(Q36629300)

15 August 2017

Computational assessment of drug-induced effects on the electrocardiogram: from ion channel to body surface potentials (English)

1 reference

15 August 2017

1 reference

Joe Pitt-Francis

7

0 references

Nejib Zemzemi

Nejib Zemzemi

1

0 references

Jonathan Cooper

Jonathan Cooper

4

0 references

Javier Saiz

Javier Saiz

3

0 references

Gary R. Mirams

Gary R Mirams

6

0 references

author name string

Miguel O Bernabeu

2

1 reference

15 August 2017

Pras Pathmanathan

5

1 reference

15 August 2017

Blanca Rodriguez

8

1 reference

15 August 2017

language of work or name

English

0 references

publication date

1 February 2013

1 reference

British Journal of Pharmacology

15 August 2017

1 reference

15 August 2017

168

1 reference

15 August 2017

3

1 reference

15 August 2017

718-733

1 reference

Repolarization gradients in the intact heart: transmural or apico-basal?

15 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3579290

Verification of cardiac tissue electrophysiology simulators using an N-version benchmark.

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3579290

A computational model to predict the effects of class I anti-arrhythmic drugs on ventricular rhythms

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3579290

Rabbit-specific ventricular model of cardiac electrophysiological function including specialized conduction system

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3579290

Novel approaches to assessing cardiac safety--proceedings of a workshop: regulators, industry and academia discuss the future of in silico cardiac modelling to predict the proarrhythmic safety of drugs

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3579290

Simulation of multiple ion channel block provides improved early prediction of compounds' clinical torsadogenic risk

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3579290

An evaluation of hERG current assay performance: Translating preclinical safety studies to clinical QT prolongation

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3579290

A numerical guide to the solution of the bi-domain equations of cardiac electrophysiology

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3579290

Arrhythmic risk biomarkers for the assessment of drug cardiotoxicity: from experiments to computer simulations

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3579290

Predicting drug-induced slowing of conduction and pro-arrhythmia: identifying the 'bad' sodium current blockers

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3579290

An introduction to QT interval prolongation and non-clinical approaches to assessing and reducing risk

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3579290

Transmural dispersion of repolarization in failing and nonfailing human ventricle

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3579290

Modeling and simulation of preclinical cardiac safety: towards an integrative framework

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3579290

Multiscale modelling of drug-induced effects on cardiac electrophysiological activity

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3579290

Physiological properties of hERG 1a/1b heteromeric currents and a hERG 1b-specific mutation associated with Long-QT syndrome

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3579290

The hERG potassium channel and hERG screening for drug-induced torsades de pointes

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3579290

Principles of safety pharmacology

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3579290

Safety and secondary pharmacology: successes, threats, challenges and opportunities

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3579290

Computational models of the heart and their use in assessing the actions of drugs

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3579290

Predicting drug-induced changes in QT interval and arrhythmias: QT-shortening drugs point to gaps in the ICHS7B Guidelines

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3579290

Sex, age, and regional differences in L-type calcium current are important determinants of arrhythmia phenotype in rabbit hearts with drug-induced long QT type 2

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3579290

Cardiac side effects of psychiatric drugs

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3579290

Estimating the cost of new drug development: is it really 802 million dollars?

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3579290

Predicting drug-hERG channel interactions that cause acquired long QT syndrome.

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3579290

QT prolongation through hERG K(+) channel blockade: current knowledge and strategies for the early prediction during drug development

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3579290

Review of the predictive value of the Langendorff heart model (Screenit system) in assessing the proarrhythmic potential of drugs

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3579290

Sex differences in ventricular repolarization: from cardiac electrophysiology to Torsades de Pointes

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3579290

Drug induced QT prolongation and torsades de pointes

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3579290

Ventricular repolarization components on the electrocardiogram: cellular basis and clinical significance

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3579290

Relationships between preclinical cardiac electrophysiology, clinical QT interval prolongation and torsade de pointes for a broad range of drugs: evidence for a provisional safety margin in drug development

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3579290

Ionic current basis of electrocardiographic waveforms: a model study

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3579290

Relation between QT and RR intervals is highly individual among healthy subjects: implications for heart rate correction of the QT interval

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3579290

HERG K+ channels: friend and foe.

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3579290

Progress in the understanding of cardiac early afterdepolarizations and torsades de pointes: time to revise current concepts

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3579290

In vitro and in vivo drug interactions involving human CYP3A.

