(Q36659976)

15 August 2017

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title

SIRT1: linking adaptive cellular responses to aging-associated changes in organismal physiology (English)

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15 August 2017

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Dimitrios Anastasiou

1

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15 August 2017

Wilhelm Krek

series ordinal

2

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15 August 2017

publication date

1 December 2006

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15 August 2017

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15 August 2017

volume

21

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15 August 2017

page(s)

404-410

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Silent information regulator 2alpha, a longevity factor and class III histone deacetylase, is an essential endogenous apoptosis inhibitor in cardiac myocytes

15 August 2017

cites work

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00031.2006

Increased nuclear NAD biosynthesis and SIRT1 activation prevent axonal degeneration

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00031.2006

Therapeutic potential of resveratrol: the in vivo evidence

21 January 2018

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https://api.crossref.org/works/10.1152%2FPHYSIOL.00031.2006

The Sir2 family of protein deacetylases

21 January 2018

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https://api.crossref.org/works/10.1152%2FPHYSIOL.00031.2006

Extended longevity in mice lacking the insulin receptor in adipose tissue

21 January 2018

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https://api.crossref.org/works/10.1152%2FPHYSIOL.00031.2006

Post-translational modification of p53 in tumorigenesis

21 January 2018

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https://api.crossref.org/works/10.1152%2FPHYSIOL.00031.2006

Calorie restriction, SIRT1 and metabolism: understanding longevity

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00031.2006

Sirt1 regulates insulin secretion by repressing UCP2 in pancreatic beta cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00031.2006

Advances in protein kinase B signalling: AKTion on multiple fronts

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00031.2006

Stress-dependent regulation of FOXO transcription factors by the SIRT1 deacetylase

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00031.2006

Senescent cells, tumor suppression, and organismal aging: good citizens, bad neighbors

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00031.2006

Shaping the nuclear action of NF-kappaB

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00031.2006

Tumor suppressor HIC1 directly regulates SIRT1 to modulate p53-dependent DNA-damage responses

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00031.2006

Developmental defects and p53 hyperacetylation in Sir2 homolog (SIRT1)-deficient mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00031.2006

Control of multidrug resistance gene mdr1 and cancer resistance to chemotherapy by the longevity gene sirt1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00031.2006

Mammalian SIRT1 limits replicative life span in response to chronic genotoxic stress

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00031.2006

Acetylation of the C terminus of Ku70 by CBP and PCAF controls Bax-mediated apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00031.2006

Silent information regulator 2 potentiates Foxo1-mediated transcription through its deacetylase activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00031.2006

Linking chromatin function with metabolic networks: Sir2 family of NAD(+)-dependent deacetylases

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00031.2006

The Sir 2 family of protein deacetylases

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00031.2006

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00031.2006

Obesity wars: molecular progress confronts an expanding epidemic

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00031.2006

Loss of acetylation at Lys16 and trimethylation at Lys20 of histone H4 is a common hallmark of human cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00031.2006

Phylogenetic classification of prokaryotic and eukaryotic Sir2-like proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00031.2006

Sir2 regulates skeletal muscle differentiation as a potential sensor of the redox state

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00031.2006

The interaction between FOXO and SIRT1: tipping the balance towards survival

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00031.2006

Calorie restriction--the SIR2 connection

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00031.2006

The future of aging therapies

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00031.2006

Sirtuins deacetylate and activate mammalian acetyl-CoA synthetases

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00031.2006

21 January 2018

The Hallmarks of Cancer

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00031.2006

What functions do linker histones provide?

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00031.2006

IkappaB kinase promotes tumorigenesis through inhibition of forkhead FOXO3a

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00031.2006

Transcriptional silencing and longevity protein Sir2 is an NAD-dependent histone deacetylase

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00031.2006

NF-kappaB and cancer: mechanisms and targets

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00031.2006

Innate immunity gone awry: linking microbial infections to chronic inflammation and cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00031.2006

The plasticity of aging: insights from long-lived mutants

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00031.2006

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00031.2006

FoxO1 protects against pancreatic beta cell failure through NeuroD and MafA induction

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00031.2006

Acetylation: a regulatory modification to rival phosphorylation?

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00031.2006

Composition and histone substrates of polycomb repressive group complexes change during cellular differentiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00031.2006

Human SIR2 deacetylates p53 and antagonizes PML/p53-induced cellular senescence

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00031.2006

Mouse Sir2 homolog SIRT6 is a nuclear ADP-ribosyltransferase

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00031.2006

DNA repair, genome stability, and aging

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00031.2006

Towards a molecular understanding of adaptive thermogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00031.2006

A work in progress: the metabolic syndrome.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00031.2006

Negative control of p53 by Sir2alpha promotes cell survival under stress

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00031.2006

The mammalian SIR2alpha protein has a role in embryogenesis and gametogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00031.2006

Histone deacetylase inhibitors and the promise of epigenetic (and more) treatments for cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00031.2006

Genomic instability and aging-like phenotype in the absence of mammalian SIRT6

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00031.2006

Mammalian SIRT1 represses forkhead transcription factors

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00031.2006

IGF-1, inflammation and stem cells: interactions during muscle regeneration.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00031.2006

Increased dosage of mammalian Sir2 in pancreatic beta cells enhances glucose-stimulated insulin secretion in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00031.2006

Mechanisms of ageing: public or private?

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00031.2006

Sirt1 promotes fat mobilization in white adipocytes by repressing PPAR-gamma

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00031.2006

Akt-dependent transformation: there is more to growth than just surviving

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00031.2006

Insulin-like growth factors and neoplasia.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00031.2006

Inhibition of SIRT1 reactivates silenced cancer genes without loss of promoter DNA hypermethylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00031.2006

A novel mechanism of gene regulation and tumor suppression by the transcription factor FKHR.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00031.2006

Resveratrol mimics ischemic preconditioning in the brain

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00031.2006

Cell biology. Twists in the tale of the aging yeast

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00031.2006

Nutrient control of glucose homeostasis through a complex of PGC-1alpha and SIRT1

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00031.2006

Predominant expression of Sir2alpha, an NAD-dependent histone deacetylase, in the embryonic mouse heart and brain.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00031.2006

Sir2-dependent activation of acetyl-CoA synthetase by deacetylation of active lysine

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00031.2006

Identification of the protein acetyltransferase (Pat) enzyme that acetylates acetyl-CoA synthetase in Salmonella enterica

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00031.2006

Increased dosage of a sir-2 gene extends lifespan in Caenorhabditis elegans

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00031.2006

FOXO4 is acetylated upon peroxide stress and deacetylated by the longevity protein hSir2(SIRT1)

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00031.2006

The constantly changing face of chromatin

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00031.2006

Human SirT1 interacts with histone H1 and promotes formation of facultative heterochromatin

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00031.2006

hSIR2(SIRT1) functions as an NAD-dependent p53 deacetylase

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00031.2006

Suppression of FOXO1 activity by FHL2 through SIRT1-mediated deacetylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00031.2006

Distinct pathways of insulin-regulated versus diabetes-regulated gene expression: an in vivo analysis in MIRKO mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00031.2006

Modulation of NF-kappaB-dependent transcription and cell survival by the SIRT1 deacetylase

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00031.2006

Regulation of MEF2 by histone deacetylase 4- and SIRT1 deacetylase-mediated lysine modifications

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00031.2006

10.1152/PHYSIOL.00031.2006

21 January 2018

Identifiers

DOI

1 reference

15 August 2017

1 reference