(Q34665881)

3 August 2017

1 reference

title

A mechanistic approach to understanding the factors affecting drug absorption: a review of fundamentals (English)

1 reference

3 August 2017

2

Gordon L Amidon

1 reference

3 August 2017

Marilyn N Martinez

1

1 reference

3 August 2017

publication date

1 June 2002

1 reference

The Journal of Clinical Pharmacology

3 August 2017

published in

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3 August 2017

volume

42

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3 August 2017

issue

6

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3 August 2017

page(s)

620-643

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A theoretical basis for a biopharmaceutic drug classification: the correlation of in vitro drug product dissolution and in vivo bioavailability

3 August 2017

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Modern bioavailability, bioequivalence and biopharmaceutics classification system. New scientific approaches to international regulatory standards

21 January 2018

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Quantitative structure-pharmacokinetic relationships and drug design

21 January 2018

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Meal composition effects on the oral bioavailability of indinavir in HIV-infected patients

21 January 2018

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Drug, meal and formulation interactions influencing drug absorption after oral administration. Clinical implications

21 January 2018

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A computer perspective of membranes: molecular dynamics studies of lipid bilayer systems

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Virtual screening of intestinal drug permeability

21 January 2018

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https://api.crossref.org/works/10.1177%2F00970002042006005

Does fluid flow across the intestinal mucosa affect quantitative oral drug absorption? Is it time for a reevaluation?

21 January 2018

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Species differences in size discrimination in the paracellular pathway reflected by oral bioavailability of poly(ethylene glycol) and D-peptides

21 January 2018

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Transport approaches to the biopharmaceutical design of oral drug delivery systems: prediction of intestinal absorption

21 January 2018

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On the heterogeneity of drug dissolution and release

21 January 2018

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An integrated model for determining causes of poor oral drug absorption.

21 January 2018

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Effect of change in shape factor of a single crystal on its dissolution behavior.

21 January 2018

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Gastrointestinal transit of nondisintegrating, nonerodible oral dosage forms in pigs

21 January 2018

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The impact of formulation and process changes on in vitro dissolution and the bioequivalence of piroxicam capsules

21 January 2018

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Setting bioequivalence requirements for drug development based on preclinical data: optimizing oral drug delivery systems

21 January 2018

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Effects of intestinal CYP3A4 and P-glycoprotein on oral drug absorption--theoretical approach

21 January 2018

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Metabolism of drugs and other xenobiotics in the gut lumen and wall

21 January 2018

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Extrahepatic metabolism of drugs in humans

21 January 2018

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First-pass metabolism of midazolam by the human intestine.

21 January 2018

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https://api.crossref.org/works/10.1177%2F00970002042006005

Low bioavailability of amoxicillin in rats as a consequence of presystemic degradation in the intestine

21 January 2018

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https://api.crossref.org/works/10.1177%2F00970002042006005

Role of P-glycoprotein and cytochrome P450 3A in limiting oral absorption of peptides and peptidomimetics

21 January 2018

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Influence of D-glucose-induced water absorption on rat jejunal uptake of two passively absorbed drugs.

21 January 2018

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Pharmacogenomics: the promise of personalized medicine

21 January 2018

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The biopharmaceutics classification system (BCS): class III drugs - better candidates for BA/BE waiver?

21 January 2018

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Reversal of multidrug resistance by surfactants

21 January 2018

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Inhibition of etoposide elimination in the isolated perfused rat liver by Cremophor EL and Tween 80.

21 January 2018

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Studies of beneficial interactions between active medicaments and excipients in pharmaceutical formulations

21 January 2018

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Quality and functionality of excipients

21 January 2018

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https://api.crossref.org/works/10.1177%2F00970002042006005

The influence of the interdigestive migrating myoelectric complex on the gastric emptying of liquids

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F00970002042006005

Migrating electrical spike activity in the fasting human small intestine

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F00970002042006005

The interdigestive myo-electric complex of the stomach and small bowel of dogs

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F00970002042006005

Paracellular drug transport across intestinal epithelia: influence of charge and induced water flux.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F00970002042006005

Permeability of the rat small intestinal epithelium along the villus-crypt axis: effects of glucose transport

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F00970002042006005

Drug marker absorption in relation to pellet size, gastric motility and viscous meals in humans.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F00970002042006005

The effects of diet, aging and disease-states on presystemic elimination and oral drug bioavailability in humans

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F00970002042006005

Mechanisms and variations in the food effect on propranolol bioavailability

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F00970002042006005

Influence of food and fluid ingestion on aspirin bioavailability

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F00970002042006005

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F00970002042006005

Effects of an acidic beverage (Coca-Cola) on absorption of ketoconazole

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F00970002042006005

In vitro and in vivo evaluation in dogs and pigs of a hydrophilic matrix containing propylthiouracil.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F00970002042006005

Geography of intestinal permeability and absorption

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F00970002042006005

Heterogeneous tube model for the study of small intestinal transit flow

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F00970002042006005

Gastrointestinal drug absorption: is it time to consider heterogeneity as well as homogeneity?