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3579290

Spatial features of calcium transients during early and delayed afterdepolarizations

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3579290

A molecular basis for cardiac arrhythmia: HERG mutations cause long QT syndrome

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3579290

Torsade De Pointes, an atypical ventricular tachycardia

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3579290

The Na+/K+ pump is an important modulator of refractoriness and rotor dynamics in human atrial tissue

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3579290

Influence of I(Ks) heterogeneities on the genesis of the T-wave: a computational evaluation.

28 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3579290

Mathematical modeling of electrocardiograms: a numerical study.

28 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3579290

Relation between QT intervals and heart rates from 40 to 120 beats/min in rest electrocardiograms of men and a simple method to adjust QT interval values.

28 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3579290

Differentiation of the transmembrane Na and Ca channels in mammalian cardiac fibres by the use of specific inhibitors.

28 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3579290

Effects of quinidine on action potentials and ionic currents in isolated canine ventricular myocytes.

28 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3579290

Directional differences of impulse spread in trabecular muscle from mammalian heart

28 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3579290

An in silico canine cardiac midmyocardial action potential duration model as a tool for early drug safety assessment.

28 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3579290

Effects of the antiarrhythmic drug dofetilide on transmural dispersion of repolarization in ventriculum. A computer modeling study.

20 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3579290

Mechanisms of ventricular rate adaptation as a predictor of arrhythmic risk

20 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3579290

Impact of ionic current variability on human ventricular cellular electrophysiology.

20 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3579290

Cardiac anisotropy in boundary-element models for the electrocardiogram

20 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3579290

Cell model for efficient simulation of wave propagation in human ventricular tissue under normal and pathological conditions.

20 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3579290

Cardiac excitation-contraction coupling is altered in myocytes from aged male mice but not in cells from aged female mice.

20 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3579290

Common sodium channel promoter haplotype in asian subjects underlies variability in cardiac conduction.

20 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3579290

Gender disparities in cardiac cellular electrophysiology and arrhythmia susceptibility in human failing ventricular myocytes.

20 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3579290

Activation dynamics in anisotropic cardiac tissue via decoupling.

20 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3579290

The relationship of clinical QT prolongation to outcome in the conscious dog using a beat-to-beat QT-RR interval assessment

20 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3579290

Comparison of Rule-Based and DTMRI-Derived Fibre Architecture in a Whole Rat Ventricular Computational Model

20 September 2018

1 reference

Crossref

https://api.crossref.org/works/10.1111%2FJ.1476-5381.2012.02200.X

Chaste: A test-driven approach to software development for biological modelling

21 January 2018

1 reference

Crossref

https://api.crossref.org/works/10.1111%2FJ.1476-5381.2012.02200.X

Linking a genetic defect to its cellular phenotype in a cardiac arrhythmia

21 January 2018

1 reference

Crossref

https://api.crossref.org/works/10.1111%2FJ.1476-5381.2012.02200.X

EEG Electrode Sensitivity-An Application of Reciprocity

21 January 2018

1 reference

12 December 2020

Anisotropy in the dielectric properties of skeletal muscle

1 reference

12 December 2020

Extracellular potassium modulation of drug block of IKr. Implications for torsade de pointes and reverse use-dependence

1 reference

12 December 2020

Sodium channel block with mexiletine is effective in reducing dispersion of repolarization and preventing torsade des pointes in LQT2 and LQT3 models of the long-QT syndrome

1 reference

12 December 2020

The conductivity of living tissues

1 reference

12 December 2020

Anti-HERG activity and the risk of drug-induced arrhythmias and sudden death

1 reference

12 December 2020

Non-cardiac QTc-prolonging drugs and the risk of sudden cardiac death

1 reference

12 December 2020

Instability and triangulation of the action potential predict serious proarrhythmia, but action potential duration prolongation is antiarrhythmic

1 reference

12 December 2020

Cellular consequences of HERG mutations in the long QT syndrome: precursors to sudden cardiac death

1 reference

12 December 2020

Interaction of specialized cardiac conduction system with antiarrhythmic drugs: a simulation study

1 reference

12 December 2020

10.1111/J.1476-5381.2012.02200.X

Identifiers

DOI

1 reference

15 August 2017

1 reference

15 August 2017

PubMed publication ID

22946617

1 reference