(Q36611001)

15 August 2017

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title

Signalling platforms that modulate the inflammatory response: new targets for drug development (English)

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15 August 2017

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Christopher A McCulloch

series ordinal

1

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15 August 2017

Gregory P Downey

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2

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15 August 2017

Hani El-Gabalawy

series ordinal

3

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15 August 2017

publication date

1 October 2006

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Nature Reviews Drug Discovery

15 August 2017

published in

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15 August 2017

volume

5

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15 August 2017

issue

10

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15 August 2017

page(s)

864-876

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Acute-phase proteins and other systemic responses to inflammation

15 August 2017

cites work

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31 March 2020

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31 March 2020

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Sub-cellular distribution of endothelin signaling pathway components in ventricular myocytes and heart: lack of preformed caveolar signalosomes

31 March 2020

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31 March 2020

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31 March 2020

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31 March 2020

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Interleukin-1 blockade by anakinra improves clinical symptoms in patients with neonatal-onset multisystem inflammatory disease

31 March 2020

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Neonatal-onset multisystem inflammatory disease (NOMID) due to a novel S331R mutation of the CIAS1 gene and response to interleukin-1 receptor antagonist treatment

31 March 2020

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Pralnacasan, an inhibitor of interleukin-1beta converting enzyme, reduces joint damage in two murine models of osteoarthritis

31 March 2020

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The interleukin-1 beta-converting enzyme inhibitor pralnacasan reduces dextran sulfate sodium-induced murine colitis and T helper 1 T-cell activation

31 March 2020

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Cytokine traps: multi-component, high-affinity blockers of cytokine action

31 March 2020

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Current challenges in quantitative modeling of epidermal growth factor signaling

31 March 2020

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The emerging role of the COP9 signalosome in cancer

31 March 2020

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Recruitment of tumor necrosis factor receptor-associated factor family proteins to apoptosis signal-regulating kinase 1 signalosome is essential for oxidative stress-induced cell death

31 March 2020

1 reference

Distinct domains in the SHP-2 phosphatase differentially regulate epidermal growth factor receptor/NF-kappaB activation through Gab1 in glioblastoma cells

31 March 2020

1 reference

Interleukin-1-induced calcium flux in human fibroblasts is mediated through focal adhesions

31 March 2020

1 reference

Focal adhesions - the cytoskeletal connection

31 March 2020

1 reference

Focal adhesions, contractility, and signaling

31 March 2020

1 reference

The inner lives of focal adhesions

31 March 2020

1 reference

Focal adhesion and actin dynamics: a place where kinases and proteases meet to promote invasion

31 March 2020

1 reference

The recruitment of the interleukin-1 (IL-1) receptor-associated kinase (IRAK) into focal adhesion complexes is required for IL-1beta -induced ERK activation

31 March 2020

1 reference

IL‐1 induced release of Ca2+from internal stores is dependent on cell‐matrix interactions and regulates ERK activation

31 March 2020

1 reference

Hierarchical assembly of cell-matrix adhesion complexes

31 March 2020

1 reference

Live-cell monitoring of tyrosine phosphorylation in focal adhesions following microtubule disruption.

31 March 2020

1 reference

Reduced cell motility and enhanced focal adhesion contact formation in cells from FAK-deficient mice

31 March 2020

1 reference

RAG-2-deficient mice lack mature lymphocytes owing to inability to initiate V(D)J rearrangement

31 March 2020

1 reference

Src family kinases are required for integrin but not PDGFR signal transduction.

31 March 2020

1 reference

Synergistic roles for receptor occupancy and aggregation in integrin transmembrane function.

31 March 2020

1 reference

Targeting membrane-localized focal adhesion kinase to focal adhesions: roles of tyrosine phosphorylation and SRC family kinases

31 March 2020

1 reference

Tyrosine phosphatase SHP-2 regulates IL-1 signaling in fibroblasts through focal adhesions

31 March 2020

1 reference

Protein tyrosine phosphatases in the human genome

31 March 2020

1 reference

Redox redux: revisiting PTPs and the control of cell signaling

31 March 2020

1 reference

A SHPing tale: perspectives on the regulation of SHP-1 and SHP-2 tyrosine phosphatases by the C-terminal tail

31 March 2020

1 reference

The FERM domain: a unique module involved in the linkage of cytoplasmic proteins to the membrane

31 March 2020

1 reference

A novel membrane glycoprotein, SHPS-1, that binds the SH2-domain-containing protein tyrosine phosphatase SHP-2 in response to mitogens and cell adhesion

31 March 2020

1 reference

Integrin-mediated tyrosine phosphorylation of SHPS-1 and its association with SHP-2. Roles of Fak and Src family kinases

31 March 2020

1 reference

Protein-tyrosine phosphatase Shp-2 regulates cell spreading, migration, and focal adhesion

31 March 2020

1 reference

Regulation of early events in integrin signaling by protein tyrosine phosphatase SHP-2.

31 March 2020

1 reference

Involvement of an SHP-2-Rho small G protein pathway in hepatocyte growth factor/scatter factor-induced cell scattering.

31 March 2020

1 reference

The protein tyrosine phosphatase Shp-2 regulates RhoA activity

31 March 2020

1 reference

Regulation of Ras and Rho small G proteins by SHP-2.

