(Q36638623)

English

The structures of the E22Δ mutant-type amyloid-β alloforms and the impact of E22Δ mutation on the structures of the wild-type amyloid-β alloforms.

scientific article published on 18 December 2012

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scholarly article

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24 February 2020

The structures of the E22Δ mutant-type amyloid-β alloforms and the impact of E22Δ mutation on the structures of the wild-type amyloid-β alloforms (English)

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24 February 2020

3

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24 February 2020

Orkide Coşkuner-Weber

1

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24 February 2020

author name string

Olivia Wise-Scira

2

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24 February 2020

Taizo Kitahara

4

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24 February 2020

publication date

18 December 2012

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24 February 2020

ACS Chemical Neuroscience

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24 February 2020

4

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24 February 2020

2

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24 February 2020

310-320

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24 February 2020

Structures and free energy landscapes of aqueous zinc(II)-bound amyloid-β(1-40) and zinc(II)-bound amyloid-β(1-42) with dynamics.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3582298

30 September 2017

Amyloid-β peptide structure in aqueous solution varies with fragment size

1 reference

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30 September 2017

The Japanese Mutant Aβ (ΔE22-Aβ1−39) Forms Fibrils Instantaneously, with Low-Thioflavin T Fluorescence: Seeding of Wild-Type Aβ1−40into Atypical Fibrils by ΔE22-Aβ1−39

1 reference

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30 September 2017

Atomic-level characterization of the ensemble of the Aβ(1-42) monomer in water using unbiased molecular dynamics simulations and spectral algorithms

1 reference

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30 September 2017

Influence of preformed Asp23-Lys28 salt bridge on the conformational fluctuations of monomers and dimers of Abeta peptides with implications for rates of fibril formation

1 reference

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30 September 2017

Amyloid beta-protein assembly and Alzheimer disease

1 reference

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30 September 2017

Amyloid beta-protein monomer folding: free-energy surfaces reveal alloform-specific differences

1 reference

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30 September 2017

Effects of familial Alzheimer's disease mutations on the folding nucleation of the amyloid beta-protein

1 reference

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30 September 2017

Amyloid-beta E22Delta variant induces synaptic alteration in mouse hippocampal slices

1 reference

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30 September 2017

The Alzheimer's peptides Abeta40 and 42 adopt distinct conformations in water: a combined MD / NMR study

1 reference

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30 September 2017

Comparison of multiple Amber force fields and development of improved protein backbone parameters

1 reference

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30 September 2017

The alpha-to-beta conformational transition of Alzheimer's Abeta-(1-42) peptide in aqueous media is reversible: a step by step conformational analysis suggests the location of beta conformation seeding

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3582298

30 September 2017

Solvent and mutation effects on the nucleation of amyloid beta-protein folding

1 reference

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30 September 2017

The amyloid-beta precursor protein: integrating structure with biological function

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3582298

30 September 2017

Folding events in the 21-30 region of amyloid beta-protein (Abeta) studied in silico

1 reference

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30 September 2017

Novel amyloid precursor protein gene missense mutation (D678N) in probable familial Alzheimer's disease

1 reference

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30 September 2017

Exploring protein native states and large-scale conformational changes with a modified generalized born model

1 reference

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30 September 2017

MD simulation of protein-ligand interaction: formation and dissociation of an insulin-phenol complex

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3582298

30 September 2017

Amyloid beta -protein (Abeta) assembly: Abeta 40 and Abeta 42 oligomerize through distinct pathways

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3582298

30 September 2017

The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3582298

30 September 2017

The 'Arctic' APP mutation (E693G) causes Alzheimer's disease by enhanced Abeta protofibril formation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3582298

30 September 2017

Calculating structures and free energies of complex molecules: combining molecular mechanics and continuum models

1 reference

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30 September 2017

Translating cell biology into therapeutic advances in Alzheimer's disease

1 reference

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30 September 2017

Distinct sites of intracellular production for Alzheimer's disease A beta40/42 amyloid peptides.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3582298

30 September 2017

Kinetic theory of fibrillogenesis of amyloid beta-protein

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3582298

30 September 2017

On the nucleation and growth of amyloid beta-protein fibrils: detection of nuclei and quantitation of rate constants

