017

Aurora-A regulation of nuclear factor-kappaB signaling by phosphorylation of IkappaBalpha

1 reference

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The chemokine growth-regulated oncogene 1 (Gro-1) links RAS signaling to the senescence of stromal fibroblasts and ovarian tumorigenesis

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DNA damage checkpoint kinase Chk2 triggers replicative senescence

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Identifiers

10.1002/EMMM.201201378

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18 February 2020

PMC publication ID

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18 February 2020

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18 February 2020

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