(Q36602296)

15 August 2017

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title

What we owe to alpha(1)-antitrypsin and to Carl-Bertil Laurell (English)

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15 August 2017

Robin W Carrell

1

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15 August 2017

language of work or name

English

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publication date

1 April 2004

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COPD: Journal of Chronic Obstructive Pulmonary Disease

15 August 2017

number of pages

14

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based on heuristic

inferred from page(s)

published in

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15 August 2017

volume

1

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15 August 2017

issue

1

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15 August 2017

page(s)

71-84

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The serpins are an expanding superfamily of structurally similar but functionally diverse proteins. Evolution, mechanism of inhibition, novel functions, and a revised nomenclature

15 August 2017

cites work

1 reference

https://api.crossref.org/works/10.1081%2FCOPD-120028703

Serpin structure, mechanism, and function

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FCOPD-120028703

Alpha1-antitrypsin deficiency--a model for conformational diseases

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FCOPD-120028703

Implications of the three-dimensional structure of alpha 1-antitrypsin for structure and function of serpins

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FCOPD-120028703

21 January 2018

Conformational disease

1 reference

https://api.crossref.org/works/10.1081%2FCOPD-120028703

Serpinopathies and the conformational dementias

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FCOPD-120028703

Drosophila necrotic mutations mirror disease-associated variants of human serpins

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FCOPD-120028703

Liver disease in adults with alpha-1 -antitrypsin deficiency.

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FCOPD-120028703

Characterization of α1-Antitrypsin in the Inclusion Bodies from the Liver in α1-Antitrypsin Deficiency

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FCOPD-120028703

Purification and Partial Characterization of PAS-Positive Inclusion Bodies from the Liver in Alpha1-Antitrypsin Deficiency

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FCOPD-120028703

Cigarette Smoke Inhalation Decreases α 1 -Antitrypsin Activity in Rat Lung

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FCOPD-120028703

Antitrypsin and emphysema. Perspective and prospects

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FCOPD-120028703

Cigarette Smoking Induces Functional Antiprotease Deficiency in the Lower Respiratory Tract of Humans

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FCOPD-120028703

In vitro suppression of serum elastase-inhibitory capacity by reactive oxygen species generated by phagocytosing polymorphonuclear leukocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FCOPD-120028703

Molecular abnormality of human alpha1-antitrypsin variant (Pi-ZZ) associated with plasma activity deficiency

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FCOPD-120028703

Properties of Isolated Human alpha1-Antitrypsins of Pi Types M, S and Z

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FCOPD-120028703

α-1-Antitrypsin: Structural relationships of the substitutions of the S and Z variants

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FCOPD-120028703

Human plasma proteinase inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FCOPD-120028703

The interaction of alpha 1-antitrypsin with trypsin, chymotrypsin and human leukocyte elastase as revealed by end group analysis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FCOPD-120028703

Mutation of antitrypsin to antithrombin. alpha 1-antitrypsin Pittsburgh (358 Met leads to Arg), a fatal bleeding disorder

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FCOPD-120028703

Structure and variation of human alpha 1-antitrypsin

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FCOPD-120028703

Cloning and sequence of cDNA coding for alpha 1-antitrypsin

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FCOPD-120028703

Alpha 1-antitrypsin and serum albumin mRNA accumulation in normal, acute phase and ZZ human liver.

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FCOPD-120028703

alpha 1-Antitrypsin: molecular pathology, leukocytes, and tissue damage

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FCOPD-120028703

Human alpha 1-proteinase inhibitor. Crystal structure analysis of two crystal modifications, molecular model and preliminary analysis of the implications for function

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FCOPD-120028703

Inhibitory conformation of the reactive loop of alpha 1-antitrypsin

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FCOPD-120028703

Structure of a serpin-protease complex shows inhibition by deformation

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FCOPD-120028703

Carboxy terminal fragment of human α-1-antitrypsin from hydroxylamine clevage: Homology with antithrombin III

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FCOPD-120028703

A surprising new protein superfamily containing ovalbumin, antithrombin-III, and alpha 1-proteinase inhibitor

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FCOPD-120028703

What do dysfunctional serpins tell us about molecular mobility and disease?

