(Q42469934)

1 November 2017

Effects of intestinal CYP3A4 and P-glycoprotein on oral drug absorption--theoretical approach (English)

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1 November 2017

K Ito

1

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1 November 2017

H Kusuhara

series ordinal

2

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1 November 2017

Y Sugiyama

series ordinal

3

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1 November 2017

language of work or name

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1 February 1999

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1 November 2017

Pharmaceutical Research

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1 November 2017

16

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1 November 2017

2

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1 November 2017

225-231

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Physiological measurements of luminal stirring in the dog and human small bowel

1 November 2017

1 reference

12 December 2020

Prediction of pharmacokinetic alterations caused by drug-drug interactions: metabolic interaction in the liver

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12 December 2020

Construction of a physiologically based pharmacokinetic model to describe the hepatobiliary excretion process of ligands: quantitative estimation of intracellular diffusion.

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12 December 2020

Correlation between oral drug absorption in humans and apparent drug permeability coefficients in human intestinal epithelial (Caco-2) cells

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12 December 2020

Identification of rifampin-inducible P450IIIA4 (CYP3A4) in human small bowel enterocytes

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12 December 2020

Cyclosporin-erythromycin interaction in renal transplant patients

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12 December 2020

Possible involvement of multiple P-glycoprotein-mediated efflux systems in the transport of verapamil and other organic cations across rat intestine

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12 December 2020

A quantitative study of fluorescein isothiocyanate-dextran transport in the microcirculation of the isolated perfused rat liver

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12 December 2020

Role of intestinal P-glycoprotein (mdr1) in interpatient variation in the oral bioavailability of cyclosporine

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12 December 2020

Expression of enzymatically active CYP3A4 by Caco-2 cells grown on extracellular matrix-coated permeable supports in the presence of 1alpha,25-dihydroxyvitamin D3.

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12 December 2020

Development of Caco-2 cells expressing high levels of cDNA-derived cytochrome P4503A4.

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12 December 2020

Prediction of in vivo drug disposition from in vitro data based on physiological pharmacokinetics

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12 December 2020

Overlapping substrate specificities and tissue distribution of cytochrome P450 3A and P-glycoprotein: implications for drug delivery and activity in cancer chemotherapy.

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12 December 2020

Prediction of in vivo drug metabolism in the human liver from in vitro metabolism data

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12 December 2020

The effects of ketoconazole on the intestinal metabolism and bioavailability of cyclosporine

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12 December 2020

Quantitative prediction of in vivo drug clearance and drug interactions from in vitro data on metabolism, together with binding and transport

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12 December 2020

Oral first-pass elimination of midazolam involves both gastrointestinal and hepatic CYP3A-mediated metabolism.

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12 December 2020

Cytochrome P 450 isoenzymes, epoxide hydrolase and glutathione transferases in rat and human hepatic and extrahepatic tissues

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12 December 2020

Differentiation of absorption and first-pass gut and hepatic metabolism in humans: Studies with cyclosporine*

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12 December 2020

How crowded is the cytoplasm?

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12 December 2020

Active secretion of drugs from the small intestinal epithelium in rats by P-glycoprotein functioning as an absorption barrier

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12 December 2020

Overlapping substrate specificities of cytochrome P450 3A and P-glycoprotein for a novel cysteine protease inhibitor

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12 December 2020

First-pass metabolism of cyclosporin by the gut

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12 December 2020

Characterization of interintestinal and intraintestinal variations in human CYP3A-dependent metabolism.

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12 December 2020

Analysis of drug permeation across Caco-2 monolayer: implication for predicting in vivo drug absorption.

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12 December 2020

Bioavailability of cyclosporine with concomitant rifampin administration is markedly less than predicted by hepatic enzyme induction

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12 December 2020

Strategic proposals for avoiding toxic interactions with drugs for clinical use during development and after marketing of a new drug: pharmacokinetic consideration

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12 December 2020

Modulators and substrates of P-glycoprotein and cytochrome P4503A coordinately up-regulate these proteins in human colon carcinoma cells.

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12 December 2020

Hepatic and intestinal metabolism of indinavir, an HIV protease inhibitor, in rat and human microsomes. Major role of CYP3A

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12 December 2020

Identifiers

DOI

10.1023/A:1018872207437

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1 November 2017

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