(Q36606532)

English

Characterization and engineering of the biosynthesis gene cluster for antitumor macrolides PM100117 and PM100118 from a marine actinobacteria: generation of a novel improved derivative

scientific article published on 22 February 2016

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scholarly article

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Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26905289%20AND%20SRC:MED&resulttype=core&format=json

8 March 2020

Characterization and engineering of the biosynthesis gene cluster for antitumor macrolides PM100117 and PM100118 from a marine actinobacteria: generation of a novel improved derivative (English)

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26905289%20AND%20SRC:MED&resulttype=core&format=json

8 March 2020

2

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8 March 2020

author name string

Raúl García Salcedo

1

1 reference

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8 March 2020

Cristina Gómez

3

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8 March 2020

Rogelio Fernández

4

1 reference

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8 March 2020

Alfredo F Braña

5

1 reference

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8 March 2020

Carmen Méndez

6

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8 March 2020

Fernando de la Calle

7

1 reference

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8 March 2020

José A Salas

8

1 reference

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8 March 2020

language of work or name

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publication date

22 February 2016

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8 March 2020

Microbial Cell Factories

1 reference

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8 March 2020

15

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8 March 2020

44

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8 March 2020

https://scigraph.springernature.com/pub.10.1186/s12934-016-0443-5

0 references

PM100117 and PM100118, new antitumor macrolides produced by a marine Streptomyces caniferus GUA-06-05-006A.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4763440

30 September 2017

Computational approaches to natural product discovery

1 reference

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30 September 2017

Minimum Information about a Biosynthetic Gene cluster.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4763440

30 September 2017

Discovery of microbial natural products by activation of silent biosynthetic gene clusters

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4763440

30 September 2017

Identification and analysis of the bacterial endosymbiont specialized for production of the chemotherapeutic natural product ET-743.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4763440

30 September 2017

antiSMASH 3.0-a comprehensive resource for the genome mining of biosynthetic gene clusters

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4763440

30 September 2017

Genome Mining of Streptomyces sp. Tü 6176: Characterization of the Nataxazole Biosynthesis Pathway

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4763440

30 September 2017

The EMBL-EBI bioinformatics web and programmatic tools framework.

1 reference

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30 September 2017

A MarR Family Transcriptional Regulator, DptR3, Activates Daptomycin Biosynthesis and Morphological Differentiation in Streptomyces roseosporus

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4763440

30 September 2017

Structural and biochemical characterization of Chlamydia trachomatis hypothetical protein CT263 supports that menaquinone synthesis occurs through the futalosine pathway.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4763440

30 September 2017

Lomaiviticin biosynthesis employs a new strategy for starter unit generation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4763440

30 September 2017

Menaquinone biosynthesis: formation of aminofutalosine requires a unique radical SAM enzyme

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4763440

30 September 2017

Vitamin k2, a naturally occurring menaquinone, exerts therapeutic effects on both hormone-dependent and hormone-independent prostate cancer cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4763440

30 September 2017

Advantages of Single-Molecule Real-Time Sequencing in High-GC Content Genomes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4763440

30 September 2017

Cascades and networks of regulatory genes that control antibiotic biosynthesis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4763440

30 September 2017

Diversity of P450 enzymes in the biosynthesis of natural products

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4763440

30 September 2017

LAL regulators SCO0877 and SCO7173 as pleiotropic modulators of phosphate starvation response and actinorhodin biosynthesis in Streptomyces coelicolor

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4763440

30 September 2017

Unusual carbon fixation gives rise to diverse polyketide extender units

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4763440

30 September 2017

Beyond ethylmalonyl-CoA: the functional role of crotonyl-CoA carboxylase/reductase homologs in expanding polyketide diversity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4763440

30 September 2017

Biosynthesis of the RNA polymerase inhibitor streptolydigin in Streptomyces lydicus: tailoring modification of 3-methyl-aspartate

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4763440

30 September 2017

A guide to successful bioprospecting: informed by actinobacterial systematics

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4763440

30 September 2017

Antibiotic discovery in the twenty-first century: current trends and future perspectives

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4763440

30 September 2017

Post-PKS tailoring steps in natural product-producing actinomycetes from the perspective of combinatorial biosynthesis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4763440

30 September 2017

Assembly algorithms for next-generation sequencing data

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4763440

30 September 2017

Microbial antitumor drugs: natural products of microbial origin as anticancer agents.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4763440

30 September 2017

Antitumor compounds from marine actinomycetes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4763440

30 September 2017

An alternative menaquinone biosynthetic pathway operating in microorganisms: an attractive target for drug discovery to pathogenic Helicobacter and Chlamydia strains.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4763440

30 September 2017

Automated genome mining for natural products.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4763440

30 September 2017

Mechanistic and functional insights into fatty acid activation in Mycobacterium tuberculosis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4763440

30 September 2017

An alternative menaquinone biosynthetic pathway operating in microorganisms

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4763440

30 September 2017

Improving production of bioactive secondary metabolites in actinomycetes by metabolic engineering

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4763440

30 September 2017

Renaissance in antibacterial discovery from actinomycetes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4763440

30 September 2017

Organization of the biosynthetic gene cluster for the macrolide antibiotic spiramycin in Streptomyces ambofaciens

