(Q36617944)

English

N-terminal cleavage of the mitochondrial fusion GTPase OPA1 occurs via a caspase-independent mechanism in cerebellar granule neurons exposed to oxidative or nitrosative stress

scientific article published on 7 December 2012

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scholarly article

1 reference

Europe PubMed Central

PMC publication ID

15 August 2017

N-terminal cleavage of the mitochondrial fusion GTPase OPA1 occurs via a caspase-independent mechanism in cerebellar granule neurons exposed to oxidative or nitrosative stress (English)

1 reference

Europe PubMed Central

PMC publication ID

15 August 2017

author name string

Josie J Gray

1

1 reference

Europe PubMed Central

PMC publication ID

15 August 2017

Amelia E Zommer

2

1 reference

Europe PubMed Central

PMC publication ID

15 August 2017

Ron J Bouchard

3

1 reference

Europe PubMed Central

PMC publication ID

15 August 2017

Nathan Duval

4

1 reference

Europe PubMed Central

PMC publication ID

15 August 2017

Craig Blackstone

5

1 reference

Europe PubMed Central

PMC publication ID

15 August 2017

Daniel A Linseman

6

1 reference

Europe PubMed Central

PMC publication ID

15 August 2017

language of work or name

0 references

publication date

7 December 2012

1 reference

Europe PubMed Central

PMC publication ID

15 August 2017

1 reference

Europe PubMed Central

PMC publication ID

15 August 2017

1494

1 reference

Europe PubMed Central

PMC publication ID

15 August 2017

28-43

1 reference

Europe PubMed Central

PMC publication ID

15 August 2017

The impact of aging on mitochondrial function and biogenesis pathways in skeletal muscle of sedentary high- and low-functioning elderly individuals

1 reference

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The axonal transport of mitochondria

1 reference

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A new vicious cycle involving glutamate excitotoxicity, oxidative stress and mitochondrial dynamics

1 reference

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The PINK1/Parkin pathway regulates mitochondrial dynamics and function in mammalian hippocampal and dopaminergic neurons

1 reference

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30 September 2017

Mutant huntingtin binds the mitochondrial fission GTPase dynamin-related protein-1 and increases its enzymatic activity

1 reference

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Apoptotic microtubule network organization and maintenance depend on high cellular ATP levels and energized mitochondria

1 reference

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30 September 2017

Mitochondrial fission/fusion dynamics and apoptosis

1 reference

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Mitochondrial dynamics in cell death and neurodegeneration

1 reference

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30 September 2017

The BH3-only Bnip3 binds to the dynamin Opa1 to promote mitochondrial fragmentation and apoptosis by distinct mechanisms

1 reference

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30 September 2017

Calpain plays a central role in 1-methyl-4-phenylpyridinium (MPP+)-induced neurotoxicity in cerebellar granule neurons.

1 reference

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30 September 2017

OPA1 (dys)functions.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3575199

30 September 2017

Regulation of OPA1 processing and mitochondrial fusion by m-AAA protease isoenzymes and OMA1

1 reference

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Oxidative stress in ALS: key role in motor neuron injury and therapeutic target

1 reference

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30 September 2017

Impaired balance of mitochondrial fission and fusion in Alzheimer's disease

1 reference

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30 September 2017

OPA1-associated disorders: phenotypes and pathophysiology.

1 reference

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30 September 2017

Heterozygous mutation of Opa1 in Drosophila shortens lifespan mediated through increased reactive oxygen species production.

1 reference

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30 September 2017

Amyloid-beta overproduction causes abnormal mitochondrial dynamics via differential modulation of mitochondrial fission/fusion proteins

1 reference

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30 September 2017

Caspases indirectly regulate cleavage of the mitochondrial fusion GTPase OPA1 in neurons undergoing apoptosis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3575199

30 September 2017

The Parkinson's disease genes pink1 and parkin promote mitochondrial fission and/or inhibit fusion in Drosophila

1 reference

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30 September 2017

Opa1-mediated cristae opening is Bax/Bak and BH3 dependent, required for apoptosis, and independent of Bak oligomerization

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3575199

30 September 2017

Cytochrome c: functions beyond respiration

1 reference

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30 September 2017

Mitochondrial fragmentation in neurodegeneration

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3575199

30 September 2017

OPA1 mutations induce mitochondrial DNA instability and optic atrophy 'plus' phenotypes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3575199

30 September 2017

Functions and dysfunctions of mitochondrial dynamics

1 reference

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30 September 2017

Regulation of the mitochondrial dynamin-like protein Opa1 by proteolytic cleavage

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3575199

30 September 2017

OPA1 processing controls mitochondrial fusion and is regulated by mRNA splicing, membrane potential, and Yme1L.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3575199

30 September 2017

A splice site mutation in the murine Opa1 gene features pathology of autosomal dominant optic atrophy.

