(Q36609758)

15 August 2017

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title

Preclinical formulations for discovery and toxicology: physicochemical challenges (English)

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15 August 2017

Seshadri Neervannan

1

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15 August 2017

language of work or name

English

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publication date

1 October 2006

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Expert Opinion on Drug Metabolism & Toxicology

15 August 2017

published in

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15 August 2017

volume

2

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15 August 2017

issue

5

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15 August 2017

page(s)

715-731

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Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings

15 August 2017

cites work

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.5.715

Role of the development scientist in compound lead selection and optimization

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.5.715

Drug-like properties and the causes of poor solubility and poor permeability

21 January 2018

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https://api.crossref.org/works/10.1517%2F17425255.2.5.715

High throughput physicochemical profiling for drug discovery

21 January 2018

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https://api.crossref.org/works/10.1517%2F17425255.2.5.715

Drugs as materials: valuing physical form in drug discovery

21 January 2018

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https://api.crossref.org/works/10.1517%2F17425255.2.5.715

The new pre-preclinical paradigm: compound optimization in early and late phase drug discovery

21 January 2018

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https://api.crossref.org/works/10.1517%2F17425255.2.5.715

Strategies to improve oral drug bioavailability

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.5.715

Biopharmaceutical Considerations in Subcutaneous and Intramuscular Drug Administration

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.5.715

Gastric pH profiles of beagle dogs and their use as an alternative to human testing.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.5.715

Comparison of canine and human gastrointestinal physiology

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.5.715

A mechanistic approach to understanding the factors affecting drug absorption: a review of fundamentals

21 January 2018

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An integrated model for determining causes of poor oral drug absorption.

21 January 2018

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A good practice guide to the administration of substances and removal of blood, including routes and volumes

21 January 2018

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Assessment of side effects induced by injection of different adjuvant/antigen combinations in rabbits and mice

21 January 2018

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Pluronic P85 increases permeability of a broad spectrum of drugs in polarized BBMEC and Caco-2 cell monolayers

21 January 2018

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Role of formulation vehicles in taxane pharmacology

21 January 2018

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Intestinal drug efflux: formulation and food effects

21 January 2018

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Combined effect of cosolvent and cyclodextrin on solubilization of nonpolar drugs.

21 January 2018

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https://api.crossref.org/works/10.1517%2F17425255.2.5.715

Cyclodextrins: their future in drug formulation and delivery

21 January 2018

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Alteration of the intravenous pharmacokinetics of a synthetic ozonide antimalarial in the presence of a modified cyclodextrin

21 January 2018

1 reference

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The effects of cyclodextrins on the disposition of intravenously injected drugs in the rat.

21 January 2018

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Solubilization of thiazolobenzimidazole using a combination of pH adjustment and complexation with 2-hydroxypropyl-beta-cyclodextrin

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.5.715

Stable supersaturated aqueous solutions of silatecan 7-t-butyldimethylsilyl-10-hydroxycamptothecin via chemical conversion in the presence of a chemically modified beta-cyclodextrin

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.5.715

Solubilization of a tripeptide HIV protease inhibitor using a combination of ionization and complexation with chemically modified cyclodextrins

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.5.715

Development of supersaturatable self-emulsifying drug delivery system formulations for improving the oral absorption of poorly soluble drugs

21 January 2018

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Nanosuspensions in drug delivery

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.5.715

Self-emulsifying drug delivery systems: formulation and biopharmaceutic evaluation of an investigational lipophilic compound

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.5.715

Self-emulsifying drug delivery systems (SEDDS) for improved oral delivery of lipophilic drugs

21 January 2018

1 reference

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Nanosuspensions as particulate drug formulations in therapy. Rationale for development and what we can expect for the future.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.5.715

A dynamic artificial gastrointestinal system for studying the behavior of orally administered drug dosage forms under various physiological conditions

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.5.715

pH-dependent dissolution in vitro and absorption in vivo of weakly basic drugs: development of a canine model

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.5.715

Evaluation of using dog as an animal model to study the fraction of oral dose absorbed of 43 drugs in humans.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.5.715

Comparison of gastrointestinal pH in dogs and humans: implications on the use of the beagle dog as a model for oral absorption in humans.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.5.715

Excipient effects on gastrointestinal transit and drug absorption in beagle dogs

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.5.715

A guide to drug discovery: The role of the medicinal chemist in drug discovery — then and now

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.5.715

21 January 2018

Identifiers

DOI

10.1517/17425255.2.5.715

1 reference

15 August 2017

1 reference