31 March 2020

1 reference

The protein tyrosine phosphatase SHP-2 regulates interleukin-1-induced ERK activation in fibroblasts

31 March 2020

1 reference

SHP-2 modulates interleukin-1-induced Ca2+ flux and ERK activation via phosphorylation of phospholipase Cgamma1.

31 March 2020

1 reference

Requirements of focal adhesions and calcium fluxes for interleukin-1-induced ERK kinase activation and c-fos expression in fibroblasts

31 March 2020

1 reference

The carboxyl-terminal tyrosine residue of protein-tyrosine phosphatase alpha mediates association with focal adhesion plaques

31 March 2020

1 reference

RPTP-alpha acts as a transducer of mechanical force on alphav/beta3-integrin-cytoskeleton linkages

31 March 2020

1 reference

Receptor protein tyrosine phosphatase alpha activates Src-family kinases and controls integrin-mediated responses in fibroblasts

31 March 2020

1 reference

Mechanisms controlling gene expression by nuclear calcium signals.

31 March 2020

1 reference

Requirement of the inositol trisphosphate receptor for activation of store-operated Ca2+ channels

31 March 2020

1 reference

Inositol 1,4,5-trisphosphate receptors as signal integrators

31 March 2020

1 reference

Deficiency of Src homology 2-containing phosphatase 1 results in abnormalities in murine neutrophil function: studies in motheaten mice

31 March 2020

1 reference

Cancer treatment with kinase inhibitors: what have we learnt from imatinib?

31 March 2020

1 reference

Gefitinib therapy in advanced bronchioloalveolar carcinoma: Southwest Oncology Group Study S0126.

31 March 2020

1 reference

Phase I study of EKB-569, an irreversible inhibitor of the epidermal growth factor receptor, in patients with advanced solid tumors

31 March 2020

1 reference

Phase I study of the humanised anti-EGFR monoclonal antibody matuzumab (EMD 72000) combined with gemcitabine in advanced pancreatic cancer

31 March 2020

1 reference

Complete radiological and metabolic response of metastatic renal cell carcinoma to SU5416 (semaxanib) in a patient with probable von Hippel-Lindau syndrome

31 March 2020

1 reference

Effects of scaling and root planing on the amounts of interleukin-1 and interleukin-1 receptor antagonist and the mRNA expression of interleukin-1beta in gingival crevicular fluid and gingival tissues

31 March 2020

1 reference

Is JAK3 a new drug target for immunomodulation-based therapies?

31 March 2020

1 reference

Protein tyrosine phosphatase 1B inhibitors for diabetes

31 March 2020

1 reference

Protein tyrosine phosphatases and the immune response

31 March 2020

1 reference

Targeting the PTPome in human disease

31 March 2020

1 reference

Long-term effects of vanadyl treatment on streptozocin-induced diabetes in rats.

31 March 2020

1 reference

Vanadate normalizes hyperglycemia in two mouse models of non-insulin-dependent diabetes mellitus

31 March 2020

1 reference

Treatment of diabetes mellitus.

31 March 2020

1 reference

A new concept: the use of vanadium complexes in the treatment of diabetes mellitus

31 March 2020

1 reference

31 March 2020

Vanadium and diabetes

1 reference

Vanadium salts as insulin substitutes: mechanisms of action, a scientific and therapeutic tool in diabetes mellitus research

31 March 2020

1 reference

Effect of vanadium(IV) compounds in the treatment of diabetes: in vivo and in vitro studies with vanadyl sulfate and bis(maltolato)oxovandium(IV).

31 March 2020

1 reference

In silico structure-based design of a potent and selective small peptide inhibitor of protein tyrosine phosphatase 1B, a novel therapeutic target for obesity and type 2 diabetes mellitus: a computer modeling approach

31 March 2020

1 reference

Hematopoietic cell phosphatase, SHP-1, is constitutively associated with the SH2 domain-containing leukocyte protein, SLP-76, in B cells

31 March 2020

1 reference

Direct association with and dephosphorylation of Jak2 kinase by the SH2-domain-containing protein tyrosine phosphatase SHP-1

31 March 2020

1 reference

Revealing mechanisms for SH2 domain mediated regulation of the protein tyrosine phosphatase SHP-2.

31 March 2020

1 reference

The specificity of the N-terminal SH2 domain of SHP-2 is modified by a single point mutation

31 March 2020

1 reference

Protein-tyrosine phosphatase MEG2 is expressed by human neutrophils. Localization to the phagosome and activation by polyphosphoinositides.

31 March 2020

1 reference

PTP1B inhibitors as potential therapeutics in the treatment of type 2 diabetes and obesity

31 March 2020

1 reference

Discovery of a novel shp2 protein tyrosine phosphatase inhibitor

31 March 2020

1 reference

Recruitment of the IKK signalosome to the p55 TNF receptor: RIP and A20 bind to NEMO (IKKgamma) upon receptor stimulation

31 March 2020

1 reference

A nonspecific phosphotyrosine phosphatase inhibitor, bis(maltolato)oxovanadium(IV), improves glucose tolerance and prevents diabetes in Zucker diabetic fatty rats

31 March 2020

1 reference

inferred from DOI database lookup

7 January 2021

based on heuristic

Identifiers

DOI

10.1038/NRD2109

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Dimensions Publication ID

15 August 2017

1037894147

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