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4763440

30 September 2017

Clustal W and Clustal X version 2.0

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4763440

30 September 2017

Distribution and physiology of ABC-type transporters contributing to multidrug resistance in bacteria

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4763440

30 September 2017

Dual role of OhrR as a repressor and an activator in response to organic hydroperoxides in Streptomyces coelicolor

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4763440

30 September 2017

Diversity and biogeography of marine actinobacteria

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4763440

30 September 2017

Combinatorial biosynthesis--potential and problems

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4763440

30 September 2017

Natural products from marine organisms and their associated microbes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4763440

30 September 2017

Genome sequencing in microfabricated high-density picolitre reactors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4763440

30 September 2017

Bryostatin-1: a novel PKC inhibitor in clinical development

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4763440

30 September 2017

The tylosin-biosynthetic genes of Streptomyces fradiae

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4763440

30 September 2017

Structural basis for the interaction of antibiotics with the peptidyl transferase centre in eubacteria

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4763440

30 September 2017

Search and discovery strategies for biotechnology: the paradigm shift

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4763440

30 September 2017

Gapped BLAST and PSI-BLAST: a new generation of protein database search programs

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4763440

30 September 2017

New colorimetric cytotoxicity assay for anticancer-drug screening

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4763440

30 September 2017

Differential plasmid rescue from transgenic mouse DNAs into Escherichia coli methylation-restriction mutants

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4763440

30 September 2017

Plasmid cloning vectors for the conjugal transfer of DNA from Escherichia coli to Streptomyces spp.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4763440

30 September 2017

Heme and menaquinone induced electron transport in lactic acid bacteria

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4763440

28 June 2018

Liposidolide A, a new antifungal macrolide antibiotic.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4763440

28 June 2018

6-Deoxyerythronolide-B synthase 2 from Saccharopolyspora erythraea. Cloning of the structural gene, sequence analysis and inferred domain structure of the multifunctional enzyme.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4763440

28 June 2018

Menaquinone biosyntheses in microorganisms.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4763440

20 September 2018

Engineered biosynthesis of glycosylated derivatives of narbomycin and evaluation of their antibacterial activities.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4763440

20 September 2018

Chapter 11. Sugar biosynthesis and modification

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4763440

20 September 2018

Improved antifungal polyene macrolides via engineering of the nystatin biosynthetic genes in Streptomyces noursei

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4763440

20 September 2018

ClustScan: an integrated program package for the semi-automatic annotation of modular biosynthetic gene clusters and in silico prediction of novel chemical structures

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4763440

20 September 2018

PimM, a PAS domain positive regulator of pimaricin biosynthesis in Streptomyces natalensis.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4763440

20 September 2018

Neopikromycin and novapikromycin from the pikromycin biosynthetic pathway of Streptomyces venezuelae.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4763440

20 September 2018

Biosynthesis of amphotericin derivatives lacking exocyclic carboxyl groups

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4763440

20 September 2018

Diazepinomicin, a new antimicrobial alkaloid from a marine Micromonospora sp.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4763440

20 September 2018

The hedamycin locus implicates a novel aromatic PKS priming mechanism.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4763440

20 September 2018

Biosynthesis of the angiogenesis inhibitor borrelidin by Streptomyces parvulus Tü4055: insights into nitrile formation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4763440

20 September 2018

Ketosynthases in the initiation and elongation modules of aromatic polyketide synthases have orthogonal acyl carrier protein specificity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4763440

20 September 2018

Computational approach for prediction of domain organization and substrate specificity of modular polyketide synthases

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4763440

20 September 2018

The hidden steps of domain skipping: macrolactone ring size determination in the pikromycin modular polyketide synthase

1 reference

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20 September 2018

Engineered biosynthesis of novel polyenes: a pimaricin derivative produced by targeted gene disruption in Streptomyces natalensis.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4763440

20 September 2018

[Structure determination of new antifungal antibiotics, polaramycins A and B]

1 reference

https://pubmed.ncbi.nlm.nih.gov/26905289

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Thiocoraline, a novel depsipeptide with antitumor activity produced by a marine Micromonospora. II. Physico-chemical properties and structure determination

1 reference

https://pubmed.ncbi.nlm.nih.gov/26905289

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Optimization of the sulforhodamine B colorimetric assay

1 reference

https://pubmed.ncbi.nlm.nih.gov/26905289

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A tailoring activity is responsible for generating polyene amide derivatives in Streptomyces diastaticus var. 108

1 reference

https://pubmed.ncbi.nlm.nih.gov/26905289

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A chain initiation factor common to both modular and aromatic polyketide synthases

1 reference

https://pubmed.ncbi.nlm.nih.gov/26905289

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Antitumor effects of vitamins K1, K2 and K3 on hepatocellular carcinoma in vitro and in vivo

1 reference

https://pubmed.ncbi.nlm.nih.gov/26905289

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Langkolide, a 32-Membered Macrolactone Antibiotic Produced by Streptomyces sp. Acta 3062

1 reference

https://pubmed.ncbi.nlm.nih.gov/26905289

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1186/S12934-016-0443-5

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26905289%20AND%20SRC:MED&resulttype=core&format=json

8 March 2020

Dimensions Publication ID

0 references

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26905289%20AND%20SRC:MED&resulttype=core&format=json

8 March 2020

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26905289%20AND%20SRC:MED&resulttype=core&format=json

8 March 2020

ResearchGate publication ID

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