1 reference

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Mitochondrial dysfunction and oxidative stress in neurodegenerative diseases

1 reference

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30 September 2017

Proteolytic processing of OPA1 links mitochondrial dysfunction to alterations in mitochondrial morphology

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3575199

30 September 2017

OPA1 controls apoptotic cristae remodeling independently from mitochondrial fusion

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3575199

30 September 2017

Mitochondrial rhomboid PARL regulates cytochrome c release during apoptosis via OPA1-dependent cristae remodeling

1 reference

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30 September 2017

Regulation of mitochondrial morphology through proteolytic cleavage of OPA1

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3575199

30 September 2017

Disruption of fusion results in mitochondrial heterogeneity and dysfunction

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3575199

30 September 2017

OPA1 requires mitofusin 1 to promote mitochondrial fusion

1 reference

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Rotenone-induced apoptosis is mediated by p38 and JNK MAP kinases in human dopaminergic SH-SY5Y cells

1 reference

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Mitochondrial fission in apoptosis, neurodegeneration and aging

1 reference

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Localization of dynein light chains 1 and 2 and their pro-apoptotic ligands

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30 September 2017

Oxidative stress in Parkinson's disease

1 reference

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30 September 2017

Loss of OPA1 perturbates the mitochondrial inner membrane structure and integrity, leading to cytochrome c release and apoptosis

1 reference

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Spatial and temporal association of Bax with mitochondrial fission sites, Drp1, and Mfn2 during apoptosis

1 reference

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30 September 2017

Is oxidative damage the fundamental pathogenic mechanism of Alzheimer's and other neurodegenerative diseases?

1 reference

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30 September 2017

Caspase activation of mammalian sterile 20-like kinase 3 (Mst3). Nuclear translocation and induction of apoptosis

1 reference

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30 September 2017

Mutation spectrum and splicing variants in the OPA1 gene

1 reference

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30 September 2017

Signal transduction by the JNK group of MAP kinases

1 reference

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30 September 2017

Nuclear gene OPA1, encoding a mitochondrial dynamin-related protein, is mutated in dominant optic atrophy

1 reference

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Proteolytic activation of PKN by caspase-3 or related protease during apoptosis

1 reference

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Cleavage of BID by caspase 8 mediates the mitochondrial damage in the Fas pathway of apoptosis

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Activation of hPAK65 by caspase cleavage induces some of the morphological and biochemical changes of apoptosis

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Defective mitochondrial adenosine triphosphate production in skeletal muscle from patients with dominant optic atrophy due to OPA1 mutations.

1 reference

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Assay and properties of the mitochondrial dynamin related protein Opa1.

1 reference

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1 reference

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Rotenone inhibition of tubulin self-assembly

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20 September 2018

Unopposed mitochondrial fission leads to severe lifespan shortening.

1 reference

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20 September 2018

Subtle neurological and metabolic abnormalities in an Opa1 mouse model of autosomal dominant optic atrophy

1 reference

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20 September 2018

OPA1 mutations associated with dominant optic atrophy impair oxidative phosphorylation and mitochondrial fusion

1 reference

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20 September 2018

Metalloprotease-mediated OPA1 processing is modulated by the mitochondrial membrane potential

1 reference

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Mitochondrial fission is an upstream and required event for bax foci formation in response to nitric oxide in cortical neurons.

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The parkinsonism producing neurotoxin MPP+ affects microtubule dynamics by acting as a destabilising factor

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Loss of the intermembrane space protein Mgm1/OPA1 induces swelling and localized constrictions along the lengths of mitochondria

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Peroxynitrite oxidation of tubulin sulfhydryls inhibits microtubule polymerization

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Widespread peroxynitrite-mediated damage in Alzheimer's disease.

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Loss of molecular interaction between cytochrome c and cardiolipin due to lipid peroxidation

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12 December 2020

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1 reference

https://pubmed.ncbi.nlm.nih.gov/23220553

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based on heuristic

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Proteolytic activation of protein kinase C-epsilon by caspase-mediated processing and transduction of antiapoptotic signals

1 reference

https://pubmed.ncbi.nlm.nih.gov/23220553

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1016/J.BRAINRES.2012.12.001

1 reference

Europe PubMed Central

PMC publication ID

15 August 2017

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

15 August 2017

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

15 August 2017

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