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FCOPD-120028703

Occurrence of Alpha-1-antitrypsin Deficiency in 155 Patients with Alcoholic Liver Disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FCOPD-120028703

Crystal structure of ovalbumin as a model for the reactive centre of serpins

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FCOPD-120028703

Crystal structure of uncleaved ovalbumin at 1.95 A resolution

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FCOPD-120028703

Serpin tertiary structure transformation

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FCOPD-120028703

The mechanism of Z alpha 1-antitrypsin accumulation in the liver

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FCOPD-120028703

Mutations which impede loop/sheet polymerization enhance the secretion of human alpha 1-antitrypsin deficiency variants.

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FCOPD-120028703

A lag in intracellular degradation of mutant alpha 1-antitrypsin correlates with the liver disease phenotype in homozygous PiZZ alpha 1-antitrypsin deficiency

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FCOPD-120028703

The Z type variation of human alpha 1-antitrypsin causes a protein folding defect

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FCOPD-120028703

Conformational changes and disease--serpins, prions and Alzheimer's.

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FCOPD-120028703

21 January 2018

Conformational disease

1 reference

https://api.crossref.org/works/10.1081%2FCOPD-120028703

Familial encephalopathy with neuroserpin inclusion bodies

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FCOPD-120028703

Association between conformational mutations in neuroserpin and onset and severity of dementia

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FCOPD-120028703

Serpin polymerization is prevented by a hydrogen bond network that is centered on his-334 and stabilized by glycerol

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FCOPD-120028703

Origin of the multiple components of human ?1-antitrypsin

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FCOPD-120028703

The Electrophoretic α;1-Globulin Pattern of Serum in α;1-Antitrypsin Deficiency

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FCOPD-120028703

Investigations in Serum Copper. II. Isolation of the Copper Containing Protein, and a Description of some of its Properties

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FCOPD-120028703

The contents of phytic acid P in Norwegian flour and bread types; factors influencing phytic acid decomposition during breadmaking and the contents of phytic acid P in ordinary Norwegian bread

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FCOPD-120028703

Mobile reactive centre of serpins and the control of thrombosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FCOPD-120028703

[alpha1-Antitrypsin from human serum]

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FCOPD-120028703

Glycoproteins in serum from patients with myeloma, macroglobulinemia and related conditions

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FCOPD-120028703

Liver Disease in Alpha1-Antitrypsin Deficiency Detected by Screening of 200,000 Infants

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FCOPD-120028703

The polymorphism of "prealbumins" and alpha-1-antitrypsin in human sera

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FCOPD-120028703

Risk of cirrhosis and primary liver cancer in alpha 1-antitrypsin deficiency

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FCOPD-120028703

Intermediate Alpha1-Antitrypsin Deficiency Resulting from a Null Gene (M– Phenotype)

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FCOPD-120028703

The induction of pulmonary emphysema with human leukocyte elastase

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FCOPD-120028703

Is alpha 1-protease inhibitor inactivated by smoking?

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FCOPD-120028703

Amino acid substitution Glu→Lys in α1-antitrypsin PiZ

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FCOPD-120028703

The abnormality of the S variant of human α-1-antitrypsin

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FCOPD-120028703

The reactive site of alpha 1-antitrypsin is C-terminal, not N-terminal

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FCOPD-120028703

Circulating proalbumin associated with a variant proteinase inhibitor

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FCOPD-120028703

Yeast KEX2 protease has the properties of a human proalbumin converting enzyme

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FCOPD-120028703

alpha 1-Antitrypsin microheterogeneity. Isolation and physiological significance of isoforms

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FCOPD-120028703

In vitro synthesis of M and Z forms of human alpha 1-antitrypsin

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FCOPD-120028703

Translation and processing of normal (PiMM) and abnormal (PiZZ) human alpha 1-antitrypsin

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FCOPD-120028703

Xenopusoocytes can synthesise but do not secrete the Z variant of human α1-antitrypsin

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FCOPD-120028703

Human alpha 1-antitrypsin expression in Xenopus oocytes. Secretion of the normal (PiM) and abnormal (PiZ) forms

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FCOPD-120028703

Aggregation of plasma Z type alpha 1-antitrypsin suggests basic defect for the deficiency

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FCOPD-120028703

Quantitative estimation of proteins by electrophoresis in agarose gel containing antibodies

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FCOPD-120028703

21 January 2018

Identifiers

DOI

10.1081/COPD-120028703

1 reference

15 August 2017

1 reference