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3582298

30 September 2017

The carboxy terminus of the beta amyloid protein is critical for the seeding of amyloid formation: implications for the pathogenesis of Alzheimer's disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3582298

30 September 2017

Structure-activity analyses of beta-amyloid peptides: contributions of the beta 25-35 region to aggregation and neurotoxicity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3582298

30 September 2017

Structure of amyloid A4-(1-40)-peptide of Alzheimer's disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3582298

30 September 2017

Dictionary of protein secondary structure: pattern recognition of hydrogen-bonded and geometrical features

1 reference

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30 September 2017

Alzheimer's disease: the amyloid cascade hypothesis

1 reference

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30 September 2017

Structural dynamics of the ΔE22 (Osaka) familial Alzheimer's disease-linked amyloid β-protein.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3582298

28 June 2018

E22Δ Mutation in Amyloid β-Protein Promotes β-Sheet Transformation, Radical Production, and Synaptotoxicity, But Not Neurotoxicity.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3582298

28 June 2018

Amyloid beta-protein monomer structure: a computational and experimental study.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3582298

28 June 2018

On the nucleation of amyloid beta-protein monomer folding

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3582298

28 June 2018

Probing and trapping a sensitive conformation: amyloid-β fibrils, oligomers, and dimers.

1 reference

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20 September 2018

Alzheimer's disease amyloid β-protein mutations and deletions that define neuronal binding/internalization as early stage nonfibrillar/fibrillar aggregates and late stage fibrils.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3582298

20 September 2018

A mouse model of amyloid beta oligomers: their contribution to synaptic alteration, abnormal tau phosphorylation, glial activation, and neuronal loss in vivo.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3582298

20 September 2018

A temperature predictor for parallel tempering simulations.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3582298

20 September 2018

Comparative molecular dynamics studies of wild-type and oxidized forms of full-length Alzheimer amyloid beta-peptides Abeta(1-40) and Abeta(1-42).

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3582298

20 September 2018

A new amyloid beta variant favoring oligomerization in Alzheimer's-type dementia.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3582298

20 September 2018

Characterizations of distinct amyloidogenic conformations of the Abeta (1-40) and (1-42) peptides.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3582298

20 September 2018

Structure of the 21-30 fragment of amyloid beta-protein.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3582298

20 September 2018

Solution NMR studies of the A beta(1-40) and A beta(1-42) peptides establish that the Met35 oxidation state affects the mechanism of amyloid formation

1 reference

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20 September 2018

Neurotoxicity and physicochemical properties of Abeta mutant peptides from cerebral amyloid angiopathy: implication for the pathogenesis of cerebral amyloid angiopathy and Alzheimer's disease

1 reference

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20 September 2018

Early onset familial Alzheimer's disease: Mutation frequency in 31 families.

1 reference

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20 September 2018

Oligomeric and fibrillar species of amyloid-beta peptides differentially affect neuronal viability.

1 reference

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20 September 2018

Novel amyloid precursor protein mutation in an Iowa family with dementia and severe cerebral amyloid angiopathy

1 reference

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20 September 2018

Structural and kinetic features of amyloid beta-protein fibrillogenesis.

1 reference

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20 September 2018

Amyloid beta-protein fibrillogenesis. Detection of a protofibrillar intermediate.

1 reference

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20 September 2018

Evidence that A beta 42 is the real culprit in Alzheimer's disease.

1 reference

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20 September 2018

Dynamics of Asp23-Lys28 salt-bridge formation in Abeta10-35 monomers

1 reference

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21 October 2018

The Osaka FAD mutation E22Δ leads to the formation of a previously unknown type of amyloid β fibrils and modulates Aβ neurotoxicity

1 reference

https://pubmed.ncbi.nlm.nih.gov/23421682

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Replica Temperatures for Uniform Exchange and Efficient Roundtrip Times in Explicit Solvent Parallel Tempering Simulations

1 reference

https://pubmed.ncbi.nlm.nih.gov/23421682

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Secondary structure of amyloid beta peptide correlates with neurotoxic activity in vitro

1 reference

https://pubmed.ncbi.nlm.nih.gov/23421682

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1021/CN300149J

1 reference

Europe PubMed Central

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24 February 2020

1 reference

Europe PubMed Central

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24 February 2020

1 reference

Europe PubMed Central

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24 February 2020

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