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F00970002042006005

Biology of membrane transport proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F00970002042006005

The multidrug resistance protein family.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F00970002042006005

21 January 2018

Membrane transporters

1 reference

https://api.crossref.org/works/10.1177%2F00970002042006005

Role of transport proteins in drug absorption, distribution and excretion

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F00970002042006005

Human membrane transporter database: a Web-accessible relational database for drug transport studies and pharmacogenomics

21 January 2018

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Intestinal peptide transport systems and oral drug availability

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F00970002042006005

Role of metabolic enzymes and efflux transporters in the absorption of drugs from the small intestine

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F00970002042006005

Intestinal drug efflux: formulation and food effects

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F00970002042006005

Expression and protein kinase C-dependent regulation of peptide/H+ co-transport system in the Caco-2 human colon carcinoma cell line

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F00970002042006005

Inhibition of the H+/peptide cotransporter in the human intestinal cell line Caco-2 by cyclic AMP.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F00970002042006005

A rapid screening system to determine drug affinities for the intestinal dipeptide transporter 2: affinities of ACE inhibitors.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F00970002042006005

Structural Basis for Recognition of Dipeptides by Peptide Transporters

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F00970002042006005

Determination of intrinsic membrane transport parameters from perfused intestine experiments: A boundary layer approach to estimating the aqueous and unbiased membrane permeabilities

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F00970002042006005

A heterotrimeric G protein of the Gi family is required for cAMP-triggered trafficking of aquaporin 2 in kidney epithelial cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F00970002042006005

Characterization and distribution of alpha 2-adrenergic receptors in the human intestinal mucosa

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F00970002042006005

Mechanism of intestinal absorption. Effect of clonidine on rabbit ileal villus and crypt cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F00970002042006005

Structural biology. The xyz of ABC transporters

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F00970002042006005

Analysis of the structure and expression pattern of MRP7 (ABCC10), a new member of the MRP subfamily

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F00970002042006005

Characterization of the regional intestinal kinetics of drug efflux in rat and human intestine and in Caco-2 cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F00970002042006005

Drug exsorption from blood into the gastrointestinal tract

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F00970002042006005

Intestinal MDR transport proteins and P-450 enzymes as barriers to oral drug delivery

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F00970002042006005

Relevance of p-glycoprotein for the enteral absorption of cyclosporin A: in vitro-in vivo correlation

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F00970002042006005

Repacking of the transmembrane domains of P-glycoprotein during the transport ATPase cycle

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F00970002042006005

Structure-activity relationship of P-glycoprotein substrates and modifiers.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F00970002042006005

The drug efflux-metabolism alliance: biochemical aspects.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F00970002042006005

Grapefruit juice increases felodipine oral availability in humans by decreasing intestinal CYP3A protein expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F00970002042006005

Disposition and bioavailability of the beta 1-adrenoceptor antagonist talinolol in man.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F00970002042006005

Celiprolol. An updated review of its pharmacodynamic and pharmacokinetic properties, and therapeutic efficacy in cardiovascular disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F00970002042006005

Biochemistry of multidrug resistance mediated by the multidrug transporter

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F00970002042006005

Reversal of multidrug resistance phenotype by surfactants: relationship to membrane lipid fluidity

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F00970002042006005

Modulation of P-glycoprotein expression by cytochrome P450 3A inducers in male and female rat livers.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F00970002042006005

Limited oral bioavailability and active epithelial excretion of paclitaxel (Taxol) caused by P-glycoprotein in the intestine

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F00970002042006005

Functional polymorphisms of the human multidrug-resistance gene: multiple sequence variations and correlation of one allele with P-glycoprotein expression and activity in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F00970002042006005

Effects of sodium deoxycholate and sodium caprate on the transport of epirubicin in human intestinal epithelial Caco-2 cell layers and everted gut sacs of rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F00970002042006005

Non-ionic detergent Tween 80 modulates VP-16 resistance in classical multidrug resistant K562 cells via enhancement of VP-16 influx.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F00970002042006005

The effect of water-soluble vitamin E on cyclosporine pharmacokinetics in healthy volunteers

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F00970002042006005

Membrane fluidization by ether, other anesthetics, and certain agents abolishes P-glycoprotein ATPase activity and modulates efflux from multidrug-resistant cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F00970002042006005

Reversal of multidrug resistance and increase in plasma membrane fluidity in CHO cells with R-verapamil and bile salts

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F00970002042006005

Apical uptake of organic cations by human intestinal Caco-2 cells: putative involvement of ASF transporters

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F00970002042006005

Intestinal lipid absorption and transport

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F00970002042006005

From interaction of lipidic vehicles with intestinal epithelial cell membranes to the formation and secretion of chylomicrons

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F00970002042006005

Dietary cholesterol absorption; more than just bile

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F00970002042006005

Intestinal absorption of triglyceride and cholesterol. Dietary and pharmacological inhibition to reduce cardiovascular risk

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F00970002042006005

Accumulation of dietary cholesterol in sitosterolemia caused by mutations in adjacent ABC transporters

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F00970002042006005

10.1177/00970002042006005

21 January 2018

Identifiers

DOI

1 reference

3 August 2017

1 reference